Anne Janin

Publications (118)595.42 Total impact

• Article: Specific lymph node involvement in scleromyxedema: a new diagnostic entity for hypermetabolic lymphadenopathy.

  Julie Delyon, Maud Bézier, Michel Rybojad, Josette Brière, Pierre Validire, Martine Bagot, Anne Janin, Maxime Battistella
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  ABSTRACT: Scleromyxedema is a generalized skin disease mostly associated with monoclonal gammopathy. In its chronic course, it can lead to systemic disorders related to mucin deposits in organs. We describe here specific lymph node involvement, hitherto not reported in scleromyxedema. A 68-year-old man with a 1-year history of micropapular eruption and skin sclerosis involving the neck, trunk, hands, and face was diagnosed with scleromyxedema associated with IgG kappa monoclonal gammopathy. Enlarged mediastinal lymph nodes found on thoracic X-ray and computed tomography scan were hypermetabolic on positron emission tomography. Lymph node biopsy showed partial nodal infiltration by numerous fibroblasts surrounded by mucin and collagen deposits, the same being observed on the skin biopsy. Lymph node and skin lesions both improved after intravenous immunoglobulin and corticosteroid treatment. Lymph node involvement in scleromyxedema should be considered in the etiological diagnosis of hypermetabolic, enlarged lymph nodes, especially if monoclonal gammopathy is associated.
  Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 05/2013; · 2.49 Impact Factor
• Article: Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.

  Jacqueline Lehmann-Che, Anne Sophie Hamy, Raphael Porcher, Marc Barritault, Fatiha Bouhidel, Hanadi Habuellelah, Solenne Leman-Detours, Anne de Roquancourt, Laurence Cahen-Doidy, Edwige Bourstyn, Patricia de Cremoux, Cedric de Bazelaire, Marcela Albiter, Sylvie Giacchetti, Caroline Cuvier, Anne Janin, Marc Espie, Hugues de The, Philippe Bertheau
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  ABSTRACT: INTRODUCTION: Molecular apocrine (MA) tumors are estrogen receptor (ER) negative breast cancers characterized by androgen receptor (AR) expression. We analysed a group of 58 transcriptionally defined MA tumors and proposed a new tool to identify these tumors. METHODS: We performed quantitative reverse transcription PCR (qRT-PCR) for ER, AR, FOXA1 and AR-related genes, and immunohistochemistry (IHC) for ER, PR, HER2, CK5/6, CK17, EGFR, Ki67, AR, FOXA1 and GCDFP15 and we analysed clinical features. RESULTS: MA tumors were all characterized by ER(-) AR(+) FOXA1(+) and AR-related genes positive mRNA profile. IHC staining on these tumors showed 93% ER(-), only 58% AR(+) and 90% FOXA1(+). 67% and 57% MA tumors were HER2(3+) and GCDFP15(+), respectively. Almost all MA tumors (94%) had the IHC signature "HER2(3+) or GCDFP15(+)" but none of 13 control basal-like (BL) tumors did. Clinically, MA tumors were rather aggressive, with poor prognostic factors. CONCLUSION: MA tumors could be better defined by their qRT-PCR-AR profile than by AR IHC. In addition, we found that "HER2 or GCDFP15" protein overexpression is a sensitive and specific tool to differentiate MA from BL in the context of ER negative tumors. A composite molecular and IHC signature could therefore help to identify MA tumors in the daily practice.
  Breast cancer research: BCR 05/2013; 15(3):R37. · 5.24 Impact Factor
• Article: [A complex tumoral disease].

  Maya Nourieh, Josette Brière, Emile Sarfati, Faten Hammedi, Anne Janin, Philippe Bertheau
  Annales de Pathologie 04/2013; 33(2):118-21. · 0.25 Impact Factor
• Article: Donor-Derived Keratinocytes in Actinic Keratosis and Squamous Cell Carcinoma in Patients with Kidney Transplant.

  Laurence Verneuil, Mariana Varna, Christophe Leboeuf, Louis François Plassa, Morad Elbouchtaoui, Irmine Loisel-Ferreira, Fatiha Bouhidel, Marie-Noelle Peraldi, Celeste Lebbé, Philippe Ratajczak, Anne Janin
  Journal of Investigative Dermatology 11/2012; · 6.31 Impact Factor
• Article: Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes.

