M. Girke

Forschungsinstitut Havelhöhe, Berlín, Berlin, Germany

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Publications (41)40.45 Total impact

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    ABSTRACT: Cancer-related fatigue (CRF) is a burdensome symptom for breast cancer (BC) patients. In this pilot study, we tested several questionnaires as predictors for treatment responsiveness, along with the implementation of a multimodal therapy concept consisting of sleep, psycho-education, eurythmy, painting therapy and standard aerobic training.At the Community Hospital Havelhöhe and the Hannover Medical School, 31 BC patients suffering from CRF could be evaluated in a 10-week intervention study. CRF was assessed by the Cancer Fatigue Scale (CFS-D). Further questionnaires were the Pittsburgh Sleep Quality Index, the autonomic regulation scale, Self-Regulation Scale (SRS), the Internal Coherence Scale (ICS) and the European Organization of Research and Treatment Health-Related Quality of Life Core Questionnaire scale. We estimated the regression coefficients of all scales on CFS-D by simple and multiple linear regression analyses and compared regression slopes and variances between the different questionnaires on CFS-D at the end of treatment.We found a significant impact of SRS and ICS at baseline on CFS-D at the end of the intervention [absolute standardised multiple regression coefficient values ranging from 0.319 (SRS) to 0.269 (ICS)] but not for the other questionnaires.In conclusion, this study supports the hypothesis that the SRS or ICS measuring adaptive capacities could be more appropriate as outcome predictors than classical questionnaire measures in complex interventions studies.
    European Journal of Cancer Care 02/2015; DOI:10.1111/ecc.12278 · 1.76 Impact Factor
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    ABSTRACT: Cancer-related fatigue (CRF) has a major impact on the quality of life in breast cancer patients (BC). So far, only a few prospective studies have investigated the effect of adaptive salutogenic mechanisms on CRF. The aim of our study was to evaluate the possible prospective influence of autonomic Regulation (aR) and self-regulation (SR) on CRF and distress in long-term survivors. 95 BC and 80 healthy female controls (C) had been included in the observational study between 2000 and 2001 and completed the questionnaires on aR, SR and Hospital Anxiety and Depression Scale (HADS). Of these, 62 BC, and 58 C participated in the re-evaluation 6.6 years later: 16 participants were deceased (14 BC and 2 C). During follow-up, participants were requested to answer questions involving (Cancer Fatigue Scales) CFS-D, aR, SR and HADS. Multiple regression analysis was used to evaluate the influence of aR, SR, age, Charlson co-morbidity-index and diagnosis on CFS-D and HADS, and to select further potentially relevant factors. High aR values showed significant effects, namely inverse relationships with CFS-D, cognitive fatigue, anxiety and depression. SR showed a reduced influence on anxiety and depression (all p < 0.05). Autonomic regulation might have an independent, reductive influence on global fatigue, cognitive fatigue and - together with self-regulation - it seems to have a protective influence on anxiety and depression. The connection between these parameters is still unclear and awaits further evaluation. AR seems to be a prognostic factor in breast cancer survivors, capable of reducing cancer-related fatigue and self-regulation distress as well. Further research is necessary in order to show how aR can be improved by therapeutic interventions.
    Journal of Cancer Survivorship 11/2013; 8(2). DOI:10.1007/s11764-013-0314-6 · 3.29 Impact Factor
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    ABSTRACT: Although eurythmy therapy (ET) has been used in the context of anthroposophic medicine (AM) for the treatment of, among other conditions, arterial hypertension (AH) for more than 80 years, there are as yet no studies on its effectiveness on disease entity. However, it has been shown that ET can increase heart rate variability comparably to ergometer training. To determine whether a 10-week course of ET has an impact on AH and if so, to determine the strength of the effect. The impact of ET on state-autonomic regulation, self-regulation, internal coherence, and quality of life is also explored. Consecutive inclusion of 9 subjects (6 female, 3 male, mean age of 64 years, SD 8.26) with AH diagnosed by their general practitioners. Inclusion criteria: no or unchanged antihypertensive medication from 4 weeks prior to the start of the study until the end of the study. ET was carried out with weekly instruction along with a daily, home-based program for 10 weeks with specific exercises. Twenty-four-hour blood pressure (BP) measuring was carried