Kye Jin Jeon

Samsung Advanced Institute of Technology, Usan-ri, Gyeonggi Province, South Korea

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Publications (12)10.38 Total impact

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    ABSTRACT: A compact and easy-to-use home health monitor was developed. A palm-size health monitor contained a finger probe as sensor unit. In the finger probe, light from a light emitting diode (LED) array was illuminated on a finger nail bed, and transmitted light was measured to obtain photoplethysmography (PPG) signals. Hematocrit, pulse, respiration rate, and saturated oxygen in arterial blood (SpO(2)) were measured simultaneously from PPGs using five different wavelengths: 569, 660, 805, 904, and 975 nm. To predict hematocrit, a dedicated algorithm was used based on scattering theory of red blood cells using these wavelengths. Preliminary clinical tests showed that the achieved percent errors were +/- 8.2% for hematocrit when tested with 549 persons (N = 549). Digital filtering techniques were used to extract respiratory information from a single PPG signal. SpO(2) was predicted on the basis of the ratio of the wavelengths 660 nm and 940 nm. The accuracies were within clinically acceptable errors. In addition, the compact home health monitor included a blood pressure monitoring unit. For convenient and simultaneous measurement with the other previously mentioned signals, blood pressure was measured on a finger. An air cuff was installed on the same finger where PPGs were measured. Achieved mean differences were +/- 3.8 mmHg for systole and +/- 5.1 mmHg for diastole. One can use the palm-size monitor simply by inserting a finger into the home health monitor that is suitable for telemedicine.
    Telemedicine and e-Health 01/2006; 11(6):660-7. · 1.40 Impact Factor
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    ABSTRACT: Glucose determination based on near-IR spectroscopy is investigated for reflectance and transmittance measurement. A wavelength range is 1100 to 2500 nm, which includes both the combination and overtone bands of glucose absorption. Intralipid solutions are used as samples, where glucose concentrations vary between 0 and 1000 mg/dl. Sample thickness for reflectance is 10 cm and 1- and 2-mm-thick samples are used for transmission. Partial least-squares regression (PLSR) analyses are performed to predict glucose concentrations. The standard errors of calibration are comparable between reflectance and 2-mm-thick transmittance. The reflectance method is inferior to the transmittance method in terms of the standard errors of prediction. Loading vector analysis for reflectance does not show glucose absorption features. Reflected light may not have enough information of glucose since a major portion of detected light has a short optical path length. In addition, prediction becomes more dependent on medium scattering rather than glucose, compared with transmission measurement. Loading vectors obtained from a PLSR transmittance analysis have glucose absorption profiles. The 1-mm-thick samples give better results than the 2-mm-thick samples for both calibration and prediction models. The transmittance setup is recommended for noninvasive glucose monitoring.
    Journal of Biomedical Optics 01/2006; 11(1):014022. · 2.75 Impact Factor
  • G Yoon, S J Kim, K J Jeon
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    ABSTRACT: The development of a non-invasive monitor of total haemoglobin has been reported previously. The paper presents the design and testing of a finger probe used in that optical haemoglobin monitor. When a finger is inserted into the probe, light is radiated onto the nail, and a silicon detector measures transmitted light. This finger probe can have different values or settings for design parameters such as the internal colour, detector area, the emission area of a light source and the distance between the light source and detector. Design of experiment (DOE) was introduced to select the best combination of design parameters that were robust to external conditions such as finger alignment and ambient light. An optimally designed finger probe from DOE analysis, compared with the initial design, increased the correlation coefficient from 0.696 to 0.869 and improved the standard deviation from 1.18 to 0.81 g dl(-1) in predicting total haemoglobin. This was under different conditions of finger-probe alignment. Under different ambient light conditions, the optimum design improved the correlation coefficient from 0.735 to 0.870 and reduced the standard deviation from 1.14 to 0.83 g dl(-1).
