Ellen Imbernon

Institut de veille sanitaire, Charenton, Île-de-France, France

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Publications (166)297.3 Total impact

  • M Valenty · J Homère · A Lemaitre · J Plaine · M Ruhlman · C Cohidon · E Imbernon
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    ABSTRACT: The surveillance programme for uncompensated work-related diseases (UWRDs) in France relies on a network of occupational physicians (OPs) who volunteer to report all UWRDs diagnosed during a biannual 2-week observation period. To describe this programme and the usefulness of its results. During the observation period, OPs record job title and employment sector for each worker. For each potential UWRD, they complete a one-page report form. Between 2007 and 2012, the number of reporting OPs ranged from 705 to 965 and they saw between 78884 and 114154 employees annually. The UWRD incidence rate reports varied from 5 to 5.3% for men and from 6.5 to 7.7% for women, with musculoskeletal disorders (MSDs) being most frequent, followed by mental ill-health. Incidence rates, except for hearing loss, were higher for women than men in all categories and, in 2012, were twice as high for women (3.1%) as for men (1.4%) for mental ill-health. Incidence rates in every category increased with age up to 54 years. The highest rates for MSDs were observed among blue-collar workers (6.9% in women and 4% in men in 2012) and the lowest rates in professionals/managers (1.1 and 0.4%, respectively). Conversely, the latter had the highest incidence of mental health disorders (5.9 and 3.3%). This 'Fortnight' protocol provides useful data on the frequency of diseases linked to employment and allows us to estimate the incidence of UWRDs, whether recognized as compensable or not, as well as their trends over time. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    Occupational Medicine 07/2015; DOI:10.1093/occmed/kqv104 · 1.47 Impact Factor
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    ABSTRACT: The aim of Evalutil is to document occupational exposure to asbestos and man-made mineral fibers. These databases provide grouped descriptive and metrological data from observed situations of occupational exposure, collected through the analysis of scientific articles and technical reports by industrial hygienists. Over 5,000 measurements were collected. We describe the occupations, economic activities, fiber-containing products, and operations on them that have been documented most often. Graphical measurement syntheses of these data show that the situations presented for asbestos and RCF, except mineral wools, report fiber concentrations mainly above historical occupational exposure limits. Free access to these data in French and in English on the Internet (https://ssl2.isped.u-bordeaux2.fr/eva_003/) helps public health and prevention professionals to identify and characterize occupational exposures to fibers. Extended recently to nanoscale particles, Evalutil continues to contribute to the improvement of knowledge about exposure to inhaled particles and the health risks associated with them. Am. J. Ind. Med. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    American Journal of Industrial Medicine 07/2015; DOI:10.1002/ajim.22498 · 1.59 Impact Factor
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    ABSTRACT: Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes. As part of a French population-based case-control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CI) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression. There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models and a synergistic interaction between duration and intensity (p-interaction = 0.04). High intensity exposure to insecticides was positively associated with PD among those with low intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (p-heterogeneity = 0.60), for tremor dominant (p--trend < 0.01) than for non-tremor dominant PD (p--trend = 0.24). This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor dominant PD in men, the most typical PD presentation.
    Environmental Health Perspectives 03/2015; DOI:10.1289/ehp.1307970 · 7.98 Impact Factor
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    ABSTRACT: Objective To explore mortality of French professional male firefighters.Methods Standardized mortality ratios (SMR) were calculated for 10,829 professional male firefighters employed in 1979 and compared with the French male population between 1979–2008. Firefighters were identified from 89 French administrative departments (93% of population).ResultsOne thousand six hundred forty two deaths were identified, representing significantly lower all-cause mortality than in the general population (SMR = 0.81; 95%CI: 0.77–0.85). SMR increased with age and was not different from 1 for firefighters >70 years. No significant excess of mortality was observed for any specific cause, but a greater number of deaths than expected were found for various digestive neoplasms (rectum/anus, pancreas, buccal-pharynx, stomach, liver, and larynx).Conclusion We observed lower all and leading-cause mortality likely due to the healthy worker effect in this cohort, with diseases of the respiratory system considerably lower (SMR = 0.57). Non-significant excesses for digestive neoplasms are notable, but should not be over-interpreted at this stage. Am. J. Ind. Med. © 2015 Wiley Periodicals, Inc.