out, and the questionnaires were administered before and after the intervention. In addition, after a further 6 months during which 8 of the 9 patients carried on with the exercises of their own accord, the aforementioned parameters were assessed for a third time. Parameters of the 24-hour BP measurements show a moderate, but not significant, improvement immediately after the intervention and 6 months after the intervention. After the 10-week intervention, we saw an improvement of the State-autonomic Regulation questionnaire, the subscale on "Rest/Activity regulation," of the Self-regulation questionnaire, and the subscale "Initiative and Interest" of the Herdecke Quality of Life Questionnaire (HLQ) (all P < .045). After the 6-month post-study observation period, the aforementioned parameters improved further still, and an additional, significant improvement was seen for the Trait-autonomic Regulation subscale "Rest/Activity regulation," the HLQ-sum score, and the HLQ subscales "social interaction," "mental balance," and "physical ability." A 10-week course of ET does not result in a significant improvement in BP. The average BP measurements improved post-intervention by an absolute 3.2/2.0 mmHg and after 6 months of independent continuation of ET by 6.3/4.4 mmHg (systolic/diastolic). Despite the small group size, the regulation and quality-of-life parameters improved significantly after the intervention and further still after the 6-month observation period. The results need to be validated with larger patient collectives and control groups.
    01/2013; 2(1):24-30. DOI:10.7453/gahmj.2013.2.1.006
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    Forschende Komplementärmedizin / Research in Complementary Medicine 01/2013; 20(6):465-8. DOI:10.1159/000357485 · 1.65 Impact Factor
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    ABSTRACT: Hypothese: Cancer-related fatigue (CRF) and sleep disorders are some of the most wearing and common symptoms in disease-free breast cancer patients (BC). Aerobic training (AT) is the treatment with the best available evidence, even though it seems to be insufficient with regards to improvements in cognitive fatigue. We introduced a new multimodal therapy concept (MM) consisting of psycho-, sleep-education and new approaches based on anthroposophic medicine such as eurythmy and painting therapy. STUDY DESIGN: This pilot study will test the implementation of MM and yield first results of the MM and AE in our centres. METHODS: 31 out of 34 patients suffering from BC and CRF were fully assessed in a ten-week intervention study. 21 patients chose MM and 10 decided on AT. CRF was measured with the help of the Cancer Fatigue Scale (CFS-D), and the global quality of sleep was measured with the Pittsburgh Sleep Quality Index (PSQI). We also captured autonomic regulation (aR) and patients' satisfaction with questionnaires. Statistical analysis was done with SAS 9.1.3 for windows. RESULTS: The new MM therapy can be implemented with high satisfaction among patients. Significant improvements were found in the MM group with regards to CFS-D, global quality of sleep, sleep efficiency (PSQI), aR and rest/activity regulation compared to baseline (all p<0.05). In the AT group aR orthostatic-circulatory and rest/activity regulation improved significantly (p<0.05), too. However, no improvement in cognitive fatigue was seen in either group. CONCLUSION: The multimodal therapy concept was feasible and improved cancer fatigue, sleep quality, autonomic and rest-/activity regulation in breast cancer patients. It may therefore constitute a valuable treatment option in addition to aerobic training for BC patients with CRF. A further study with larger sample size needs to be carried out to assess the efficacy of combined multimodal-aerobic therapy.
    Integrative Cancer Therapies 12/2012; 12(4). DOI:10.1177/1534735412464552 · 2.01 Impact Factor
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    ABSTRACT: Current quality of life inventories used in oncology mainly measure the effects of chemo- or radiotherapy alongside functional and role scales. A new approach is to measure the autonomic state of regulation with the trait-inventory of autonomic regulation (Trait-aR). Loss of Trait-aR has been shown in different medical conditions such as breast cancer (BC) but not in colorectal cancer patients (CRC). In this paper we report the validation of a new state autonomic regulation scale (State-aR) of the last week. Study 1 included 114 participants: (41 women/16 men with cancer and 57 age- and gender-matched healthy people) to conduct a reliability-, factor- and validity-analysis. Concurrent and convergent validity was evaluated with Trait-aR, Fatigue-Numerical-Scale, Hospital Anxiety and Depression Scale (HADS-D) and the self-regulation scale, 65 participants were retested. Study 2 completed 42 participants: 17 with BC and 25 with CRC receiving chemotherapy. The State-aR was administered prior, during and after chemotherapy for measuring responsiveness. The factor analysis loaded to four subscales of State-aR (rest-activity, orthostatic-circulatory, thermo-sweating and digestive regulation) with a: Cronbach-α r(α) = 0.77?0.83 and a test-retest-reliability r(rt) = 0.60?0.80. The sum- and subscales correlated with their concurrent subscales in the Trait-aR (0.48?0.74) and with the sum-scale moderately with all convergent criteria (r = 0.41?