Erhan Varoglu

Bağcılar Training And Research Hospital, İstanbul, Istanbul, Turkey

Are you Erhan Varoglu?

Claim your profile

Publications (56)91.98 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Here, we report 1 case of Brucella orchitis detected by 99mTc human immunoglobulin scintigraphy and confirmed by testicular ultrasound. A 29-year-old farmer was admitted to our hospital with fever, fatigue, arthralgia, and painful scrotal swelling that had appeared 12 days before admission. Clinically, right sacroiliitis was recorded through the Fabere test Unilateral sacroiliitis and orchitis were detected by 99mTc human immunoglobulin scintigraphy. Hypoechoic left testicular lesions and swelling of the concurrent epididymis were seen on a testicular ultrasound examination. Wright agglutination test and blood specimen culture for Brucella species were positive.
    Clinical nuclear medicine 07/2012; 37(7):671-3. · 3.92 Impact Factor
  • Sinan Yapici, Hayrettin Eroglu, Erhan Varoglu
    [Show abstract] [Hide abstract]
    ABSTRACT: This work presents an investigation on the bio-sorption of Tl-201 radionuclide used in nuclear medicine on olive pomace. The experimental parameters were chosen as temperature, the initial pH of the solution, stirring speed, bio-sorbent dose and nominal particle size of bio-sorbent. The initial pH of the solution was found to be the most effective parameter. Thermodynamic analysis gave negative values for ΔG and ΔH. The kinetics of the bio-sorption process fitted very well to the pseudo-second order rate model.
    Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine 03/2011; 69(3):614-22. · 1.09 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The radionuclides 67Ga is used in nuclear medicine. This paper presents a bioadsorption study of 67Ga from aqueous solution by solid tea factory waste. The experimental parameters were chosen as temperature, pH, stirring speed, nominal particle size and bioadsorbent dose in the ranges of 10.0–40.0 °C, 2.0–8.0, 300–720 rpm, 0.15–1.4 mm and 1.0–15.0 g/L, respectively. The most effective parameter was determined to be pH, and then temperature, particle size, and bioadsorbent dose in decreasing order. Fourier transform infrared spectroscopy was performed for the characterisation of the bioadsorption of 67Ga on tea waste. The equilibrium results showed that the data exhibited good agreement with the isotherm models of Freundlich, Halsey, and Handerson and Smith. In thermodynamic analysis, ΔG and ΔH values were determined and their values demonstrated that the bioadsorption process was endothermic and spontaneous. Bioadsorption kinetics analysis proved that the rate corresponded to a pseudo second order model, and that the bioadsorption mechanism is governed by intra-particular diffusion.
    Chemical Engineering Journal. 12/2010;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To prospectively evaluate the regional myocardial deformation changes and viability in anterior acute myocardial infarction (AMI) patients before and after primary coronary intervention (PCI) by strain (S)/strain rate (Sr) imaging. Twenty-one patients presented during the first six hours of an anterior AMI and twenty controls were included in this study. Echocardiographic recordings were obtained from the apical/parasternal images just before PCI, one week and one month after PCI. The S/Sr and velocity (V) were measured from the basal mid and apical segments of the walls supplied by the left anterior descending artery. Myocardial perfusion scintigraphy was performed in the 1st month after PCI. Mann-Whitney U and Wilcoxon tests were used for statistical analysis. Acute myocardial infarction resulted in the reduction of deformation indices (S/Sr/V) in all segments. Deformation indices were increased after successful PCI. The S/Sr values of the normal and ischemic segments after PCI were higher compared to the baseline (ischemic Sr:-1.3 ± 0.3 vs. -1.1 ± 0.3, p=0.04). No difference was noted in the S/Sr values of the necrotic segments during the first week (Sr:-1.1 ± 0.3 vs. -1.0 ± 0.3, p=0.054). For V measurements, no difference was observed between the viability types at the follow-up measurements (p ≤ 0.05). The remedial effect of PCI on the deformation values was observed in the first week and continued during the first month. In the early reperfusion period, S/Sr indices have the potential to differentiate necrotic tissue from other viability types. Strain/Strain rate imaging can be used for determination of myocardial deformation changes and parameters of viability. However, V values were insufficient.
