Karen S Galea

Publications of Karen S Galea

• The relationship between workers' self-reported changes in health and their attitudes towards a workplace intervention: lessons from smoke-free legislation across the UK hospitality industry.

  Authors: Laura Maccalman, Sean Semple, Karen S Galea, Martie van Tongeren, Scott Dempsey, Shona Hilton, Ivan Gee, John G Ayres

  BMC public health. 05/2012; 12(1):324.

  ABSTRACT: BACKGROUND: The evaluation of smoke-free legislation (SFL) in the UK examined the impacts on exposure to second-hand smoke, workers' attitudes and changes in respiratory health. StudiesABSTRACT: BACKGROUND: The evaluation of smoke-free legislation (SFL) in the UK examined the impacts on exposure to second-hand smoke, workers' attitudes and changes in respiratory health. Studies that investigate changes in the health of groups of people often use self-reported symptoms. Due to the subjective nature it is of interest to determine whether workers' attitudes towards the change in their working conditions may be linked to the change in health they report. Bar workers were recruited before the introduction of the SFL in Scotland and England. They were asked about their attitudes towards SFL and the presence of respiratory and sensory symptoms both before SFL and one year later. Here we examine the relationship between initial attitudes and reported symptoms. RESULTS: There was no difference in the initial attitudes towards SFL between those working in Scotland and England. Bar workers who were educated to a higher level tended to be more positive towards SFL. Attitude towards SFL was not found to be related to change in reported symptoms, with the exception of respiratory symptoms reported by Scottish bar workers, where those who were initially more negative to SFL experienced a greater improvement in self-reported health. CONCLUSIONS: There was no evidence that workers who were more positive towards SFL reported greater improvements in respiratory and sensory symptoms. This may not be the case in all interventions and we recommend examining subjects' attitudes towards the proposed intervention when evaluating possible health benefits using self-reported methods.

• Secondhand smoke in cars: assessing children's potential exposure during typical journey conditions.

  Authors: Sean Semple, Andrew Apsley, Karen S Galea, Laura Maccalman, Brenda Friel, Vicki Snelgrove

  Tobacco control. 01/2012;

  ObjectiveTo measure levels of fine particulate matter in the rear passenger area of cars where smoking does and does not take place during typical real-life car journeys.MethodsFine particulateObjectiveTo measure levels of fine particulate matter in the rear passenger area of cars where smoking does and does not take place during typical real-life car journeys.MethodsFine particulate matter (PM(2.5)) was used as a marker of secondhand smoke and was measured and logged every minute of each car journey undertaken by smoking and non-smoking study participants. The monitoring instrument was located at breathing zone height in the rear seating area of each car. Participants were asked to carry out their normal driving and smoking behaviours over a 3-day period.Results17 subjects (14 smokers) completed a total of 104 journeys (63 smoking journeys). Journeys averaged 27 min (range 5-70 min). PM(2.5) levels averaged 85 and 7.4 μg/m(3) during smoking and non-smoking car journeys, respectively. During smoking journeys, peak PM(2.5) concentrations averaged 385 μg/m(3), with one journey measuring over 880 μg/m(3). PM(2.5) concentrations were strongly linked to rate of smoking (cigarettes per minute). Use of forced ventilation and opening of car windows were very common during smoking journeys, but PM(2.5) concentrations were still found to exceed WHO indoor air quality guidance (25 μg/m(3)) at some point in the measurement period during all smoking journeys.ConclusionsPM(2.5) concentrations in cars where smoking takes place are high and greatly exceed international indoor air quality guidance values. Children exposed to these levels of fine particulate are likely to suffer ill-health effects. There are increasing numbers of countries legislating against smoking in cars and such measures may be appropriate to prevent the exposure of children to these high levels of secondhand smoke.

• Biological monitoring of pesticide exposures in residents living near agricultural land.

