Publications (22)17.69 Total impact
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Article: Observations on degenerative changes within the optic nerve in patients with primary open glaucoma and arterial hypertension: 6-month follow-up.
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ABSTRACT: J Clin Hypertens (Greenwich). 2012;14:701-710. ©2012 Wiley Periodicals, Inc. The authors aimed to determine the effect of the time of hypotensive drug administration on the progress of degenerative changes within the optic nerve in patients with hypertension and glaucoma. Two groups were included in the study: group A comprised patients-dippers taking drugs in the mornings, and group B comprised patients-nondippers taking drugs both in the mornings and in the evenings. After 6 months, group B showed significant drops in nocturnal diastolic blood pressure (BP) (month 1=73.27 mm Hg vs month 6=67.50 mm Hg), nocturnal mean BP (89.34 vs 84.65 mm Hg), and minimum diastolic BP (50.74 vs 44.03 mm Hg). Group B also showed significant reductions in nocturnal ocular perfusion pressure (43.0 vs 39.73), retinal nerve fiber layer thickness (131.31 vs 113.12 μm), and flow in the eye vessels. Taking hypotensive drugs in the evening may significantly decrease blood flow in the eye arteries, cause degenerative changes within the optic nerves, and result in greater loss in the field of vision.Journal of Clinical Hypertension 10/2012; 14(10):701-10. · 1.83 Impact Factor -
Article: Effects of the time of antihypertensive drugs administration on the stage of primary open-angle glaucoma in patients with arterial hypertension.
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ABSTRACT: Many patients with glaucoma suffer from arterial hypertension (AH). It has been proved that both AH and low blood pressure (BP) at night are important vascular risk factors for primary open-angle glaucoma (POAG). The aims of this study were to assess the severity of pathological changes within the optic nerve and characteristics of blood flow in selected arteries of the eyeball and orbit in patients with POAG and controlled hypertension, in relation to the time of hypotensive drugs administration. Eighty-eight patients with POAG and treated, controlled hypertension were examined. The patients were divided into two subgroups, consisting of group A (n = 43), in whom hypotensive drugs were dosed only in the morning and group B (n = 45), in whom hypotensive drugs were also taken in the evening. In patients who were taking hypotensive drugs also in the evening (group B), there was a statistically significant lower mean perfusion pressure at night, a greater visual field loss and reduced amplitude of evoked potentials. Our analysis showed significantly worse changes in the parameters relating to the optic nerve in patients taking hypertensive medicines in the evening and also significantly lower perfusion pressures at night.Blood pressure 03/2012; 21(4):240-8. · 1.26 Impact Factor -
Article: A marked fall in nocturnal blood pressure is associated with the stage of primary open-angle glaucoma in patients with arterial hypertension.
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ABSTRACT: The aim of this study was to assess blood flow in the vessels of the eyeball and changes in the optic nerve in patients with arterial hypertension and primary open-angle glaucoma. The patients were divided into groups: 1 (night blood pressure, BP, fall, NBPF, not more than 10%; non-dippers); 2 (NBPF 10-15%, dippers) and 3 (NBPF>15%; extreme dippers). In the group of dippers and extreme dippers, perfusion pressure was significantly lower than that in the non-dippers group, there was reduced thickness of the nerve fibers and a greater decrease in the visual field. Significant relationships between peak systolic, end-diastolic flow in the ophthalmic and central retinal arteries and night perfusion pressure, thickness of nerve fibers, and a loss of visual field were observed. In patients with glaucoma and well-controlled hypertension, a nocturnal BP fall of more than 10% is associated with a greater visual field defect and greater degeneration of the optic nerve fibers. Low minimum diastolic pressure and the level of nocturnal BP fall, but not the absolute value of average arterial BP at night, should be included in the group of specific risk factors in patients with hypertension and open-angle glaucoma. These findings also suggest avoiding excessive lowering of BP at night in this group.Blood pressure 12/2010; 20(3):171-81. · 1.26 Impact Factor -
Article: [Smoking enhances the decrease of adiponectin level in patients with coronary artery disease, carriers of MTHFR 677T and PON1 55M alleles].
