Takaya Fukumoto

Publications (13)27.33 Total impact

• Article: Successful treatment of diffuse normolipemic plane xanthoma with probucol.

  Fumi Miyagawa, Takaya Fukumoto, Nobuhiko Kobayashi, Hideo Asada
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  ABSTRACT: We report on a 70-year-old woman with diffuse normolipemic plane xanthoma (DNPX) who developed macular yellowish patches on the eyelids, both cheeks, and the nose. Histology revealed the accumulation of CD68-positive foam cells and Touton giant cells in the superficial dermis. Plasma lipid levels were within normal limits. The patient had no underlying hematological diseases. Her extensive lesions precluded surgical excision. The patient was given oral probucol instead, which resulted in a significant reduction of the lesions after 2 weeks. The lesions almost disappeared within 8 months. Plane xanthoma is primarily treated with excisional or abrasive therapies; however, probucol can be a safe and effective alternative therapy for DNPX.
  Case Reports in Dermatology 05/2013; 5(2):148-51.
• Article: CD8+ primary cutaneous peripheral T-cell lymphoma in an 18-year-old woman.

  Fumi Miyagawa, Takaya Fukumoto, Satoshi Yurugi, Hirokazu Nakamine, Hideo Asada
  The Journal of Dermatology 04/2013; · 1.49 Impact Factor
• Article: Identification of thymus and activation-regulated chemokine (TARC/CCL17) as a potential marker for early indication of disease and prediction of disease activity in drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS).

  Kohei Ogawa, Hironori Morito, Ayako Hasegawa, Natsuko Daikoku, Fumi Miyagawa, Aiko Okazaki, Takaya Fukumoto, Nobuhiko Kobayashi, Takahiko Kasai, Hideaki Watanabe, Hirohiko Sueki, Masafumi Iijima, Mikiko Tohyama, Koji Hashimoto, Hideo Asada
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  ABSTRACT: BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a serious acute drug reaction with fever, cutaneous eruption, lymphadenopathy, and several visceral dysfunctions. Eosinophilia is a common hematological abnormality in DIHS/DRESS suggesting that the Th2-type immune response is involved. Thymus and activation-regulated chemokine (TARC/CCL17) is a family of CC chemokines known to play an important role in Th2-mediated immune-inflammatory processes. OBJECTIVE: We investigated the pathogenic role of TARC in patients with DIHS. METHODS: Sera were obtained from 8 patients with DIHS, 7 patients with Stevens-Johnson syndrome/Toxic epidermal necrolysis (SJS/TEN), and 14 patients with drug-induced maculopapular exanthema (MPE). Serum TARC levels were measured by ELISA. TARC levels were then compared with clinical symptoms and various hematological parameters. In addition, a biopsy was taken from the lesional skin of patients with DIHS and stained with anti-TARC Ab and anti-CD11c Ab. RESULTS: Serum TARC levels in patients with DIHS were significantly higher than those in patients with SJS/TEN and MPE during the acute phase. Serum TARC levels in DIHS patients correlated with skin eruptions, serum sIL-2R levels, eosinophil counts, and serum IL-5 levels. Immunohistochemical staining revealed that TARC was mainly expressed on CD11c+ dermal dendritic cells in patients with DIHS. CONCLUSION: Serum TARC levels may be associated with the initial presentation of DIHS as well as disease activity during the course. Thus, they could be useful as an indicator for early diagnosis and assessment of disease activity in DIHS. CD11c+ dendritic cells may be the main source of TARC in patients with DIHS.
  Journal of dermatological science 10/2012; · 3.71 Impact Factor
• Article: A case of eosinophilic pustular folliculitis with response to infliximab.

  Ayako Hasegawa, Nobuhiko Kobayashi, Takaya Fukumoto, Hideo Asada
  Journal of the American Academy of Dermatology 10/2012; 67(4):e136-7. · 3.99 Impact Factor
• Article: Case of drug-induced hypersensitivity syndrome involving multiple-drug hypersensitivity.

  Kohei Ogawa, Hironori Morito, Nobuhiko Kobayashi, Takaya Fukumoto, Hideo Asada
  The Journal of Dermatology 01/2012; · 1.49 Impact Factor
• Article: Drug eruption with eosinophilia and systemic syndrome associated with reactivation of human herpesvirus 7, not human herpesvirus 6.

  Hironori Morito, Kana Kitamura, Takaya Fukumoto, Nobuhiko Kobayashi, Masamitsu Kuwahara, Hideo Asada
  The Journal of Dermatology 11/2011; 39(7):669-70. · 1.49 Impact Factor
• Article: Atypical epidermolysis bullosa simplex with a missense keratin 14 mutation p.Arg125Cys.

  Daisuke Tsuruta, Junko Sowa, Chiharu Tateishi, Yuko Obase, Airo Tsubura, Takaya Fukumoto, Masamitsu Ishii, Hiromi Kobayashi, Sachiko Sakaguchi, Takashi Hashimoto, Takahiro Hamada
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  ABSTRACT: Epidermolysis bullosa (EB) is a group of hereditary autosomal dominant bullous diseases. EB is divided into four major phenotypes: intraepidermal EB (or EB simplex), junctional EB, dermolytic EB and mixed EB (Kindler syndrome). EB simplex is further divided into three subtypes: localized EB simplex, Dowling-Meara EB simplex and other generalized EB simplex. We report a 28-year-old man with EB simplex with a missense keratin 14 mutation p.Arg125Cys associated with clumping of keratin filaments and acantholysis in mainly the spinous cells and basal cells. Immunohistochemistry revealed that the broader expression of keratin 5 and 14 was observed in the epidermis, while the expression of keratin 1/10 was quite normal. Dysregulated expression of keratin 5/14 may hinder some functions or roles of keratin 1/10, namely filament assembly of keratin 1/10 in spinous cell integrity, although the expression of keratin 1/10 was not affected and this has not been demonstrated before.
  The Journal of Dermatology 10/2011; 38(12):1177-9. · 1.49 Impact Factor
• Article: Drug-induced hypersensitivity syndrome followed by persistent arthritis.

