Yukihiko Nosé

Baylor College of Medicine, Houston, Texas, United States

Are you Yukihiko Nosé?

Claim your profile

Publications (740)1020.39 Total impact

  • Shun Murabayashi · Yukihiko Nose ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Bioengineers have contributed to biocompatibility research. Many materials have been designed, synthesized and characterized by use of various analytical instruments. The blood compatibility of materials has been studied by focusing on the blood-material interfacial reactions. Although much information has been accumulated regarding such local reactions, understanding of biocompatibility is still limited. A more global approach to study is needed. A new approach to understanding biocompatibility is proposed and discussed. Three points are stressed: interaction within body's defense system and its effect on blood-material reactions; induction of a systemic reaction by a local reaction, which then affects the blood-material interaction; the time sequence of such interactions between local and systemic reactions. To establish a logical approach to study biocompatibility is most important at this moment for the future progress in biocompatibility research.
    Bio-medical materials and engineering 02/2013; 23(1):129-42. DOI:10.3233/BME-120738 · 1.09 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The Gyro centrifugal pump developed as a totally implantable artificial heart was designed with a free impeller, in which the rotational shaft (male bearing) of the impeller was completely separated from the female bearing. For this type of pump, it is very important to keep the proper magnet balance (impeller-magnet and actuator-magnet) in order to prevent thrombus formation and/or bearing wear. When the magnet balance is not proper, the impeller is jerked down into the bottom bearing. On the other hand, if magnet balance is proper, the impeller lifted off the bottom of the pump housing within a certain range of pumping conditions. In this study, this floating phenomenon was investigated in detail. The floating phenomenon was proved by observation of the impeller behavior using a transparent acrylic pump. The impeller floating phenomenon was mapped on a pump performance curve. The impeller floating phenomenon is affected by the magnet-magnet coupling distance and rotational speed of the impeller. In order to keep the proper magnet balance and to maintain the impeller floating phenomenon at the driving condition of right and left pump, the magnet-magnet coupling distance was altered by a spacer which was installed between the pump and actuator. It became clear that the same pump could handle different conditions (right and left ventricular assist), by just changing the thickness of the spacer. When magnet balance is proper, the floating impeller phenomenon occurs automatically in response to the impeller rev. It is called "the dynamic RPM suspension".
    Bio-medical materials and engineering 02/2013; 23(1):49-55. DOI:10.3233/BME-120731 · 1.09 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: An implantable centrifugal blood pump has been developed with original features for a ventricle assist device (VAD). This pump is part of a multicenter and international study with objective to offer simple, affordable, and reliable devices to developing countries. Previous computational fluid dynamics investigations were performed followed by prototyping and in vitro tests. Also, previous blood tests for assessment of hemolysis showed mean normalized index of hemolysis (NIH) results of 0.0054 ± 2.46 × 10⁻³ mg/100 L (at 5 L/min and 100 mm Hg). To precede in vivo evaluation, measurements of magnetic coupling interference and enhancements of actuator control were necessary. Methodology was based on the study of two different work situations (1 and 2) studied with two different types of motors (A and B). Situation 1 is when the rotor of pump is closest to the motor and situation 2 its opposite. Torque and mechanical power were collected with a dynamometer (80 g/cm) and then plotted and compared for two situations and both motors. The results showed that motor A has better mechanical behavior and less influence of coupling. Results for situation 1 showed that it is more often under magnetic coupling influence than situation 2. The studies lead to the conclusion that motor A is the best option for in vivo studies as it has less influence of magnetic coupling in both situations.
    ASAIO journal (American Society for Artificial Internal Organs: 1992) 08/2011; 57(5):462-5. DOI:10.1097/MAT.0b013e31823005dc · 1.52 Impact Factor
  • Yukihiko Nosé ·
    [Show abstract] [Hide abstract]
    ABSTRACT: No abstract is available for this article.
    Artificial Organs 07/2011; 35(7):679-81. DOI:10.1111/j.1525-1594.2011.01299.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Our previous studies concluded Egyptian cotton was the most appropriate material for making a second generation granulocytapheresis (G-CAP) column as structural dimensions of the cotton fibers are able to attract granulocytes. Unfortunately, it is considered to be blood incompatible as its fibers are of non-synthetic origins. In this study we examined the alteration of the removal rates of blood cells with different surface modifications of Egyptian cotton to enhance its blood compatibility. The surface-modified cotton fibers were compared after three kinds of combination treatments. There were no differences in the removal rates of white blood cells (WBCs) and particularly neutrophils with the use of three kinds of biolized cottons. Next, an ex vivo animal study with a healthy dog was performed with the prototype of the G-CAP column. The dog's blood pressure (BP) decreased to approximately 80% of the initial values of BP at 20 min after the start of the extracorporeal circulation. The decrease in BP gradually reverted to normal. WBCs and particularly neutrophils decreased significantly at 15 min after the start of the extracorporeal circulation and remained low during the extracorporeal circulation. The ability of this column to remove WBCs was maintained during extracorporeal circulation. Especially, neutrophils at the inlet of the column were thoroughly removed for 1 h. Based upon these results, a second generation G-CAP column could be fabricated with Egyptian cotton and applied for clinical use on the condition that the biocompatibility of the Egyptian cotton needs to be improved by the appropriate biolization method.
    Journal of Artificial Organs 06/2011; 14(4):342-7. DOI:10.1007/s10047-011-0583-7 · 1.44 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Controlled immunological shock, induced by bioincompatible material apheresis for cancer (BIC MAC) therapy, produces an immunoactive status in experimental subjects. However, in order to provide a safe, painless, effective, and reproducible BIC MAC therapy, it is mandatory to provide general anesthesia with endotracheal intubation not only during apheresis procedures of 1-h duration but also for an additional 5 h. Using this procedure, there was no mortality experienced during animal experiments. Also, there were no procedurally related physical or sensory abnormalities demonstrated. This general anesthesia of 6 h covered not only the initial 30 min of the hypotension and hypoxic stages but also the recovery stages to hemodynamically normalize the experimental animals. After 6 h, the accumulated leukocytes in the lung are released back to the systemic circulation. In general, granulocytes decreased almost 100% while lymphocytes decreased only 40-50%. During these 6 h, increases of cytokines (tumor necrosis factor-α, interleukin-6, etc.) sometimes up to 1000 times occurred. After the 6-h procedure, leukocytes returned nearly to preoperative levels but tended to be continuously increased. After the fourth day, leukocyte counts more than doubled. These cellular and humoral activations were normalized after 2 weeks. These studies were conducted on six normal mongrel dogs. Currently, similar studies are planned to be conducted on tumor-bearing experimental animals. This procedurally induced immunoactivation by apheresis may be able to produce effective apoptosis in malignant tumor cells.
    Artificial Organs 03/2011; 35(3):308-15. DOI:10.1111/j.1525-1594.2010.01196.x · 2.05 Impact Factor
  • Yukihiko Nosé · Paul S. Malchesky ·

