A Mautone

Università degli Studi di Bari Aldo Moro, Bari, Apulia, Italy

Are you A Mautone?

Claim your profile

Publications (83)117.06 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Congenital hypothyroidism is associated with increased incidence of congenital defects (15.6%), frequently involving the heart (5.8%). Only few studies have evaluated the association between congenital hypothyroidism and patent ductus arteriosus. We report on two term newborns affected by thyroid agenesis and patent ductus arteriosus that closed after starting L-thyroxine substitutive therapy. This association suggests a close relation between hypothyroidism and patent ductus arteriosus. Hypothyroidism should be considered in term infants with patent ductus arteriosus because thyroid hormone production is among the prerequisites for postnatal ductal closure.
    Pediatric Cardiology 04/2008; 29(2):455-6. · 1.20 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Congenital hypothyroidism is associated with an increased incidence of congenital defects (15.6%), frequently involving the heart (5.8%). Only a few studies have evaluated the association between congenital hypothyroidism and patent ductus arteriosus. We report on two term newborns affected by thyroid agenesis and patent ductus arteriosus that closed after starting L: -thyroxine substitutive therapy. This association suggests a close relation between hypothyroidism and patent ductus arteriosus. Hypothyroidism should be considered in term infants with patent ductus arteriosus, because thyroid hormone production is among the prerequisites for postnatal ductal closure.
    Pediatric Cardiology 02/2008; 29(1):183-4. · 1.20 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the effects of fermented formula (FF) with Bifidobacterium breve C50 and Streptococcus thermophilus 065 on thymus size and stool pH of healthy term infants, ultrasound examinations and evaluations of thymus sizes and thymus indices (TI) and measurements of stool pH were performed in the same 90 term neonates on the 3rd d of life and on the 1st, 2nd, 3rd, and 4th mo of life. Thirty newborns were exclusively breast-fed while the remaining 60 were randomly assigned to receive either a FF or a standard formula (SF). The fecal pH of the breast-fed group was lower than the SF group (p < 0.05), although it was similar to that of the FF group on the third postnatal day, persisting for the entire 4 mo of the study. The difference in TI was statistically significant over repeated measurements among the groups. The FF infants showed a TI similar to the breast-fed newborns. Probiotic fermentation products have effects comparable to those of the bacteria composing the intestinal microflora supporting the idea that intestinal bacterial balance plays an important role in improving host immune responses.
    Pediatric Research 08/2007; 62(1):98-100. · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Calprotectin, a protein composed by two subunits of 8 and 14 kD respectively, is released by neutrophils in the biological fluids under inflammatory states. For instance, detection of calprotectin in faeces represents a diagnostic tool in the case of inflammatory bowel disease. Quite interestingly, calprotectin is increased in the stool of healthy newborns from day three up to day thirty and, physiologically, this increase may be interpreted as a defense mechanism against yeast and fungi. Therapeutic attempts at inhibiting the deleterious effect of calprotectin have been experimentally made by using lycoricinidol. This natural compound is able to hamper the calprotectin-induced apoptosis on the one hand. On the other hand, the same compound plays a prophylactic role in the course of experimental arthritis in rats.
    Endocrine Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune Endocrine & Metabolic Disorders) 04/2007; 7(1):1-5.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The association between gastroesophageal reflux and apnoea of prematurity is still controversial. Available data are biased by the heterogeneity of the infants enrolled as regard to some confounding factors and by the use of the traditional pH monitoring that is unable to detect non acid reflux events which might be prevalent in infants receiving frequent milk feeding. Multichannel intraluminal impedance has been recently introduced as a pH-independent method to investigate the bolus transport in hollow organs. To assess if combined multichannel intraluminal impedance-pH study could be useful to detect an association between gastroesophageal reflux and apnoea of prematurity. We prospectively evaluated a group of premature infants with apnoea of prematurity in absence of any confounding factors (ventilatory support, treatment with caffeine, permanent nasogastric tube, post-natal age older than 30 days) by simultaneous recording