Cosimo Del Gratta

Publications (43)145.31 Total impact

• Source

  Available from: Domenico De Berardis

  Article: Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study.

  Gianna Sepede, Domenico De Berardis, Daniela Campanella, Mauro Gianni Perrucci, Antonio Ferretti, Nicola Serroni, Francesco Saverio Moschetta, Cosimo Del Gratta, Rosa Maria Salerno, Filippo Maria Ferro, Massimo Di Giannantonio, Marco Onofrj, Gian Luca Romani, Francesco Gambi
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  ABSTRACT: Sepede G, De Berardis D, Campanella D, Perrucci MG, Ferretti A, Serroni N, Moschetta FS, Del Gratta C, Salerno RM, Ferro FM, Di Giannantonio M, Onofrj M, Romani GL, Gambi F. Impaired sustained attention in euthymic bipolar disorder patients and non-affected relatives: an fMRI study. Bipolar Disord 2012: 00: 000-000. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Behavioral deficits in sustained attention have been reported during both acute and euthymic phases of type I bipolar disorder (BD-I) and also in non-affected relatives of bipolar disorder (BD) patients. In particular, selective failure in target recognition was proposed as a potential trait marker for BD, but there are few studies exploring the neural correlates. The aim of the present study was to analyze the behavioral and functional magnetic resonance imaging (fMRI) response of euthymic BD-I patients and non-affected relatives during a sustained attention task. Methods:  Twenty-four euthymic BD-I patients, 22 non-affected first-degree relatives of BD-I subjects, and 24 matched controls underwent a continuous performance test (CPT) with two levels of difficulty during event-related fMRI scanning. Results:  Both patients and relatives showed a lower accuracy in target detection when compared to controls. The fMRI data analysis revealed between-group differences in several brain regions involved in sustained attention. During error in target recognition, both patients and relatives showed a larger activation in the bilateral insula and the posterior part of the middle cingulate cortex. By contrast, during correct target response, only patients failed to activate the right insula, whereas relatives showed an increased activation of the left insula and bilateral inferior parietal lobule - limited to the higher attention load - and an augmented deactivation of the posterior cingulate/retrosplenial cortex. Conclusions:  A selective impairment in target recognition during a CPT was behaviorally and functionally detectable in both euthymic BD-I patients and non-affected first-degree relatives, suggesting that specific sustained attention deficits may be a potential trait marker for BD-I.
  Bipolar Disorders 10/2012; · 5.29 Impact Factor
• Article: The role of left superior parietal lobe in male sexual behavior: dynamics of distinct components revealed by FMRI.

  Nicoletta Cera, Ezio D Di Pierro, Gianna Sepede, Francesco Gambi, Mauro Gianni Perrucci, Arcangelo Merla, Armando Tartaro, Cosimo Del Gratta, Giuseppe Galatioto Paradiso, Carlo Vicentini, Gian Luca Romani, Antonio Ferretti
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  ABSTRACT: Despite the interest for the brain correlates of male sexual arousal, few studies investigated neural mechanisms underlying psychogenic erectile dysfunction (ED). Although these studies showed several brain regions active in ED patients during visual erotic stimulation, the dynamics of inhibition of sexual response is still unclear. This study investigated the dynamics of brain regions involved in the psychogenic ED. Functional magnetic resonance imaging (fMRI) and simultaneous penile tumescence (PT) were used to study brain activity evoked in 17 outpatients with psychogenic ED and 19 healthy controls during visual erotic stimulation. Patterns of brain activation related to different phases of sexual response in the two groups were compared. Simultaneous recording of blood oxygen level-dependent fMRI responses and PT during visual erotic stimulation. During visual erotic stimuli, a larger activation was observed for the patient group in the left superior parietal lobe, ventromedial prefrontal cortex, and posterior cingulate cortex, whereas the control group showed larger activation in the right middle insula and dorsal anterior cingulate cortex and hippocampus. Moreover, the left superior parietal lobe showed a larger activation in patients than controls especially during the later stage of sexual response. Our results suggest that, among regions more active in patient group, the left superior parietal lobe plays a crucial role in inhibition of sexual response. Previous studies showed that left superior parietal lobe is involved in monitoring of internal body representation. The larger activation of this region in patients during later stages of sexual response suggests a high monitoring of the internal body representation, possibly affecting the behavioral response. These findings provide insight on brain mechanisms involved in psychogenic ED.
  Journal of Sexual Medicine 04/2012; 9(6):1602-12. · 3.55 Impact Factor
• Article: Effects of mobile phone signals over BOLD response while performing a cognitive task.