    MRS Online Proceeding Library 01/2011; 110. DOI:10.1557/PROC-110-723
  • Yukihiko Nosé · Kazuhide Ohta · Wadi N Suki · Junji Takaba · Hiroshi Miyamoto ·

    Artificial Organs 01/2011; 35(1):4-8. DOI:10.1111/j.1525-1594.2010.01178.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: As a therapeutic VAD to be combined with drugs, apheresis, and cellular implants, it is advisable to develop a wearable VAD for less than 6 months of application. Such an example was shown by describing the therapeutic BCM Gyro centrifugal VAD.
    Artificial Organs 12/2010; 34(12):1069-76. DOI:10.1111/j.1525-1594.2010.01163.x · 2.05 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: External microwave (EMW) hyperthermia system (2.45 GHz wave frequency) was evaluated by in vitro studies and in vivo pleural metastasis animal model. Three different non-small-cell lung cancer cells and normal fibroblast cells (control) were treated once a day for 3 days with the prototype EMW system applying mild (39 degrees C), moderate (43 degrees C), and severe (47 degrees C) hyperthermia. On Day-4, tested cells were retrieved and examined by apoptosis assay kit and Western blot analysis. Cancer cells treated with moderate hyperthermia showed significant apoptosis; yet no major damage was observed to normal fibroblast cells. Western blot analysis indicated cleavage on caspase-3, -9 and PARP. Also in the cell cycle analysis, increase of sub G0-G1 population was identified. After optimization of the heating intensity for in vivo environment, we created pleural metastatic animal model in 24 immune deficiency mice (male nu/nu mice) to evaluate inhibitory effect of systemic EMW hyperthermia for disseminated tumor growth. Out of 24 mice, 8 received mild and 8 received moderate hyperthermia, and remaining 8 were the no treatment control. Whole chest area of the experimental animals was irradiated 3 times a week for 2 weeks (total of 6 time irradiations). No significant adverse event was observed including abnormal weight loss, skin burn, ulceration, and death. Metastasized tumors around the pleura and chest cavity were 75% reduced in size and weight compared to non-treated control group. Harvested tumors were stained and TUNEL assay demonstrated significant apoptosis in a moderate hyperthermia group. The EMW hyperthermia system may be possible alternative tool as a systemic hyperthermia therapy in severely advanced lung cancer patients. Further study is necessary to determine device safeness, efficacy, and synergistic effect to other possible combination therapies.
    Oncology Reports 09/2010; 24(3):591-8. DOI:10.3892/or_00000896 · 2.30 Impact Factor
  • Yukihiko Nosé ·