of 24-h multichannel intraluminal impedance-pH and cardiorespiratory monitoring. A temporal relationship between an apnoea and a reflux event was considered if both commenced within 20s of each other. Six premature infants [three male; median gestational age 31 weeks (range 27-36); birth weight 1335g (range 1200-2350); age at study 17 days (range 7-28)] were studied. A total of 405 reflux events [306 (76%) weakly acid and 99 acid reflux] and 142 apnoeas were detected. The frequency of apnoeas occurring during the reflux events period was significantly greater than the one calculated for reflux-free period [0.42/min (0.00-1.28) versus 0.016/min (0.003-0.028); p<0.05]. The sub-analysis based on chemical composition and duration of refluxate showed that the frequency of apnoeas associated with weakly acid reflux events was significantly greater than the one calculated for reflux-free period [0.416/min (0.00-1.30) versus 0.016/min (0.003-0.028), respectively; p<0.05] and that the frequency of apnoeas occurring during reflux events longer than 30s was significantly higher than those occurring during shorter reflux events (22% versus 11%; p<0.004). Our data show that weakly acidic reflux events are more prevalent than acid reflux events in premature infants, confirming the need for the use of multichannel intraluminal impedance-pH monitoring for diagnosis of gastroesophageal reflux in those patients. Gastroesophageal reflux and apnoea of prematurity are both common occurrences and, in our experience, may be temporally related especially as regard to weakly acid refluxate and reflux events longer than 30s.
    Digestive and Liver Disease 03/2007; 39(3):216-21. · 3.16 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Several reports indicate a decreased cortisol response to adrenocorticotropic hormone in preterm infants developing chronic lung disease and in preterm infants with refractory hypotension. Low-dose hydrocortisone (HC) may allow for beneficial effects. Our aim was to assess whether HC is able to increase survival without chronic lung disease. We performed a double-blind, randomized, placebo-controlled trial. Fifty mechanically ventilated infants (birth weight: 500-1,249 g) were randomized to receive treatment (HC 0.5 mg/kg/12 h for 9 days, then HC 0.5 mg/kg/24 h for 3 days) or placebo. Major outcome was survival without oxygen dependence at 36 weeks of postconceptional age (O(2)-free survival). The basic characteristics were similar between the two groups. O(2)-free survival was higher in the HC group (64 vs. 32%). The advantage was particularly evident among infants without antenatal steroids. The mortality rate was 16% in the HC group versus 40% in the control group (difference not significant). Hypotension after recruitment was reduced by HC (0 vs. 30%). The incidence of gastrointestinal perforation and other adverse effects was similar between the two groups. HC prophylaxis improved O(2)-free survival and early cardiocirculatory function in our population, without important short-term effects. The neurodevelopmental outcome will be assessed at 2 years.
    Neonatology 02/2007; 91(4):217-21. · 2.57 Impact Factor
  • Digestive and Liver Disease - DIG LIVER DIS. 01/2007; 39(10).
  • Digestive and Liver Disease - DIG LIVER DIS. 01/2006; 38(10).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The relationship between GER and AOP in newborns is still controversial. The aim of our study was to assess if MII-pH study could be useful to detect the association between GER and AOP in a subgroup of preterms selected for the absence of confounding factors. Were included newborns who satisfied the following criteria: postnatal age less than 30 days, no response to conventional treatment of AOP, no ventilatory support, full enteral feeding (intermittent suckling bolus) and absence of known causes of AOP. Five newborns [3 M; median ga 32 weeks (range 29–36); bw 1740 gr (range 1300–2350); age at study 15 days (range 8–21)] underwent simultaneous 24hours recording of MII-pH, continuous pulse oximeter saturation and ECG. A reflux event (RE) was defined by MII when a fall in impedance <50% from baseline occurred in at least the two distal channels in an aboral direction. A temporal association between RE and apnea and/or bradycardia was considered present if these events commenced within 20 seconds the onset of a RE. In the recording period a total of 285 RE [median rate of 55 per recording (range: 41–71)] and 115 apnoea [median rate of 24 per recording (range: 3–35)] were detected. Thirty-six AOP were associated with RE (31%). Frequency of events during RE was significantly greater than in reflux-free period [0.48/min (0 - 1.28) vs. 0.013/min (0.003 - 0.05); p<0.05]. Out of 36 RE-associated apnea, 31 were not acid (86%). Frequency of events during non-acid RE was greater than in reflux-free period [0.38/min (0 - 1.3) vs. 0.004/min (0.02 - 0.036); p<0.05]. No difference was found in the frequency of events associated and not associated with acid-RE.