-0.44; p <0.001). During chemotherapy the State-aR-sum and rest-activity-scale decreased significantly compared to the change in the Trait-aR (p <0.05). These findings support that the state autonomic regulation scale has satisfactory to good reliability, good validity and acceptable responsiveness in the context of chemotherapy treatment.
    European journal of medical research 10/2011; 16(10):457-68. DOI:10.1186/2047-783X-16-10-457 · 1.40 Impact Factor
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    Phytomedicine 10/2011; 18. DOI:10.1016/j.phymed.2011.09.059 · 2.88 Impact Factor
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    Phytomedicine 10/2011; 18. DOI:10.1016/j.phymed.2011.09.039 · 2.88 Impact Factor
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    ABSTRACT: Cancer Related Fatigue (CRF) and circadian rhythm have a great impact on the quality of life (HRQL) of patients with breast (BC) and colon cancer (CRC). Other patient related outcomes in oncology are measured by new instruments focusing on adaptive characteristics such as sense of coherence or self-regulation, which could be more appropriate as a prognostic tool than classical HRQL. The aim of this study was to assess the association of autonomic regulation (aR) and self-regulation (SR) with survival. 146 cancer patients and 120 healthy controls took part in an initial evaluation in 2000/2001. At a median follow up of 5.9 years later, 62 of 95 BC, 17 of 51 CRC patients, and 85 of 117 healthy controls took part in the follow-up study. 41 participants had died. For the follow-up evaluation, participants were requested to complete the standardized aR and SR questionnaires. On average, cancer patients had survived for 10.1 years with the disease. Using a Cox proportional hazard regression with stepwise variables such as age, diagnosis group, Charlson co-morbidity index, body mass index (BMI)) aR and SR. SR were identified as independent parameters with potential prognostic relevance on survival While aR did not significantly influence survival, SR showed a positive and independent impact on survival (OR = 0.589; 95%-CI: 0.354 - 0.979). This positive effect persisted significantly in the sensitivity analysis of the subgroup of tumour patients and in the subscale 'Achieve satisfaction and well-being' and by tendency in the UICC stages nested for the different diagnoses groups. Self-regulation might be an independent prognostic factor for the survival of breast and colon carcinoma patients and merits further prospective studies.
    Health and Quality of Life Outcomes 09/2011; 9:85. DOI:10.1186/1477-7525-9-85 · 2.10 Impact Factor
  • European Journal of Integrative Medicine 12/2010; 2(4):218-218. DOI:10.1016/j.eujim.2010.09.094 · 0.65 Impact Factor
  • R. Zerm, D. Brauer, M. Girke, M. Kröz
    European Journal of Integrative Medicine 12/2010; 2(4):219-219. DOI:10.1016/j.eujim.2010.09.097 · 0.65 Impact Factor
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    European Journal of Integrative Medicine 12/2010; 2(4):258-259. DOI:10.1016/j.eujim.2010.09.182 · 0.65 Impact Factor
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    ABSTRACT: The current debate on medical professionalism is challenged by situations of co-existent “conventional” and “complementary/alternative” medical approaches. The issue of this article is how to realize professional behaviour in such pluralistic context.Medical pluralism is presented as consequence of the inherent pluralistic feature of science. Both conventional and complementary medical approaches need to adhere to the ethical principles and commitments of the medical profession. Though questioning scientific mainstream models, professional pluralism means to comply with scientific attitude. It calls for an unfolding of the premises and consequences of the respective therapeutic concepts. Scientific orientation of individual therapy includes competence, rational assessment of the patient's situation, clinical experience, knowledge of external evidence, and a critical evaluation of the course of disease. Furthermore, shared decision making on individual therapy requires empathy and the consideration of the patient's perspective.
    European Journal of Integrative Medicine 06/2010; 2(2):53-56. DOI:10.1016/j.eujim.2010.04.002 · 0.65 Impact Factor