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 11/2010; 10(6):479-87. · 0.72 Impact Factor
  • Hayrettin Eroglu, Sinan Yapici, Erhan Varoglu
    [Show abstract] [Hide abstract]
    ABSTRACT: This study investigates the adsorption of gallium-67, routinely used in nuclear medicine laboratories, in aqueous solution by using the waste of a rose-oil processing factory (rose residue). The experimental parameters were determined to be as follows: temperature, (10.0 to 40.0) °C; pH, (2.0 to 10.0); stirring speed, (300 to 720) rpm; particle size, (0.15 to 1.40) mm; and adsorbent dose, (1.0 to 15.0) g·L−1. It was seen that the most important parameters were pH, temperature, particle size, and adsorbent dose. The adsorption mechanism of the rose residue was examined by comparing the Fourier transform infrared (FTIR) spectra before and after adsorption. The ΔG and ΔH values were determined, and it was concluded that the absorption was endothermic and spontaneous. Absorption kinetics was studied, and it was observed that they fit a pseudo second-order model. As a result, it was found that the rose residue was a perfect absorbent for the adsorption of gallium-67.
    Journal of Chemical and Engineering Data - J CHEM ENG DATA. 06/2010; 55(8).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The inhibitory effects of thallium-201 ((201)Tl) solution on human erythrocyte glucose 6-phosphate dehydrogenase (G6PD) activity were investigated. For this purpose, erythrocyte G6PD was initially purified 835-fold at a yield of 41.7% using 2',5'-Adenosine diphosphate sepharose 4B affinity gel chromatography. The purification was monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which showed a single band for the final enzyme preparation. The in vitro and in vivo effects of the (201)Tl solution including Tl(+), Fe(+3) and Cu(+2) metals and the in vitro effects of the radiation effect of the (201)Tl solution and non-radioactive Tl(+), Fe(+3) and Cu(+2) metals on human erythrocyte G6PD enzyme were studied. Enzyme activity was determined with the Beutler method at 340 nm using a spectrophotometer. All purification procedures were carried out at +4 degrees C. (201)Tl solution and radiation exposure had inhibitory effects on the enzyme activity. IC(50) value of (201)Tl solution was 36.86 microl ([Tl(+)]: 0.0036 microM, [Cu(+2)]: 0.0116 microM, [Fe(+3)]: 0.0132 microM), of human erythrocytes G6PD. Seven human patients were also used for in vivo studies of (201)Tl solution. Furthermore, non-radioactive Tl(+), Fe(+3) and Cu(+2) were found not to have influenced the enzyme in vitro. Human erythrocyte G6PD activity was inhibited by exposure for up to 10 minutes to 0.057 mCi/kg (201)Tl solution. It was detected in in vitro and in vivo studies that the human erythrocyte G6PD enzyme is inhibited due to the radiation effect of (201)Tl solution.
    Nuclear Medicine and Biology 04/2010; 37(3):389-94. · 2.52 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Parathyroid adenomas (PA) are benign tumors. We report an unusual case of delayed diagnosis of a PA and concomitant Vitamin D deficiency presenting as tetraparesia. A 30-year-woman was admitted to our clinic with an inability to walk. Our examination revealed tetraparesia and common, severe muscular atrophy. Laboratory investigations showed the following: creatinine phosphokinase (CK): 37 IU/L (15-130), calcium (Ca): 11.5 mg/dL (9-11), phosphorus (P): 1.5 mg/dL (2.5-5), parathyroid hormone (PTH): 736.1 pq/mL (15-65), 25-hydroxyvitamin D (25-OHvit D): 4 ng/mL (11-43), and alkaline phosphatase (ALP): 1029.5 lU (64-300). Parathyroid scintigraphy revealed PA. A year after Vitamin D replacement, the patient's neurological status and laboratory findings improved. We suggest that the physicians always keep in mind the primary hyperparathyroidism (HPT) and concomitant Vitamin D deficiency in the differential diagnosis of hypercalcemia when facing atypical neurological symptoms such as tetraparesia.
    Neuro endocrinology letters 01/2010; 31(4):451-3. · 0.93 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Osteoporosis is a secondary problem in multiple sclerosis (MS) patients. There have been only a few reports about the effect of interferon beta (IFNB) 1b on bone mineral density (BMD). We aimed to determine bone mass in patients using IFNB 1b. We enrolled 17 patients taking IFNB 1b (group I), 15 patients not taking IFNB (group II). We measured the BMD and T scores values and the patients were distinguished as normal, osteopenia and osteoporosis. In the lumbar spine, there was no difference between groups I and II (p=0.3). In the left femur, no significant difference was detected between groups I and II (p=1). There was an inverse correlation between the BMD at the both regions and the Expanded Disability Status Scale score (r= -0.39, p=0.03; r=-0.52, p=0.002, respectively). IFNB 1b may be used safely in MS patients, even in those undergoing pulse steroid therapies, because IFNB 1b has no effect on BMD.
    Journal of Back and Musculoskeletal Rehabilitation 01/2010; 23(1):25-9. · 0.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to evaluate the alterations in salivary gland function in patients who receiving continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure (CRF) using technetium-99m pertechnetate ((99m)Tc-P) salivary gland scintigraphy. The study population consisted of 36 CAPD patients (16 males and 20 females, ranging in age from 19 to 73 years, mean age 44.94+/-15.01 years) and 20 healthy controls (11 males and 9 females, ranging in age from 31 to 51 years, mean age 41.25+/-5.62 years). All patients and healthy controls underwent salivary gland scintigraphy. After the intravenous administration of 185MBq of (99m)Tc-P, dynamic salivary gland scintigraphy was performed for 25min. On the basis of the time-activity curves, the following glandular function parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation, and ejection fraction. Our results showed: All functional parameters obtained for CAPD patients were significantly lower than for healthy controls (P<0.05). In conclusion, this study demonstrated that salivary gland function, an important determinant of oral health, is impaired among the CRF patients treated with CAPD compared with healthy controls, as evaluated by (99m)Tc-P salivary gland scintigraphy.
    Hellenic journal of nuclear medicine 01/2010; 13(1):26-9. · 0.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this research was to test the removal of Ga-67 radionuclides from aqueous solutions by biosorption onto waste pomace of an olive oil factory (WPOOF). Batch adsorption studies were performed in order to investigate the temperature, the initial pH of the solution, the stirring speed, the biosorbent dose, and the nominal particle size of the biosorbent in the experimental work. The most effective parameter was found to be the initial pH. A high biosorption yield of 98 was obtained. The equilibrium values were fitted to the isotherm models. The values of DeltaG and DeltaH were calculated to be negative. The adsorption kinetics calculations showed that the kinetics of the biosorption process fitted well to the pseudo-second order rate model.
    Journal of hazardous materials 08/2009; 172(2-3):729-38. · 4.14 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Nuclear medicine workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation may have damaging effects on chromosomes. In the present study, we investigated the genotoxic effects of ionizing radiation on nuclear medicine workers. We used two different indicators of genotoxicity methods: sister chromatid exchange (SCE) and micronucleus (MN). The present research was carried out using 21 nuclear medicine workers (11 females and 10 males) during two periods: during normal working conditions and after a 1-month vacation. The radiation dose varied from 1.20 to 48.56 mSv, which accumulated during the occupational exposure time between two vacations. Peripheral blood samples were taken from each subject for two distinct lymphocyte cultures (SCE and MN) in each period. In nearly all subjects, SCE values increased significantly during radiation exposure compared to the postvacation period (P<.05). Similarly, MN frequencies in most of the subjects increased significantly during radiation exposure compared to the postvacation period (P<.05). This study revealed that both SCE and MN frequencies in most of the subjects were significantly higher during exposure to ionizing radiation than after a 1-month vacation period. However, this genotoxic effect was reversible in most of the subjects.
