Tae Hoon Lee

Sungkyunkwan University, Sŏul, Seoul, South Korea

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Publications (106)292.36 Total impact

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    ABSTRACT: Inpatient status can cause inadequate bowel preparation. The majority of previous studies regarding bowel preparation have focused on comparing the effects of different purgative regimens in outpatients. However, data on bowel preparation for inpatients are lacking. The aim of this study was to investigate whether bisacodyl plus polyethylene glycol (PEG) can improve bowel preparation in hospitalized patients. A prospective, randomized and observer-blind study was performed. A total of 196 hospitalized patients undergoing colonoscopy were randomized to receive 4 L PEG (PEG only group) or 4 L PEG+bisacodyl 10 mg (bisacodyl added group). The adequacy of bowel preparation was scored using the Ottawa bowel preparation scale. One hundred and eighty-three subjects completed the study; 96 in the bisacodyl added group and 87 in the PEG only group. There were no significant differences between the bisacodyl added group and the PEG only group with respect to the score of bowel cleansing (3.59±B1;2.81 vs. 3.82±B1;3.03, p=0.607), quality of bowel cleansing (adequate preparation 89.6% vs. 85.1%, p=0.380), and overall adverse events (66.7% vs. 52.9%, p=0.057). However, a larger proportion of patients in the PEG only group were able to ingest the entire solution as prescribed than in the bisacodyl added group (98.9% vs. 75.0%, p<0.001). In hospitalized patients, the quality of bowel preparation did not differ depending on whether bisacodyl is added or not. In addition, patient compliance based on consumption of cleansing agent was better in the PEG only group. (Korean J Gastroenterol 2014;64:268-277).
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 11/2014; 64(5):268-77.
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    ABSTRACT: New or missed gastric cancer rates after negative endoscopy are high. However, the clinicopathologic characteristics of missed or interval early gastric cancer (EGC) are not well known. The aim of this study was to evaluate clinicopathologic and endoscopic characteristics of missed or interval EGC after negative endoscopy.
    Digestive Diseases and Sciences 10/2014; · 2.26 Impact Factor
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    ABSTRACT: Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status.
    Endocrinology and metabolism (Seoul, Korea). 09/2014;
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    ABSTRACT: Chronic kidney disease (CKD) is considered one of the most common risk factors for cardiovascular disease. Coronary artery calcification (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects.
    Endocrinology and metabolism (Seoul, Korea). 09/2014; 29(3):312-9.
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    ABSTRACT: Adenoma detection rate (ADR) is widely used as an index of colonoscopy quality management. Although advanced adenomas can be found less frequently than non-advanced adenomas, advanced adenomas have a higher clinical significance during screening for colorectal cancer. The aim of this study was to investigate the correlation between advanced and non-advanced ADR among colonoscopists.
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 07/2014; 64(1):18-23.
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    ABSTRACT: The hypertriglyceridemic waist (HTGW) phenotype is a simple and inexpensive screening parameter to identify people at increased risk of cardiovascular disease. We evaluated whether the HTGW phenotype predicts diabetes in urban Korean adults.
    Endocrinology and metabolism (Seoul, Korea). 07/2014;
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    ABSTRACT: We demonstrate distinct entanglement of single-walled carbon nanotube (SWCNT) and multiwalled carbon nanotube (MWCNT) clusters in nematic liquid crystal medium using scanning electron microscopy technique and the entanglement influence on electric field-induced stretching phenomena of the said clusters in the same medium under optical microscopy investigation. The observed stretching threshold field for MWCNT clusters is found to be higher than the SWCNT counterpart caused by the interplay between attractive field-induced dipolar interaction of intercarbon nanotube (CNT) bundles and the distinct degree of entanglement of neighboring CNT bundles. Subsequently observed different tensile elasticity modulus results for different CNT kinds also confirm different CNT bundle entanglement and attractive dipolar interaction between adjacent CNT bundles in CNT clusters are responsible for distinct stretching threshold field behavior.
    Physical Review E 07/2014; 90(1-1):012508. · 2.33 Impact Factor
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    ABSTRACT: The risk of various complications after Achilles tendon lengthening is mainly related to the length of surgical exposure and the lengthening method. A comprehensive technique to minimize the complications is required.
    Clinics in orthopedic surgery 06/2014; 6(2):208-215.
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    ABSTRACT: Redox balance has been suggested as an important determinant of “stemness” in embryonic stem cells (ESCs). In this study, we demonstrate that peroxiredoxin (Prx) plays a pivotal role in maintenance of ESC stemness during neurogenesis through suppression of reactive oxygen species (ROS)-sensitive signaling. During neurogenesis, Prx I and Oct4 are expressed in a mutually dependent manner and their expression is abruptly downregulated by an excess of ROS. Thus, in Prx I−/− or Prx II−/− ESCs, rapid loss of stemness can occur due to spontaneous ROS overload, leading to their active commitment into neurons; however, stemness is restored by the addition of an antioxidant or an inhibitor of c-Jun N-terminal kinase (JNK). In addition, Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas. These results suggest that Prx functions as a protector of ESC stemness by opposing ROS/JNK cascades during neurogenesis. Therefore, our findings have important implications for understanding of maintenance of ESC stemness through involvement of antioxidant enzymes and may lead to development of an alternative stem cell-based therapeutic strategy for production of high-quality neurons in large quantity. Stem Cells 2014;32:998–1011
    Stem Cells 04/2014; 32(4). · 7.70 Impact Factor
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    ABSTRACT: The objectives of this study were to assess the potential value of Ki-67 in predicting response to neoadjuvant chemotherapy in breast cancer patients and to suggest a reasonable cutoff value for classifying Ki-67 expression. This study included 74 breast cancer patients who underwent surgery after anthracycline-based neoadjuvant chemotherapy between 2007 and 2012. We analyzed the clinical and immunohistochemical characteristics using core biopsy specimens obtained before neoadjuvant chemotherapy to determine their correlations with the response to chemotherapy. A clinical complete response was observed in 6 patients (8.1%); a clinical partial response, in 44 patients (59.5%); and clinical stable disease, in 24 patients (32.4%). A pathologic complete response (pCR) was observed in 10 patients (13.5%). In univariate analysis, estrogen receptor (ER) negativity (p=0.031), human epidermal growth factor receptor 2 (HER2) positivity (p=0.040), and high Ki-67 expression (p=0.036) were predictive factors for a pCR. In multivariate analysis, Ki-67 was the only independent predictor of a pCR (p=0.049). The analysis of Ki-67 values revealed that 25% was a reasonable cutoff value for predicting the response to chemotherapy. In subgroup analysis, a higher Ki-67 value (≥25%) was a significant predictive factor for the response to neoadjuvant chemotherapy, especially in ER-negative and HER2-positive breast cancer patients. Ki-67 expression in breast cancer tissue may be an effective factor for predicting the response to neoadjuvant chemotherapy. We suggest that a 25% level of Ki-67 expression is a reasonable cutoff value for predicting a response to chemotherapy. Moreover, Ki-67 is a useful predictive factor for pCR, especially in patients with ER-negative and HER2-positive breast cancer.
    Journal of Breast Cancer 03/2014; 17(1):40-6. · 1.32 Impact Factor
  • Sunnyeo Lee, Jonghyun Sim, Tae Hoon Lee
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    ABSTRACT: We consider a Higgs boson field coupled to Brans-Dicke gravity and calculate its contributions to the energy density and pressure in the Friedmann-Robertson-Walker spacetime. We seek de Sitter solutions for the cosmic scale factor with well-incorporated Higgs and Brans-Dicke fields and investigate the stability properties of the solutions by using a linear approximation. We discuss the possibility that the late-time acceleration and the inflationary era of our universe can be described by means of scalar fields with self-interactions and a Yukawa potential.
    01/2014; 64(4).
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    ABSTRACT: We report vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimised ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.
