Publications (26)38.22 Total impact
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Article: Ophiamides A-B, new potent urease inhibitory sphingolipids from Heliotropium ophioglossum.
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ABSTRACT: Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-D: -glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.Archives of Pharmacal Research 07/2012; 35(7):1133-7. · 1.59 Impact Factor -
Article: Biologically active bergenin derivatives from Bergenia stracheyi.
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ABSTRACT: New bergenin derivatives, bergecins A and B (1 and 2, resp.), have been isolated from the AcOEt-soluble fraction of Bergenia stracheyi, along with bergenin (3), and their structures were elucidated on the basis of (1) H- and (13) C-NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme lipoxygenase, while 1 was moderately active. On the other hand, both compounds exhibited significant antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay.Chemistry & Biodiversity 01/2012; 9(1):91-8. · 1.80 Impact Factor -
Article: Sorbicins A and B, new urease and serine protease inhibitory triterpenes from Sorbus cashmiriana.
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ABSTRACT: Two new lupene-type triterpenes, sorbicins A and B, have been isolated from the chloroform-soluble fraction of the MeOH extract from the whole plant of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including 2D NMR. Both compounds displayed urease and α-chymotrypsin inhibitory potential.Journal of Asian natural products research 12/2011; 13(12):1081-6. · 0.61 Impact Factor -
Article: Pregnane derivatives from Potentilla evestita.
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ABSTRACT: A new pregnane derivative, 2,6beta,7beta-trihydroxy-4-methyl-19-norpregna-1,3,5(10)-trien-17-one, has been isolated from the ethyl acetate soluble fraction of Potentilla evestita along with a pregnane derivative, 11alpha,17alpha,21-trihydroxypregna-4,16(22)-diene-3,20-dione, that is reported for the first time as a natural product. Their structures were elucidated with the aid of 1H and 13C NMR spectra and by COSY, HMQC, HMBC and NOESY experiments.Natural product communications 08/2011; 6(8):1083-4. · 1.24 Impact Factor -
Article: Secondary metabolites from Caragana ambigua
Journal- Chemical Society of Pakistan 01/2011; · 1.38 Impact Factor -
Article: Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis.
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ABSTRACT: Nine compounds have been isolated from the ethyl acetate soluble fraction of C. sinensis, namely protocatechuic acid (1), trans-caffeic acid (2), methyl rosmarinate (3), rosmarinic acid (4), kaempferide-3-O-β-D-glucopyranoside (5), kaempferol-3-O-β-D-glucopyranoside (6), quercetin-3-O-β-D-glucopyranoside (7), kaempferide-3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (8) and kaempferol-3-O-α-L-rhamno-pyranosyl (1→6)-β-D-glucopyranoside (9), all reported for the first time from this species. The structures of these compounds were deduced on the basis of spectroscopic studies, including 1D and 2D NMR techniques. Compounds 1-9 were investigated for biological activity and showed significant anti-inflammatory activity in the carrageen induced rat paw edema test. The antioxidant activities of isolated compounds 1-9 were evaluated by the DPPH radical scavenging test, and compounds 1, 2, 4 and 7-9 exhibited marked scavenging activity compared to the standard BHA. These compounds were further studied for their anti-glycation properties and some compounds showed significant anti-glycation inhibitory activity. The purity of compounds 2-5, 8 and 9 was confirmed by HPLC. The implications of these results for the chemotaxonomic studies of the genus Cordia have also been discussed.Molecules 01/2011; 16(12):10214-26. · 2.39 Impact Factor -
Article: Potent anti-platelet constituents from Centaurea iberica.
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ABSTRACT: New naturally occurring nitrogenous compounds 1 and 2, along with a new dimeric lignan glucoside 3, have been isolated from the ethyl acetate soluble fraction of Centaurea iberica. Their structures have been elucidated through spectroscopic techniques. All the isolated compounds showed significant platelet aggregation inhibition.Molecules 01/2011; 16(3):2053-64. · 2.39 Impact Factor -
Article: Dimorphamide A-C, new polyphenolic amides from Atriplex dimorphostagia
Helvetica Chimica Acta 01/2011; · 1.48 Impact Factor -
Article: Xanthine oxidase/tyrosinase inhibiting, antioxidant, and antifungal oxindole alkaloids from Isatis costata.