  Authors: Karen S Galea, Laura MacCalman, Kate Jones, John Cocker, Paul Teedon, Anne J Sleeuwenhoek, John W Cherrie, Martie van Tongeren

  BMC public health. 11/2011; 11:856.

  There is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessingThere is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessing pesticide exposure for regulatory purposes are appropriate for farm workers 1. However, there were indications that the exposures of bystanders may sometimes be underestimated. The previous study did not collect data for residents. Therefore, this study aims to collect measurements to determine if the current methods and tools are appropriate for assessing pesticide exposure for residents living near agricultural fields. The study will recruit owners of farms and orchards (hereafter both will be referred to as farms) that spray their agricultural crops with certain specified pesticides, and which have residential areas in close proximity to these fields. Recruited farms will be asked to provide details of their pesticide usage throughout the spray season. Informed consenting residents (adults (18 years and over) and children (aged 4-12 years)) will be asked to provide urine samples and accompanying activity diaries during the spraying season and in addition for a limited number of weeks before/after the spray season to allow background pesticide metabolite levels to be determined. Selected urine samples will be analysed for the pesticide metabolites of interest. Statistical analysis and mathematical modelling will use the laboratory results, along with the additional data collected from the farmers and residents, to determine systemic exposure levels amongst residents. Surveys will be carried out in selected areas of the United Kingdom over two years (2011 and 2012), covering two spraying seasons and the time between the spraying seasons. The described study protocol was implemented for the sample and data collection procedures carried out in 2011. Based on experience to date, no major changes to the protocol are anticipated for the 2012 spray season although the pesticides and regional areas for inclusion in 2012 are still to be confirmed.

• Oil mist and vapour concentrations from drilling fluids: inter- and intra-laboratory comparison of chemical analyses.

  Authors: Karen S Galea, Alison Searl, Araceli Sánchez-Jiménez, Torill Woldbæk, Kristin Halgard, Syvert Thorud, Kjersti Steinsvåg, Kirsti Krüger, Laura Maccalman, John W Cherrie, Martie van Tongeren

  The Annals of occupational hygiene. 09/2011; 56(1):61-9.

  There are no recognized analytical methods for measuring oil mist and vapours arising from drilling fluids used in offshore petroleum drilling industry. To inform the future development of improvedThere are no recognized analytical methods for measuring oil mist and vapours arising from drilling fluids used in offshore petroleum drilling industry. To inform the future development of improved methods of analysis for oil mist and vapours this study assessed the inter- and intra-laboratory variability in oil mist and vapour analysis. In addition, sample losses during transportation and storage were assessed. Replicate samples for oil mist and vapour were collected using the 37-mm Millipore closed cassette and charcoal tube assembly. Sampling was conducted in a simulated shale shaker room, similar to that found offshore for processing drilling fluids. Samples were analysed at two different laboratories, one in Norway and one in the UK. Oil mist samples were analysed using Fourier transform infrared spectroscopy (FTIR), while oil vapour samples were analysed by gas chromatography (GC). The comparison of replicate samples showed substantial within- and between-laboratory variability in reported oil mist concentrations. The variability in oil vapour results was considerably reduced compared to oil mist, provided that a common method of calibration and quantification was adopted. The study also showed that losses can occur during transportation and storage of samples. There is a need to develop a harmonized method for the quantification of oil mist on filter and oil vapour on charcoal supported by a suitable proficiency testing scheme for laboratories involved in the analysis of occupational hygiene samples for the petroleum industry. The uncertainties in oil mist and vapour measurement have substantial implications in relation to compliance with occupational exposure limits and also in the reliability of any exposure-response information reported in epidemiological studies.

• Comparison of the SidePak personal monitor with the Aerosol Particle Sizer (APS).

  Authors: Araceli Sánchez Jiménez, Martie van Tongeren, Karen S Galea, Kjersti Steinsvåg, Laura MacCalman, John W Cherrie

  Journal of environmental monitoring : JEM. 06/2011; 13(6):1841-6.

