Paweł Murawa

Publications (7)5.06 Total impact

• Source

  Available from: Piotr Nowaczyk

  Article: Analysis of sentinel lymph node biopsy results in colon cancer in regard of the anthropometric features of the population and body composition assessment formulas.

  Piotr Nowaczyk, Dawid Murawa, Karol Połom, Magdalena Waszyk-Nowaczyk, Arkadiusz Spychała, Michał Michalak, Paweł Murawa
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  ABSTRACT: The aim of the study was to assess sentinel lymph node biopsy (SLNB) results in colon cancer (CC) regarding basic anthropometric features of the studied population and their derivatives calculated using mathematical formulas. One hundred three SLNBs in CC have been analysed. Various indicators were calculated for every patient using mathematical formulas: BMI, Roher's index, lean body weight, body fat percentage and body weight/ideal body weight for a given height ratios using the following formulas: Broca's, Broca's ideal weight, Broca-Brugsch, Lorenz's, Potton's, Devine's, Robinson's, Miller's and Hamwi. The results were compared with accuracy, sensitivity and false negative results percentage by means of ROC curves and the test for structure indicators (for determined cut-off points). No statistically significant relationship between the results and patients' sex or age were found. ROC curve analysis did not reveal statistically significant relationships between the obtained results and indicators calculated on the basis of growth and weigh (all p > 0.05). The analyses of sensitivity and accuracy with determined cut-off point, in spite of differences amounting to 19 % (analysis of lean body weight/weight ratio), showed no statistical significance for any of the relationships (all p > 0.05). No indicator with high diagnostic and prognostic value has been found. The problem of qualifying patients for SLNB in CC in regard of the anthropometric features of the population and body composition assessment formulas remains open and requires further analysis on larger populations.
  Langenbeck s Archives of Surgery 03/2012; 397(5):779-86. · 1.81 Impact Factor
• Article: One hundred consecutive cases of sentinel lymph node mapping in colon cancer-the results of prospective, single--centre feasibility study with implementation of immunohistochemical staining.

  Dawid Murawa, Piotr Nowaczyk, Michael Hünerbein, Karol Połom, Violetta Filas, Jan Bręborowicz, Paweł Murawa
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  ABSTRACT: Although the importance of sentinel node biopsy (SNB) in colon cancer (CC) has not been clearly established, this method is proposed as potentially enabling more appropriate staging by means of immunohistochemistry (IHS). The aim of the study was to evaluate the SNB method used in CC treatment taking into consideration the results of the IHS examination. In the period from May 2005 to September 2010 in the 1st Department of Surgical Oncology and General Surgery, Wielkopolska Cancer Centre, 100 SNB in CC were performed. Sentinel nodes (SN) were identified intraoperatively with the use of Patent Blue dye. In the case of negative hematoxylin and eosin staining, the SN material was subjected to immunohistochemical examination. Finally, the histopathological findings of sentinel and non-sentinel lymph nodes were compared with the results of the immunohistochemical staining. At least one SN was identified in 99 of 100 patients (99%). The SN was the only place of metastases in 12.1% (12/99) of the patients. The accuracy of SNB in determining the regional lymph node status was 93.9% (93/99). The sensitivity of the method was 83.3% (30/36). The false-negative rate amounted to 16.7% (6/36). Upstaging obtained by the implementation of the immunohistochemical method was 10% (7/70). The application of the immunohistochemical staining enables upstaging of some patients, potentially benefiting from adjuvant chemotherapy. For full and definitive assessment of SNB in CC, further research is required especially in terms of additional factors determining a patient's eligibility for this procedure.
  International Journal of Colorectal Disease 03/2011; 26(7):897-902. · 2.38 Impact Factor
• Article: [Reconstruction of the hypopharynx and cervical esophagus with gastric pull-up technique in the patient with recurrence carcinoma of the hypopharynx].

  Wojciech Golusiński, Jakub Pazdrowski, Magdalena Kordylewska, Piotr Pieńkowski, Anna Wegner, Paweł Murawa, Janusz Wasiewicz, Sławomir Marszalek, Maria Kusnierkiewicz
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  ABSTRACT: Patient with hypopharyngeal cancer are difficult to treat because they usually present with advanced disease, poor general health status and severe nutritional problems. Because of the poor prognosis, careful consideration has to be given regarding the choice of the correct surgical approach for respirato-digestive tract reconstruction. The authors present a case of recurrent hypopharyngeal cancer with cervical esophagus infiltration successfully treated with total laryngectomy and esophagectomy and gastric pull up reconstruction. Indications for technique, method of reconstruction and complications are, discussed. As most authors we consider the gastric transposition method as the preferred approach to restore digestive continuity after total esophagectomy. As the method is the single stage procedure it provides the best palliation of dysphagia and allows early resumption of an oral diet.
  Otolaryngologia polska. The Polish otolaryngology 02/2008; 62(5):616-20.
• Article: [Late recognition of primary pancreatic carcinoid--case report].