    Nuclear Medicine and Biology 07/2009; 36(5):575-8. · 2.52 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique. METHODS: Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique. RESULTS: HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
    Hellenic journal of nuclear medicine 01/2009; 12(1):55-8. · 0.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to assess the effect of levocetirizine (xyzal) on salivary glands function in patients with allergic rhinitis using technetium-99m pertechnetate ((99m)Tc-P) salivary gland scintigraphy. The study population consisted of 67 patients with allergic rhinitis and 31 healthy controls (14 males and 17 females, mean age 30.1+/-6.8 years). The patients were divided into two groups: an untreated patient Group of 32 patients, 17 males and 15 females, mean age 29.9+/-6.5 years and a levocetirizine-treated with 5mg.day(-1) for 4 weeks patient Group, consisted of 35 patients, 16 males and 19 females, mean age 33.5+/-7.8 years. All patients and healthy controls underwent salivary glands scintigraphy. After the intravenous administration of 185 MBq of (99m)Tc-P, dynamic salivary glands scintigraphy was performed for 25 min. By the time-activity curves, the following glandular function parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation, and ejection fraction. Our results showed: All functional parameters obtained for the untreated patient Group were significantly lower than for the levocetirizine-treated patient Group and healthy controls (P<0.05). There was no significant difference in any functional parameters between the levocetirizine-treated patient Group and healthy controls (P>0.05). In conclusion, results of our study indicate that patients with allergic rhinitis treated with levocetirizine showed a significantly higher salivary glands function compared with untreated patients and healthy controls. Levocetirizine treatment showed no side effects on salivary glands function.
    Hellenic journal of nuclear medicine 01/2009; 12(2):119-22. · 0.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This work presents an investigation of the adsorption of the radionuclide of Tl-201 from waste water on the fibrous tea factory waste. The experimental parameters were chosen as temperature, pH, stirring speed, adsorbent dose and nominal particle size in the ranges of 10.0-40.0 degrees C, 2.0-10.0, 300-720 rpm, 1.0-15.0 g/L and 0.15-0.71 mm, respectively. The most effective parameter on the adsorption yield was found to be pH of the solution. Fourier transforms infrared and electron paramagnetic resonance spectroscopy studies were performed for the characterisation of the adsorption on tea waste. The experimental data were found to be in good agreement with the isotherm models of Freundlich, Halsey, Handerson and Dubinin-Radushkevich. Thermodynamic analysis showed that the values of Delta G and Delta H are negative. It was obtained that the adsorption rate can be represented very well by second-order pseudo homogeneous kinetic model. All the results proved that fibrous tea plant waste makes an excellent adsorbent for Tl-201 radionuclide.
    Journal of hazardous materials 08/2008; 163(2-3):607-17. · 4.14 Impact Factor
  • Hellenic journal of nuclear medicine 01/2008; 11(1):53-4. · 0.68 Impact Factor
  • Clinical Radiology 10/2007; 62(9):904-6. · 1.82 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To demonstrate the localization of leukocytes in the pancreas during acute pancreatitis and to evaluate the potential use of 99mTc-HMPAO-labelled leukocytes in the diagnostic assessment of patients with acute pancreatitis. The study was performed with 20 patients (11 females, nine males; ranging in age from 26 to 86 years, mean 55 years). Labelled leukocyte scintigraphy using planar imaging was performed on all patients, seven of whom were also examined by single photon emission computed tomography (SPECT). According to Ranson criteria, 10 patients had mild pancreatitis (group A), six had severe pancreatitis (group B) and four had necrotic pancreatitis (group C). Twelve patients had biliary pancreatitis and the other eight patients had no obvious cause. All patients of group C, four of group B, two of group A had a positive leukocyte scan. The positive leukocyte scintigraphy value for the detection of a lethal course of acute pancreatitis was 100%; of a severe course, 66.7%; and of a mild course, 20%. These findings are statistically significant (P=0.005 in chi-squared tests result). The results of leukocyte scintigraphy compared with those of CT were also statistically significant (P=0.001 in chi-squared tests). All the patients diagnosed with pancreatic necrosis by CT had a positive leukocyte scan, but only three of 13 patients without pancreatic necrosis that could be detected by computed tomography had a positive leukocyte scan. There was a significant correlation between the severity of the disease and leukocyte infiltration. Considering these results, we believe that leukocyte infiltration in acute pancreatitis can be demonstrated rapidly and accurately and by noninvasive 99mTc-HMPAO labelled leukocyte scintigraphy.