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ABSTRACT: Decreased adiponectin level, the adipose tissues hormone, is related to high body mass and insulin resistance, which are risk factors for atherosclerosis. It was shown, that cigarette smoking and high homocysteine (Hcy) level are associated with low level of adiponectin. In the presented study we search for the associations between 5 polymorphisms in genes involved in Hcy metabolism - methylenetetrahydrofolate reductase (MTHFR) and paraoxonase 1 (PON1), smoking, adiponectin levels and insulin resistance in subjects with coronary artery disease (CAD). The studied group consisted of 152 patients subjected to coronary arteriography. In 116 patients significant atherosclerotic changes in vascular vessels were confirmed (CAD group), remaining patients were considered as the control group. In studied group, the levels of glucose, insulin, adiponectin and blood lipids profile were measured. Adiponectin and insulin levels were determined by radioimmunological assays. The insulin resistance was calculated using mathematical HOMA model. MTHFR 677C>T, 1298A>C, PON1 -108C>T, L55M, Q192R polymorphisms were ascertained by PCR-RFLP methods. In the studied group (N = 152), significantly decreased adiponectin levels and higher degree of insulin resistance were present in subjects with angina pectoris (N = 129) and peripheral atherosclerosis (N = 32), whereas in the cases of CAD, confirmed in coronary arteriography (N = 116), only the higher degree of insulin resistance was noted. Arterial hypertension (p = 0.004), diabetes mellitus (p = 0.03) and smoking (p = 0.04) were the most significant vascular risk factors associated with the low adiponectin levels. In CAD group, negative correlations between the level of adiponectin and the dose of MTHFR 677T (r = - 0.238; p < 0.05) and PON1 55M (r = -0.251; p < 0.05 alleles were found. The MTHFR 677T allele was also correlated with degree of insulin resistance (r = 0.391; p < 0.05). In smokers, these genetic associations were stronger (r = -0.394; = -0.353; r = 0.440; respectively), which demonstrates, that the negative effects of MTHFR 677T and PON1 55M alleles are enhanced by smoking. Moreover, only in smokers the correlations between adiponectin levels and: the degree of insulin resistance (r = -0.465; p < 0.01) and the levels of HDLC (r = 0.479; p < 0.01) were seen. In summary, in CAD patients, particularly in smokers, occurrence of MTHFR and PON1 risk alleles is associated with the decreased adiponectin levels and/or increased degree of insulin resistance.Przegla̧d lekarski 01/2010; 67(10):859-65. -
Article: The relationship between resting heart rate and atherosclerosis risk factors.
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ABSTRACT: The imbalance between sympathetic and parasympathetic activity is one of the important factors in pathogenesis of cardiovascular diseases (CVD). There is a relationship between sympathetic activity and some CVD risk factors. Also heart rate (HR) is related to the autonomic nervous system. We analysed the relation of mean resting HR to hypertension, diabetes, obesity and to some risk factors [body mass index (BMI), hsCRP, systolic blood pressure (SBP), diastolic blood pressure (DBP), LDL cholesterol (LDL), triglycerides (TG) and glucose (G)]. 6977 men and 7792 women, aged 20-74, randomly selected from the Polish population, were screened in 2003-2005 within the framework of the National Multicentre Health Survey (WOBASZ). Resting HR and blood pressure were measured 3 times using an automatic device and for analyses only the mean value of the 2nd and 3rd measurement was used. Out of screened subjects, HR <60/min was found in 11% of men and 7% of women, and HR >90/min - in 6% and 5% respectively. Medication that influenced HR was taken by 16% of men and 17% of women. Resting HR was correlated (p <0.0001) with BMI, SBP, DBP, hsCRP, LDL and G in men and with SBP, DBP, hsCRP and G in women. After adjustment for medication significantly higher HR was observed both in men and in women with obesity, diabetes, hypertension, high hsCRP and in smoking persons. The prevalence of obesity, diabetes, hypertension, high hsCRP and smoking habit rose with increasing HR and the highest one was found in persons with HR >90/min. In multivariate logistic regression models resting HR was positively associated with hypertension, obesity and diabetes. In men, with every increase in HR by 10 beats/min, OR for hypertension was 1.28 (95% CI: 1.22-1.35), for obesity 1.24 (95% CI 1.17-1.30) and for diabetes 1.36 (95% CI: 1.26-1.48) after adjustment for age, medication and other factors (in women: 1.42 for hypertension, 1.14 for obesity and 1.47 for diabetes). Resting heart rate is correlated with cardiovascular risk factors (body mass index, blood pressure, glucose and cholesterol level) and with high hsCRP. Heart rate is positively associated with hypertension, obesity and diabetes which indirectly confirms the autonomic nervous system contribution to the pathogenesis of these diseases.Kardiologia polska 11/2008; 66(10):1069-75; discussion 1076-8. · 0.51 Impact Factor -
Article: Is there relationship between the A1166C polymorphism of the angiotensin II receptor AT1 and plasma renin activity, insulin resistance and reduction of blood pressure after angiotensin-converting enzyme inhibitor therapy?