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    Physikalische Medizin Rehabilitationsmedizin Kurortmedizin 06/2010; 20(03):152-157. DOI:10.1055/s-0029-1241853 · 0.45 Impact Factor
  • Physikalische Medizin Rehabilitationsmedizin Kurortmedizin 04/2010; 20(02):86-91. DOI:10.1055/s-0029-1241854 · 0.45 Impact Factor
  • European Journal of Integrative Medicine 12/2009; 1(4):253-254. DOI:10.1016/j.eujim.2009.08.059 · 0.65 Impact Factor
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    ABSTRACT: Background Subclinical hyperthyroidism (sH) due to thyroid autonomy is very common, especially in iodine-deficient areas. In anthroposophic medicine, a form of complementary medicine, Colchicum autumnale (CAU) is used in the treatment of various thyroid disorders. The objective of this pilot study was to examine the effect of CAU in patients with sH. Patients and methods We carried out an observational study (OS) on 18 patients (15 females, 3 males) with sH. After 3 months the clinical pathology based on the Hyperthyroid-Symptom-Scale (HSS) and the hormone status (thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3)) were investigated. Patients with immunogenic TSH-suppression were excluded. Results A total of 16 patients took CAU over a 3-month period (2 dropouts). Within that time, there was a significant decrease in the HSS (from 7.9±6.0 to 2.9±2.9; p<0.01) and in the fT3 (from 3.98±0.71 pg/ml to 3.61±0.48 pg/ml; p<0.05). Direction and strength of changes in peripheral hormones depended on their initial values; linear regression was significant for fT3- (fT3-change against initial value: p<0,01) and fT4-change (p<0.05). Patients tolerated the treatment well and there were no serious adverse drug events. Conclusions In this first OS on the effects of CAU, patients with sH showed positive changes on the clinical pathology and normalization of peripheral hormones that would not be expected in a natural course of sH. Controlled studies with larger collectives and comparison groups are required.
    European Journal of Integrative Medicine 12/2009; 1(4):199-200. DOI:10.1016/j.eujim.2009.08.107 · 0.65 Impact Factor
  • European Journal of Integrative Medicine 12/2009; 1(4):247-248. DOI:10.1016/j.eujim.2009.08.048 · 0.65 Impact Factor
  • European Journal of Integrative Medicine 12/2009; 1(4):254-254. DOI:10.1016/j.eujim.2009.08.062 · 0.65 Impact Factor
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    ABSTRACT: Current inventories on quality of life used in oncology mainly focus on functional aspects of patients in the context of disease adaptation and treatments (side) effects (EORTC QLQ C30) or generically the status of common functions (Medical Outcome Study SF 36). Beyond circumscribed dimensions of quality of life (i.e., physical, emotional, social, cognitive etc.), there is a lack of inventories which also address other relevant dimensions such as the 'sense of coherence' (SOC) in cancer patients. SOC is important because of its potential prognostic relevance in cancer patients, but the current SOC scale has mainly been validated for psychiatric and psychosomatic patients. Our two-step validation study addresses the internal coherence (ICS) scale, which is based on expert rating, using specific items for oncological patients, with respect to its reliability, validity and sensitivity to chemotherapy. The items were tested on 114 participants (57 cancer patients and a matched control group), alongside questions on autonomic regulation (aR), the Hospital Anxiety and Depression Scale (HADS), self-regulation (SRQ) and Karnofsky the Performance-Index (KPI). A retest of 65 participants was carried out after a median time span of four weeks.In the second part of the study, the ICS was used to assess internal coherence during chemotherapy in 25 patients with colorectal carcinoma (CRC) and 17 breast cancer patients. ICS was recorded before, during and 4-8 weeks after treatment. The 10-item scale of 'internal coherence' (ICS) shows good to very good reliability: Cronbach-alpha r = 0.91, retest-reliability r = 0.80. The ICS correlates with r = 0.43-0.72 to the convergence criteria (all p < 0.001). We are able to show decreased ICS-values after the third cycle for CRC and breast cancer patients, with a subsequent increase of ICS scores after the end of chemotherapy. The ICS has good to very good reliability, validity and sensitivity to chemotherapy.
    Health and Quality of Life Outcomes 06/2009; 7:59. DOI:10.1186/1477-7525-7-59 · 2.10 Impact Factor

Publication Stats

122 Citations
40.45 Total Impact Points

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Institutions

  • 2001–2015
    • Forschungsinstitut Havelhöhe
      Berlín, Berlin, Germany
  • 2007–2011
    • Hospital Havelhoehe
      Berlín, Berlin, Germany