    Artificial Organs 07/2010; 34(7):527-8. DOI:10.1111/j.1525-1594.2010.01055.x · 2.05 Impact Factor
  • Yukihiko Nosé ·

    Artificial Organs 06/2010; 34(6):451-2. DOI:10.1111/j.1525-1594.2010.01043.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The preliminary studies for developing a second generation granulocytapheresis (G-CAP) column were made. In the past, the G-CAP column has been used for the treatment of ulcerative colitis and rheumatoid arthritis. However, recent clinical studies have revealed that the therapeutic effects of the G-CAP column are not significant compared with those of the sham column. These results were considered to be due to insufficient reduction of granulocytes. Thus, development of a better granulocyte removal column was attempted. Realizing that white cells adhered on small-diameter synthetic fibers of 1-2 microm, small diameter cotton fibers were subjected to the studies of their granulocyte-removing capabilities. Three types of cotton, Pakistani, Australian and Egyptian cottons, were evaluated using normal human blood in vitro. Miniature columns were made of each fiber, and CBC and WBC differentiation was compared between pre- and post-filtered blood. The Egyptian cotton removed leukocytes, especially granulocytes, the most efficiently of the three types of cotton. The Egyptian cotton's granulocyte adhesion properties were not altered after different chemical treatments. A 4-ml column of packaged Egyptian cotton with a density of more than 0.125 g/ml could remove granulocytes effectively up to 80 ml of blood passages. Based upon these studies, second generation G-CAP could be carried out with Egyptian cotton fibers as a scaled-up clinical module.
    Journal of Artificial Organs 04/2010; 13(2):92-6. DOI:10.1007/s10047-010-0498-8 · 1.44 Impact Factor
  • Yukihiko Nosé ·

    Nature Reviews Cardiology 04/2010; 7(4):184-6. DOI:10.1038/nrcardio.2010.13 · 9.18 Impact Factor
  • Yukihiko Nosé ·

    Artificial Organs 09/2009; 33(9):674-8. DOI:10.1111/j.1525-1594.2009.00904.x · 2.05 Impact Factor
  • Yukihiko Nosé ·