    American Journal of Industrial Medicine 02/2015; 58(4). DOI:10.1002/ajim.22434 · 1.59 Impact Factor
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    ABSTRACT: Objective: To examine the incidence and risk factors for incident thoracic spine pain (TSP) in workers representative of a French region's working population.Methods: Prospective study: 3,710 workers were assessed in 2002-2005, and 2,332 (62.9%) of them were re-assessed in 2007-2010. TSP was assessed by a self-administered Nordic questionnaire at baseline and at follow-up. At baseline all participants completed a self-administered questionnaire on personal factors and work exposure. A total of 1,886 subjects (1,124 men and 762 women) without TSP at baseline were eligible for analysis. Associations between incident TSP and risk factors at baseline were analyzed by multivariate logistic regression.Results: The incidence rate of TSP was 5.2% [95% CI 3.9-6.6]) per 100 males and 10.0 [7.8-12.1] per 100 females. TSP was often associated with low back pain and neck pain. TSP in men was associated with age (ORs ranging from 2.6 [0.95–7.1] at 30-49 years to 6.0 [2.1 –17.3] at 50 years and over), being tall (OR 2.2 [1.2-3.9]), frequent/sustained trunk bending (OR 3.0 [1.5- 6.1]), lack of recovery period or change in the task (OR 2.0 [1.2-3.6]) and driving vehicles (OR 2.8 [1.4-5.5]). Being overweight and obesity were associated with lower risk (OR 0.5 [0.3-0.96]). TSP in women was associated with high perceived physical workload (OR 1.9 [1.1-3.3]), after adjustment for confounding variables.Conclusion: The risk model of TSP combined personal and work-related organizational and physical factors. Trunk bending appeared to be a strong independent predictor of TSP in this working population. © 2014 American College of Rheumatology.
    11/2014; 66(11). DOI:10.1002/acr.22323
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    ABSTRACT: Two years after the 2001 Toulouse industrial disaster, a longitudinal study was set up to evaluate the impact of the disaster. The current substudy examines the medium-term impact (5 years) the incident had on the mental health of 3,004 participants. As part of the monitoring, data relating to the psychotropic drug use of 2,494 participants were collected from administrative databases 4 years after the disaster. Use of psychotropics was higher among women for anxiolytics (10.4% for men and 15.0% for women), hypnotics (10.5% and 17.0%), and antidepressants (7.6% and 11.2%). Exposure to the disaster, especially proximity to the exposure, was significantly associated with the use of antidepressants in men, OR = 3.22, 95% CI[1.57, 6.61]. This was also the case for other exposure factors (saw dead or injury, injured, home damage, death or injury loved one, psychological disorders, exposure toxic fumes): range of OR 1.75 to 2.52 in men, 1.48 to 1.62 in women. In conclusion, this study highlights the medium-term psychological impact of an industrial disaster on psychotropic drug use and the potential for using medical records data as a means for tracking postdisaster mental health.
    Journal of Traumatic Stress 08/2014; 27(4). DOI:10.1002/jts.21940 · 2.72 Impact Factor
  • C. Pilorget · J. Spinosi · M. El Yamani · E. Imbernon
    Archives des Maladies Professionnelles et de l Environnement 06/2014; 75(3):318. DOI:10.1016/j.admp.2014.03.187 · 0.09 Impact Factor
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    ABSTRACT: To estimate prevalence and risk of current asthma among affiliates to the health insurance for self-employed workers according to economic activities.
    Occupational and Environmental Medicine 06/2014; 71 Suppl 1:A19. DOI:10.1136/oemed-2014-102362.60 · 3.23 Impact Factor
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    ABSTRACT: An excessive risk of suicide among agriculture workers has been observed in several studies in France and abroad. Accordingly, French Institute for Public Health Surveillance and Social Insurance in agriculture sector launched collaboration with aim at producing indicators of suicide mortality among agriculture workers population on a regular basis.
    Occupational and Environmental Medicine 06/2014; 71 Suppl 1:A18. DOI:10.1136/oemed-2014-102362.56 · 3.23 Impact Factor
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    ABSTRACT: Background Organizational downsizing has become highly common during the global recession of the late 2000s with severe repercussions on employment. We examine whether the severity of the downsizing process is associated with a greater likelihood of depressive symptoms among displaced workers, internally redeployed workers and lay-off survivors. Methods A cross-sectional survey involving telephone interviews was carried out in France, Hungary, Sweden and the United Kingdom. The study analyzes data from 758 workers affected by medium- and large-scale downsizing, using multiple logistic regression. Main Results Both unemployment and surviving layoffs were significantly associated with depressive symptoms, as compared to reemployment, but the perceived procedural justice of a socially responsible downsizing process considerably mitigated the odds of symptoms. Perception of high versus low justice was assessed along several downsizing dimensions. In the overall sample, chances to have depressive symptoms were significantly reduced if respondents perceived the process as transparent and understandable, fair and unbiased, well planned