Publications (14)19.96 Total impact
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Article: Off-pump coronary artery bypass surgery in patients with coronary artery disease and malign neoplasia: results of ten patients and review of the literature.
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ABSTRACT: Cardiopulmonary bypass has been reported to have many effects on the immune system. The aim of this study was to investigate the efficiency and usefulness of off-pump coronary artery bypass (OPCAB) surgery on patients who had coronary artery disease besides malign neoplasia. We applied OPCAB operations to 217 patients between March 2001 and April 2004, ten of whom had malign neoplasia. These patients were diagnosed to have coronary artery disease on their routine examination for their oncologic operation. The malignancies were stomach cancer (2 patients), colon-rectum carcinoma (3 patients), breast carcinoma (2 patients), surrenal carcinoma (1 patient), larynx carcinoma (1 patient), and meningioma (1 patient). The patients were operated on for their neoplasia by the related clinics at a mean of 42 days after the OPCAB surgery. The patients were discharged with surgical success and without any cardiac complications. Coronary artery bypass surgery before a noncardiac major operation may effectively decrease the long-term mortality due to myocardial ischemia. Severe coronary artery disease should be surgically treated in those patients who are scheduled to undergo an operation for malign neoplasia. Extracorporeal circulation impairs the immune system and negatively affects the defense of host against malignancy. Therefore, patients with severe coronary artery disease who are candidates for oncologic operation should be treated with OPCAB.Heart and Vessels 12/2006; 21(6):365-7. · 2.05 Impact Factor -
Article: Giant extracardiac unruptured sinus of Valsalva aneurysm in a patient with left ventricular dysfunction.
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ABSTRACT: Extracardiac unruptured sinus of Valsalva aneurysm (SVA) is an infrequent cardiac anomaly. Unruptured SVAs are typically symptom-free until rupture occurs. We describe a case of an unruptured extracardiac SVA originating from noncoronary sinus with left ventricular dysfunction. The patient was asymptomatic. The diagnosis was made by transthoracic echocardiography, computed tomography, and cardiac catheterization. The aneurysm was surgically resected and the sinus was successfully reconstructed with a patch. The patient remained asymptomatic throughout the postoperative follow-up period. Early surgical repair should be the choice of treatment for extracardiac SVAs in order to prevent sudden death.Heart and Vessels 10/2006; 21(5):328-30. · 2.05 Impact Factor -
Article: A novel multi-planed mechanical aortic valve for increasing the effective orifice area.
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ABSTRACT: Today, there is still confusion about mismatch of the orifice area of the mechanical valve and body surface area of the patient in aortic valve surgery. Creating a larger effective orifice area is the aim with this new valve design. This valve is multi-planed, one housing is seated at the aortic annulus for the coronary orifices to receive blood in diastole, the other housing or housings are seated to the ascending aorta obliquely to increase the orifice area of the valve. The ascending aorta can be enlarged if necessary. Valves with orifice areas larger than 6 cm(2) can be achieved with multi-planed aortic valves. The use of this valve depends on the fact that the aorta is a living tissue and can grow over time to normal values.Heart Lung & Circulation 07/2006; 15(3):182-5. · 1.20 Impact Factor -
Article: Surgical treatment of prosthetic valve thrombosis: ten years' experience.
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ABSTRACT: Prosthetic valve thrombosis (PVT) is a rare, but serious, complication of heart valve replacement with a mechanical substitute. Herein is presented the authors' surgical experience of 18 patients with PVT. A total of 1,584 heart valve operations was performed in 1,365 patients at the authors' institution between June 1995 and September 2005. Surgical reports of prosthetic valve reoperations over the same period were screened. Preoperative, operative and postoperative data were collected from the patient cohorts. Since July 1997, 18 patients (12 females, six males; mean age 35.9 +/- 11.3 years; range: 22-60 years) presented with PVT. The subtherapeutic anticoagulation level was the major etiologic factor involved in the pathogenesis of PVT. Thrombosis occurred in the mitral position in 14 patients (78%), and in the aortic position in four (22%). All mechanical valves implanted were bileaflet (1,097 St. Jude Medical, 324 CarboMedics, and 163 Sorin). The mean duration from valve replacement to PVT was 48.3 +/- 15.4 months. The majority of patients presented with poor functional status (56% in NYHA class IV) and poor anticoagulation (INR < or = 2 in 72% of cases). Valve re-replacement was performed for all patients. The 30-day mortality was 16.7%. PVT is a potentially fatal complication of heart valve replacement. These acceptable results suggest that early surgical intervention might be a safe and effective treatment of choice in patients with PVT. Patients with mechanical valve prostheses should be informed adequately about the need for, and the importance of, an effective anticoagulation regimen.The Journal of heart valve disease 05/2006; 15(3):400-3. · 0.81 Impact Factor -
Article: Intracoronary shunt reduces postoperative troponin leaks: a prospective randomized study.
