Anthony J Bella

Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

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Publications (90)262.3 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: IntroductionErectile dysfunction is a major complication of radical prostatectomy, commonly associated with penile neuropathy. In animal models of peripheral nerve injury, glial growth factor-2 (GGF2), a member of the neuregulin family of growth factors, has neuroprotective and neurorestorative properties, but this potential has not been established after cavernous nerve (CN) injury.AimsThe effectiveness of GGF2 in preserving axonal integrity and recovering erectile function in a rat model of radical prostatectomy-associated CN injury.Methods Adult male Sprague-Dawley rats underwent bilateral CN crush injury (BCNI) or sham surgery. Rats were administered GGF2 (0.5, 5, or 15 mg/kg) or vehicle subcutaneously 24 hour pre and 24-hour post-BCNI, and once weekly for 5 weeks. Erectile function was assessed in response to electrical stimulation of the CN. CN survival was assessed by fluorogold retrograde axonal tracing in major pelvic ganglia (MPG). Unmyelinated axons in the CNs were quantitated by electron microscopy.Main Outcome MeasuresErectile function recovery, CN survival, and unmyelinated CN axon preservation in response to GGF2 treatment following BCNI.ResultsErectile function was decreased (P < 0.05) after BCNI, and it was improved (P < 0.05) by all doses of GGF2. The number of fluorogold-labeled cells in the MPG was reduced (P < 0.05) by BCNI and was increased (P < 0.05) by GGF2 (0.5 and 5 mg/kg). The percentage of denervated Schwann cells in the BCNI group was higher (P < 0.05) than that in the sham-treated group and was decreased (P < 0.05) in the GGF2-treated (5 mg/kg) BCNI group. In the BCNI + GGF2 (5 mg/kg) group, the unmyelinated fiber histogram demonstrated a rightward shift, indicating an increased number of unmyelinated axons per Schwann cell compared with the BCNI group.ConclusionsGGF2 promotes erectile function recovery following CN injury in conjunction with preserving unmyelinated CN fibers. Our findings suggest the clinical opportunity to develop GGF2 as a neuroprotective therapy for radical prostatectomy. Burnett AL, Sezen SF, Hoke A, Caggiano AO, Iaci J, Lagoda G, Musicki B, and Bella AJ. GGF2 is neuroprotective in a rat model of cavernous nerve injury-induced erectile dysfunction. J Sex Med **;**:**–**.
    Journal of Sexual Medicine 02/2015; · 3.15 Impact Factor
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    ABSTRACT: Alternative reservoir site placement (ARP) has become an accepted technique for inflatable penile prosthesis (IPP) patients. There have been no prospective evaluations of this technique, which is currently off-label. The authors performed a prospective, multicenter, multinational, and internal review board (IRB)-approved study to evaluate the effectiveness and safety of ARP MATERIAL AND METHODS: The PROPPER registry was initiated in June, 2011, and is a database containing patient outcomes for IPP implantation. Patients with American Medical Systems (AMS) penile prostheses continue to be enrolled at 13 North American sites. Data from the PROPPER study was examined to determine surgical implantation use patterns for the AMS 700 series. Reservoir implantation site and complications by implantation site were evaluated.
    The Journal of urology. 07/2014;
  • Anthony J Bella, Rany Shamloul
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    ABSTRACT: There has been a long history of man’s fascination with better and stronger sex drive and performance across different cultures. Several literature texts from the Hindu, Egyptian, Chinese and Roman civilizations document the human endless search for substances that can enhance sexual experiences and/or treat erectile dysfunction.
    Phytotherapy Research 06/2014; 28(6):831-5. · 2.40 Impact Factor
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    ABSTRACT: There are several contraceptive methods to prevent pregnancy, reversible as well as nonreversible ones. The sexual satisfaction of couples is affected by many types of contraceptives used. The aim of this study was to evaluate prospectively the effect of vasectomy on the sexual life and satisfaction of couples. Seventy-six couples took part in this evaluation and filled out respective questionnaires before and after vasectomy. All the questionnaires were evaluated statistically for differences in the respective sexual domain scores. Standardized questionnaires were used. The International Index of Erectile Function (IIEF) as well as postoperative pain score were completed by men. Female Sexual Function Index (FSFI) was completed by the female partner. For statistical analysis, the T-Square Test was used. The average age of couples, who chose the vasectomy procedure, was 37 years for women and 39 years for men. The contraception method most frequently used prior to the vasectomy was the birth control pill. For the male partner, the IIEF showed no significant change in the respective domains. Out of the 76 couples, 93% of the males and 96% of their female partners would recommend and do vasectomy again. The postoperative pain score was 3.5 on 0-10 scale, and there were no postoperative complications reported. The best improvement of the sexual function was noticed for the female partners. The FSFI showed a significant improvement in the domains desire (P < 0.05), arousal (P < 0.05), orgasm (P < 0.05), lubrication (P < 0.05), and satisfaction (P < 0.05). This is the first report to our very best knowledge that showed the positive impact of vasectomy on sexual satisfaction of couples. Vasectomy is a safe operation with minimal complication rates. Mohamad Al-Ali B, Shamloul R, Ramsauer J, Bella A, Scrinzi U, Treu T, and Jungwirth A. The effect of vasectomy on the sexual life of couples. J Sex Med **;**:**-**.
    Journal of Sexual Medicine 05/2014; · 3.15 Impact Factor
  • Rany Shamloul, Anthony Bella
    Journal of Sexual Medicine 04/2014; 11(4):1097-8. · 3.15 Impact Factor
  • Rany Shamloul, Anthony J Bella
    Colloquium Series on Integrated Systems Physiology: From Molecule to Function. 03/2014; 6(2):1-71.
  • Anthony J Bella, Rany Shamloul
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    ABSTRACT: Sexual dysfunction (SD) is common in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect compromising treatment compliance. Mechanisms involved in psychotropics-induced SD are either largely unknown or poorly understood. The aim of this review is to present an updated analysis of SD associated with the use of psychotropic drugs in psychiatric patients. Contemporary evidence from available studies demonstrates that SD rates are drug-related rather than drug-class specific, and that these rates vary widely. Mechanisms involved in psychotropics-induced SD are either largely unknown or poorly understood. Our understanding of psychotropics-induced SD is limited by the inability to differentiate whether these effects are really drug-induced or due to different inclusion criteria. Rigorous research, basic and clinical, is needed to understand the exact incidence, severity and mechanisms involved in the development of SD induced by various psychotropic treatment regimens.
    Central European journal of urology. 01/2014; 66(4):466-471.
    This article is viewable in ResearchGate's enriched format
  • Adham Zaazaa, Anthony J Bella, Rany Shamloul
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    ABSTRACT: This article attempts to review the most current and the well-established facts concerning drug addiction and sexual dysfunction. Surprisingly, even though alcohol is prevalent in many societies with many myths surrounding its sexual-enhancing effects, current scientific research cannot provide a solid conclusion on its effect on sexual function. Unfortunately, the same concept applies to tobacco smoking; however, most of the current knowledge tends to support the notion that it, indeed, can negatively affect sexual function. Similar ambiguities also prevail with substances of abuse.
    Endocrinology and metabolism clinics of North America 09/2013; 42(3):585-92. · 3.56 Impact Factor
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    ABSTRACT: To issue a consensus document on the prevention, management, and research of infection associated with penile prostheses, as neither professional associations nor governmental entities have issued guidelines that are specific to this infection. Sixteen North American experts on infection of penile prostheses were identified and assembled to select and discuss certain issues related to infection of penile prostheses. After performing an extensive search of clinically important issues in published reports, the 16 experts met twice in person to finalize the selection, discuss the issues that were deemed most important, and issue pertinent recommendations. Although many subjects relevant to infection of penile prostheses were initially identified, the experts selected 10 issues as currently being the most important issues and for which there exists some support in the published data. The examined issues involved prevention, management, or research of infections associated with penile prostheses. In the absence of pertinent guidelines, the consensus document issued by experts in the field of prosthetic urology is anticipated to improve the quality of patient care, streamline the prevention and management of infected penile prostheses, and stimulate collaborative research. Although this consensus document could serve as best practice recommendations, the lack of adherence to these recommendations would not indicate improper care.
    Urology 08/2013; · 2.13 Impact Factor
  • Anthony J Bella, Rany Shamloul
    Canadian Urological Association journal = Journal de l'Association des urologues du Canada 07/2013; 7(7-8):258-9. · 1.92 Impact Factor
  • Anthony J Bella
    Journal of Sexual Medicine 08/2011; 8(8):2391-2. · 3.15 Impact Factor
  • The Journal of Urology 04/2011; 185(4). · 3.75 Impact Factor
  • The Journal of Urology 04/2011; 185(4). · 3.75 Impact Factor
  • Rany Shamloul, Anthony J Bella
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    ABSTRACT: Cannabis (marijuana) is the most widely used illicit drug globally. Given the prevalence of nonprescription illicit drug abuse, there is a growing interest in the study of its potential effects on male sexual health. In this review, we discuss the effects of cannabis on male sexual health. In this review, we discuss the effects of cannabis on male sexual health. METHODS AND MAIN OUTCOME MEASURE: Critical review of scientific literature examining the impact of cannabis use on male sexual health. Studies examining the effects of cannabis use on male sexual function have been limited in both quality and quantity. Most results of these studies are conflicting and contradictory. While some did outline the beneficial effects of cannabis in enhancing erectile function, others did not. However, recent animal and in vitro studies have identified potential links between cannabis and sexual health. It appears that cannabis may actually have peripheral antagonizing effects on erectile function by stimulating specific receptors in the cavernous tissue. Given the prevalence of cannabis use, and the potential relationships between use and the development of potentially hazardous effects on male sexual function, we encourage renewed use of research resources to determine in-depth mechanistic knowledge, and new clinically oriented studies examining the effect of cannabis on male sexual function.
    Journal of Sexual Medicine 04/2011; 8(4):971-5. · 3.15 Impact Factor
  • Rany Shamloul, Anthony J. Bella, Michael Adams
    The Journal of Urology 04/2011; 185(4). · 3.75 Impact Factor
  • The Journal of Urology 04/2011; 185(4). · 3.75 Impact Factor
  • Brian Christine, Anthony J. Bella
    Journal of Men s Health 04/2011; 185(4). · 0.68 Impact Factor
  • The Journal of Urology 04/2011; 185(4). · 3.75 Impact Factor
  • Anthony J. Bella, Rany Shamloul
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    ABSTRACT: The male genital system consists of both external and internal sexual and reproductive organs, including the penis as well as the testis, epididymis, vas deferens, seminal vesicle and the prostate. In this chapter, an overview of the gross and microscopic anatomy of the male genitalia is provided. KeywordsAnatomy-Prostate-Arterial supply-Cavernous nerves-Penis
    12/2010: pages 3-12;
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    ABSTRACT: The prognostic significance of capsular incision (CapI) into tumor during radical prostatectomy (RP) with otherwise organ-confined disease remains uncertain. To evaluate the impact of CapI into tumor on oncologic outcome. A retrospective review of 8110 consecutive patients with prostate cancer treated at Ottawa Hospital and at Memorial Sloan-Kettering Cancer Center, both tertiary academic centers, between 1985 and 2008. All patients underwent an open, laparoscopic or robotic RP. Patients were divided into four pathologic categories: group 1 (CapI group), positive surgical margins (PSMs) without extraprostatic extension (EPE); group 2, negative surgical margins (NSMs) without EPE; group 3, NSM with EPE; group 4, PSMs with EPE. Estimates of recurrence-free survival were generated with the Kaplan-Meier method. Recurrence was defined as a prostate-specific antigen (PSA) >0.2 ng/ml and rising. Cox proportional hazards regression was used to estimate the hazard ratio (HR) for recurrence controlling for pretreatment PSA, RP date, RP Gleason sum, seminal vesicle invasion, and lymph node involvement. Pathologic categories were defined in the model by including the variables EPE and surgical margins (SMs) as well as their interaction. Median follow-up was 37.3 mo. The 5-yr recurrence-free probability after RP for the CapI group was 77% (95% confidence interval [CI], 72-83). This was not only inferior to patients with NSMs and no EPE (log rank p<0.0001) but also to those with NSMs and EPE (log rank p=0.0002). In multivariate analysis the interaction between EPE and SM was not significant (p=0.26). In the adjusted model excluding the interaction term, patients with EPE had an increased risk for recurrence (HR: 1.80; 95% CI, 1.49-2.17; p<0.0001) as did those with positive margins (HR: 1.81; 95% CI, 1.51-2.15; p<0.0001). This was a retrospective study. CapI into tumor has a significant impact on patient outcome following RP. Patients, who otherwise would have organ-confined disease, will now have a higher probability of recurrence than those with completely resected extraprostatic disease.
    European Urology 12/2010; 59(4):613-8. · 10.48 Impact Factor

Publication Stats

670 Citations
262.30 Total Impact Points

Institutions

  • 2014
    • Ottawa Hospital Research Institute
      Ottawa, Ontario, Canada
  • 2007–2014
    • University of Ottawa
      • • Department of Neurosurgery
      • • Department of Surgery
      Ottawa, Ontario, Canada
  • 2010
    • Memorial Sloan-Kettering Cancer Center
      • Department of Surgery
      New York City, New York, United States
  • 2009
    • Lawson Health Research Institute
      London, Ontario, Canada
  • 2006–2009
    • University of California, San Francisco
      • • Division of Hospital Medicine
      • • Department of Urology
      San Francisco, California, United States
    • Johannes Gutenberg-Universität Mainz
      Mayence, Rheinland-Pfalz, Germany
  • 2008
    • The Ottawa Hospital
      Ottawa, Ontario, Canada
  • 2003–2007
    • The University of Western Ontario
      • • Department of Surgery
      • • Division of Urology
      London, Ontario, Canada