A Körber

Publications (52)54.48 Total impact

• Article: [Annular erythematous plaques].

  C Dullweber, A Körber, J Dissemond
  Der Hautarzt 03/2006; 57(2):150-4. · 0.58 Impact Factor
• Article: Allergisches Kontaktekzem durch einen Hydrokolloidverband bei Sensibilisierung auf Kolofonium

  A. Körber, S. Kohaus, M. Geisheimer, S. Grabbe, J. Dissemond
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  ABSTRACT: Eine 62-jhrige Patientin mit einem Ulcus cruris venosum entwickelte im Rahmen der Wundgrundkonditionierung mit dem Hydrokolloidverband Varihesive ein massives Ekzem. In der Epikutantestung besttigte sich neben der Sensibilisierung gegen Kolofonium eine ausgeprgte Sensibilisierung gegen den Hydrokolloidverband. Nach Durchsicht der aktuellen Literatur fiel auf, dass bereits Fallberichte ber Kontaktsensibilisierungen gegen identische Hydrokolloidverbnde, die in anderen Lndern unter anderen Namen vertrieben werden, seit 10Jahren bekannt sind. Der als Inhaltsstoff gefundene Pentaerythritolester von hydrogeniertem Harz vermittelt die Sensibilisierung gegen Kolofonium. Insbesondere Patienten mit chronischen Wunden neigen zur Ausbildung von Kontaktsensibilisierungen. Kolofonium ist als Allergen ubiquitr vorhanden und in Deutschland aktuell das am vierthufigsten nachgewiesene Allergen. Daher ist zu fordern, dass hochpotente Allergene wie beispielsweise Kolofonium als Inhaltsstoff von modernen Wundauflagen strikt gemiedenen werden sollten.A 62-year-old female patient with a venous leg ulcer developed massive eczema during wound bed preparation with the hydrocolloid dressing Varihesive. The patch testing confirmed a pronounced sensitization to the hydrocolloid dressing apart from the sensitization to colophony. After review of the current literature we found several case reports from the last 10years about sensitization to hydrocolloids which were identical but distributed under different brand names in different countries. These dressings contain the pentaerythritol ester of hydrogenated rosin as the tackifying agent which is the substance retaining the sensitizing potential of colophony. Especially patients with chronic wounds frequently tend to contact sensitizations, and colophony currently represents the 4th most frequent allergen in Germany. Therefore, highly potent allergens such as colophony should be strictly avoided as a content material of modern wound dressings.
  Der Hautarzt 02/2006; 57(3):242-245. · 0.58 Impact Factor
• Article: Erfolgreiche Therapie eines Ulcus cruris rheumaticum mit systemischen Immunglobulinen

  A. Körber, M. Lehnen, J. Rietkötter, S. Grabbe, J. Dissemond
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  ABSTRACT: Die rheumatoide Arthritis (RA) ist eine systemische chronisch entzndliche Autoimmunerkrankung. Im Rahmen der extraartikulren Manifestationen zeigt sich das oft vaskulitisch induzierte Ulcus cruris rheumaticum als interdisziplinre therapeutische Herausforderung. Wir berichten ber eine 69-jhrige multimorbide Patientin mit ausgedehnten therapierefraktren vaskulitisch induzierten Ulzera am rechten Unterschenkel. Aufgrund von wundheilungsbehindernden Nebenwirkungen der bisherigen Therapien erfolgte die Initiierung einer Behandlung mit intravensen Immunglobulinen, worunter eine vollstndige Abheilung der Ulzera erreicht werden konnte. Es zeigte sich zudem eine rasche Reduktion der serologischen Aktivittsparameter der RA sowie eine subjektive Besserung der rheumatischen Symptomatik. Intravense Immunglobuline stellten somit bei dieser Patientin eine effiziente und nebenwirkungsarme Option in der Therapie von vaskulitisch induzierten Ulcera crura im Rahmen einer RA dar.Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease. Leg ulcers in rheumatoid arthritis may be caused by vasculitis and are an interdisciplinary therapeutic challenge. A 69year old women with rheumatoid arthritis and many other medical problems presented with widespread vasculitis-induced therapy-resistant ulceration on her right lower leg. Since previous therapeutic efforts had a negative effect on wound healing, we administered intravenous immunoglobulins which led to complete healing of the ulcer was achieved. Both the serological and rheumatologic features of her rheumatoid arthritis also improved. Intravenous immunoglobulins represented an effective therapeutic option with fewer side effects in the therapy of vasculitis-induced leg ulceration in this patient with rheumatoid arthritis.
  Der Hautarzt 01/2006; 57(12):1106-1110. · 0.58 Impact Factor
• Article: [Physical exercise in thte treatment of ulcus cruris venosum].