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ABSTRACT: The purpose of this study was to evaluate whether intracoronary shunt usage reduced the myocardial damage on the basis of the cardiac markers when compared with the shuntless anastomosis in off-pump coronary artery bypass grafting (OPCABG) surgery of isolated left anterior descending artery lesions. Forty patients who had stable angina with isolated left anterior descending (LAD) coronary artery lesion undergoing OPCABG surgery were randomized into two groups. Shunt group consisted of 20 patients who had OPCABG using intracoronary shunt, whereas the shuntless group consisted of 20 patients who underwent OPCABG without using intracoronary shunt. Cardiac troponin I, CK, and CK-MB before and 24h after the surgery were assessed in the groups. There were no deaths in the study. The two groups were similar with respect to sex and age. Duration of LIMA-LAD anastomosis was significantly higher in the shunt group (p=0.01). There was no significant difference between the groups concerning the preoperative and postoperative CK and CK-MB levels. The preoperative troponin I levels of the groups were not different (p=0.238; NS), whereas postoperative levels of this marker was significantly higher in the shuntless group (p=0.003). Intracoronary shunt reduced the postoperative troponin I levels significantly, so it may be indicated in the patients who are thought to be susceptible to transient ischemia.European Journal of Cardio-Thoracic Surgery 03/2006; 29(2):186-9. · 2.55 Impact Factor -
Article: Repair of post-infarct ventricular septal rupture with an infarct-exclusion technique: early results.
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ABSTRACT: Ventricular septal rupture is a rare but life-threatening complication of acute myocardial infarction. The mortality rate with medical treatment is more than 90%, whereas the mortality rate after surgical repair varies between 19% and 60% in different studies. This study reviews our experience based on early closure of the septal rupture with an infarct-exclusion technique. Eighteen consecutive patients who underwent post-infarct ventricular septal rupture operation between June 1, 2000, and November 1, 2005, were included in the study. There were 12 male and 6 female patients. Mean age was 65.72 +/- 5.21 years. All patients had echocardiography and coronary angiography before the operation. Rupture was closed with an infarct-exclusion technique in all patients. Preoperative, operative, and postoperative information were collected from patient cohorts. The median time from myocardial infarction to diagnosis of the ventricular septal rupture was 4.22 +/- 1.61 days. Fourteen of the patients had intra-aortic balloon pump support, and 5 had mechanic ventilator support preoperatively. Surgical repair was done 1 to 4 days after the diagnosis. Ten anterior and 8 posterior ventricular septal ruptures were found. Additional coronary artery bypass surgery was performed with a median of 1.27 +/- 0.8 grafts in 15 (83.3%) patients. The mean postoperative mechanic ventilator support time was 34.13 +/- 45.11 hours. Overall 30-day mortality was 16.7% with 3 patients. The mean intensive care unit stay was 3.3 +/- 1.6 days. Postoperative transthoracic echocardiography showed minimal residual shunts in 4 patients. Patch closure of the ventricular septal rupture with an infarct-exclusion technique provided acceptable results. Concomitant coronary artery bypass grafting might be beneficial to control additional risk of an associated coronary artery lesion. Prompt diagnosis followed by early surgical intervention is essential for patients with ventricular septal rupture.Heart Surgery Forum 02/2006; 9(4):E737-40. · 0.63 Impact Factor -
Article: The progress of mitral regurgitation after isolated coronary artery bypass in cases of ischemic mitral regurgitation.