  Hironori Morito, Kohei Ogawa, Nobuhiko Kobayashi, Takaya Fukumoto, Hideo Asada
  The Journal of Dermatology 07/2011; 39(2):178-9. · 1.49 Impact Factor
• Article: Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation.

  Kana Kitamura, Hideo Asada, Hideyuki Iida, Takaya Fukumoto, Nobuhiko Kobayashi, Hironori Niizeki, Takeshi Morii, Hiroshi Kimura, Sachiko Miyagawa
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  ABSTRACT: The relationship between herpesvirus reactivation and graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) is unclear. We sought to examine the relationship between human herpesvirus (HHV) reactivation and rash/GVHD after allo-SCT by prospective evaluation. Fifteen patients who had received allo-SCT underwent prospective serial examinations for human herpesvirus 6 (HHV-6), HHV-7, cytomegalovirus, and Epstein-Barr virus DNA in the blood by polymerase chain reaction and real-time polymerase chain reaction. Serum interferon gamma, interleukins 4 and 10, tumor necrosis factor alpha, and soluble interleukin 2 receptor (sIL-2R) were also measured. In 10 of 15 patients, macular/papular eruptions were seen after allo-SCT and GVHD was diagnosed. In 8 patients with rash, HHV-6 DNA levels correlated with the cutaneous manifestation. Interleukin 10 and sIL-2R also increased in association with rash. The number of patients in our study was relatively small. Not all patients were examined for cytokines and sIL-2R. HHV-6 reactivation may be involved in the pathogenesis of rash/GVHD after allo-SCT.
  Journal of the American Academy of Dermatology 06/2008; 58(5):802-9. · 3.99 Impact Factor
• Article: Paraneoplastic pemphigus presenting as erythrodermic lichenoid dermatitis with concomitant features of pemphigus foliaceus.

  Takaya Fukumoto, Yoshimi Shiroyama, Hironori Niizeki, Nobuhiko Kobayashi, Hideo Asada, Norito Ishii, Takashi Hashimoto, Sachiko Miyagawa
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  ABSTRACT: We describe a patient with paraneoplastic pemphigus who presented with erythrodermic lichenoid dermatitis, later developing blisters of pemphigus foliaceus type and oral erosive lesions. In addition to antibodies against the plakin family proteins, the patient's serum was positive for anti-desmoglein 1 antibodies without coexisting anti-desmoglein 3 activities by enzyme-linked immunosorbent assay, which is a very rare autoantibody profile in paraneoplastic pemphigus.
  The Journal of Dermatology 10/2007; 34(9):645-9. · 1.49 Impact Factor
• Article: Trichoblastic infundibular cyst.

  Shin-Ichi Ansai, Masaaki Tsuda, Hajime Nagato, Keiko Nishimaki, Masahiko Wako, Motomu Manabe, Takaya Fukumoto, Tetsunori Kimura
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  ABSTRACT: We report 4 cases of an infundibular cyst that histopathologically showed small papillary projections of follicular germinative cells emanating from the basal layer of the cyst wall. Some of these projections branched and formed a reticulated pattern. This cystic lesion is histopathologically distinctive. We propose to designate it as a trichoblastic infundibular cyst because its lining resembles that of an infundibular cyst, yet it has cells that resemble those of the follicular germ in its wall.
  American Journal of Dermatopathology 01/2007; 28(6):507-9. · 1.20 Impact Factor
• Article: Erythema induratum of Bazin in an infant after Bacille Calmette-Guerin vaccination.

  Tomoko Inoue, Takaya Fukumoto, Shinichi Ansai, Tetsunori Kimura
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  ABSTRACT: We report the first case of erythema induratum of Bazin (EIB) after Bacille Calmette-Guerin (BCG) vaccination in an infant. The patient developed recurrent multiple erythematous and subcutaneous nodules on his legs 2 months after a BCG vaccination. He had no other symptoms or family history of tuberculosis (TB). Histopathological findings revealed a granulomatous lobular panniculitis. EIB often appears as a chronic, nodular eruptions that frequently occur on the lower legs of females with tuberculin hypersensitivity. To date, only a few cases of infants with EIB have been reported. There have been no clinical reports of EIB after BCG vaccination. Our case suggests that Mycobacterium bovis in the BCG vaccination may have caused EIB.
  The Journal of Dermatology 05/2006; 33(4):268-72. · 1.49 Impact Factor
• Article: Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen.

  Takaya Fukumoto, Toshiki Umekawa, Masanori Higuchi, Takashi Hashimoto, Hauke Shumann, Leena Bruckner-Tuderman, Hideo Asada, Sachiko Miyagawa
  Journal of the American Academy of Dermatology 04/2004; 50(3):480-2. · 3.99 Impact Factor