  Carole Le Pogam, Patricia Krief, Stephanie Beurlet, Annie Soulié, Nicole Balitrand, Bruno Cassinat, Helene Cavé, Olivier Kosmider, Niclas Setterblad, Christophe Leboeuf, [......], Pascal Merlet, Maria-Elena Noguera, Anne Janin, Marika Pla, Michaela Fontenay, Lionel Adès, Pierre Fenaux, Christine Chomienne, Rose Ann Padua, Nader Omidvar
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  ABSTRACT: We have previously demonstrated that two prognostic features of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), mutant NRAS and over-expressing BCL-2, cooperate physically and functionally in vivo. Screening of MDS patient bone marrow (BM) identified NRAS:BCL-2 co-localization in 64% cases, correlating with percentage BM blasts, apoptotic features and disease status (p<0.0001). Localization of the complex at the plasma membrane or the mitochondria correlated with disease and apoptosis features in MDS patients, whilst caspase-9 mediated mechanism was elucidated in vivo and in vitro. The intensity and localization of the RAS:BCL-2 complex merits further evaluation as a novel biomarker of MDS.
  Leukemia research 11/2012; · 2.36 Impact Factor
• Source

  Available from: Luc G. Legres

  Article: [Virtual slides in fundamental and clinical research.]

  Anne Janin, Luc Legrès, Christophe Leboeuf, Jean-Yves Scoazec, Philippe Bertheau
  Medecine sciences: M/S 11/2012; 28(11):990-992. · 0.64 Impact Factor
• Article: Human Herpesvirus-6 cytopathic inclusions: an exceptional and recognizable finding on skin biopsy during HHV6 reactivation after autologous stem-cell transplantation.

  Jennifer Roux, Maxime Battistella, Luc Fornecker, Jérôme Legoff, Bénédicte Deau, Nadira Houhou, Jean-David Bouaziz, Catherine Thieblemont, Anne Janin
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  ABSTRACT: Skin rash are common in immunocompromised patients, particularly after bone marrow transplantation. Human herpes virus 6 (HHV6) reactivation is often suspected, but its clinical presentation and the routine laboratory tests may be unspecific, thus leading to late diagnosis. In this case, we report specific intralymphocytic cytopathic inclusions on skin biopsy as a sign of systemic HHV6 reactivation. A 56-year-old patient presented progressive erythroderma and fever occurring after autologous hematopoietic stem-cell transplantation for mantle cell lymphoma. The skin biopsy showed a perivascular infiltrate of medium-to-large lymphocytes with irregular nuclei containing a large central basophilic inclusion surrounded by a clear halo. High levels of HHV-6 genomic in skin biopsy confirm HHV-6-induced cytopathic effect. The clinical course improved with intravenous foscavir. The specific histopathological findings encountered in this case are exceptional but recognizable, and along with HHV-6 DNA detection allow a prompt recognition of HHV6 skin rash.
  The American Journal of dermatopathology 05/2012; 34(6):e73-6. · 1.30 Impact Factor
• Article: Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease.

  Paula Rodriguez-Otero, Raphael Porcher, Régis Peffault de Latour, Margarita Contreras, Yoram Bouhnik, Aliénor Xhaard, Annalisa Andreoli, Patricia Ribaud, Nathalie Kapel, Anne Janin, Gérard Socié, Marie Robin
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  ABSTRACT: Diagnosis of gastrointestinal GVHD (GI-GVHD) is based on clinical symptoms and histologic findings. No biomarkers predicting responses to treatment are routinely available even though 30% to 50% of patients will not respond to corticosteroids. In this study, we aimed to evaluate fecal calprotectin, α-1-antitrypsin (α(1)-AT), and elastase at the time of first symptoms as diagnostic and prognostic tools for GI-GVHD in 72 consecutive patients, of whom 51 developed GI-GVHD. The prognostic value of markers was evaluated by their association with complete response (CR) and steroid-resistant (SR) GVHD. Calprotectin and α(1)-AT concentrations increased with GI-GVHD initial stages but patients with initial stage 1 GI-GVHD had similar marker levels to patients without GI-GVHD, so sensitivity to diagnose GI-GVHD was weak. In contrast, calprotectin and α(1)-AT were predictors for SR-GVHD and CR. Multiple regression modeling identified calprotectin and α(1)-AT concentration as independently predicting SR-GVHD together with initial stage > 2 GI-GVHD. Our results showed that fecal calprotectin and α(1)-AT levels at the time of diagnosis are predictive for responses to treatment but are not diagnostic markers for initial stage 1 to 3 GI-GVHD.
  Blood 05/2012; 119(24):5909-17. · 9.90 Impact Factor
• Article: BCL2 expression in CD105 positive neoangiogenic cells and tumor progression in angioimmunoblastic T-cell lymphoma.

  Philippe Ratajczak, Christophe Leboeuf, Li Wang, Josette Brière, Irmine Loisel-Ferreira, Catherine Thiéblemont, Wei-Li Zhao, Anne Janin
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  ABSTRACT: The angiogenic microenvironment has been known to be a component of angioimmunoblastic T-cell lymphoma since its initial characterization. We have shown that angioimmunoblastic T-cell lymphoma endothelial cells produce vascular endothelial growth factor-A (VEGFA), and participate in lymphoma progression. In squamous cell carcinoma, endothelial BCL2 expression induces a crosstalk with tumor cells through VEGFA, a major mediator of tumoral angiogenesis. In the present study, we analyzed BCL2 and VEGFA in 30 angioimmunoblastic T-cell lymphomas, using triple immunofluorescence to identify protein coexpression in well-characterized lymphoma cells and microenvironment neoangiogenic endothelial cells. Using quantitative real-time PCR, we assessed mRNA expression levels in laser-microdissected endothelial and lymphoma cells. In lymphoma cells, as in endothelial cells, BCL2 and VEGFA proteins were coexpressed. BCL2 was expressed only in neoangiogenic CD34(+)CD105(+) endothelial cells. In laser-microdissected cells, mRNA studies showed a significant relationship between BCL2 and VEGFA levels in CD34(+) endothelial cells, but not in CD3(+)CD10(+)lymphoma cells, or in CD34(+) endothelial cells from lymph node hyperplasia. Further study showed that, in AITL, BCL2 mRNA levels in CD34(+)CD105(+) neoangiogenic endothelial cells also correlated with microvessel density, International Prognostic Index, Ann Arbor stage, bone marrow involvement and elevated LDH. BCL2 expression by CD105(+) neoangiogenic endothelial cells is related to tumor progression in angioimmunoblastic T-cell lymphoma.
  Modern Pathology 02/2012; 25(6):805-14. · 4.79 Impact Factor
• Source

  Available from: dx.plos.org

  Article: A reliable method for the selection of exploitable melanoma archival paraffin embedded tissues for transcript biomarker profiling.

  Celeste Lebbe, Mickael Guedj, Nicole Basset-Seguin, Marie Pierre Podgorniak, Suzanne Menashi, Anne Janin, Samia Mourah
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  ABSTRACT: The source tissue for biomarkers mRNA expression profiling of tumors has traditionally been fresh-frozen tissue. The adaptation of formalin-fixed, paraffin-embedded (FFPE) tissues for routine mRNA profiling would however be invaluable in view of their abundance and the clinical information related to them. However, their use in the clinic remains a challenge due to the poor quality of RNA extracted from such tissues. Here, we developed a method for the selection of melanoma archival paraffin-embedded tissues that can be reliably used for transcript biomarker profiling. For that, we used qRT-PCR to conduct a comparative study in matched pairs of frozen and FFPE melanoma tissues of the expression of 25 genes involved in angiogenesis/tumor invasion and 15 housekeeping genes. A classification method was developed that can select the samples with a good frozen/FFPE correlation and identify those that should be discarded on the basis of paraffin data for four reference genes only. We propose therefore a simple and inexpensive assay which improves reliability of mRNA profiling in FFPE samples by allowing the identification and analysis of "good" samples only. This assay which can be extended to other genes would however need validation at the clinical level and on independent tumor series.
  PLoS ONE 01/2012; 7(1):e29143. · 4.09 Impact Factor
• Article: Necrosis assessment in renal carcinoma.

  Cédric de Bazelaire, Jacqueline Rivet, Mariana Varna, Sandrine Katsahian, Christophe Leboeuf, Wissam Sandid, Philippe Bertheau, Anne Janin
  Human pathology 01/2012; 43(1):150-1; author reply 151-2. · 3.03 Impact Factor
• Source

  Available from: dx.plos.org

  Article: Active chronic sarcoidosis is characterized by increased transitional blood B cells, increased IL-10-producing regulatory B cells and high BAFF levels.

  Anne Saussine, Abdellatif Tazi, Séverine Feuillet, Michel Rybojad, Caroline Juillard, Anne Bergeron, Valérie Dessirier, Fatiha Bouhidel, Anne Janin, Armand Bensussan, Martine Bagot, Jean-David Bouaziz
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  ABSTRACT: Sarcoidosis is a multisystemic disease of unknown etiology characterized by a disproportionate Th1 granulomatous immune response in the organs involved. Plasmatic hypergammaglobulinemia and B cell accumulation in granulomatous lesions suggest the possible role of humoral immune responses in the pathogenesis of sarcoidosis. The purpose of this study is to describe B cell peripheral compartment in sarcoidosis. We analyzed blood B cell subsets and BAFF levels in 33 patients with chronic sarcoidosis (active sarcoidosis n = 18; inactive sarcoidosis n = 15) and 18 healthy donors. Active chronic sarcoidosis patients had significantly less circulating memory B cells (p<0.01), more transitional (p<0.01) and increased numbers of IL-10-producing regulatory B cells (p<0.05) compared with healthy donors and patients with inactive sarcoidosis. BAFF serum levels were significantly higher in patients with active sarcoidosis (p<0.01 versus healthy donors and inactive sarcoidosis patients) and strongly correlated with serum hypergammaglobulinemia (r = 0.53, p<0.01) and angiotensin converting enzyme levels (r = 0.61, p = <0.01). These data show that there is an altered B cell homeostasis in active sarcoidosis and suggest BAFF antagonist drugs as potential new treatments of this disease.
  PLoS ONE 01/2012; 7(8):e43588. · 4.09 Impact Factor
• Article: Sweet-like reaction due to arthropod bites: a histopathologic pitfall.

  Maxime Battistella, Emmanuelle Bourrat, Laurence Fardet, Véronique Saada, Anne Janin, Marie-Dominique Vignon-Pennamen
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  ABSTRACT: The histopathology of arthropod bite reactions is classically described as "dermal edema" with superficial and middle to deep dermal inflammation in a perivascular and wedge-shaped distribution. The composition of the infiltrate may vary, but a characteristic feature is the presence of prominent eosinophils between collagen bundles. Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is characterized by dermal edema and a dense neutrophilic infiltrate, associated with a constellation of clinical and biological signs. We describe herein 2 cases of arthropod bite reactions with impressive clinical lesions and histopathological findings reminiscent of Sweet syndrome. However, the patients were lacking other criteria for Sweet syndrome and were diagnosed as Sweet-like reaction to arthropod bites. Pathologists should be careful in rendering a diagnosis of neutrophilic dermatosis, which requires clinicopathological correlation, and should consider arthropod bite reactions in the differential diagnosis.
  The American Journal of dermatopathology 12/2011; 34(4):442-5. · 1.30 Impact Factor
• Article: Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

  Ariane Galaup, Elisa Gomez, Rachid Souktani, Mélanie Durand, Aurélie Cazes, Catherine Monnot, Jérémie Teillon, Sébastien Le Jan, Claire Bouleti, Gaëlle Briois, [......], Philippe Ratajczak, Anne Janin, Gavin Thurston, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Renaud Tissier, Alain Berdeaux, Bijan Ghaleh, Stéphane Germain
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  ABSTRACT: Increased permeability, predominantly controlled by endothelial junction stability, is an early event in the deterioration of vascular integrity in ischemic disorders. Hemorrhage, edema, and inflammation are the main features of reperfusion injuries, as observed in acute myocardial infarction (AMI). Thus, preservation of vascular integrity is fundamental in ischemic heart disease. Angiopoietins are pivotal modulators of cell-cell junctions and vascular integrity. We hypothesized that hypoxic induction of angiopoietin-like protein 4 (ANGPTL4) might modulate vascular damage, infarct size, and no-reflow during AMI. We showed that vascular permeability, hemorrhage, edema, inflammation, and infarct severity were increased in angptl4-deficient mice. We determined that decrease in vascular endothelial growth factor receptor 2 (VEGFR2) and VE-cadherin expression and increase in Src kinase phosphorylation downstream of VEGFR2 were accentuated after ischemia-reperfusion in the coronary microcirculation of angptl4-deficient mice. Both events led to altered VEGFR2/VE-cadherin complexes and to disrupted adherens junctions in the endothelial cells of angptl4-deficient mice that correlated with increased no-reflow. In vivo injection of recombinant human ANGPTL4 protected VEGF-driven dissociation of the VEGFR2/VE-cadherin complex, reduced myocardial infarct size, and the extent of no-reflow in mice and rabbits. These data showed that ANGPTL4 might constitute a relevant target for therapeutic vasculoprotection aimed at counteracting the effects of VEGF, thus being crucial for preventing no-reflow and conferring secondary cardioprotection during AMI.
  Circulation 11/2011; 125(1):140-9. · 14.74 Impact Factor
• Article: Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.

  Keli L Hippen, Christoph Bucher, Dawn K Schirm, Amanda M Bearl, Ty Brender, Kathy A Mink, Kimberly S Waggie, Regis Peffault de Latour, Anne Janin, Julie M Curtsinger, Stacey R Dillon, Jeffrey S Miller, Gerard Socie, Bruce R Blazar
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  ABSTRACT: In rodent graft-versus-host disease (GVHD) models, anti-IL-21 neutralizing mAb treatment ameliorates lethality and is associated with decreases in Th1 cytokine production and gastrointestinal tract injury. GVHD prevention was dependent on the in vivo generation of donor-inducible regulatory T cells (Tregs). To determine whether the IL-21 pathway might be targeted for GVHD prevention, skin and colon samples obtained from patients with no GVHD or grade 2 to 4 GVHD were analyzed for IL-21 protein expression. By immunohistochemistry staining, IL-21 protein-producing cells were present in all gastrointestinal tract samples and 54% of skin samples obtained from GVHD patients but not GVHD-free controls. In a human xenogeneic GVHD model, human IL-21-secreting cells were present in the colon of GVHD recipients and were associated with elevated serum IL-21 levels. A neutralizing anti-human IL-21 mAb given prophylactically significantly reduced GVHD-associated weight loss and mortality, resulting in a concomitant increase in Tregs and a decrease in T cells secreting IFN-γ or granzyme B. Based on these findings, anti-IL-21 mAb could be considered for GVHD prevention in the clinic.
  Blood 11/2011; 119(2):619-28. · 9.90 Impact Factor
• Article: IDO in human gut graft-versus-host disease.

  Philippe Ratajczak, Anne Janin, Régis Peffault de Larour, Lisa Koch, Brigitte Roche, David Munn, Bruce R Blazar, Gérard Socié
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  ABSTRACT: Although rodent graft-versus-host disease (GVHD) models have suggested that indoleamine 2,3-dioxygenase (IDO) is a critical regulator of gastrointestinal GVHD, parallel human studies on IDO expression have not been reported. IDO expression was assessed in 20 patients who underwent duodenal biopsy. IDO was upregulated in epithelial cells. In situ analyses reveal that macrophages and dendritic cells stain positive for IDO, but that most of the IDO(+) cells were a novel population of CD3(+)CD4(+)IDO(+) cells. The proportion of CD4(+)IDO(+) T cells was significantly higher in patients with moderate GVHD. In situ regulatory T cell and Th17 numbers correlated with overall severity. Although needing confirmatory results from larger sample sets, these data are consistent with the hypothesis that IDO is involved in regulating gastrointestinal GVHD.
  Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 08/2011; 18(1):150-5. · 3.15 Impact Factor
• Article: The complex relationship between human herpesvirus 6 and acute graft-versus-host disease.