    Medical & Biological Engineering & Computing 02/2005; 43(1):121-5. · 1.79 Impact Factor
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    ABSTRACT: For noninvasive measurement of bio-fluid substances in human body based on optical spectroscopy, optical measurement system is one of the most important parts. We studied glucose specificities by analyzing the factors in the partial least squares regression models for the two cases of reflectance and transmittance measurements. Glucose -intralipid solutions were used as the samples whose scatterer's concentrations were varied. We used intralipid concentrations of 4%, 4.08% and 4.16% in the solution and these values were comparable to tissue scattering. Temperature was maintained at 30°C during measurement. Factor analysis for reflectance data didn't show glucose absorption feature and the factors were very noisy particularly in the combination band. It is speculated that light does not have enough information of glucose since the pathlength in reflectance is very short. On the other hand, the factors obtained from the PLS analysis of transmittance revealed glucose signatures. We suggest that transmittance measurement is preferred for in vivo glucose monitoring than reflectance measurement.
    Proc SPIE 07/2004;
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    ABSTRACT: Photo-plethysmography measures pulsatile blood flow in real-time and non-invasively. One of widely known applications of PPG is the measurement of saturated oxygen in arterial blood(SpO2). In our work, using several wavelengths more than those used in a pulse oximeter, an algorithm and instrument have been developed to measure hematocrit, saturated oxygen, pulse and respiratory rates simultaneously. To predict hematocrit, a dedicated algorithm is developed based on scattering of RBC and a protocol for detecting outlier signals is used to increase accuracy and reliability. Digital filtering techniques are used to extract respiratory rate signals. Utilization of wavelengths under 1000nm and a multi-wavelength LED array chip and digital-oriented electronics enable us to make a compact device. Our preliminary clinical trials show that the achieved percent errors are +/- 8.2% for hematocrit when tested with 594 persons, R2 for SpO2 fitting is 0.99985 when tested with a Bi-Tek pulse oximeter simulator and the SpO2 error for in vivo test is +/- 2.5% over the range of 75~100%. The error of pulse rates is less than +/- 5%. We obtained a positive predictive value of 96% for respiratory rates in qualitative analysis.
    Proc SPIE 09/2002;
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    ABSTRACT: A method and device for measuring glucose concentration in a scattering medium have been developed. A spectral range of 800-1800 nm is considered for wavelength selection because of its deeper penetration into biological tissue and the presence of a glucose absorption band. An algorithm based on selected wavelengths is proposed to minimize interference from other components. The optimal distance between the light source and the detector for diffuse reflectance measurement minimizes the influence of medium scattering. The proposed algorithm and measuring device are tested with a solution containing milk with added glucose. Glucose concentrations between 0 and 2000 mg/dl are determined with a correlation coefficient of 0.977. We also investigate the influence of concentration variations of other substances such as water, hemoglobin, albumin, and cholesterol when they are mixed in a scattering medium.
    Applied Optics 04/2002; 41(7):1469-75. · 1.69 Impact Factor
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    ABSTRACT: Wavelength selection and prediction algorithm for determining total hemoglobin concentration are investigated. A model based on the difference in optical density induced by the pulsation of the heart beat is developed by taking an approximation of Twersky's theory on the assumption that the variation of blood vessel size is small during arterial pulsing. A device is constructed with a five-wavelength light emitting diode array as the light source. The selected wavelengths are two isobestic points and three in compensation for tissue scattering. Data are collected from 129 outpatients who are randomly grouped as calibration and prediction sets. The ratio of the variations of optical density between systole and diastole at two different wavelengths is used as a variable. We selected several such variables that show high reproducibility among all variables. Multiple linear regression analysis is made in order to predict total hemoglobin concentration. The correlation coefficient is 0.804 and the standard deviation is 0.864 g/dL for the calibration set. The relative percent error and standard deviation of the prediction set are 8.5% and 1.142 g/dL, respectively. We successfully demonstrate the possibility of noninvasive hemoglobin measurement, particularly, using the wavelengths below 1000 nm.