  Giuseppe Curcio, Davide Nardo, Mauro Gianni Perrucci, Patrizio Pasqualetti, Tzu Ling Chen, Cosimo Del Gratta, Gian Luca Romani, Paolo Maria Rossini
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  ABSTRACT: The aim of this study was to investigate the effects induced by an exposure to a GSM signal (Global System for Mobile Communication) on brain BOLD (blood-oxygen-level dependent) response, as well as its time course while performing a Go-NoGo task. Participants were tested twice, once in presence of a "real" exposure to GSM radiofrequency signal and once under a "sham" exposure (placebo condition). BOLD response of active brain areas and reaction times (RTs) while performing the task were measured both before and after the exposure. RTs to the somatosensory task did not change as a function of exposure (real vs sham) to GSM signal. BOLD results revealed significant activations in inferior parietal lobule, insula, precentral and postcentral gyri associated with Go responses after both ''real'' and ''sham'' exposure, whereas no significant effects were observed in the ROI analysis. The present fMRI study did not detect any brain activity changes by mobile phones. Also RTs in a somatosensory task resulted unaffected. No changes in BOLD response have been observed as a consequence of RF-EMFs exposure.
  Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 07/2011; 123(1):129-36. · 3.12 Impact Factor
• Source

  Available from: Nicoletta Savini

  Article: Passive tactile recognition of geometrical shape in humans: An fMRI study.

  Nicoletta Savini, Claudio Babiloni, Marcella Brunetti, Massimo Caulo, Cosimo Del Gratta, Mauro Gianni Perrucci, Paolo Maria Rossini, Gian Luca Romani, Antonio Ferretti
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  ABSTRACT: Tactile shape discrimination involves frontal other than somatosensory cortex (Palva et al., 2005 [48]), but it is unclear if this frontal activity is related to exploratory concomitants. In this study, we investigated topographical details of prefrontal, premotor, and parietal areas during passive tactile recognition of 2D geometrical shapes in conditions avoiding exploratory movements. Functional magnetic resonance imaging (fMRI) was performed while the same wooden 2D geometrical shapes were blindly pressed on subjects' passive right palm in three conditions. In the RAW condition, shapes were pressed while subjects were asked to attend to the stimuli but were not trained to recognize them. After a brief training, in the SHAPE condition subjects were asked to covertly recognize shapes. In the RECOGNITION condition, they were asked to overtly recognize shapes, using response buttons with their opposite hand. Results showed that somatosensory cortex including contralateral SII, contralateral SI, and left insula was active in all conditions, confirming its importance in processing tactile shapes. In the RAW vs. SHAPE contrast, bilateral posterior parietal, insular, premotor, prefrontal, and (left) Broca's areas were more active in the latter. In the RECOGNITION, activation of (left) Broca's area correlated with correct responses. These results suggest that, even without exploratory movements, passive recognition of tactile geometrical shapes involves prefrontal and premotor as well as somatosensory regions. In this framework, Broca's area might be involved in a successful selection and/or execution of the correct responses.
  Brain research bulletin 10/2010; 83(5):223-31. · 2.18 Impact Factor
• Article: Effects of somatosensory stimulation and attention on human somatosensory cortex: an fMRI study.