    Pediatric Research 08/2005; 58(2):375-375. · 2.67 Impact Factor
  • Acta Paediatrica 03/2005; 94(2):254-5. · 1.97 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND Several reports showed decreased cortisol response to adreno-corticotropic hormone in preterms developing chronic lung disease (CLD). Administration of prophylactic low-dose hydrocortisone (HC) may allow for beneficial effects, particularly in infants with histologic chorioamnionitis. However, there are concerns regarding short and long-term effects of corticosteroid therapy in preterms.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Breast fed newborns had significant larger thymus compared to that standard formula fed. We report for the first time a double blind study on healthy term newborns evaluating the effect of human milk versus a standard formula and versus a fermented formula (bifidobacterium c50 and Streptococcus thermophilus 065) on thymus index and stool pH. 90 newborns were enrolled in the study. 30 newborns, were exclusively breast feeded, and the other 60 were randomly assigned to receive, a fermented formula, and a standard formula,with the same nutritional composition. All newborns were matched for sex birth weight and gestational age. The newborns were evaluated at third day of life, at first, second, third and fourth month of age. Weight, length, head circumference, stool pH, and ultrasound measurement of thymus size were recorded. Results are shown in table like mean and standard deviation.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Unconjugated bilirubin(UCB) may be responsible of a damage on intestinal mucosa of the jaundiced newborns.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: At present no data are available on the effects of unconjugated bilirubin (UCB) on the gut of the preterm. We evaluated 25 jaundiced preterm (12 male, GA 35.0±1.0 wks, BW 2152.2±301.3 g, serum bilirubin201.7millimol/L (range 97.4 - 265). Gastric electrical activity was recorded by cutaneous electrogastrography (EGG module UPS 2020 - MMS) for 30 minutes before and one hour after formula feed and the following parameters evaluated: gastric frequency and power, instability coefficient of frequency and power, percentage of normal slow wave, bradygastria and tachygastria. The urinary lactulose/mannitol ratio (La/Ma ratio) was measured after oral ingestion of a solution containing 8.6 g of lactulose and 140 mg of mannitol per 100 ml water at a dose of 2 ml/kg. Urine was then collected for five hours; lactulose and mannitol concentrations were measured by HPLC (high liquid phase chromatography) (mg/l) and La/Ma ratio calculated. Fecal calprotectin (FC) was measured by an ELISA kit (Calprest) and the stool samples were treated following the manufacturer s instructions. In the preprandial period, serum bilirubin correlates positively with the percentage of normal slow waves (r=0.60; p< 0.001) and negatively with percentage of tachygastria (r-0.42; p< 0.03). Correlations were lost in the postprandial period. A multiple linear regression model showed that intestinal permeability (La/Ma ratio) (mean 0.25 ± 0.15) is influenced by both UCB and FC (mean 319.8± 4.5) (r=051; p=0.03). These data show that UCB affects IP, gastric motility and gut inflammation. We believe that UCB represents a condition of increased risk for preterms due to a complex involvment of the whole intestinal apparatus that has never been hypothesised before.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Preterm newborns frequently have a slow postnatal growth and a close relationship between growth and both energy and protein intake has been demonstrated. The evaluation of the protein content of breast milk after a preterm delivery, using a quick and simple method, could be very useful to decide how to reach preterm nutritional needs. To evaluate the protein content of preterm breast milk by turbidimetric method. From April 2003 to March 2005 we collected breast milk from mothers who delivered preterm (G.A.24.8–35wks). The protein content (PC) in colostrum, transition milk (3 days after the beginning of lactation), and mature milk (1 week after the beginning of lactation) was measured. Maternal age, parity, diet, social status, as well as the cause of premature delivery, the mode of delivery, and gemellarity have been recorded. Milk was stored in plastic bottles at 4 C (max 12 hours) or at -20 C. PC was measured by a modified turbidimetric Kingsbury method (Milk screen, Callegari, Italy). 