    ACS Nano 01/2014; · 12.03 Impact Factor
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    ABSTRACT: Electric field induced dynamic reorientation phenomenon of graphene/graphitic flakes in homogeneously aligned nematic liquid crystal (NLC) medium has been demonstrated by optical microscopy. The flakes reorient from parallel to perpendicular configuration with respect to boundary plates of confining cells for an applied field strength of as low as tens of millivolt per micrometer. After field removal the reoriented flakes recover to their initial state with the help of relaxation of NLC. Considering flake reorientation phenomenon both in positive and negative dielectric anisotropy NLCs, the reorientation process depends on interfacial Maxwell-Wagner polarization and NLC director reorientation. We propose a phenomenological model based on electric field induced potential energy of graphitic flakes and coupling contribution of positive NLC to generate the rotational kinetic energy for flake reorientation. The model successfully explains the dependence of flake reorientation time over flake shape anisotropy, electric-field strength, and flake area. Using present operating scheme it is possible to generate dark field-off state and bright field-on state, having application potential for electro-optic light modulation devices.
    Optics Express 08/2013; 21(17):19867-19879. · 3.53 Impact Factor
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    ABSTRACT: OBJECTIVES: The mechanism of pancreatitis development following endoscopic papillary balloon dilation (EPBD) remains unknown. Antegrade dilation with percutaneous transhepatic papillary balloon dilation (PTPBD) allows the removal of bile duct stones or fragments during percutaneous choledochoscopic lithotomy, with less mechanical trauma to the papilla than with EPBD-mediated stone removal. METHODS: A total of 56 patients with bile duct stones underwent antegrade dilation with PTPBD from March 2006 to February 2011. A total of 208 patients with CBD stones underwent retrograde dilation with EPBD during the same period. The conditions of papillary balloon dilation were identical in both groups. The frequencies of pancreatitis and hyperamylasemia were compared in both groups. RESULTS: Pancreatitis occurred in 14 (6.7%) of 208 patients in the EPBD group (mild: nine, moderate: four, severe: one). There was no case of pancreatitis among 56 patients in the PTPBD group (P < 0.05). Hyperamylasemia developed in significantly more patients treated in the EPBD group (62, 29.8%) compared with the PTPBD group (4, 7.1%; P < 0.05). Complete bile duct clearance was achieved in 98.2% of PTPBD group and 97.1% of EPBD group. CONCLUSIONS: The rates of post-procedural pancreatitis and hyperamylasemia were significantly higher after retrograde dilation with EPBD than after antegrade dilation with PTPBD for the removal of bile duct stones. Although the mechanism of pancreatitis following papillary balloon dilation remains unclear, post-EPBD pancreatitis may be associated with procedures before and after balloon dilation similar to mechanical lithotripsy, rather than balloon dilation itself.
    Journal of Gastroenterology and Hepatology 05/2013; · 3.33 Impact Factor
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    ABSTRACT: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score. One hundred seven patients with biopsy-proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve. In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate aminotransferase/alanine aminotransferase ratio (OR, 1.73; p<0.01), and international normalized ratio (INR) (OR, 8.85; p<0.01) were independently significant factors. The BARDI score was created by adding the INR to the BARD. The area under the ROC curve of the BARDI score was significantly larger than that of the BARD score (0.881 vs 0.808, p<0.01). A BARDI score of 3 or more showed a positive predictive value (PPV) of 51.0% and a negative predictive value (NPV) of 96.0%. The BARDI score had an improved PPV over the BARD score and maintained an excellent NPV. Further study is warranted for its external validation and comparison with other models.
    Gut and liver 05/2013; 7(3):323-328. · 1.49 Impact Factor
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    ABSTRACT: BACKGROUND: Endoscopic management of recurrent bile duct stones after endoscopic sphincterotomy (EST) is effective and safe. However, repeat EST for extension of a previous EST for recurrent bile duct stones may involve substantial risk. The aim of the present study was to evaluate the safety and efficacy of endoscopic papillary large balloon dilation (EPLBD) without repeat EST for recurrent difficult bile duct stones after previous EST. PATIENTS AND METHODS: From January 2006 to October 2010, a total of 52 patients were enrolled; all had undergone EPLBD (balloon diameter: 12-20 mm) to remove recurrent difficult bile duct stones after previous EST. In all patients, stone removal had failed with conventional methods using a basket and/or balloon. The size of the balloon for EPLBD was selected to fit the diameter of the common bile duct or the largest stone. RESULTS: The median interval between initial EST and stone recurrence was 2.2 years (range 1-10). Median diameters of thelargest stone and balloon were 20.1 mm (range 12-40) and 14.7 mm (range 12-20), respectively. Complete stone removal was achieved in all patients (100%). The median number of endoscopic retrograde cholangiopancreatography sessions needed for complete stone removal was 1.6 (range 1-3). Additional lithotripsy was required in 16 patients (30.7%). No procedure-related complications were documented, with the exception of four cases of asymptomatic hyperamylasemia. The recurrence rate of CBD stones after bile duct clearance was 17.3% (9/52) during the follow-up period (mean 27.0 ± 14.1 months). CONCLUSIONS: EPLBD without repeat EST is effective and relatively safe for the extraction of recurrent difficult bile duct stones after previous EST.