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ABSTRACT: Mitral valve intervention combined with coronary artery bypass surgery is inevitable in the case of severe mitral regurgitation in patients with coronary artery disease because the prognosis is poor without mitral correction. The best treatment protocol for patients with a moderate degree of mitral regurgitation is under debate. To clarify the optimal management for these patients, we evaluated the progress of mitral regurgitation after isolated coronary artery bypass surgery in cases of ischemic mitral regurgitation. METHODS; The study was conducted between March 2001 and April 2003. Forty-seven patients (70% men, with a mean age of 61 years, a mean ejection fraction of 43.7%, and a mean New York Heart Association class of 2.53) with preoperative diagnoses of moderate degree ischemic mitral regurgitation (Grade 3 mitral regurgitation on a scale of 0 to 4) and coronary artery disease, without leaflet pathology, underwent isolated coronary artery bypass surgery. Patients were followed-up at a mean of 22 months and an echocardiographic evaluation was done to determine the progress of the mitral disease. The 30-day operative mortality rate was 2.1%. In the postoperative period, the mean ejection fraction was 46.9% and the mean functional capacity of the patients was 1.31. Mitral regurgitation regressed to a mild degree in 56.9% of the patients. The 2-year survival rate was 93.7%. Patients with moderate ischemic mitral regurgitation and coronary artery disease who underwent coronary artery bypass surgery alone had acceptable results. We are of the opinion that isolated coronary artery bypass surgery might be a good treatment choice for moderate degree ischemic mitral regurgitation.Heart Surgery Forum 02/2006; 9(2):E555-9. · 0.63 Impact Factor -
Article: Whole-body perfusion under moderate-degree hypothermia during aortic arch repair.
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ABSTRACT: There continue to be some controversies concerning aortic arch reconstruction, especially the cerebral protection methods. We report our operative and postoperative outcomes for cases of aortic arch replacement using whole-body perfusion during aortic reconstruction under 28 degrees C moderate hypothermia. A total of 12 patients were operated on between March 2003 and November 2005. Two of the patients were female. The mean age of the patients was 53.5 x 7.3 years (range, 42-65 years). We cannulated the right axillary artery for cerebral perfusion and the right femoral artery for body perfusion. Arch replacement was done under continuous antegrade cerebral perfusion through the right axillary artery and continuous body perfusion through the right femoral artery via intra-aortic occlusion of the proximal descending aorta with an intra-aortic occlusion catheter. Perioperative data and postoperative outcomes, blood urea nitrogen, serum creatinine, and alanin aminotransferase values were evaluated retrospectively in the patients. There was only 1 hospital mortality. There were no neurologic complications. Postoperative levels of blood urea nitrogen and creatinin did not show significant difference but the alanin aminotransferase levels were significantly higher in the postoperative period, which was within the normal ranges of cardiopulmonary bypass effect. Whole-body perfusion through the axillary and femoral arteries may provide more time for the surgeon and good cerebral and visceral protection, which are especially important for surgical teams in the learning curve.Heart Surgery Forum 02/2006; 9(4):E686-9. · 0.63 Impact Factor -
Article: Surgical treatment of postinfarction left ventricular pseudoaneurysms.