  The aim of this study was to compare the performance of the TSI Aerodynamic Particle Sizer (APS) and the TSI portable photometer SidePak to measure airborne oil mist particulate matter (PM) withThe aim of this study was to compare the performance of the TSI Aerodynamic Particle Sizer (APS) and the TSI portable photometer SidePak to measure airborne oil mist particulate matter (PM) with aerodynamic diameters below 10 μm, 2.5 μm and 1 μm (PM(10), PM(2.5) and PM(1)). Three SidePaks each fitted with either a PM(10), PM(2.5) or a PM(1) impactor and an APS were run side by side in a controlled chamber. Oil mist from two different mineral oils and two different drilling fluid systems commonly used in offshore drilling technologies were generated using a nebulizer. Compared to the APS, the SidePaks overestimated the concentration of PM(10) and PM(2.5) by one order of magnitude and PM(1) concentrations by two orders of magnitude after exposure to oil mist for 3.3-6.5 min at concentrations ranging from 0.003 to 18.1 mg m(-3) for PM(10), 0.002 to 3.96 mg m(-3) for PM(2.5) and 0.001 to 0.418 mg m(-3) for PM(1) (as measured by the APS). In a second experiment a SidePak monitor previously exposed to oil mist overestimated PM(10) concentrations by 27% compared to measurements from another SidePak never exposed to oil mist. This could be a result of condensation of oil mist droplets in the optical system of the SidePak. The SidePak is a very useful instrument for personal monitoring in occupational hygiene due to its light weight and quiet pump. However, it may not be suitable for the measurement of particle concentrations from oil mist.

• Effect of drilling fluid systems and temperature on oil mist and vapour levels generated from shale shaker.

  Authors: Kjersti Steinsvåg, Karen S Galea, Kirsti Krüger, Vegard Peikli, Araceli Sánchez-Jiménez, Esther Sætvedt, Alison Searl, John W Cherrie, Martie van Tongeren

  The Annals of occupational hygiene. 01/2011; 55(4):347-56.

  Workers in the drilling section of the offshore petroleum industry are exposed to air pollutants generated by drilling fluids. Oil mist and oil vapour concentrations have been measured in theWorkers in the drilling section of the offshore petroleum industry are exposed to air pollutants generated by drilling fluids. Oil mist and oil vapour concentrations have been measured in the drilling fluid processing areas for decades; however, little work has been carried out to investigate exposure determinants such as drilling fluid viscosity and temperature. A study was undertaken to investigate the effect of two different oil-based drilling fluid systems and their temperature on oil mist, oil vapour, and total volatile organic compounds (TVOC) levels in a simulated shale shaker room at a purpose-built test centre. Oil mist and oil vapour concentrations were sampled simultaneously using a sampling arrangement consisting of a Millipore closed cassette loaded with glass fibre and cellulose acetate filters attached to a backup charcoal tube. TVOCs were measured by a PhoCheck photo-ionization detector direct reading instrument. Concentrations of oil mist, oil vapour, and TVOC in the atmosphere surrounding the shale shaker were assessed during three separate test periods. Two oil-based drilling fluids, denoted 'System 2.0' and 'System 3.5', containing base oils with a viscosity of 2.0 and 3.3-3.7 mm(2) s(-1) at 40°C, respectively, were used at temperatures ranging from 40 to 75°C. In general, the System 2.0 yielded low oil mist levels, but high oil vapour concentrations, while the opposite was found for the System 3.5. Statistical significant differences between the drilling fluid systems were found for oil mist (P = 0.025),vapour (P < 0.001), and TVOC (P = 0.011). Increasing temperature increased the oil mist, oil vapour, and TVOC levels. Oil vapour levels at the test facility exceeded the Norwegian oil vapour occupational exposure limit (OEL) of 30 mg m(-3) when the drilling fluid temperature was ≥50°C. The practice of testing compliance of oil vapour exposure from drilling fluids systems containing base oils with viscosity of ≤2.0 mm(2) s(-1) at 40°C against the Norwegian oil vapour OEL is questioned since these base oils are very similar to white spirit. To reduce exposures, relevant technical control measures in this area are to cool the drilling fluid <50°C before it enters the shale shaker units, enclose shale shakers and related equipment, in addition to careful consideration of which fluid system to use.