and democratic; if they trusted the employer’s veracity and agreed with the necessity for downsizing. The burden of symptoms was significantly greater if the process was perceived to be chaotic. We further tested whether perceived justice differently affects the likelihood of depressive symptoms among distinct groups of workers. Findings were that the odds of symptoms largely followed the same patterns of effects across all groups of workers. Redeploying and supporting surplus employees through the career change process–rather than forcing them to become unemployed–makes a substantial difference as to whether they will suffer from depressive symptoms. Conclusions While depressive symptoms affect both unemployed and survivors, a just and socially responsible downsizing process is important for the emotional health of workers.
    PLoS ONE 05/2014; 9(5):e97063. DOI:10.1371/journal.pone.0097063 · 3.23 Impact Factor
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    ABSTRACT: The aim of the study was to assess both personal and occupational risk factors for non-specific neck disorder (ND) in a representative working population characterized by various levels of exposure to work-related constraints. ND during the preceding 7 days was assessed in 3,710 workers surveyed by 83 occupational physicians between 2002 and 2005. Personal risk factors and work exposure were assessed by a standardized examination and a self-administered questionnaire. Associations between ND and personal and occupational factors were analyzed using logistic regression modeling separately in men and in women. Results: The personal risk factors for ND were age (OR for 1-year increment 1.02, 95% CI 1.01 to 1.03 in men and 1.03 [1.01-1.04] in women) and previous history of arthritis disease (OR 2.39 [1.17-4.91] in men and 3.95 [1.92-8.12] in women). The risk of ND increased with previous history or upper limb musculoskeletal disorders in men (OR 1.58 [1.17-2.13]) and decreased with BMI in women (OR for 1-kg/m2 increment 0.96, [0.93-0.99]). The work-related risk factors of ND were sustained or repeated arm abduction (OR 2.08 [1.35-3.21] in men and 2.22 [1.27-3.86] in women) and neck flexion (OR 1.64 [1.26-2.12] in women). Work pace dependent on customers (OR 1.42 [1.10-1.83]) and psychological demand of the task (OR 1.49 [1.15-1.92]) increased the risk of ND in men. Work pace dependent on quantified targets (OR 1.37 [1.05-1.79]) and low supervisor support (OR 1.68 [1.30-2.17]) increased the risk of ND in women. This study highlighted the multifactorial nature of ND.
    Journal of Occupational Health 02/2014; 56(2). DOI:10.1136/oemed-2011-100382.386 · 1.10 Impact Factor
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    ABSTRACT: To estimate the proportion of pleural mesothelioma cases that can be attributed to asbestos exposure in France including non-occupational exposure. A population-based case-control study including 437 incident cases and 874 controls was conducted from 1998 to 2002. Occupational and non-occupational asbestos exposure was assessed retrospectively by two expert hygienists. ORs of pleural mesothelioma for asbestos-exposed subjects compared to non-exposed subjects, and population-attributable risk (ARp) of asbestos exposure were estimated using a conditional logistic regression. A clear dose-response relationship was observed between occupational asbestos exposure and pleural mesothelioma (OR=4.0 (99% CI 1.9 to 8.3) for men exposed at less than 0.1 f/mL-year vs 67.0 (99% CI 25.6 to 175.1) for men exposed at more than 10 f/mL-year). The occupational asbestos ARp was 83.1% (99% CI 74.5% to 91.7%) for men and 41.7% (99% CI 25.3% to 58.0%) for women. A higher risk of pleural mesothelioma was observed in subjects non-occupationally exposed to asbestos compared to those never exposed. The non-occupational asbestos ARp for these subjects was 20.0% (99% CI -33.5% to 73.5%) in men and 38.7% (99% CI 8.4% to 69.0%) in women. When considering all kinds of asbestos exposure, ARp was 87.3% (99% CI 78.9% to 95.7%) for men and 64.8% (99% CI 45.4% to 84.3%) for women. Our study suggests that the overall ARp in women is largely driven by non-occupational asbestos exposure arguing for the strong impact of such exposure in pleural mesothelioma occurrence. Considering the difficulty in assessing domestic or environmental asbestos exposure, this could explain the observed difference in ARp between men and women.
    Thorax 02/2014; 69(6). DOI:10.1136/thoraxjnl-2013-203744 · 8.56 Impact Factor
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    ABSTRACT: Mesothelioma is a rare disease less than 0.3% of cancers in France, very aggressive and resistant to the majority of conventional therapies. Asbestos exposure is nearly the only recognized cause of mesothelioma in men observed in 80% of case. In 1990, the projections based on mortality predicted a raise of incidence in mesothelioma for the next three decades. Nowadays, the diagnosis of this cancer is based on pathology, but the histological presentation frequently heterogeneous, is responsible for numerous pitfalls and major problems of early detection toward effective therapy. Facing such a diagnostic, epidemiological and medico-legal context, a national and international multidisciplinary network has been progressively set up in order to answer to epidemiological survey, translational or academic research questions. Moreover, in response to the action of the French Cancer Program (action 23.1) a network of pathologists was organized for expert pathological second opinion using a standardized procedure of certification for mesothelioma diagnosis. We describe the network organization and show the results during this last 15years period of time from 1998-2013. These results show the major impact on patient's management, and confirm the interest of this second opinion to provide accuracy of epidemiological data, quality of medico-legal acknowledgement and accuracy of clinical diagnostic for the benefit of patients. We also show the impact of these collaborative efforts for creating a high quality clinicobiological, epidemiological and therapeutic data collection for improvement of the knowledge of this dramatic disease.