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ABSTRACT: Left ventricular pseudoaneurysm is a rare but serious complication of acute myocardial infarction. It is under debate whether surgical intervention is mandatory in asymptomatic patients. The aim of this report was to present our experience based on surgical treatment and midterm outcomes of patients with postinfarction left ventricular pseudoaneurysm. Eight consecutive patients who underwent left ventricular pseudoaneurysm operation between January 1, 1995, and January 1, 2006, were included in the study. There were 5 male and 3 female patients. Mean age was 62.87 +/- 5.03 years. All patients had echocardiography and coronary angiography before the operation. Two anterior and 6 posterior pseudoaneurysms were detected. Left ventricular pseudoaneurysm was repaired with a synthetic patch by the remodeling ventriculoplasty method of Dor in all patients. Coronary revascularization was performed if necessary. Preoperative, operative, and postoperative data were collected from the patient cohorts. The mean duration from myocardial infarction to diagnosis of the ventricular septal rupture was 13.5 +/- 12 days. Additional coronary artery bypass surgery was performed with a median of 1.2 grafts in 5 patients (62.5%). The mean postoperative mechanic ventilator support time was 20.12 +/- 29.22 hours. Overall 30-day mortality was 12.5% with 1 patient death. The mean intensive care unit stay was 3.75 +/- 2.1 days. The late mortality rate was 12.5%. In the follow-up period (mean, 30.66 +/- 16.86 months), of the 6 patients who were alive, 5 were in New York Heart Association class I or II and 1 was in class III because of pre-existing low left ventricular ejection fraction. Transthoracic echocardiography showed good left ventricular configurations without a false aneurysm together with increases in the ejection fractions. Prompt diagnosis and early surgical intervention is essential for patients with large or expanding left ventricular pseudoaneurysms due to the high propensity of fatal rupture. Associated coronary artery bypass grafting may reduce early mortality of patients with left ventricular pseudoaneurysm by resuscitating the ischemic myocardium.Heart Surgery Forum 02/2006; 9(6):E876-9. · 0.63 Impact Factor -
Article: Aortic valve replacement in true severe aortic stenosis with low gradient and low ejection fraction.
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ABSTRACT: The results of aortic valve replacement are uncertain among patients with severe aortic stenosis, reduced left ventricular ejection fraction, and low mean transvalvular gradient. The aim of the present study was to report on 27 patients who underwent surgery for aortic stenosis with left ventricular ejection fraction <or=30% and mean transvalvular gradient <30 mmHg. The study was performed between January 2000 and December 2005. Twenty-seven patients with aortic stenosis with a calculated valve area <1.0 cm2, aortic mean transvalvular gradient <30 mmHg, and ejection fraction <or=30% were studied. Exclusion criteria were coronary artery disease, concomitant valvular operation, previous aortic valve replacement, or more than moderate aortic valve regurgitation. Preoperative clinical, echocardiography and dobutamine echocardiography, cardiac catheterization and coronary angiography, and operative data were recorded in all patients. Patients who were diagnosed with true aortic stenosis were divided into 2 groups according to left ventricular ejection fraction changes during dobutamine echocardiography, 16 with recruitable myocardium (group 1) versus 11 without (group 2). One patient from group 2 died. The functional capacities of all of the patients in group 1 significantly improved in the postoperative period (P = .001). All of the patients except for 1 in group 1 had improved left ventricular ejection fraction after the operation (P <.001). The comparison of the preoperative and postoperative functional status of these patients in group 2 was also statistically significant (P = .001). The 10 of the 11 patients in group 2 who were alive had left ventricular ejection fraction value changes that were not significant statistically (P = .096). The comparison of the improvement of functional capacities of the groups revealed a significant difference; that is, the improvement was higher in group 1 (P = .039). Left ventricular ejection fraction and functional capacity improved after aortic valve replacement in patients with left ventricular dysfunction, low mean transvalvular gradient, and aortic valve replacement in these patients has acceptable mortality rates with significantly improved functional status.Heart Surgery Forum 01/2006; 9(4):E681-5. · 0.63 Impact Factor -
Article: Cardiovascular involvement in Crohn's disease in the absence of ankylosing spondylitis.
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ABSTRACT: We describe a patient who had aortic regurgitation associated with Crohn's disease in the absence of ankylosing spondylitis. Aortitis and aortic insufficiency are fairly uncommon in Crohn's disease. The patient required aortic valve replacement because of severely uncoated cusps secondary to inflammation of the aortic wall and aortic valve. There was a saccular formation just above the right non-coronary commissure. This sac was closed with a pericardial patch. Pledgeted sutures were used for implantation of the prosthetic valve to avoid periprosthetic leakage. The right coronary ostium had narrowed due to aortic wall thickening. A right internal thoracic artery to right coronary artery bypass was done since there was no necessity for proximal anastomosis.Heart and Vessels 08/2005; 20(4):164-6. · 2.05 Impact Factor -
Article: Experimental study of a multiplaned mechanical aortic valve using bovine aorta.