  Tzu Ling Chen, Claudio Babiloni, Antonio Ferretti, Mauro Gianni Perrucci, Gian Luca Romani, Paolo Maria Rossini, Armando Tartaro, Cosimo Del Gratta
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  ABSTRACT: It is well known that primary and non-primary areas of human somatosensory cortex are involved in the processing of adequate deviant/rare stimuli and omission of frequent stimuli. However, the relative weight and interaction of these variables is poorly known. This functional magnetic resonance imaging (fMRI) study tested the hypothesis that somatosensory stimulus processing and attention especially interact in non-primary somatosensory areas including secondary somatosensory cortex (SII) and insula. To test this hypothesis, responses of somatosensory cortex were mapped during four conditions of an oddball paradigm: DELIVERED COUNT and IGNORE (count or ignore deviant/rare electrical stimuli, respectively); OMITTED COUNT and IGNORE (count or ignore the rare omission of frequent electrical stimuli, respectively). The deviant/rare and frequent electrical stimuli were delivered to median and ulnar nerve, respectively. It was observed that contralateral (left) primary somatosensory responses were not markedly modulated by the mentioned deviant/rare events. Furthermore, contralateral SII and insula responded to all but not OMITTED IGNORE (purely attentive) condition, whereas ipsilateral (right) SII responded to all conditions. Finally, ipsilateral insula responded to the COUNT (attentive) conditions, regardless of the physical presence of the deviant/rare stimuli. The results suggest that in somatosensory modality, bilateral SII and left (contralateral) insula reflect complex integrative processes of stimulus elaboration and attention, whereas right (ipsilateral) insula mainly sub-serves active attention to deviance within a sequence of somatosensory stimuli.
  NeuroImage 10/2010; 53(1):181-8. · 5.89 Impact Factor
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  Available from: Mauro Gianni Perrucci

  Article: Neural correlates of focused attention and cognitive monitoring in meditation.

  Antonietta Manna, Antonino Raffone, Mauro Gianni Perrucci, Davide Nardo, Antonio Ferretti, Armando Tartaro, Alessandro Londei, Cosimo Del Gratta, Marta Olivetti Belardinelli, Gian Luca Romani
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  ABSTRACT: Meditation refers to a family of complex emotional and attentional regulatory practices, which can be classified into two main styles - focused attention (FA) and open monitoring (OM) - involving different attentional, cognitive monitoring and awareness processes. In a functional magnetic resonance study we originally characterized and contrasted FA and OM meditation forms within the same experiment, by an integrated FA-OM design. Theravada Buddhist monks, expert in both FA and OM meditation forms, and lay novices with 10 days of meditation practice, participated in the experiment. Our evidence suggests that expert meditators control cognitive engagement in conscious processing of sensory-related, thought and emotion contents, by massive self-regulation of fronto-parietal and insular areas in the left hemisphere, in a meditation state-dependent fashion. We also found that anterior cingulate and dorsolateral prefrontal cortices play antagonist roles in the executive control of the attention setting in meditation tasks. Our findings resolve the controversy between the hypothesis that meditative states are associated to transient hypofrontality or deactivation of executive brain areas, and evidence about the activation of executive brain areas in meditation. Finally, our study suggests that a functional reorganization of brain activity patterns for focused attention and cognitive monitoring takes place with mental practice, and that meditation-related neuroplasticity is crucially associated to a functional reorganization of activity patterns in prefrontal cortex and in the insula.
  Brain research bulletin 03/2010; 82(1-2):46-56. · 2.18 Impact Factor
• Article: A difference exists in somatosensory processing between the anterior and posterior parts of the tongue.

  Kiwako Sakamoto, Hiroki Nakata, Koji Inui, Mauro Gianni Perrucci, Cosimo Del Gratta, Ryusuke Kakigi, Gian Luca Romani
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  ABSTRACT: The somatic sensation of the tongue is necessary for daily life, but it is difficult to know the underlying neural mechanisms. In particular, because of the vomiting reflex and several morphological problems, no neuroimaging studies have examined somatosensory processing by stimulating the posterior part of the tongue, except for two magnetoencephalographic studies (Sakamoto et al., 2008a,b). This is the first study to clarify the human cortical processing for sensory perception by the posterior part of the tongue with a newly developed device and functional magnetic resonance imaging (fMRI). Stimulation of the left and right postero-lateral parts of the tongue induced significant activity in the primary somatosensory cortex (SI) and Brodmann area 40 in the right hemisphere and the anterior cingulate cortex (ACC). In contrast, antero-lateral stimulation produced activity only in the right SI. The activated region in SI was significantly larger following stimulation of the posterior than anterior part. These results indicate that a clear difference exists in somatosensory processing between stimulation of the antero-lateral and postero-lateral parts of the tongue, and a right hemisphere is dominant for the stimulation of both antero-lateral and postero-lateral areas. The activity in BA 40 and ACC may imply that the posterior of the tongue belongs to the visceral system.
  Neuroscience Research 11/2009; 66(2):173-9. · 2.25 Impact Factor
• Article: Negative BOLD effect on somato-motor inhibitory processing: an fMRI study.