• Exposure to rubber process dust and fume since 1970s in the United Kingdom; influence of origin of measurement data.

  Authors: Michela Agostini, Frank de Vocht, Martie van Tongeren, John W Cherrie, Karen S Galea, Hans Kromhout

  Journal of environmental monitoring : JEM. 05/2010; 12(5):1170-8.

  The objective of this study was to compare measured concentrations of rubber process dust and rubber fume originating from different sources in the British rubber manufacturing industry. Almost 8000The objective of this study was to compare measured concentrations of rubber process dust and rubber fume originating from different sources in the British rubber manufacturing industry. Almost 8000 exposure measurements were obtained from industry-based survey results collected by the British Rubber Manufacturers' Association (BRMA), and covering the years 1977 to 2002, and from a series of small surveys contained in the Health and Safety Executive's (HSE) National Exposure Database (HSE-NEDB) from 1980 to 2002. The analysis investigated temporal trends in the exposure concentrations and the underlying main factors responsible for these changes. Analyses were carried out using hierarchical linear mixed effects models. Average personal exposures to rubber process dust and rubber fumes were respectively a factor 2 and 4 higher for the HSE-NEDB data when compared to data originating from the industry (BRMA data). Personal exposure to rubber process dust decreased on average by 4.1% (95% CI 4.7-3.6) annually for the BRMA data and slightly less at 2.3% (95% CI 5.2-0.7%) per annum for the HSE-NEDB data. Personal exposure to rubber fume also showed a downward temporal trend of 2.9% (95% CI 3.6-2.3%) and 4.8% (95% CI 7.4-2.1%) annually for the BRMA and HSE-NEDB data, respectively. These trends differed considerably between departments. No major changes in the estimated temporal trends in exposure concentrations were observed after including the presence of local exhaust ventilation in the models for any department in the BRMA and HSE-NEDB datasets. Lack of information on the quality and status of the local exhaust ventilation is the most likely explanation for this. In conclusion, even though there were relatively similar downward time trends in both rubber process dust and fume concentrations in both datasets, the source of exposure data was an important determinant of average exposure concentrations present in the British rubber manufacturing industry. Lack of detailed auxiliary information on company size, reason for sampling, measurement strategy and other potentially important determinants of exposure prevented an explanation for the observed differences in exposure level.

• UK smoke-free legislation: changes in PM2.5 concentrations in bars in Scotland, England, and Wales.

  Authors: Sean Semple, Martie van Tongeren, Karen S Galea, Laura MacCalman, Ivan Gee, Odette Parry, Audrey Naji, Jon G Ayres

  The Annals of occupational hygiene. 02/2010; 54(3):272-80.

  Evaluate the effect of smoke-free legislation on fine particulate [particulate matter <2.5 microm in diameter (PM(2.5))] air pollution levels in bars in Scotland, England, and Wales. Design: AirEvaluate the effect of smoke-free legislation on fine particulate [particulate matter <2.5 microm in diameter (PM(2.5))] air pollution levels in bars in Scotland, England, and Wales. Design: Air quality was measured in 106 randomly selected bars in Scotland, England, and Wales before and after the introduction of smoking restrictions. PM(2.5) concentrations were measured covertly for 30-min periods before smoke-free legislation was introduced, again at 1-2 months post-ban (except Wales) and then at 12-months post-baseline (except Scotland). In Scotland and England, overt measurements were carried out to assess bar workers' full-shift personal exposures to PM(2.5). Postcode data were used to determine socio-economic status of the bar location. PM(2.5) levels prior to smoke-free legislation were highest in Scotland (median 197 microg m(-3)), followed by Wales (median 184 microg m(-3)) and England (median 92 microg m(-3)). All three countries experienced a substantial reduction in PM(2.5) concentrations following the introduction of the legislation with the median reduction ranging from 84 to 93%. Personal exposure reductions were also within this range. There was evidence that bars located in more deprived postcodes had higher PM(2.5) levels prior to the legislation. Prior to legislation PM(2.5) concentrations within bars across the UK were much higher than the 65 microg m(-3) 'unhealthy' threshold for outdoor air quality as set by the US Environmental Protection Agency. Concentrations in Scottish and Welsh bars were, on average, two or more times greater than in English bars for which seasonal influences may be responsible. Legislation in all three countries produced improvements in indoor air quality that are consistent with other international studies.