    Annales de Pathologie 02/2014; 34(1):51-63. DOI:10.1016/j.annpat.2014.01.009 · 0.29 Impact Factor
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    ABSTRACT: This study was designed to describe the difficulties of epidemiological follow-up of employees by occupational health services.
  • Archives des Maladies Professionnelles et de l Environnement 12/2013; 74(6):670. DOI:10.1016/j.admp.2013.09.025 · 0.09 Impact Factor
  • J. Chatelot · M. Houot · M. El Yamani · E. Imbernon
    Archives des Maladies Professionnelles et de l Environnement 12/2013; 74(6):664. DOI:10.1016/j.admp.2012.03.256 · 0.09 Impact Factor
  • Revue d Épidémiologie et de Santé Publique 10/2013; 61:S254. DOI:10.1016/j.respe.2013.07.170 · 0.66 Impact Factor
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    ABSTRACT: In 2003, a cluster of renal cell carcinoma (RCC) cases was reported among men working at a French chemical plant using a proprietary process to produce vitamin A. The 10 index cases yielded a standardised incidence ratio of 13.1 for 1994-2002. Nine of these 10 cases were diagnosed by a plant-specific abdominal ultrasonography screening programme that targeted exposure to an intermediate chemical, 4-chloro-1,1-dimethoxy-3-methyl-2-butene, commonly named 'chloracetal C5', suspected as the cause by some experts. Epidemiological investigations sought to examine the relations between occupational exposures and RCC. A retrospective cohort mortality study and a nested case-control study were conducted. The cohort study included all workers who had been employed at the plant for at least 6 months between 1960 and 2003. The case-control study included an extensive search within the region for other kidney cancer cases among the cohort members. Industrial hygienists assessed occupational exposure. From 1968 to 2006, no significant excess mortality was observed for all causes of death or for all cancers. We found excess mortality for kidney cancer only among women. The nested case-control study showed a dose-response relation for cumulative exposure to chloracetal C5: the OR rose from 2.5 in the low-exposure category to 10.5 in the high-exposure group. Adjustment for screening attenuated this relation. The results of the case-control study were consistent with the positive results of in vivo genotoxic tests and suggest that chloracetal C5 can have a causal role in RCC.
    Occupational and environmental medicine 08/2013; 71(1). DOI:10.1136/oemed-2013-101477 · 3.23 Impact Factor
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    ABSTRACT: More than 80% of mesothelioma cases in men are attributable to occupational asbestos exposure compared to only 40% in women. The objective of the study was to characterize a series of female pleural mesotheliomas according to known and suspected risk factors. From the exhaustive recording of 318 female mesothelioma cases in the French National Mesothelioma Surveillance Program between 1998 and 2009, multiple correspondence analysis and hybrid clustering were performed to characterize these cases according to expert assessed occupational and non-occupational exposure to asbestos and man-made vitreous fibers, X-ray exposure, and history of cancer and non-malignant respiratory diseases. Four clusters were identified: (1) occupational exposure to asbestos and man-made vitreous fibers (7.9% of subjects); (2) radiation exposure during radiotherapy (12.9%); (3) increased asbestos exposure (19.8%); and (4) "non-exposure" characteristics (59.4%). These results will allow hypotheses to be generated about associations between mesothelioma and non-occupational asbestos exposure, X-ray exposure and history of respiratory disease. Am. J. Ind. Med. © 2013 Wiley Periodicals, Inc.
    American Journal of Industrial Medicine 08/2013; DOI:10.1002/ajim.22229 · 1.59 Impact Factor

Publication Stats

1k Citations
297.30 Total Impact Points

Institutions

  • 2003–2015
    • Institut de veille sanitaire
      • Department of Occupational Health
      Charenton, Île-de-France, France
  • 2011
    • Institut National du Cancer
      Billancourt, Île-de-France, France
    • Agence Régionale de Santé (ARS)
      Lutetia Parisorum, Île-de-France, France
  • 2008
    • University of Angers
      • Laboratoire d'Ergonomie et d'Épidémiologie en Santé au Travail
      Angers, Pays de la Loire, France
  • 2007
    • French Institute of Health and Medical Research
      • Center for Research in Epidemiology and Population Health CESP
      Lutetia Parisorum, Île-de-France, France
  • 1993–2005
    • Électricité de France (EDF)
      Lutetia Parisorum, Île-de-France, France
  • 2001
    • Unité Inserm U1077
      Caen, Lower Normandy, France