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ABSTRACT: The aim of this study was to assess the relationship between the A1166C polymorphism of the angiotensin AT1 receptor gene and reduction of blood pressure and pulse pressure in patients with mild and moderate arterial hypertension. Moreover, we sought to investigate the impact of insulin resistance and plasma renin activity on blood pressure reduction following treatment with perindopril depending on the A1166C polymorphism of the AT1 receptor gene. The study included 64 patients with mild-to-moderate essential hypertension, with a mean age of 40.5 +/-16.4 years. Before and after treatment with angiotensin-converting enzyme inhibitors (ACEI) blood pressure measurement with a traditional method and ambulatory blood pressure monitoring were performed and blood samples were taken for laboratory investigation. The A1166C genotype distribution was: AA 53.1% in 34 patients, AC 43.8% in 28 patients, CC 3.1% in 2 patients. There were no statistically significant differences in the magnitude of blood pressure reduction and pulse pressure after treatment with perindopril between genotypes. Only in patients with genotype AA insulin resistance correlated with body mass index and only in these patients we observed a significant correlation between plasma renin activity and reduction of diastolic blood pressure. There was an inverse correlation between insulin resistance and reduction of systolic blood pressure only in patients with genotype AC. The A1166C polymorphism of the AT1 receptor gene is not associated with reduction of blood pressure after treatment with ACEI in patients with essential hypertension. There is a negative correlation between plasma renin activity and reduction of diastolic blood pressure only in patients with genotype AA. There is an inverse correlation between insulin resistance and systolic blood pressure only in patients with AC genotype.Polskie archiwum medycyny wewnȩtrznej 05/2008; 118(4):194-200. · 1.37 Impact Factor -
Article: [In patients with coronary artery disease and left ventricular contractile insufficiency the pathogenicity of smoking associates with imbalance in metabolism of homocysteine].
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ABSTRACT: Development of the systolic left ventricular insufficiency in patients with coronary artery disease (CAD) markedly decreases the survival rates, so the factors affecting the clinical status of these patients should be reevaluated. The left ventricular contractile function has been assessed by measurements of the left ventricular ejection fraction (LVEF) values. The studied group of 160 males comprised 102 CAD patients diagnosed by coronarography, and 58 persons without CAD and left ventricular systolic insufficiency. The CAD patients were divided into 2 subgroups according to the LVEF values: 53 patients qualified to have normal left ventricular contractile function (with LVEF > 40%), and 49-patients, with LVEF < or = 40%, were considered as subgroup with the left ventricular contractile insufficiency. In the case-control set up the effects of smoking, concentrations of homocysteine (Hcy) and folic acid (FA) and of the known risk factors of the vascular diseases in the development of the left ventricular contractile insufficiency were assessed. Moreover, analysis was performed of the association between LV insufficiency and the statin therapy and the number of infarcts. LV insufficiency in CAD patients associated with increased diastolic pressure (p = 0.006) and with increased uric acid concentrations in plasma (p = 0.02). The smoking, decrease in HDL-C and increased index TC/HDLC were the risk factors of CAD, independent of the LV insufficiency. In comparison to the CAD patients with the preserved systolic function, in the group of CAD patients with LV systolic insufficiency, more persons had recurrent infarcts (34.7% vs. 5.7%), and less persons had no infarct (8.2% vs. 20.8%, p < 0.05). In CAD patients with LV systolic insufficiency smoking associated with the higher values of HC/FA index (p = 0.01), younger age of the patients (p = 0.01), the number of persons not treated with statins (0.01) and the number of persons not having had heart infarct before (p < 0.05). These findings confirm both the effects of infarcts on the development of LV insufficiency, and the presumed association between the pathogenicity of smoking in LV insufficiency and the unbalanced metabolism of Hcy. The straight of the effect of smoking on the development of LV insufficiency in susceptible persons is shown also by the findings of the younger age of the smoking CAD patients as compared to the nonsmoking patients with LV insufficiency.Przegla̧d lekarski 02/2006; 63(10):951-6. -
Article: [Indications for calcium channel antagonist therapy according to the latest large clinical trials].
Polskie archiwum medycyny wewnȩtrznej 01/2006; 114(6):1244-51. · 1.37 Impact Factor -
Article: [Vascular stiffness in chronic renal failure patients treated by hemodialysis].
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ABSTRACT: Cardiovascular disease is a major cause of morbidity in patients with end-stage renal failure. Arterial stiffness measured by pulse wave velocity (PWV) is an independent risk factor for morbidity in end stage renal failure patients. The aim of our study was to evaluate the arterial stiffness in patients with chronic renal failure. In 20 chronic renal failure patients treated by hemodialysis (HD) we assessed the PWV of the carotic artery as well as artery diameter and distensibility, systolic pressure (SBP), diastolic pressure (DBP), pulse pressure (PP), and basal biochemical parameters and compared them with the values determined in 20 healthy controls of comparable age. PWV and PP are significantly (p < 0.001, p < 0.05) higher and distensibility of the carotic artery was significantly lower (p < 0.001) compared to a control group SBP and DBP were < 140/90 mmHg in HD patients (high normotensive range) but were significantly (p < 0.05) higher than in a control group. In HD patients PP was correlated with arterial distensibility r = -0.600 (p < 0.005), and systolic artery rice r = -0.408 (p < 0.05). SBP was correlated with PP r = 0.689 (p < 0.0007) and with arterial distensibility r = -0.476 (p < 0.03), arterial diameter to systolic artery rice r = -0.463 (p < 0.03), systolic artery rice to arterial distensibility r = 0.885 (p < 0.00001), intima media to arterial distensibility r = 0.815 (p < 0.00001), intima media to arterial compliance r = 0.893 (p < 0.00001). Our results suggest that not only established hypertension but also high normotensive pressure could cause arterial stiffness absened in chronic renal failure patients.Polskie archiwum medycyny wewnȩtrznej 12/2005; 114(5):1072-8. · 1.37 Impact Factor -
Article: [Is it recommended simultaneous use of acetylsalicylic acid and angiotensin converting enzyme inhibitors?].
Polskie archiwum medycyny wewnȩtrznej 10/2005; 114(3):906-12. · 1.37 Impact Factor -
Article: [Cardiovascular events in patients with systemic lupus erythematosus and rheumatoid arthrosis. New view on the old problem].
Polskie archiwum medycyny wewnȩtrznej 09/2005; 114(2):785-91. · 1.37 Impact Factor -
Article: Effects of social intervention on detection and efficacy of treatment for arterial hypertension. Main results of the Polish Four Cities Programme.