    Digestive Endoscopy 04/2013; · 1.61 Impact Factor
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    Sang Jin Kim, Tae Hoon Lee, Seong Yi
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    ABSTRACT: There are many cases in which degenerative changes are prevalent in both the cervical and lumbar spine, and the relation between both spinal degenerative findings of MRI is controversial. The authors analyzed the prevalence of abnormal findings on MRI, and suggested a model to explain the relationship between cervical and lumbar disc in asymptomatic Korean subjects. We performed 3 T MRI sagittal scans on 102 asymptomatic subjects (50 men and 52 women) who visited our hospital between the ages of 14 and 82 years (mean age 46.3 years). Scores pertaining to herniation (HN), annular fissure (AF), and nucleus degeneration (ND) were analyzed. The total scores for the cervical and lumbar spine were analyzed using correlation coefficients and multiple linear regression with various predictive parameters, including weight, height, sex, age, smoking, occupation, and sedentary fashion. The correlation coefficients of HN, AF, and ND were 0.44, 0.50, and 0.59, respectively. We made the best model for relationship by using multiple linear regression. The results of the current study showed that there was a close relationship between the cervical score (CS) and lumbar score (LS). In addition, the correlation between CS and LS, as well as the LS value itself, can be altered by other explanatory variables. Although not absolute, there was also a linear relationship between degenerative changes of the cervical and lumbar spine. Based on these results, it can be inferred that degenerative changes of the lumbar spine will be useful in predicting the degree of cervical spine degeneration in an actual clinical setting.
    Journal of Korean Neurosurgical Society 03/2013; 53(3):167-73. · 0.52 Impact Factor
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    ABSTRACT: Iatrogenic gastric perforation is one of the most serious complications during therapeutic endoscopy, despite significant advances in endoscopic techniques and devices. This case study evaluated the clinical efficacy and safety of the rescue endoscopic band ligation (EBL) technique in iatrogenic gastric wall perforation following the failure of primary endoclip closure. Five patients were enrolled in this study. These patients underwent emergency endoscopy following the onset of acute gastric wall perforation during endoscopic procedures. The outcome measurements were primary technical success and immediate or delayed procedure-related complications. Successful endoscopic closure using band ligation was reported in all patients, with no complication occurring. We conclude that EBL may be a feasible and safe alternate technique for the management of acute gastric perforation, especially in cases where closure is difficult with endoclips.
    World Journal of Gastroenterology 02/2013; 19(6):955-9. · 2.43 Impact Factor
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    ABSTRACT: BACKGROUND: The submucosal endoscopy provide not only a reliable methods of access and closure for peritoneoscopy, but also an endoscopic working space for full-thickness resection. The aim of this study was to report the clinical outcome of submucosal endoscopy for pure natural orifice transluminal endoscopic surgery. METHODS: We prospectively evaluated 10 patients who received submucosal endoscopies. The indications of submucosal endoscopy were transgastric peritoneoscopy (TGP) and endoscopic full-thickness resection (EFTR) of a gastric subepithelial tumor. All procedures were performed with a standard gastroscope under conscious sedation with the balanced propofol method in the endoscopic unit. After a 40 mm submucosal tunnel was created using an endoscopic submucosal dissection technique, (1) in TGP, balloon dilation of a serosal puncture and intraperitoneal exploration was performed; (2) in EFTR, a full-thickness incision and snaring resection was performed. Closure of the mucosal incision was performed by endoclips. RESULTS: All cases were technically feasible. The mean times for creating the submucosal tunnel, main procedure (peritoneal exploration or resection), and closure were acceptable (10.44 ± 2.42 minutes, 18.80 ± 9.41 minutes, and 5.63 ± 2.17 minutes, respectively). The mean hospital stay was 3.8 ± 1.48 days. All TGPs were diagnostic (4 peritoneal carcinomatosis and 1 tuberculosis). En bloc and complete resections were possible in all EFTRs (3 gastrointestinal stromal tumors and 2 schwannomas; mean tumor size, 20.8 ± 3.27 mm). There were no procedure-related complications, such as significant bleeding or peritonitis. CONCLUSIONS: Human applications of submucosal endoscopy under conscious sedation for pure NOTES were feasible and safe.