• Temporal trends of flour dust exposure in the United Kingdom, 1985-2003.

  Authors: Martie van Tongeren, Karen S Galea, John Ticker, David While, Hans Kromhout, John W Cherrie

  Journal of environmental monitoring : JEM. 09/2009; 11(8):1492-7.

  The aim of the study was to examine the long-term changes in inhalation exposure to flour dust in the UK. Flour dust data held in the UK National Exposure DataBase (NEDB) and from one large companyThe aim of the study was to examine the long-term changes in inhalation exposure to flour dust in the UK. Flour dust data held in the UK National Exposure DataBase (NEDB) and from one large company from 1985 to 2003 were reviewed. Analysis of the log-transformed data was carried out using linear mixed effect models and expressed as the relative annual change in exposure. 1451 inhalable flour dust measurements were analysed. The overall mean flour dust levels ranged from 7.8 mg m(-3) in the bakeries to 17.9 mg m(-3) in the flour mills. Analysis of the data obtained from NEDB and industry revealed no statistically significant temporal trends in exposure. Considering these high levels have persisted over the last 20 years, there is a need for government and industry to implement further measures aimed at reducing flour dust exposures and the risk of developing occupational asthma.

• Trends in Wood Dust Inhalation Exposure in the UK, 1985-2005.

  Authors: Karen S Galea, Martie van Tongeren, Anne J Sleeuwenhoek, David While, Mairi Graham, Annette Bolton, Hans Kromhout, John W Cherrie

  The Annals of occupational hygiene. 08/2009;

  OBJECTIVES: Wood dust data held in the Health and Safety Executive (HSE) National Exposure DataBase (NEDB) were reviewed to investigate the long-term changes in inhalation exposure from 1985 to 2005.OBJECTIVES: Wood dust data held in the Health and Safety Executive (HSE) National Exposure DataBase (NEDB) were reviewed to investigate the long-term changes in inhalation exposure from 1985 to 2005. In addition, follow-up sampling measurements were obtained from selected companies where exposure measurements had been collected prior to 1994, thereby providing a follow-up period of at least 10 years, to determine whether changes in exposure levels had occurred, with key staff being interviewed to identify factors that might be responsible for any changes observed. METHODS: Analysis of the temporal trend in exposure concentrations was performed using Linear Mixed Effect Models on the log-transformed NEDB data set and expressed as the relative annual change in concentration. RESULTS: For the NEDB wood dust data, an annual decline of geometric mean (GM) exposure of 8.1% per year was found based on 1459 exposure measurements collected between 1985 and 2003. This trend was predominantly observed in data from inspection visits (measurements collected on a mandatory basis by a Specialist HSE Inspector) (n = 1009), while data from representative surveys (measurements collected on a voluntary basis to provide information on current practices and exposures) remained relatively stable. Ten follow-up surveys in individual workplaces in 2004-2005 resulted in 70 new measurements and for each of the companies resurveyed, the GM of the wood dust exposure decreased between sampling surveys. CONCLUSION: Analysis of the temporal trend in UK wood dust exposure concentrations revealed declines of 8% per annum. Interviews with key long-serving employees and management suggest that factors such as technological changes in production processes, response to new legislation, and enforcement agency inspections, together with global economic trends, could be linked to the downward trends observed.