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ABSTRACT: Cardiovascular diseases are the main cause of death in the adult Polish population. Beside lipid disorders and cigarette smoking, hypertension represents the most important risk factor leading to cardiovascular complications. Representative studies conducted in Poland in 1994-2002 showed that in 2002 the number of respondents in the survey who stated they knew their own blood pressure values dropped by 3.5 million, compared with 1994. This decrease was predominantly seen in small towns and in the countryside. Preventive programmes should therefore be addressed mainly to the most vulnerable communities. Modern methods of social marketing may play a substantial role in the creation of a healthy lifestyle. The aim of the Polish Four Cities Programme (PP4M), conducted in 2000-2001, was to develop the most effective methods of detection of and improvement in treatment for hypertension among the residents of small towns and rural areas. One of the programme tasks was to compare the effectiveness of a standard medical screening intervention with a similar approach combined with the use of social marketing methods.Methods. The programme was conducted by an interdisciplinary team in three small Polish towns -- Kartuzy, Oborniki Wlkp. and Braniewo, as well as in one of the districts of a large city Łódź -- Olechów. Medical intervention combined with social marketing (community intervention) took place in Oborniki Wlkp. whereas the residents of Kartuzy and Łódź were subjected only to the traditional medical intervention. Braniewo served as a control location -- neither medical nor community intervention was implemented. Community intervention with elements of social marketing consisted of a three-month, intensive education and information campaign, initiated four weeks prior to the start of medical intervention. Epidemiological situation was assessed in all the four cities before and after the completion of the preventive interventions (screening), using representative surveys, with the objective to assess the changes in the awareness of one's own blood pressure values, detection of hypertension and knowledge concerning cardiovascular risk factors.Results. In two survey locations -- Kartuzy and Łódź - awareness of one's own blood pressure values after the medical intervention did not significantly change (61% and 67.6% at baseline versus 62.1% and 71.6% after the intervention, respectively). In contrast, social marketing activities conducted in Oborniki significantly increased this parameter from 61.5% to 79.8% (p<0.01). While medical intervention did not change the proportion of non-diagnosed hypertension in a small town (a non-significant decrease from 49% to 45% in Kartuzy), its effect in a large city was clearly visible (a decrease from 46% to 28% in Łódź). In Oborniki Wlkp. (medical intervention combined with social marketing) the effects were the most noticeable -- a reduction from 50% to 27% was achieved. The efficacy of hypertension treatment at baseline was low (4.7% in Kartuzy, 6.6% in Oborniki, and 6.5% in Łódź), but it then improved significantly (a twofold increase in Kartuzy and Oborniki, and more than twofold increase in Łódź). When the target value of blood pressure was set at 160/95 mmHg, the highest efficacy of hypotensive therapy was observed directly after the completion of medical and community intervention in Oborniki (an almost twofold increase in treatment efficacy). 1. Medical intervention combined with a community intervention and marketing campaign leads to a statistically significant improvement in self-awareness of blood pressure values among residents of small towns. 2. Medical intervention combined with community intervention brings the detection rate of hypertension in small towns up to the level observed in large cities. 3. Medical intervention, especially when combined with community intervention, improves the efficacy of the treatment of hypertension, regardless of the size of agglomeration.Kardiologia polska 01/2005; 61(12):546-58; discussion 559-60. · 0.51 Impact Factor -
Article: [Socioeconomic factors and their differentiation in the Polish population. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S649-54. · 0.51 Impact Factor -
Article: [Level of C-reactive protein in adult residents of our country. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S655-8. · 0.51 Impact Factor -
Article: [Awareness of guidelines for cardiovascular disease prevention among the adult population in Poland. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S677-81. · 0.51 Impact Factor -
Article: [Evaluation of physical activity levels in the adult population of Poland. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S636-40. · 0.51 Impact Factor -
Article: [Incidence of overweight and obesity in women and men between the ages of 20-74. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S632-5. · 0.51 Impact Factor -
Article: [Intake of consumed products by adults in the Polish population. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S670-6. · 0.51 Impact Factor -
Article: [The value of a nutritious and energetic diet for adult inhabitants of Poland. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S663-9. · 0.51 Impact Factor -
Article: [Evaluation of the incidence of low levels of social interaction and depressive symptoms in the Polish population. Results of the WOBASZ program].
Kardiologia polska 01/2005; 63(6 Suppl 4):S645-8. · 0.51 Impact Factor
Top co-authors
Top Journals
Institutions
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2012
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University of Lodz
Łódź, Lodz Voivodeship, Poland
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2008–2012
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Poznan University of Medical Sciences
Poznań, Greater Poland Voivodeship, Poland
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