    Surgical Endoscopy 02/2013; · 3.31 Impact Factor
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    Tae Hoon Lee, Sang Jin Kim, Soo Mee Lim
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    ABSTRACT: Similar to back pain, neck pain has recently shown to have increasing prevalence. Magnetic resonance imaging (MRI) is useful in identifying the causes of neck pain. However, MRI shows not only pathological lesions but also physiological changes at the same time, and there are few Korean data. The authors have attempted to analyze the prevalence of disc degeneration in highly selective asymptomatic Korean subjects using MRI. We performed 3 T MRI sagittal scans from C2 to T1 on 102 asymptomatic subjects (50 men and 52 women) who visited our hospital between the ages of 14 and 82 years (mean age 46.3 years). All images were read independently by three observers (two neurosurgeons and one neuroradiologist) who were not given any information about the subjects. We classified grading for cervical disc herniation (HN), annular fissure (AF), and nucleus degeneration (ND), using disc degeneration classification. The prevalence of HN, AF, and ND were 81.0%, 85.9%, and 95.4%, respectively. High prevalence of HN, AF, and ND was shown compared to previous literature. In asymptomatic Korean subjects, the abnormal findings of 3 T MRI showed a high prevalence in HN, AF, and ND. Several factors might play important roles in these results, such as population-specific characters, MRI field strength, and disc degeneration grading system.
    Journal of Korean Neurosurgical Society 02/2013; 53(2):89-95. · 0.52 Impact Factor

Publication Stats

553 Citations
292.36 Total Impact Points

Institutions

  • 2014
    • Sungkyunkwan University
      • Department of Physics
      Sŏul, Seoul, South Korea
    • Kangbuk Samsung Hospital
      Sŏul, Seoul, South Korea
    • Chonnam National University
      • Department of Biochemistry
      Gwangju, Gwangju, South Korea
  • 2002–2014
    • Soongsil University
      • Department of Physics
      Sŏul, Seoul, South Korea
  • 2001–2014
    • Pusan National University
      • • Department of Orthopaedic Surgery
      • • Department of Mechanical Engineering
      Tsau-liang-hai, Busan, South Korea
  • 2012–2013
    • Marshall University
      • Department of Internal Medicine
      Huntington, WV, United States
    • Harvard Medical School
      Boston, Massachusetts, United States
  • 2009–2013
    • Soon Chun Hyang University Hospital
      • Department of Gastroenterology
      Sŏul, Seoul, South Korea
    • Pukyong National University
      Tsau-liang-hai, Busan, South Korea
  • 2008–2013
    • Soonchunhyang University
      • College of Medicine
      Onyang, South Chungcheong, South Korea
    • Mayo Foundation for Medical Education and Research
      • Division of Gastroenterology and Hepatology
      Scottsdale, AZ, United States
  • 2011
    • Asan Medical Center
      • Department of Gastroenterology
      Seoul, Seoul, South Korea
    • Kyung Hee University Medical Center
      Sŏul, Seoul, South Korea
  • 2002–2011
    • Yonsei University
      • Department of Electrical and Electronic Engineering
      Sŏul, Seoul, South Korea
  • 2009–2010
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2005–2009
    • Ewha Womans University
      • • Department of Neurosurgery
      • • Department of Science Education
      Sŏul, Seoul, South Korea
  • 2007
    • Mayo Clinic - Rochester
      • Department of Gastroenterology and Hepatology
      Rochester, Minnesota, United States
  • 2003–2004
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea