Hatice Yağmurdur

Publications (5)6.92 Total impact

• Article: Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study

  Turgay Akgül, Ersagun Karagüzel, Hatice Sürer, Hatice Yağmurdur, Ali Ayyıldız, Hüseyin Üstün, Cankon Germiyanoğlu
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  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on germ cell apoptosis and also on expressions of endothelial (eNOS) and inducible (iNOS) nitric oxide synthases after testicular torsion. Materials and methodsThirty-two Wistar albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) was performed on the rats in group 1, group 2 received ginkgo biloba for a month before T/D, group 3 received only gingko biloba for a month, and group 4 was the sham group. Left testicular torsion was created in group 1 and group 2, and the testes were untwisted and replaced in the scrotum for reperfusion. No procedure was applied to group 3, and after 1 month, testes were removed in all groups. ResultsMean apoptotic cell, eNOS, and iNOS were increased in group 1. Group 2 showed significantly decreased apoptotic cells, eNOS, and iNOS in testes compared to group 1 (P<0.05). The rats in group 3 had significantly decreased apoptotic cell, eNOS, and iNOS values, like the sham group (P<0.05), and this group provided basal values. ConclusionsGinkgo biloba, as a free radical scavenger, seems to have a protective role against apoptosis in testicular ischemia reperfusion injury.
  International Urology and Nephrology 04/2012; 41(3):531-536. · 1.47 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

  Turgay Akgül, Ali Ayyıldız, Barış Nuhoğlu, Ersagun Karagüzel, Elmas Öğüş, Hatice Yağmurdur, Hüseyin Üstün, Cankon Germiyanoğlu
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  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methodsThirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50mg/day) for a month before T/D, group 3 received only gingko biloba (50mg/day) for a month and group 4 was defined as sham group. After 1month the testes were removed. ResultsMean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. ConclusionsMalondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 08/2008; 40(3):685-690. · 1.47 Impact Factor
• Article: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: an experimental study.

  Hüseyin Ustün, K Turgay Akgül, Ali Ayyildiz, Hatice Yağmurdur, Bariş Nuhoğlu, Ersagun Karagüzel, Elmas Oğüş, Cankon Germiyanoğlu
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  ABSTRACT: To investigate the effects of phosphodiesterase (PDE) 5 inhibitors, sildenafil citrate and vardenafil HCl, on testicular germ cell apoptosis and also on the expressions of eNOS and iNOS within the bilateral testis after a unilateral torsion in a rat model. Forty-eight Wistar Albino rats, weighing between 210 and 262 g, were housed in individual cages. The rats were randomly assigned into four main groups and each group received drugs. Saline, sildenafil citrate and vardenafil HCl were given to each for 1 month and the last received no drug. After 1 month, testicular torsion was created for 1 h of ischemia and the left testis was untwisted and replaced to the scrotum for 2 h of reperfusion. At the end of 3 h, contralateral and ipsilateral testes were removed for histopathologic and biochemical examinations. Under light microscopy; the histopathological patterns of the contralateral testes in all groups were not affected. Mean apoptotic cell, eNOS and iNOS levels were increased in saline study group. The rats treated with vardenafil and sildenafil (groups 2s and 3s) showed significantly increased apoptotic cell, eNOS and iNOS values in ipsilateral testis (P < 0.05). Sildenafil citrate and vardenafil HCl caused an exaggerated testicular apoptosis after IR injury in rats. Additionally these drugs increased the NOSs levels in the testicular tissue.
  Pediatric Surgery International 02/2008; 24(2):205-11. · 1.25 Impact Factor
• Article: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: an experimental study

  Hüseyin Üstün, K. Turgay Akgül, Ali Ayyıldız, Hatice Yağmurdur, Barış Nuhoğlu, Ersagun Karagüzel, Elmas Öğüş, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: To investigate the effects of phosphodiesterase (PDE) 5 inhibitors, sildenafil citrate and vardenafil HCl, on testicular germ cell apoptosis and also on the expressions of eNOS and iNOS within the bilateral testis after a unilateral torsion in a rat model. Forty-eight Wistar Albino rats, weighing between 210 and 262g, were housed in individual cages. The rats were randomly assigned into four main groups and each group received drugs. Saline, sildenafil citrate and vardenafil HCl were given to each for 1month and the last received no drug. After 1month, testicular torsion was created for 1h of ischemia and the left testis was untwisted and replaced to the scrotum for 2h of reperfusion. At the end of 3h, contralateral and ipsilateral testes were removed for histopathologic and biochemical examinations. Under light microscopy; the histopathological patterns of the contralateral testes in all groups were not affected. Mean apoptotic cell, eNOS and iNOS levels were increased in saline study group. The rats treated with vardenafil and sildenafil (groups 2s and 3s) showed significantly increased apoptotic cell, eNOS and iNOS values in ipsilateral testis (P<0.05). Sildenafil citrate and vardenafil HCl caused an exaggerated testicular apoptosis after IR injury in rats. Additionally these drugs increased the NOSs levels in the testicular tissue.
  Pediatric Surgery International 01/2008; 24(2):205-211. · 1.25 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats.

  Turgay Akgül, Ali Ayyildiz, Bariş Nuhoğlu, Ersagun Karagüzel, Elmas Oğüş, Hatice Yağmurdur, Hüseyin Ustün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed. Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 11/2007; 40(3):685-90. · 1.47 Impact Factor