Abdulmajeed Al-Otay

SickKids, Toronto, Ontario, Canada

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Publications (4)23.4 Total impact

  • Lars Grosse-Wortmann, Abdulmajeed Al-Otay, Shi-Joon Yoo
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    ABSTRACT: Aortopulmonary collaterals (APCs) have been associated with increased morbidity after the Fontan operation. We aimed to quantify APC flow after bidirectional cavopulmonary connections and Fontan completions, using phase-contrast MRI, and to identify risk factors for the development of APCs. APC blood flow was quantifiable in 24 of 36 retrospectively analyzed MRI studies. Sixteen studies were performed after the bidirectional cavopulmonary connections (group A) and 8 after the Fontan operation (group B). APC blood flow was calculated by subtracting the blood flow volume through the pulmonary arteries from that through the pulmonary veins. The ratio of pulmonary to systemic blood flow (Qp/Qs) was 0.93+/-0.26 in group A and 1.27+/-0.16 in group B. APC flow was 1.42 (0.58 to 3.83) L/min/m(2) and 0.82 (0.50 to 1.81) L/min/m(2) in groups A and B, respectively. The mean inaccuracies corresponded to 7.9+/-14.5% and 7.1+/-13.6% of ascending aortic flow in groups A and B, respectively. Qp/Qs was negatively correlated with a younger age at the time of the bidirectional cavopulmonary connections operation (r=0.62, P=0.01) and positively correlated with the age at the time of the Fontan completion (r=0.81, P=0.01). Patients with a previous right-sided modified Blalock-Taussig shunt had more collateral flow to the right lung than those without. APC blood flow can be noninvasively measured in bidirectional cavopulmonary connections and Fontan patients, using MRI in the majority of patients and results in a significant left-to-right shunt.
    Circulation Cardiovascular Imaging 05/2009; 2(3):219-25. · 5.80 Impact Factor
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    ABSTRACT: To assess the feasibility of phase-contrast magnetic resonance (PCMR) in quantifying the pulmonary venous return in normal subjects. PCMR was performed in 12 healthy adult volunteers (mean age 38 years, range 27-60 years; 9 men; body surface area 1.81+/-0.15 m2) for the ascending and descending aorta, caval veins, main and branch pulmonary arteries, and pulmonary veins. Two readers independently quantified blood flow in all subjects. Intraobserver differences were -2.0% (95% confidence interval [CI]: -9.9% to 5.9%), -4.5% (95% CI: -15.6% to 6.5%), and -0.7% (95% CI: -4.5% to 3.0%) for all vessels, pulmonary veins, and other great vessels, respectively. Interobserver differences were -2.0% (95% CI: -10.6% to 6.6%), -3.1% (95% CI: -16.0% to 9.9%), and -1.4% (95% CI: -6.4% to 3.5%) for all vessels, pulmonary veins, and other great vessels, respectively. Pulmonary venous flow volume showed high correlations with the volumes of the pulmonary arterial flow, systemic arterial flow, and systemic venous flow (r=0.76-0.92, P<0.005). Flow quantification of normal pulmonary venous return using PCMR is feasible with high reproducibility and accuracy.
    Journal of Magnetic Resonance Imaging 03/2009; 29(3):588-94. · 2.57 Impact Factor
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    ABSTRACT: Pulmonary vein pathologies often present a diagnostic challenge. Among the different imaging modalities used for the evaluation of pulmonary veins, magnetic resonance is the most comprehensive in assessing anatomy and pathophysiology at the same time. Bright blood cine sequences and contrast-enhanced magnetic resonance angiography outline the course and connections of the pulmonary veins. Phase-contrast velocity mapping measures flow patterns, velocities, and volumes throughout the pulmonary circulation. This paper reviews contemporary utilization of magnetic resonance in the evaluation of pulmonary venous abnormalities in children, based on our experience over the last 5 years and on that of other investigators. We summarize how magnetic resonance imaging enhances our understanding of pulmonary vein physiology and how it can influence the diagnostic approach to children and adults with a pulmonary venous pathology, and we discuss its limitations.
    Journal of the American College of Cardiology 04/2007; 49(9):993-1002. · 14.09 Impact Factor
  • Shi-Joon Yoo, Abdulmajeed Al-Otay, Paul Babyn
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    ABSTRACT: We report a case in which a meandering right pulmonary vein connecting to the left atrium is associated with hypoplasia of the right lung, horseshoe lung, abnormal pulmonary lobation, and abnormal branching of the pulmonary arteries. We discuss its relationship to the so-called scimitar variant, and to the scimitar syndrome itself.
    Cardiology in the Young 07/2006; 16(3):300-4. · 0.95 Impact Factor