97 milk samples were collected. PC was 1.39–2.13 g/dl in colostrum, 1.23–2.04 g/dl in transition milk and 1.26–2.01 g/dl in mature milk. These results are consistent with published data using a spectrophotometric method, a technique neither simple nor easily available. PC gradually diminished from the beginning of lactation until mature milk: colostrum PC was higher compared to both transition milk (p =0.014) and mature milk (p=0.0001); similarly, transition milk PC was higher compared to mature milk (p==.001). A positive correlation has also been found between colostrum and transition milk PC. No correlations have been found between breast milk PC with other factors considered.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: INTRODUCTION Vertical transmission of hepatitis C virus (HCV) is greater in infants from pregnant women HCV-HIV (human immunodeficiency virus) coinfected when compared with infants from HCV infected HIV negative mothers. The mechanism of this greater rate of transmission remains unclear. Highly active antiretroviral therapy immune restoration has been implicated in potential adverse effects such as severe presentation of HCV disease.
    Pediatric Research 01/2005; 58(2):363-363. · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Experimental data on long term helicobacter pylori (HP) infection indicate that inflammation can develop in gastric mucosa after infection so that it could be very important the prevention of neonatal and childhood infection. Few reports have been published concerning horizontal and vertical transmission of HP infection (1,2,3).
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of our study has been to evaluate predictive value of general movements (GMs) for neurological outcome in two groups of newborns: high-risk preterm and asphyxiated fullterm. We have evaluated 23 high-risk preterm (gestational age <32 weeks) and 7 fullterm infants affected by hypoxic-ischemic encephalopathy or neonatal stroke, admitted to the NICU of the Department of Biomedicine of Evolutive Age of Bari University from January 2004 to February 2005. Infants were videotaped for 1 hour at 35 (preterm), 40 and 45 (fullterm) weeks corrected age (CA) and then again for 15 minutes at 50 and 55 weeks CA, while another operator, blind to videotape data, evaluated Prechtl method. A complete neurological examination was performed in all infants. GMs individual developmental trajectory was compared with neurological examination at the age of one year. 8 preterms and 6 fullterm infants have been evaluated at 7 months and 12 months CA. At 7 months CA, 3 infants had cerebral palsy (CP) and 4 developmental retardation (DR). At one year CA, 5 out of 7 of these infants completed the evaluation: 3 cerebral palsy have been confirmed and 2 out of 4 with DR evolved in CP. 7 infants (5 preterm and 2 fullterm) with normal (6) or abnormal (1) fidgety show normal neurological outcome; 7 infants with absent fidgety movements (3 preterm and 4 fullterm) were affected by CP (1 preterm and 4 fullterm) or DR (2); of this group 6 infants (2 preterm and 4 fullterm) showed also cramped synchronized GMs. Cramped syncronized GMs and absent fidgety movements do predict poor neurological outcome so improving early detection and diagnosis of cerebral palsy. This technique is simple, non-intrusive, reliable and quick.
    Pediatric Research 01/2005; 58(2). · 2.67 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. A longitudinal observational study was conducted. Inclusion criteria were: healthy term and preterm newborns normal for gestational age and newborns belonging to one of the following groups: newborns small for gestational age (SGA), newborns affected by respiratory distress syndrome (RDS), newborns from mothers with pre-eclampsia. Newborns with sepsis, congenital malformation or haemorrhagic disorders were excluded. Plasma PZ levels, protein C (PC) concentration, PC activity and protein-induced vitamin K absence levels were measured. 53 newborns were enrolled into the study. PZ and PC antigen levels varied significantly among analysed subgroups on day 1 (p < 0.01): lower levels of these inhibitors were found in RDS newborns (group C), newborns from mothers affected by pre-eclampsia (group D) and SGA newborns (group E) than in healthy term and preterm newborns (groups A and B). PZ deficiency occurs in newborns affected by severe RDS, in newborns from pre-eclamptic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last condition.
    Acta Paediatrica 05/2004; 93(5):654-7. · 1.97 Impact Factor
  • Journal of Pediatric Gastroenterology and Nutrition - J PEDIAT GASTROENTEROL NUTR. 01/2004; 39.

Publication Stats

271 Citations
117.06 Total Impact Points

Institutions

  • 1971–2007
    • Università degli Studi di Bari Aldo Moro
      • • Dipartimento di Scienze Biomediche ed Oncologia Umana (DIMO)
      • • Sezione di Ginecologia ed Ostetricia
      Bari, Apulia, Italy
  • 1991–2006
    • Policlinico di Bari
      Bari, Apulia, Italy
  • 1995–1998
    • Università degli Studi del Sannio
      Benevento, Campania, Italy