  Hiroki Nakata, Kiwako Sakamoto, Antonio Ferretti, Mauro Gianni Perrucci, Cosimo Del Gratta, Ryusuke Kakigi, Gian Luca Romani
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  ABSTRACT: Inhibiting inappropriate behavior and thoughts in the current context is an essential ability for humans, but the neural mechanisms for response inhibitory processing are a matter of continuous debate. The aim of this event-related functional magnetic resonance imaging (fMRI) study was to evaluate the negative blood oxygen level dependent (BOLD) effect on inhibitory processing during go/no-go paradigms. Fifteen subjects performed two different types of somatosensory go/no-go paradigm: (1) button press and (2) count. Go and no-go stimuli were presented with an even probability. We observed a common negative activation during Movement No-go and Count No-go trials in the right SFG, corresponding to BA 8. These findings suggest that the right SFG region was responsible for the negative BOLD effect on inhibitory processing, which was independent of the required response mode. We hypothesized several possible explanations for the deactivation of the SFG during no-go trials.
  Neuroscience Letters 10/2009; 462(2):101-4. · 2.11 Impact Factor
• Source

  Available from: Massimiliano Palmiero

  Article: An fMRI investigation on image generation in different sensory modalities: The influence of vividness

  Marta Olivetti Belardinelli, Massimiliano Palmiero, Sestieri Carlo, Davide Nardo, Rosalia Di Matteo, Alessandro Londei, Alessandro D'Ausilio, Antonio Ferretti, Cosimo Del Gratta, GianLuca Romani
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  ABSTRACT: a b s t r a c t In the present fMRI study the issue of the specific cortices activation during imagery generation in differ-ent sensory modalities is addressed. In particular, we tested whether the vividness variability of imagery was reflected in the BOLD signal within specific sensory cortices. Subjects were asked to generate a men-tal image for each auditory presented sentence. Each imagery modality was contrasted with an abstract sentence condition. In addition, subjects were asked to fill the Italian version of the Questionnaire Upon Mental Imagery (QMI) prior to each neuroimaging session. In general, greater involvement of sensory specific cortices in high-vivid versus low-vivid subjects was found for visual (occipital), gustatory (ante-rior insula), kinaesthetic (pre-motor), and tactile and for somatic (post-central parietal) imagery modal-ities. These results support the hypothesis that vividness is related to image format: high-vivid subjects would create more analogical representations relying on the same specific neural substrates active during perception with respect to low-vivid subjects. Results are also discussed according to the simulation perspective.
  Acta psychologica 09/2009; 132(132):190-200. · 2.19 Impact Factor
• Article: Is there "neural efficiency" during the processing of visuo-spatial information in male humans? An EEG study.

  Paolo Capotosto, M Gianni Perrucci, Marcella Brunetti, Cosimo Del Gratta, Michael Doppelmayr, Roland H Grabner, Wolfgang Klimesch, Aljoscha Neubauer, Christa Neuper, Gert Pfurtscheller, Gian Luca Romani, Claudio Babiloni
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  ABSTRACT: More intelligent persons (high IQ) typically present a higher cortical activity during tasks requiring the encoding of visuo-spatial information, namely higher alpha (about 10 Hz) event-related desynchronization (ERD; Doppelmayr et al., 2005). The opposite is true ("neural efficiency") during the retrieval of the encoded information, as revealed by both lower alpha ERD and/or lower theta (about 5 Hz) event-related synchronization (ERS; Grabner et al., 2004). To reconcile these contrasting results, here we evaluated the working hypothesis that more intelligent male subjects are characterized by a high cortical activity during the encoding phase. This deep encoding would explain the relatively low cortical activity for the retrieval of the encoded information. To test this hypothesis, electroencephalographic (EEG) data were recorded in 22 healthy young male volunteers during visuo-spatial information processing (encoding) and short-term retrieval of the encoded information. Cortical activity was indexed by theta ERS and alpha ERD. It was found that the higher the subjects' total IQ, the stronger the frontal theta ERS during the encoding task. Furthermore, the higher the subjects' total IQ, the lower the frontal high-frequency alpha ERD (about 10-12 Hz) during the retrieval task. This was not true for parietal counterpart of these EEG rhythms. These results reconcile previous contrasting evidence confirming that more intelligent persons do not ever show event-related cortical responses compatible with "neural efficiency" hypothesis. Rather, their cortical activity would depend on flexible and task-adapting features of frontal activation.
  Behavioural brain research 09/2009; 205(2):468-74. · 3.22 Impact Factor
• Source