  Claire Pichereau, Kristell Desseaux, Anne Janin, Catherine Scieux, Régis Peffault de Latour, Aliénor Xhaard, Marie Robin, Patricia Ribaud, Félix Agbalika, Sylvie Chevret, Gérard Socié
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  ABSTRACT: The most frequent manifestation of human herpesvirus 6 (HHV-6) reactivation after allogeneic hematopoietic stem cell transplantation (HSCT) is febrile rash, raising the question of its relationship with graft-versus-host disease (GVHD). In this retrospective analysis of 365 patients who underwent allogeneic HSCT, HHV-6 reactivation was significantly associated with cord blood transplantation (hazard ratio [HR], 3.20; P < .0001) and the use of unrelated donors (HR, 2.02; P = .008). On multivariate analysis, previous GVHD was a predictive factor for HHV-6 reactivation (HR, 1.80; P = .01), and previous HHV-6 reactivation was a predictive factor for acute GVHD (HR, 1.66; P = .03). Nineteen patients with no pathological evidence of GVHD later developed severe clinical GVHD (grade III-IV), suggesting the role of HHV-6 as a trigger for severe GVHD. Furthermore, 17 patients without histopathological GVHD demonstrated a significant lymphoid infiltrate suggesting "pure" HHV-6-related manifestations, and these patients could have been spared steroid therapy.
  Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 07/2011; 18(1):141-4. · 3.15 Impact Factor
• Article: Endothelial damage in all types of T-lymphocyte-mediated drug-induced eruptions.

  Laurence Verneuil, Christophe Leboeuf, Jean-Sébastien Vidal, Philippe Ratajczak, François Comoz, Jean-Claude Ameisen, Anne Janin
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  ABSTRACT: In severe drug-induced eruptions, bullous lesions can be associated with immune complex-mediated vasculitis and/or with T-lymphocyte-mediated keratinocyte apoptosis. We have recently identified endothelial cell apoptosis in severe bullous T-lymphocyte-mediated drug-induced eruptions. We assessed microvessel involvement in the whole spectrum of T-lymphocyte-mediated drug-induced eruptions. Thirty-two patients with T-lymphocyte-mediated drug-induced eruptions in 4 groups (8 cases of toxic epidermal necrolysis/Stevens-Johnson syndrome, 8 cases of drug rash with eosinophilia and systemic symptoms, 8 cases of acute generalized exanthematous pustulosis, 8 cases of drug maculopapular exanthema) and 8 healthy controls were included. On skin biopsy specimens, we performed a systematic ultrastructural study of endothelial cells, vascular walls, and inflammatory cells; a quantification of apoptotic cells, inflammatory infiltrate, and immune complex deposits; and we assessed granzyme-B, tumor necrosis factor, and Fas ligand expression. Correlations of apoptosis with clinical data of skin lesions and systemic involvement in liver, kidney, lung, and lymph nodes were then assessed. Findings from ultrastructural study showed that endothelial cell apoptosis was present in all 32 drug-induced eruptions. No leukocytoclastic vasculitis was associated. Granzyme-B and tumor necrosis factor were expressed around microvessels. In toxic epidermal necrolysis/Stevens-Johnson syndrome and drug rash with eosinophilia and systemic symptoms, the number of apoptotic endothelial cells was related to the extension of skin lesions and the presence of purpura. It was also related to liver and kidney involvement. Endothelial apoptosis occurs in skin microvessels of all types of T-lymphocyte-mediated drug-induced eruptions. This skin endothelial cell damage is related to the severity of skin lesions and systemic involvement.
  Archives of dermatology 05/2011; 147(5):579-84. · 4.76 Impact Factor
• Article: [Breast metastasis of ileal endocrine carcinoma].

  Maxime Battistella, Anne-Sophie Hamy, Anne Janin, Anne de Roquancourt
  Annales de Pathologie 04/2011; 31(2):112-4. · 0.25 Impact Factor
• Article: [Unusual mucosal changes in a severe colitis].

  Khadija Chérif, Sophie Buyse, Axèle Champault, Julie Gonin, Elisabeth Da Maia, Anne Janin, Philippe Bertheau
  Annales de Pathologie 04/2011; 31(2):124-6. · 0.25 Impact Factor