    Artificial Organs 09/2009; 33(9):679-84. DOI:10.1111/j.1525-1594.2009.00905.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We have developed a new transcutaneous energy transmission (TET) system for a totally implantable biventricular assist device (BVAD) system in the New Energy and Industrial Development Organization (NEDO) artificial heart project. The TET system mainly consists of an energy transmitter, a hybrid energy coil unit, an energy receiver, an internal battery system, and an optical telemetry system. The hybrid energy coil unit consists of an air-core energy transmission coil and an energy-receiving coil having a ferrite core. Internal units of the TET system are encapsulated in a titanium alloy casing, which has a size of 111 mm in width, 73 mm in length, and 25 mm in height. In in vitro experiments, the TET system can transmit a maximum electric energy of 60 Watts, and it has a maximum transmission efficiency of 87.3%. A maximum surface temperature of 46.1 degrees C was measured at the ferrite core of the energy-receiving coil during an energy transmission of 20 Watts in air. The long-term performance test shows that the TET system has been able to operate stably for over 4 years with a decrease of energy-transmission efficiency from 85% to 80%. In conclusion, the TET system with the hybrid energy coil can overcome the drawback of previously reported TET systems, and it promises to be the highest performance TET system in the world.
    Artificial Organs 08/2009; 33(8):622-6. DOI:10.1111/j.1525-1594.2009.00785.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A pyridoxalated-hemoglobin-polyoxyethylene conjugate (PHP) was developed from outdated human red cell hemoglobin through chemical modifications. The PHP has a mean molecular weight of approximately 90,000 daltons, with an acceptable P50 of 22 ± 0.7mmHg. This report describes exchange transfusion studies (ET) to a final hematocrit of 5 ± 2% (n = 5) with PHP in mongrel dogs. Hespan (a plasma expander) was used as a control (n = 6). All the animals with PHP tolerated the procedure well and have survived more than 8 months to date. Five out of the six dogs receiving Hespan died within a week (p = 0.004). Reduction of hematological and coagulation parameters occurred following the ET and returned to the normal range by 4 weeks post ET. Serum electrolytes and renal function parameters (urea, creatinine) remained in the normal range. A transient slight increase in the hepatic enzyme SGOT was observed. At 2 weeks post ET open biopsies of major organs showed vacuolized cells in the liver and kidneys. Normal histology was noted at 3 months. The oxygen transporting properties examined showed effective oxygen delivery to the tissues for 6 hours post ET. PHP continued to transport oxygen for up to 48 hours studied post ET. Half-life of PHP in the circulation was 36.3 ± 3.5 hours. Urinary loss of hemoglobin measured up to 48 hours after ET was 9.4 ± 1.6% of the injected net hemoglobin. The PHP effectively supported life at lethal levels of anemia and is a physiologically acceptable solution. It has a relatively long intravascular residence time and transports oxygen to the tissue effectively for at least 6 hours.
  • Yukihiko Nosé ·

    Artificial Organs 07/2009; 33(6):409-10. DOI:10.1111/j.1525-1594.2009.00840.x · 2.05 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent-related thrombosis. Thirty self-expanding mesh stents were fabricated from Ti-Ni metal wires with a dimension of 4 mm (diameter) x 25 mm (length) x 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He(+) ion beam at an energy of 150 keV with fluences of 1 x 10(14) ions/cm(2) (ion stent group). Ten stents had no treatment (non-ion stent group). The self-expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1-month patency rate for the non-ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He(+) ion-implanted collagen-coated Ti-Ni self-expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
    Artificial Organs 07/2009; 33(6):456-63. DOI:10.1111/j.1525-1594.2009.00747.x · 2.05 Impact Factor

Publication Stats

6k Citations
1,020.39 Total Impact Points


  • 1992-2013
    • Baylor College of Medicine
      • Department of Surgery
      Houston, Texas, United States
  • 2008
    • American Society for Artificial Internal Organs
      Columbus, Ohio, United States
  • 1970-2008
    • Cleveland Clinic
      Cleveland, Ohio, United States
  • 2003
    • University of Tsukuba
      Tsukuba, Ibaraki, Japan
  • 2002
    • Tohoku University
      Sendai-shi, Miyagi, Japan
  • 1999
    • Texas Medical Center
      Houston, Texas, United States
  • 1996
    • Kanagawa University
      Yokohama, Kanagawa, Japan
  • 1989-1995
    • St. Vincent Charity Medical Center
      Cleveland, Ohio, United States
    • Case Western Reserve University
      • Department of Otolaryngology, Head and Neck Surgery (University Hospitals Case Medical Center)
      Cleveland, Ohio, United States
  • 1994
    • Mie University
      • Department of Thoracic and Cardiovascular Surgery
      Tu, Mie, Japan
    • Hiroshima University
      • Faculty of Law
      Hiroshima-shi, Hiroshima-ken, Japan
  • 1993
    • Tokyo Denki University
      Edo, Tōkyō, Japan
  • 1991
    • Houston Methodist Hospital
      Houston, Texas, United States
  • 1983
    • Harvard Medical School
      Boston, Massachusetts, United States
    • Cedars-Sinai Medical Center
      Los Ángeles, California, United States