  Dawid P Murawa, Beata Juchno, Paweł Murawa
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  ABSTRACT: Primary pancreatic carcinoid is an extremely rare pancreatic neoplasm. The most frequently it metastasizes to regional lymph nodes and liver. Carcinoids of the pancreas display various nonspecific imaging features (USG, CT), which can cause diagnostic problems. Authors report a case of late recognition of pancreatic carcinoid, in a woman who complained of abdominal pain and dyspeptic symptoms. The patient underwent pancreatoduodenectomy and dissection of tumor conglomerate in retroperitoneal space. The diagnosis was established by histopathological examination of the specimen after operation. So far the patient has not presented any clinical or radiological evidence of relapse.
  Wiadomości lekarskie (Warsaw, Poland: 1960) 02/2004; 57(3-4):177-9.
• Article: [Radioimmunoguided surgery in colorectal cancer].

  Dawid Murawa, Jedrzej Hoffmann, Wojciech Nowakowski, Paweł Murawa
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  ABSTRACT: Radioimmunoguided surgery (RIGS) is a technique that enables to determine the extent of a primary, as well as of a recurrent tumour and its local and distant spread. Before the surgery the patient is administered with radiolabelled monoclonal antibodies targeted against the tumour-associated antigen. The radiotracer and, in consequence, the tumour cells localisation is detected intraoperatively using a hand-held gamma detecting probe. Local assessment of tumour, regional lymph nodes or other organs (particularly liver), may allow a more complete surgical clearance of carcinoma lesions. This article presents the idea of RIGS technique (use of monoclonal antibodies, isotopes, and gamma detecting probe) and the results of worldwide clinical investigations conducted during the last years.
  Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 11/2002; 13(76):341-4.
• Article: [Case of leiomyosarcoma: diagnosis, treatment and prognosis in the rate stomach tumor].

  Dawid Murawa, Krzysztof Reperowicz, Wojciech Nowakowski, Paweł Murawa
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  ABSTRACT: Between the years 1996 to 2000 350 patients were operated due to cancer of the stomach in the Wielkopolska Cancer Center. There were 4 cases of leiomyosarcoma in this group. This tumour is characterized by hyperplasia in the form of a nodular mass beyond the stomach lumen, which is concerned with two crucial facts: the tumour already is palpable in early phase; it is difficult to obtain histopathological material for endoscopic examination. The treatment consisted of performing two partial resections of the stomach (Billroth II method) and one total resection (Rouh--Y method). In the fourth case palliative resection was performed: with partial resection of the stomach (Billroth II method) with the resection of nodules of the celiac stump, right part large intestine and one tumour in the left hepar lobe. All the patients who were operated on were discharged from hospital in good condition.
  Przegla̧d lekarski 02/2002; 59(1):63-5.
• Article: Long-term consequences of total gastrectomy: quality of life, nutritional status, bacterial overgrowth and adaptive changes in esophagojejunostomic mucosa.

  Dawid Murawa, Paweł Murawa, Grzegorz Oszkinis, Wiesława Biczysko
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  ABSTRACT: The aim of the study was to evaluate long-term quality of life and adaptive changes in the mucosa of the proximal section of the small intestine used for esophagojejunostomy reconstruction in stomach cancer patients after total gastrectomy. Thirty-one patients who had undergone stomach cancer-related total gastrectomy were included in the study, which spanned a period of 48 to 127 months (79.6 months on the average) after the surgery. The analysis included: a) evaluation of selected biochemical parameters; b) microbiological evaluation of esophagojejunostomic area; c) evaluation of adaptive changes in esophagojejunostomic mucosa using light and electron microscopy; d) quality of life evaluation with a Troidl questionnaire. Quality of life was subjectively rated as good or very good by almost all subjects. The analyzed biochemical parameters were within the range of normal values in all the subjects with the exception of mild abnormalities in alkaline phosphatase and vitamin B12 levels in some patients. Microbiological examination of mucosal specimens from below the esophagojejunostomy revealed significant bacterial flora overgrowth in all the patients, with streptococci being the most abundant species. Light and electron microscopy examination of the epithelium confirmed it was normal and characteristic of a healthy small intestine. Long-term quality of life in patients after complete stomach resection is considered good or very good, irrespective of the reconstruction method used, and the esophagojejunostomic mucosa of the reconstructed area is normal and typical for a healthy small intestine.
  Tumori 92(1):26-33. · 0.86 Impact Factor