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ABSTRACT: Phytochemical investigations on the ethyl acetate soluble fraction of the whole plant of Isatis costata Linn. (Brassicaseae) led to the isolation of the oxindole alkaloids costinones A (1), B (2), isatinones A (3), B (4), indirubin (5), and trisindoline (6). Compounds 1-6 displayed significant to moderate inhibition against xanthine oxidase enzyme with IC50 values ranging from 90.3+/-0.06 to 179.6+/-0.04 microM, whereas the standard inhibitor of xanthine oxidase (allopurinol) had an IC(50) value of 7.4+/-0.07 microM. Compounds 1 (IC50 7.21+/-0.05 microM), 2 (IC50 9.40+/-0.03 microM), 3 (IC50 11.51+/-0.07 microM), 4 (IC50 12.53+/-0.06 microM), 5 (IC50 14.29+/-0.09 microM), and 6 (IC50 17.34+/-0.04 microM) exhibited pronounced activities when compared with the standard tyrosinase inhibitor L-mimosine (IC50 3.70+/-0.03 microM), along with DPPH radical scavenging activity with IC50 226, 270, 300, 320, 401, and 431 microM, respectively. The crude extract and compounds 1, 2, 5, and 6 showed significant antifungal activity against Trichophyton schoen leinii, Aspergillus niger, Candida albicans, Trichophyton simii, and Macrophomina phaseolina.Pharmaceutical Biology 06/2010; 48(6):716-21. · 0.88 Impact Factor -
Article: Loasifolin, a new flavonoid from Eremostachys loasifolia.
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ABSTRACT: Loasifolin (1), a new highly oxygenated flavonoid, has been isolated from Eremostachys loasifolia and its structure is assigned on the basis of spectroscopic data including 1D and 2D NMR techniques. 6,7-Dihydroxycoumarin (2) and luteolin 4'-O-beta-d-glucopyranoside (3) have also been isolated for the first time from the genus Eremostachys.Journal of Asian natural products research 04/2010; 12(4):328-30. · 0.61 Impact Factor -
Article: Coagulansins A and B, New Withanolides from Withania coagulansDunal
Helvetica Chimica Acta 03/2010; 93(3):530 - 535. · 1.48 Impact Factor -
Article: Purunusides A-C, alpha-glucosidase inhibitory homoisoflavone glucosides from Prunus domestica.
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ABSTRACT: Purunusides A-C (1-3), new homoisoflavone glucosides together with the known compounds beta-sitosterol (4) and 6,7-methylenedioxy-8-methoxycoumarin (5) have been isolated from n-butanol and ethyl acetate soluble fractions of Prunus domestica. Their structures were assigned on the basis of spectral studies. The compounds 1-3 showed potent inhibitory activity against the enzyme alpha-glucosidase.Archives of Pharmacal Research 12/2009; 32(12):1705-10. · 1.59 Impact Factor -
Article: Aitchisonides A and B, new iridoid glucosides from Aitchisonia rosea.
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ABSTRACT: Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fraction of Aitchisonia rosea along with deacetylasperulosidic acid (3) and nepetanudoside B (4), which were reported for the first time from the genus Aitchisonia. Their structures have been assigned on the basis of spectral analysis including (1)H and (13)C NMR spectra and by DEPT, 2D COSY, NOESY, and HMBC experiments.Journal of Asian natural products research 11/2009; 11(11):985-9. · 0.61 Impact Factor -
Article: Structural determination of prunusins A and B, new C-alkylated flavonoids from Prunus domestica, by 1D and 2D NMR spectroscopy.
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ABSTRACT: Prunusins A (1) and B (2), the new C-alkylated flavonoids, have been isolated from the seed kernels of Prunus domestica. Their structures were assigned from (1)H and (13)C nuclear magnetic resonating spectra, DEPT and by correlation spectroscopy, HMQC and HMBC experiments. 3, 5, 7, 4'-Tetrahydroxyflavone (3) and 3, 5, 7-trihydroxy-8, 4'-dimethoxyflavone (4) have also been reported from this species. Both compounds (1) and (2) showed significant antifungal activity against pathogenic fungus Trichophyton simmi.Magnetic Resonance in Chemistry 11/2009; 48(2):151-4. · 1.44 Impact Factor -
Article: Cashmirols A and B, new lipoxygenase inhibiting triterpenes from Sorbus cashmiriana.
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ABSTRACT: Two new triterpenes, cashmirols A and B, along with three known compounds have been isolated from the AcOEt-soluble fraction of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including two-dimensional NMR. Both compounds displayed lipoxygenase enzyme inhibitory potential.Chemistry & Biodiversity 09/2009; 6(9):1471-6. · 1.80 Impact Factor -
Article: PLEASE SCROLL DOWN FOR ARTICLE Elaeagnoside, chymotrypsin inhibiting steroidal glucoside from Elaeagnus orientalis Elaeagnoside, chymotrypsin inhibiting steroidal glucoside from Elaeagnus orientalis
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ABSTRACT: Elaeagnoside (1), a new steroidal glucoside, has been isolated from the chloroform fraction of Elaeagnus orientalis along with -sitosterol and 12-hydroxy-8,10-octadecadienoic acid. The structure of 1 has been elucidated with the help of chemical and spectral studies. It showed significant inhibitory activity against the enzyme chymotrypsin.Natural Product Letters 04/2009; 23:409-414. · 0.56 Impact Factor -
Article: Elaeagnoside, chymotrypsin inhibiting steroidal glucoside from Elaeagnus orientalis.
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ABSTRACT: Elaeagnoside (1), a new steroidal glucoside, has been isolated from the chloroform fraction of Elaeagnus orientalis along with beta-sitosterol and 12-hydroxy-8,10-octadecadienoic acid. The structure of 1 has been elucidated with the help of chemical and spectral studies. It showed significant inhibitory activity against the enzyme chymotrypsin.Natural product research 02/2009; 23(5):409-14. · 1.01 Impact Factor -
Article: Caragin, a new isoflavone from Caragana conferta.
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ABSTRACT: Caragin (1), a new isoflavone, has been isolated from the hexane soluble fraction of Caragana conferta along with docosyl-3,4 -dihydroxy-trans-cinnamate (2) and tetracosyl-3,4 -dihydroxy-trans-cinnamate (3) isolated for the first time from this species.Journal of Asian Natural Products Research 10/2008; 10(9-10):823-5. · 0.94 Impact Factor -
Article: New butyrylcholinesterase inhibitory steroid and peroxy acid from Leucas urticifolia.
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ABSTRACT: A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), beta-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.Archives of Pharmacal Research 09/2008; 31(8):999-1003. · 1.59 Impact Factor -
Article: Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from Isatis tinctoria.
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ABSTRACT: Phytochemical investigations on the alkaloidal fraction of the whole plant of the Isatis tinctoria led to the isolation of the alkaloids 1-6. Compounds 3, 2 were found to be potent butyrylcholinesterase and lipoxygenase enzymes inhibitors in a concentration-dependent manner with the IC(50) values 16.3 +/- 0.06 and 19.7 +/- 0.03 microM against BChE and 30.6 +/- 0.02 and 33.7 +/- 0.05 microM against LOX, respectively. The compounds (1-6) showed significant antifungal activity against Trichophyton schoen leinii, Aspergillus niger, Candida albicans, Trichophyton simii, and Macrophomina phaseolina.Journal of Enzyme Inhibition and Medicinal Chemistry 07/2008; 23(3):313-6. · 1.62 Impact Factor
Top co-authors
Top Journals
Institutions
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2008–2011
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H.E.J. Research Institute of Chemistry
Karachi, Sindh, Pakistan
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2010
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Kohat University of Science & Technology
Kohāt, North West Frontier Province, Pakistan
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2009
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National University of Science and Technology
Islāmābād, Islamabad Capital Territory, Pakistan
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