    Journal of Biomedical Optics 02/2002; 7(1):45-50. · 2.75 Impact Factor
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    ABSTRACT: Determination of blood substances such as total hemoglobin, glucose, protein, cholesterol was investigated based on optical spectroscopy. Measurement was made either non-invasively or from blood or serum without using a test strip or wet chemistry
    Lasers and Electro-Optics, 2001. CLEO/Pacific Rim 2001. The 4th Pacific Rim Conference on; 02/2001
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    ABSTRACT: The method and device for non-invasive measurement of blood glucose concentration based on the diffuse reflectance from the transcutaneous layers is proposed. Original normalizing ratio algorithm permitting to separate glucose absorption from absorption of other blood components is suggested. It was shown that the influence of water and some other components such as hemoglobin, albumin, globulin's and cholesterol concentration variations to the estimation of the glucose concentration can be compensated using spectral analysis of the reflection on several specially selected wavelengths and proposed algorithm. Device with optical geometry minimizing the effects of changes in the scattering background of biological tissues was developed. NIR spectral range 800 - 1800 nm was used because of its good transparency for biological tissue and presence of glucose absorption band. We used two kinds of light sources, namely LED array and Xe flash lamp. Tissue phantoms (different glucose concentration (0 - 1000 mg/dl) solutions with polystyrene beads or with milk) were used as samples. Scattering and absorption contribution to the dependence of diffuse reflection on glucose concentration was experimentally verified.
    Proc SPIE 05/1999;
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    ABSTRACT: Non-invasive methods for blood component analysis are attractive by their evident advantages such as real time monitoring, immunity to infection, possibility to control the concentrations of blood components, and providing painless measurement as often as necessary. A simple algorithm that uses the logarithmic ratio of two signals was successfully applied in the case of noninvasive bilirubin measurement. In contrast with bilirubin, glucose absorption takes place in the near infrared range where absorption by other components such as water, proteins, hemoglobin is significant. Therefore, a proper algorithm should use signal wavelengths, which are relatively free from the overlapping with the absorption bands of other major components. At the same time, the influence of other blood components whose concentrations may induce optically interfering signals should be minimized. The authors present here a simple, but efficient algorithm, which can be described on the base of analysis of the light propagation in blood. The algorithm may use any number of discrete wavelengths. A pulsed polychromatic light source is used. The light source emits a light pulse with a time duration of 500 μs in wide bandwidth which includes light in the near infrared spectrum (energy of the pulse in near infrared range is 900 mW). Light source and detector unit was carefully designed so that reflected light from the skin surface was not measured. Prisms, fiber bundles, dispersing elements, etc. were used for propagating, directing and collecting oflight. The distance between the beam and detector, which could be adjusted between 2 and 10 mm, was set to be sufficient to avoid surface reflection and to minimize the effects of tissue scattering. Four interference filters as spectral selective elements around wavelengths 1625 nm, 1364 nm, 1300 nm and 1200 nm were used. Two different light sources, flash lamp and LED array were tried for the experiment
    Lasers and Electro-Optics, 1999. CLEO/Pacific Rim '99. The Pacific Rim Conference on; 02/1999
  • K. J. Jeon, I. D. Hwang, S. Hahn, G. Yoon
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    ABSTRACT: Glucose determination based on near-IR spectroscopy is investigated for reflectance and transmittance measurement. A wavelength range is 1100 to 2500 nm, which includes both the combination and overtone bands of glucose absorption. Intralipid solutions are used as samples, where glucose concentrations vary between 0 and 1000 mg/dl. Sample thickness for reflectance is 10 cm and 1- and 2-mm-thick samples are used for transmission. Partial least-squares regression (PLSR) analyses are performed to predict glucose concentrations. The standard errors of calibration are comparable between reflectance and 2-mm-thick transmittance. The reflectance method is inferior to the transmittance method in terms of the standard errors of prediction. Loading vector analysis for reflectance does not show glucose absorption features. Reflected light may not have enough information of glucose since a major portion of detected light has a short optical path length. In addition, prediction becomes more dependent on medium scattering rather than glucose, compared with transmission measurement. Loading vectors obtained from a PLSR transmittance analysis have glucose absorption profiles. The 1-mm-thick samples give better results than the 2-mm-thick samples for both calibration and prediction models. The transmittance setup is recommended for noninvasive glucose monitoring.
    J Biomed Opt. 11(1):014022.
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    ABSTRACT: A method for non-invasive determination of blood glucose on the basis of selective spectral analysis of reflected from or transmitted through biological tissues containing blood is demonstrated. Our proposed algorithm is based on a discrete number of wavelengths. The wavelengths are selected such that the measurements of glucose levels can be most sensitive and such that the influences of other substances such as water, hemoglobin, skin, etc. may be minimized. A compact instrument is developed for measurement. Verifications of the algorithm are successfully accomplished using scattering solutions whose glucose concentrations varied up to 1000 mg/dl
    Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE;