Josephine Nguyen

Stanford University, Palo Alto, California, United States

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Publications (9)35.38 Total impact

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    ABSTRACT: Digital dermoscopy systems employ computer-based algorithms to quantitate features of pigmented skin lesions (PSLs) and provide an assessment of malignancy risk. We evaluated interobserver concordance of PSL malignancy risk between a pigmented lesion specialist and an artificial neural network (ANN)-based automated digital dermoscopy system. While digital dermoscopy provides a reliable means of image capture, storage, and comparison of PSLs over time, the ANN algorithm requires further training and validation before the malignancy risk assessment feature can be widely used in clinical practice.
    Journal of the American Academy of Dermatology 04/2007; 56(3):417-21. DOI:10.1016/j.jaad.2006.08.033 · 4.45 Impact Factor
  • Stefan C Weiss · Josephine Nguyen · Susan Chon · Alexa B Kimball
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    ABSTRACT: There are no published studies examining either the effectiveness of topical steroids in the treatment of stasis dermatitis or indicating what steroid strength or duration of treatment is optimal to treat this common condition. To investigate the efficacy of twice-daily application of the topical steroid betamethasone valerate 0.12% foam for the treatment of stasis dermatitis. 42-day randomized, double-blinded, vehicle-controlled, pilot study. Outpatient dermatology clinic at a university-affiliated clinic. 19 subjects, mean age of 73, with mild to moderate bilateral stasis dermatitis. Twice-daily application of betamethasone valerate 0.12% foam versus vehicle foam to bilateral randomly assigned lower legs for 28 days with follow-up to day 42. The primary clinical endpoints were the mean change in erythema, scale, swelling, petechiae, post-inflammatory hyperpigmentation, and self-reported pruritus, assessed on a 5-point Likert scale (0 = clear, 1 = almost clear, 2 = mild, 3 = moderate, 4 = severe). Secondary endpoints were changes in health related quality of life (HRQL) using the EuroQol-5D (EQ-5D) utility score and visual analog scale (VAS) and the Dermatology Life Quality Index (DLQI). Although there was no overall difference between the foam and vehicle-treated leg at days 14 and 28, the steroid-treated leg, but not the vehicle-treated leg, showed statistical improvement over baseline. Improvement in the steroid-treated leg was statistically better than vehicle at days 14 and 28 in terms of erythema (P < .05) and petechiae (P < .05). Improvement in VAS was notable at days 14 (7.1%), 28 (9.7%), and 42 (9.6%) (P < .001). Similarly, there was a statistically significant improvement in the DLQI compared to baseline on visit days 14 (188.9%) and 28 (126.1%) (P < .001). This study suggests that betamethasone valerate 0.12% foam is an effective and well-tolerated short-term treatment of stasis dermatitis, but that higher potency steroids may be needed to achieve better efficacy. Furthermore, these results are the first to suggest that the application of effective topical anti-inflammatory therapy can lead to improvement in HRQL.
    Journal of drugs in dermatology: JDD 01/2005; 4(3):339-45. · 1.45 Impact Factor
  • Journal of the American Academy of Dermatology 04/2004; 50(3):476-8. DOI:10.1016/j.jaad.2003.07.027 · 4.45 Impact Factor
  • Josephine Nguyen · Barbara M Egbert · Susan M Swetter
    Archives of Dermatology 04/2004; 140(3):353-8. DOI:10.1001/archderm.140.3.353-a · 4.79 Impact Factor
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    ABSTRACT: Anecdotal evidence from program directors and Mohs surgeons suggests that Mohs fellowships are becoming increasingly popular and competitive among dermatology trainees. To assess the characteristics and investigate the motivating factors of those pursuing Mohs fellowships. Anonymous surveys were distributed to recent dermatology residency graduates taking a board exam review course in years 1999-2002. In 2002, 2001, and 1999, the percentages of recently trained dermatologists pursuing Mohs fellowships were 9.4%, 8.5%, and 8.8%, respectively. There were no significant differences between Mohs fellows and the rest of the recently graduated dermatologists in terms of debt levels, marital status, parenting status, and spousal employment status. The Mohs fellows were slightly more likely to be male than their non-Mohs counterparts. The factor considered the most important by both groups when choosing a job was location. Further research is needed to discover potential factors that may be playing a role in the increased popularity of Mohs surgery. The number of Mohs surgeons is increasing and is likely to expand over time. It remains to be seen what effect the growth will have on the supply of Mohs surgery and whether it will outpace the increased demand for services.
    Dermatologic Surgery 03/2004; 30(2 Pt 1):136-8; discussion 138. DOI:10.1111/j.1524-4725.2004.30056.x · 2.11 Impact Factor
  • Josephine C. Nguyen · Alexa Kimball
    Journal of the American Academy of Dermatology 03/2004; 50(3). DOI:10.1016/j.jaad.2003.11.023 · 4.45 Impact Factor
  • Josephine C. Nguyen · Susan Swetter
    Journal of the American Academy of Dermatology 03/2004; 50(3). DOI:10.1016/j.jaad.2003.10.390 · 4.45 Impact Factor
  • Stefan C. Weiss · Josephine Nguyen · Alexa Kimball
    Journal of the American Academy of Dermatology 03/2004; 50(3). DOI:10.1016/j.jaad.2003.11.035 · 4.45 Impact Factor
  • Christine C Jacobson · Josephine C Nguyen · Alexa B Kimball
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    ABSTRACT: The increased proportion of female physicians over the last 30 years may have important implications for future physician workforce needs. To assess the roles of gender, marital status, and parenting in employment choices.Design, Setting, and Anonymous surveys were distributed to recent dermatology residency graduates taking a board examination review course from 1999 through 2002. The number of hours respondents saw patients per week and the number of hours they spent in each field of dermatology per week. There were 191 respondents to the survey in 2002, which represented 54% of the 2002 residency graduates. For clarity, this article focuses on the 2002 results except where trends over time become apparent. Of the respondents, 57% were women and 43% were men. Women saw patients a mean of 26 hours per week while men saw patients a mean of 31 hours (P =.01), although women spent more time practicing medical dermatology. Marital status did not significantly affect the number of work hours. Men and women who were not parents worked almost the same number of hours per week, but male parents saw patients a greater number of hours than female parents (34 vs 24; P<.01). Men who were parents spent more hours per week seeing patients than men who were not. In contrast, women who were parents spent fewer hours seeing patients than women who were not.Conclusion Parenting, in combination with gender, greatly influences workforce choices for professionals with young families while gender alone has little impact on those choices.
    Archives of Dermatology 02/2004; 140(2):191-6. DOI:10.1001/archderm.140.2.191 · 4.79 Impact Factor