    Nuclear Medicine Communications 05/2007; 28(4):289-95. · 1.38 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of this study was to assess the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients using rhinoscintigraphy. Twenty patients with allergic rhinitis (12 males and eight females, mean age 37.7 +/- 10.5 years) were evaluated. All the patients received levocetirizine (5 mg x day(-1)) for 4 weeks, and the speed of nasal mucociliary clearance was assessed before and after treatment. Twenty healthy controls (11 males and nine females, mean age 39.4 +/- 7.8 years) were also evaluated. The clearance values obtained for the treated group before and after treatment were significantly lower than those of the control group (P = 0.0001), but there was no significant difference in clearance speeds before and after treatment in the patient group (P = 0.444). The study demonstrated that levocetirizine did not affect the speed of nasal mucociliary clearance in allergic rhinitis patients, and that nasal mucociliary clearance can easily be evaluated by rhinoscintigraphy.
    Nuclear Medicine Communications 03/2007; 28(2):85-7. · 1.38 Impact Factor
  • Clinical Nuclear Medicine 10/2006; 31(9):552-3. · 2.96 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Carbon monoxide (CO) poisoning is the leading cause of death from intoxication. In CO poisoning, it is important to know if there are any symptoms regarding myocardial damage, which are usually unobserved as a result of hypoxia. This study was planned to assess myocardial damage in young healthy patients with CO poisoning. Eighty-three young healthy cases who had been exposed to CO were included in this study. The demographic and clinical characteristics, the origin of CO gas and smoking habits of the patients were recorded. The evaluation of ECG, peripheral ABG, complete blood count and serial cardiac biomarkers (creatine kinase, creatine kinase-myocardial band and troponin I) measurements were performed in all cases. Additionally, echocardiogram (ECHO) and myocardial perfusion single-photon emission computed tomography (SPECT) were performed at the appropriate times in all cases. The mean age of the patients was 27.3 +/- 10.9 years. The main complaint of the patients was loss of consciousness with a 62.7% rate. The average carboxyhaemoglobin level of the patients was 34.4 +/- 15.9%. Sinus tachycardia was present in 26.5% of patients. Diagnostic ischaemic ECG changes were present in 14.4% of patients. In myocardial SPECT, myocardial ischaemic damage was observed in 9 cases, in 6 of whom ECHO findings were also confirmed. Myocardial damage due to CO poisoning should not be ignored. If patients are at risk in terms of myocardial damage, further studies, such as ECHO and scintigraphy are needed to determine myocardial damage resulting from CO poisoning. However, in the young adults of the risk group, if the baseline ECG and serial cardiac biomarkers are normal, further studies such as ECHO and scintigraphy, considering the length of exposure and the severity of poisoning, may not be necessary for the evaluation of myocardial damage due to CO poisoning.
    Human &amp Experimental Toxicology 09/2006; 25(8):439-46. · 1.45 Impact Factor

Publication Stats

195 Citations
91.98 Total Impact Points

Institutions

  • 2012
    • Bağcılar Training And Research Hospital
      İstanbul, Istanbul, Turkey
  • 2006
    • Hacettepe University
      • Department of Nuclear Medicine
      Ankara, Ankara, Turkey
  • 2001–2006
    • Ataturk University
      • Department of Nuclear Medicine
      Kalikala, Erzurum, Turkey