Publications (6)15.11 Total impact
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Article: Cryptococcus gattii infection in a Spanish pet ferret (Mustela putorius furo) and asymptomatic carriage in ferrets and humans from its environment.
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ABSTRACT: A domestic ferret (Mustela putorius furo) was presented with lymphadenopathy and acute bilateral blindness. Cytologic evaluation and biopsy of an affected lymph node revealed pyogranulomatous lymphadenitis with intralesional yeast consistent with Cryptococcus sp. Subsequent studies demonstrated Cryptococcus gattii serotype B VGI/AFLP4 as the causative agent. The ferret was treated with fluconazole and prednisone. After one month of therapy, an improvement of the clinical symptoms was detected although blindness persisted. Seven months after presentation, the disease progressed to a severe neurologic condition, and it was euthanized. Postmortem exam revealed disseminated cryptococcosis with prominent neurologic involvement. Nasal swabs of other ferrets and humans from the same household revealed that two ferrets and two humans to be asymptomatic carriers of the same strain of cryptococcus as the necropsied ferret. These findings stress the importance of veterinary diagnostic work with pets and epidemiological investigations for disease prevention in them and in their owners.Medical mycology: official publication of the International Society for Human and Animal Mycology 03/2011; 49(7):779-84. · 2.13 Impact Factor -
Article: Endophthalmitis caused by Fusarium proliferatum.
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ABSTRACT: Fusarium proliferatum caused endophthalmitis after cataract surgery. Diagnosis was established by classical microbiology and molecular biology methods (PCR and DNA typing). The treatment with local amphotericin B, oral ketoconazole, and topical natamycin was successful.Journal of Clinical Microbiology 11/2005; 43(10):5372-5. · 4.15 Impact Factor -
Article: First case of human cryptococcosis due to Cryptococcus neoformans var. gattii in Spain.
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ABSTRACT: We report the first case of human cryptococcosis due to Cryptococcus neoformans var. gattii described in our country, which was presented as brain cryptococcoma in an immunocompetent patient. An extensive sampling of the patient's environment was carried out to find the source of infection.Journal of Clinical Microbiology 08/2005; 43(7):3548-50. · 4.15 Impact Factor -
Article: [First local case of human cryptococcosis in Spain caused by Cryptococcus neoformans var. gattii].
Revista Iberoamericana de Micología 01/2004; 20(4):181. · 1.16 Impact Factor -
Article: Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin.
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ABSTRACT: To assess the accuracy of the determination of Helicobacter pylori infection by a stool immunoassay in patients with upper-gastrointestinal bleeding (UGB) of peptic origin, in comparison with the routine histological study, serology, rapid urease and 13C-breath tests. Sixty-eight patients with endoscopically proven UGB of peptic origin were included. The presence of H. pylori was considered when observed on histology or, if negative, by the positive indications of two of the remaining tests (serology, rapid urease,13C-breath test). The accuracy of stool immunoassay was estimated according to results obtained with other diagnostic methods. Lesions causing gastrointestinal bleeding were 49 duodenal ulcers, 11 gastric ulcers, six pyloric channel ulcers, 13 acute lesions of the gastric mucosa, and 16 erosive duodenitis. H. pylori infection was present in 59 (86.76%) patients. Forty-one patients had received nonsteroidal anti-inflammatory drugs. The sensitivity and specificity of the diagnostic methods were 47.5% and 100% for the rapid urease test, 93% and 87.5% for the breath test, 86.4% and 77.7% for serology, 89.4% and 100% for histology, and 96.6% and 33.3% for the stool test. The detection of H. pylori antigen in stools in patients with UGB of peptic origin has a good sensitivity (96.6%) but a low specificity (33.3%) for the diagnosis of H. pylori infection, which probably makes this test an inadequate tool in this setting if utilized alone.European Journal of Gastroenterology & Hepatology 06/2003; 15(5):525-9. · 1.76 Impact Factor -
Article: Comparison of stool immunoassay with standard methods for detection ofHelicobacter pyloriinfection in patients with upper-gastrointestinal bleeding of peptic origin
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ABSTRACT: Objective: To assess the accuracy of the determination of Helicobacter pylori infection by a stool immunoassay in patients with upper‐gastrointestinal bleeding (UGB) of peptic origin, in comparison with the routine histological study, serology, rapid urease and13 C‐breath tests. Methods: Sixty‐eight patients with endoscopically proven UGB of peptic origin were included. The presence of H. pylori was considered when observed on histology or, if negative, by the positive indications of two of the remaining tests (serology, rapid urease, 13C‐breath test). The accuracy of stool immunoassay was estimated according to results obtained with other diagnostic methods. Results: Lesions causing gastrointestinal bleeding were 49 duodenal ulcers, 11 gastric ulcers, six pyloric channel ulcers, 13 acute lesions of the gastric mucosa, and 16 erosive duodenitis. H. pylori infection was present in 59 (86.76%) patients. Forty‐one patients had received nonsteroidal anti‐inflammatory drugs. The sensitivity and specificity of the diagnostic methods were 47.5% and 100% for the rapid urease test, 93% and 87.5% for the breath test, 86.4% and 77.7% for serology, 89.4% and 100% for histology, and 96.6% and 33.3% for the stool test. Conclusions: The detection of H. pylori antigen in stools in patients with UGB of peptic origin has a good sensitivity (96.6%) but a low specificity (33.3%) for the diagnosis of H. pylori infection, which probably makes this test an inadequate tool in this setting if utilized alone.European Journal of Gastroenterology & Hepatology 04/2003; 15(5):525‐529. · 1.76 Impact Factor