  Available from: Demis Basso

  Article: Sensory-motor brain network connectivity for speech comprehension.

  Alessandro Londei, Alessandro D'Ausilio, Demis Basso, Carlo Sestieri, Cosimo Del Gratta, Gian-Luca Romani, Marta Olivetti Belardinelli
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  ABSTRACT: The act of listening to speech activates a large network of brain areas. In the present work, a novel data-driven technique (the combination of independent component analysis and Granger causality) was used to extract brain network dynamics from an fMRI study of passive listening to Words, Pseudo-Words, and Reverse-played words. Using this method we show the functional connectivity modulations among classical language regions (Broca's and Wernicke's areas) and inferior parietal, somatosensory, and motor areas and right cerebellum. Word listening elicited a compact pattern of connectivity within a parieto-somato-motor network and between the superior temporal and inferior frontal gyri. Pseudo-Word stimuli induced activities similar to the Word condition, which were characterized by a highly recurrent connectivity pattern, mostly driven by the temporal lobe activity. Also the Reversed-Word condition revealed an important influence of temporal cortices, but no integrated activity of the parieto-somato-motor network. In parallel, the right cerebellum lost its functional connection with motor areas, present in both Word and Pseudo-Word listening. The inability of the participant to produce the Reversed-Word stimuli also evidenced two separate networks: the first was driven by frontal areas and the right cerebellum toward somatosensory cortices; the second was triggered by temporal and parietal sites towards motor areas. Summing up, our results suggest that semantic content modulates the general compactness of network dynamics as well as the balance between frontal and temporal language areas in driving those dynamics. The degree of reproducibility of auditory speech material modulates the connectivity pattern within and toward somatosensory and motor areas.
  Human Brain Mapping 09/2009; 31(4):567-80. · 5.88 Impact Factor
• Article: Negative BOLD during tongue movement: a functional magnetic resonance imaging study.

  Kiwako Sakamoto, Hiroki Nakata, Mauro Gianni Perrucci, Cosimo Del Gratta, Ryusuke Kakigi, Gian Luca Romani
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  ABSTRACT: The aim of this functional magnetic resonance imaging (fMRI) study was to evaluate negative blood oxygen level-dependent (BOLD) signals during voluntary tongue movement. Deactivated (Negative BOLD) regions included the posterior parietal cortex (PPC), precuneus, and middle temporal gyrus. Activated (Positive BOLD) regions included the primary somatosensory-motor area (SMI), inferior parietal lobule, medial frontal gyrus, superior temporal gyrus, insula, lentiform nucleus, and thalamus. The results were not consistent with previous studies involving unilateral hand and finger movements showing the deactivation of motor-related cortical areas including the ipsilateral MI. The areas of Negative BOLD in the PPC and precuneus might reflect specific neural networks relating to voluntary tongue movement.
  Neuroscience Letters 09/2009; 466(3):120-3. · 2.11 Impact Factor
• Article: Altered brain response without behavioral attention deficits in healthy siblings of schizophrenic patients: an event-related fMRI study.

  Gianna Sepede, Antonio Ferretti, Mauro Gianni Perrucci, Francesco Gambi, Fiore Di Donato, Francesco Nuccetelli, Cosimo Del Gratta, Armando Tartaro, Rosa Maria Salerno, Filippo Maria Ferro, Gian Luca Romani
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  ABSTRACT: Attention deficits are common in schizophrenics and sometimes reported in their healthy relatives. The aim of this study was to analyse the behavioural performance and the brain activation of healthy siblings of schizophrenic patients during a sustained-attention task. Eleven healthy siblings of schizophrenic patients and eleven matched controls performed a Continuous Performance Test (CPT), during 1.5 T fMRI. The stimuli were presented at three difficulty-levels, using different degrees of degradation (0, 25 and 40%). There were no significant differences in CPT performance (mean reaction time and percentage of errors) between the two groups. Performance worsened with increasing degradation in both groups. Differences were found when comparing the BOLD signal change in the medial frontal gyrus/dorsal anterior cingulate, right precentral gyrus, bilateral posterior cingulate and bilateral insula. The most evident between group differences were observed in the left insula/inferior frontal gyrus: siblings showed a larger activation during wrong responses and a reduced activation during correct responses in the degraded runs. In conclusion, healthy siblings of schizophrenic patients showed differences in brain function in several brain regions previously reported in schizophrenic subjects, in the absence of behavioral attention deficits. The differences were greater in the two more difficult levels of attention demand and might be expressions of altered and/or compensatory mechanisms in subjects at increased risk for schizophrenia.
  NeuroImage 08/2009; 49(1):1080-90. · 5.89 Impact Factor
• Article: Fundamentals of electroencefalography, magnetoencefalography, and functional magnetic resonance imaging.

  Claudio Babiloni, Vittorio Pizzella, Cosimo Del Gratta, Antonio Ferretti, Gian Luca Romani
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  ABSTRACT: This review introduces readers to fundamentals of electroencephalography (EEG), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI). EEG and MEG signals are mainly produced by postsynaptic ionic currents of synchronically active pyramidal cortical neurons. These signals reflect the integrative information processing of neurons representing the output of cortical neural modules. EEG and MEG signals have a high temporal resolution (<1ms) ideal to investigate an emerging propriety of brain physiology, namely the brain rhythms. A background spontaneous oscillatory activity of brain neurons at about 10Hz generates dominant alpha rhythms of resting-state EEG and MEG activity. This background activity is blocked during sensory and cognitive-motor events. Standard EEG shows a low spatial resolution (5-9cm), which partially improves by high-resolution EEG including 64-128 channels and source estimation techniques (1-3cm); source estimation of MEG data shows a better spatial resolution (0.5-2cm). fMRI is an indirect measurement of regional brain activity based on the ratio between deoxyhemoglobin and oxyhemoglobin blood (BOLD) during events referenced to baseline conditions. Event-related BOLD response has low temporal resolution (>1s) and quite high spatial resolution (<1cm), and is especially suitable to investigate spatial details of both cortical and subcortical activation.
  International Review of Neurobiology 01/2009; 86:67-80. · 2.35 Impact Factor
• Article: Understanding brain connectivity from EEG data by identifying systems composed of interacting sources.

  Laura Marzetti, Cosimo Del Gratta, Guido Nolte
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  ABSTRACT: In understanding and modeling brain functioning by EEG/MEG, it is not only important to be able to identify active areas but also to understand interference among different areas. The EEG/MEG signals result from the superimposition of underlying brain source activities volume conducted through the head. The effects of volume conduction produce spurious interactions in the measured signals. It is fundamental to separate true source interactions from noise and to unmix the contribution of different systems composed by interacting sources in order to understand interference mechanisms. As a prerequisite, we consider the problem of unmixing the contribution of uncorrelated sources to a measured field. This problem is equivalent to the problem of unmixing the contribution of different uncorrelated compound systems composed by interacting sources. To this end, we develop a principal component analysis-based method, namely, the source principal component analysis (sPCA), which exploits the underlying assumption of orthogonality for sources, estimated from linear inverse methods, for the extraction of essential features in signal space. We then consider the problem of demixing the contribution of correlated sources that comprise each of the compound systems identified by using sPCA. While the sPCA orthogonality assumption is sufficient to separate uncorrelated systems, it cannot separate the individual components within each system. To address that problem, we introduce the Minimum Overlap Component Analysis (MOCA), employing a pure spatial criterion to unmix pairs of correlates (or coherent) sources. The proposed methods are tested in simulations and applied to EEG data from human micro and alpha rhythms.
  NeuroImage 09/2008; 42(1):87-98. · 5.89 Impact Factor
• Article: Executive functions with different motor outputs in somatosensory Go/Nogo tasks: an event-related functional MRI study.

  Hiroki Nakata, Kiwako Sakamoto, Antonio Ferretti, Mauro Gianni Perrucci, Cosimo Del Gratta, Ryusuke Kakigi, Gian Luca Romani
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  ABSTRACT: The aim of this event-related functional magnetic resonance imaging (fMRI) study was to investigate and compare executive functions with different motor outputs in somatosensory Go/Nogo tasks: (1) Button press and (2) Count. Go and Nogo stimuli were presented with an even probability. We observed a common network for Movement and Count Go trials in several regions of the brain including the dorsolateral (DLPFC) and ventrolateral prefrontal cortices (VLPFC), supplementary motor area (SMA), posterior parietal cortex (PPC), inferior parietal lobule (IPL), Insula, and superior temporal gyrus (STG). Direct comparison revealed that primary sensorimotor area (SMI), premotor area (PM), and anterior cingulate cortex (ACC) were more activated during Movement than Count Go trials. In contrast, the VLPFC was more activated during Count than Movement Go trials. Our results suggest that there were two neural networks for the supramodal executive function, common and uncommon, depending on the required response mode.
  Brain research bulletin 09/2008; 77(4):197-205. · 2.18 Impact Factor
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  Available from: Dante Mantini

  Article: Large-scale brain networks account for sustained and transient activity during target detection.

  Dante Mantini, Maurizio Corbetta, Mauro Gianni Perrucci, Gian Luca Romani, Cosimo Del Gratta
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  ABSTRACT: Target detection paradigms have been widely applied in the study of human cognitive functions, particularly those associated with arousal, attention, stimulus processing and memory. In EEG recordings, the detection of task-relevant stimuli elicits the P300 component, a transient response with latency around 300 ms. The P300 response has been shown to be affected by the amount of mental effort and learning, as well as habituation. Furthermore, trial-by-trial variability of the P300 component has been associated with inter-stimulus interval, target-to-target interval or target probability; however, understanding the mechanisms underlying this variability is still an open question. In order to investigate whether it could be related to the distinct cortical networks in which coherent intrinsic activity is organized, and to understand the contribution of those networks to target detection processes, we carried out a simultaneous EEG-fMRI study, collecting data from 13 healthy subjects during a visual oddball task. We identified five large-scale networks, that largely overlap with the dorsal attention, the ventral attention, the core, the visual and the sensory-motor networks. Since the P300 component has been consistently associated with target detection, we concentrated on the first two brain networks, the time-course of which showed a modulation with the P300 response as detected in simultaneous EEG recordings. A trial-by-trial EEG-fMRI correlation approach revealed that they are involved in target detection with different functional roles: the ventral attention network, dedicated to revealing salient stimuli, was transiently activated by the occurrence of targets; the dorsal attention network, usually engaged during voluntary orienting, reflected sustained activity, possibly related to search for targets.
  NeuroImage 09/2008; 44(1):265-74. · 5.89 Impact Factor
• Article: Human secondary somatosensory cortex is involved in the processing of somatosensory rare stimuli: an fMRI study.

  Tzu Ling Chen, Claudio Babiloni, Antonio Ferretti, Mauro Gianni Perrucci, Gian Luca Romani, Paolo Maria Rossini, Armando Tartaro, Cosimo Del Gratta
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  ABSTRACT: In the human somatosensory system, the contralateral primary somatosensory cortex (SI) is presumed to process and encode type and intensity of the sensory inputs, whereas the bilateral secondary somatosensory cortex (SII) is believed to perform higher order functions including sensorimotor integration, integration of information from the two body halves, attention, learning and memory. In this fMRI study we investigated the effect of attention on the activation of SI and SII, as induced by nonpainful and painful rare deviant electric stimuli during somatosensory oddball tasks. The working hypothesis is of stronger effects of attention on SII with respect to SI. Four runs were acquired according to an oddball scheme. Frequent nonpainful electrical stimuli were delivered to the ulnar nerve at motor threshold, whereas rare/deviant stimuli were delivered to median nerve in four conditions (one condition per run): nonpainful, painful, counting nonpainful, and counting painful. Results showed a statistically significant fMRI activation in bilateral SII but not in contralateral SI when the rare/deviant median nerve stimuli were delivered at nonpainful and painful levels as well as at the two levels of attention considered (i.e., associated with counting and non-counting tasks). Furthermore, fMRI activation in SII did not differ across the different levels of stimulus intensity (nonpainful, painful) and attention (non-counting, counting). These results corroborate the notion that SII is the target of independent pathways for the processing and integration of nonpainful and painful somatosensory stimuli salient for further high-order elaborations.
  NeuroImage 06/2008; 40(4):1765-71. · 5.89 Impact Factor
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  Available from: Vittorio Gallese

  Article: The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch.

  Sjoerd J H Ebisch, Mauro G Perrucci, Antonio Ferretti, Cosimo Del Gratta, Gian Luca Romani, Vittorio Gallese
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  ABSTRACT: Previous studies have shown a shared neural circuitry in the somatosensory cortices for the experience of one's own body being touched and the sight of intentional touch. Using functional magnetic resonance imaging (fMRI), the present study aimed to elucidate whether the activation of a visuotactile mirroring mechanism during touch observation applies to the sight of any touch, that is, whether it is independent of the intentionality of observed touching agent. During fMRI scanning, healthy participants viewed video clips depicting a touch that was intentional or accidental, and occurring between animate or inanimate objects. Analyses showed equal overlapping activation for all the touch observation conditions and the experience of one's own body being touched in the bilateral secondary somatosensory cortex (SII), left inferior parietal lobule (IPL)/supramarginal gyrus, bilateral temporal-occipital junction, and left precentral gyrus. A significant difference between the sight of an intentional touch, compared to an accidental touch, was found in the left primary somatosensory cortex (SI/Brodmann's area [BA] 2). Interestingly, activation in SI/BA 2 significantly correlated with the degree of intentionality of the observed touch stimuli as rated by participants. Our findings show that activation of a visuotactile mirroring mechanism for touch observation might underpin an abstract notion of touch, whereas activation in SI might reflect a human tendency to "resonate" more with a present or assumed intentional touching agent.
  Journal of Cognitive Neuroscience 04/2008; 20(9):1611-23. · 5.18 Impact Factor
• Article: Somato-motor inhibitory processing in humans: an event-related functional MRI study.

  Hiroki Nakata, Kiwako Sakamoto, Antonio Ferretti, Mauro Gianni Perrucci, Cosimo Del Gratta, Ryusuke Kakigi, Gian Luca Romani
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  ABSTRACT: Inhibiting inappropriate behavior and thoughts is an essential ability for humans, but the regions responsible for inhibitory processing are a matter of continuous debate. This is the first study of somatosensory go/nogo tasks using event-related functional magnetic resonance imaging (fMRI). Fifteen subjects preformed two different types of go/nogo task, i.e. (1) Movement and (2) Count, to compare with previous studies using visual go/nogo tasks, and confirm whether the inhibitory processing is dependent on sensory modalities. Go and nogo stimuli were presented with an even probability. Our data indicated that the response inhibition network involved the dorsolateral (DLPFC) and ventrolateral (VLPFC) prefrontal cortices, pre-supplementary motor area (pre-SMA), anterior cingulate cortex (ACC), inferior parietal lobule (IPL), insula, and temporoparietal junction (TPJ), which were consistent with previous results obtained using visual go/nogo tasks. These activities existed in both Movement and Count Nogo trials. Therefore, our results suggest that the network for inhibitory processing is not dependent on sensory modalities but reflects common neural activities. In addition, there were differences of activation intensity between Movement and Count Nogo trials in the prefrontal cortex, temporal lobe, and ACC. Thus, inhibitory processing would involve two neural networks, common and uncommon regions, depending on the required response mode.
  NeuroImage 03/2008; 39(4):1858-66. · 5.89 Impact Factor