  J Dissemond, A Körber, L A Schneider
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  ABSTRACT: As an adjuvant measure, physical exercise should be recommended for all patients with an ulcus cruris venosum, and should be a permanent part of the patient's lifestyle on completion of wound healing. Although clinical studies have shown that physical exercise has a positive effect on numerous factors of relevance for the development of an ulcer, sports activities undertaken for therapeutic and prophylactic purposes are still made little use of by patients.
  MMW Fortschritte der Medizin 01/2006; 147(51-52):47-8.
• Article: [Multiple subcutaneous painful hyperpigmented nodules on both lower limbs].

  A Körber, M Lehnen, U Hillen, S Grabbe, J Dissemond
  Der Hautarzt 11/2005; 56(10):978-81. · 0.58 Impact Factor
• Article: [Antimicrobial peptides. A perspective for the treatment of chronic wounds?].

  A Körber, S Grabbe, J Dissemond
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  ABSTRACT: Human antimicrobial peptides play a substantial role in the immune response to various dermatological diseases, such as acne, atopic dermatitis and psoriasis vulgaris, and even mucosal HIV-protection is mediated inter alia by antimicrobial peptides. In wound healing, the antimicrobial and immune-modulating properties of, in particular, human defensins and cathelicidins can affect important controlling factors. For example, the interaction between different antimicrobial peptides and growth factors supports neoangiogenesis. Although further clinical investigations are necessary to identify the exact effects of antimicrobial peptides in chronic wounds, such peptides could be a promising therapeutic option in the near future for the treatment of patients with chronic wounds by promoting endogen expression or exogenous supplementation.
  Der Hautarzt 10/2005; 56(9):860-5. · 0.58 Impact Factor
• Article: Multiple hyperpigmentierte druckdolente subkutane Noduli beider Unterschenkel

  A. Körber, M. Lehnen, U. Hillen, S. Grabbe, J. Dissemond
  Der Hautarzt 09/2005; 56(10):978-981. · 0.58 Impact Factor
• Article: [Leg ulcers: current aspects in diagnostic].

  J Dissemond, A Körber, T Jansen, S Grabbe
  DMW - Deutsche Medizinische Wochenschrift 06/2005; 130(20):1263-6. · 0.53 Impact Factor
• Article: [Human beta defensins: a new perspective in acne treatment?].

  A Körber, M Lehnen, S Grabbe, J Dissemond
  DMW - Deutsche Medizinische Wochenschrift 03/2005; 130(5):210-2. · 0.53 Impact Factor
• Article: [Syphilis -- the return of the "scourge of humanity"].

  A Körber, S Esser, S Grabbe, J Dissemond
  DMW - Deutsche Medizinische Wochenschrift 10/2004; 129(39):2053-9. · 0.53 Impact Factor
• Article: [HIV-positive patient with multiple ulcers. Lues maligna].

  A Körber, J Dissemond, U Hillen, M Goos, St Esser
  Der Hautarzt 12/2003; 54(11):1098-102. · 0.58 Impact Factor
• Article: HIV-positiver Patient mit multiplen Ulzerationen

  A. Körber, J. Dissemond, U. Hillen, M. Goos, St. Esser
  Der Hautarzt 01/2003; 54(11):1098-1102. · 0.58 Impact Factor
• Article: Insufficient Tetanus Vaccination Status in Patients with Chronic Leg Ulcers

  A. Körber, N. Graue, J. Rietkötter, E. Kreuzfelder, S. Grabbe, J. Dissemond
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  ABSTRACT: Background: Tetanus disease is caused by Clostridium tetani and is one of the most common infectious diseases worldwide. Despite international recommendations for patients with a chronic leg ulcer, there has been a distinctive lack of protection provided by vaccination for these patients in the past decades. Methods: Within the context of our prospective clinical investigation we consecutively determined the concentrations of immunoglobulin G antibodies against C. tetani in 100 patients with a chronic leg ulcer between January 2005 and November 2006. Results: A total of 38 patients were male, and 62 were female. Their mean age was 71 years (25–94). In a total of 47% (n = 47; 13 male, 34 female, mean age: 76 years) of the patients, insufficient immunoglobulin G antibody concentrations were detected. Particularly the subanalysis indicated an insufficient tetanus protection provided by vaccination in 70% of the people aged ≥80 years. Conclusion: A chronic wound, e.g. in the form of a leg ulcer, is known as a potential entrance for C. tetani. Unlike acute wounds, however, it is hardly ever considered to be a reason for assessment of the tetanus immune status. The results of our investigation clarify that particularly elderly people suffering from a leg ulcer have to be tested for tetanus protection provided by vaccination more strictly than ever, and if necessary, vaccinations have to be renewed.
  Dermatology 08/1970; 217(1):69-73. · 2.05 Impact Factor