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ABSTRACT: A newly designed multiplaned mechanical aortic valve was created in which there would be an angle between the stents so the valve would have a greater orifice area. This study was performed to test this valve on bovine aorta to determine whether or not there would be a pressure gradient on both sides of the valve. The valve created is multiplaned with one stent thought to be seated on the aortic annulus for the coronary orifices to receive blood in diastole, whereas the other stent is thought to be seated on the ascending aorta obliquely to increase the orifice area of the valve. The ascending aorta could be enlarged if necessary. A multiplaned valve resembling the valve which has two planes was tested on a Dacron tube, one side of which was formed with a bovine aorta. Pressure readings before and after the bovine aorta was thinned were taken when a 17 L/min flow through the tube was maintained. A 65 mmHg mean pressure gradient and a zero pressure gradient were produced before and after thinning the bovine aorta. The multiplaned mechanical aortic valve produces no gradient if the aorta is elastic. This valve can solve the gradient problem in aortic valve surgery because the aorta is a living and elastic tissue.International Heart Journal 02/2005; 46(1):133-8. · 1.16 Impact Factor -
Article: Cardiac involvement of hydatid disease.
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ABSTRACT: Echinococcosis is a serious health issue occurring in some geographical region of the world. Cardiac involvement is rare and early diagnosis and prompt surgical intervention are critical. Six patients with cardiac hydatid cysts underwent surgical treatment in our institution between April, 1996 and March, 2002. Five of the patients were female and one was male. Average age was 40+/-5 years with a range of 19 to 72 years. Cysts were located in the right ventricular outflow tract in two patients, the left ventricular outflow tract in one, the right atrial in one, the right ventricular in one and the right atrioventricular groove in one. Five patients were operated on using standard cardiopulmonary bypass techniques, and one was operated on without cardiopulmonary bypass. In the perioperative and the early postoperative period, no cardiac problems was observed. On control echocardiography, a ventricular septal defect was detected in one patient in the late postoperative period. The ventricular septal defect was repaired using standard cardiopulmonary bypass and was closed with a teflon patch. Patients were followed up for a mean period of 3.4+/-2.5 years. No mortality or recurrence was observed during the follow-up period. When hydatid cyst is diagnosed, the possibility of cardiac involvement should also be investigated. The treatment of cardiac hydatid cyst is surgical extraction of the cyst. Results of surgery are generally satisfactory.The Japanese Journal of Thoracic and Cardiovascular Surgery 12/2003; 51(11):594-8. -
Article: Brucella endocarditis: the importance of surgical timing after medical treatment (five cases).
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ABSTRACT: Brucella endocarditis is a disease that is hard to treat medically and has a high mortality. Immediate surgery after medical treatment is very important because delaying surgery may lead to that are difficult to repair. Five patients who were admitted to our institution with a diagnosis of Brucella endocarditis were medically treated with doxycycline (200 mg/d), rifampin (600 mg/d), and ceftriaxone (2 g/d). Preoperative mean medical treatment time was 5.2 weeks (range, 4-6 weeks). The patients were taken for operation when their general status improved. We report in this study the results of these patients. Three patients had aortic valve replacement whereas 2 had both aortic and mitral valve replacements. No mortality or morbidity was encountered in the patients. Mean postoperative hospitalization time was 15 days (range, 12-19 days). The patients were discharged with doxycycline (200 mg/d) and rifampin (600 mg/d) but without antipyretic medication. Postoperative antibiotherapy was continued up to a mean of 3.6 months (range, 2-6 months). Mean postoperative follow-up time was 15.8 months. None of the patients needed hospitalization in their follow-up time. Adequate preoperative antibiotherapy, immediate surgery, and continuation of postoperative antibiotherapy according to clinical progress seem to be a convenient treatment strategy for Brucella endocarditis.Progress in Cardiovascular Diseases 47(4):226-9. · 4.93 Impact Factor
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2006
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Ankara Atatürk Training and Research Hospital
Ankara, Ankara, Turkey
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