-
[show abstract]
[hide abstract]
ABSTRACT: Acquired ichthyosis (AI) in association with systemic lupus erythematosus (SLE) is a rare dermatologic finding, with only 7 previously published cases worldwide. We report a 25-year-old black woman with AI associated with SLE. A skin biopsy specimen from the lower extremity showed histologic changes consistent with both ichthyosis vulgaris and SLE, a unique finding that has not been previously reported. We also review the world literature on AI and SLE.
Cutis; cutaneous medicine for the practitioner 03/2008; 81(2):159-62. · 0.81 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: We present a rare case of necrotizing sarcoid granulomatosis (NSG) with skin and pulmonary involvement. NSG with extrapulmonary involvement occurs infrequently, and reports involving skin manifestations in NSG are even more rare.
Cutis; cutaneous medicine for the practitioner 11/2007; 80(4):313-6. · 0.81 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Rickettsialpox is a self-limited febrile illness with skin lesions that may be mistaken for signs of potentially more serious diseases, such as cutaneous anthrax or chickenpox. The cluster of cutaneous anthrax cases from bioterrorism in October 2001 likely heightened awareness of and concern for cutaneous eschars.
To apply an immunohistochemical technique on paraffin-embedded skin biopsy specimens for diagnosing rickettsialpox, and to compare the reported incidence of rickettsialpox before, during, and after the cluster of cutaneous anthrax cases.
Case series.
Dermatology department in a large tertiary care hospital in New York City.
Eighteen consecutive patients with the clinical diagnosis of rickettsialpox from February 23, 2001, through October 31, 2002.
Results of immunohistochemical testing of skin biopsy specimens and of serological testing.
Immunohistochemical testing revealed spotted fever group rickettsiae in all 16 eschars and in 5 of the 9 papulovesicles tested. A 4-fold or greater increase in IgG antibody titers reactive with Rickettsia akari was observed in all 9 patients for whom acute and convalescent phase samples were available; 6 patients had single titers indicative of rickettsialpox infection (> or =1:64). Of the 18 patients, 9 (50%) presented in the 5 months following the bioterrorism attacks.
Rickettsialpox remains endemic in New York City, and the bioterrorism attacks of October 2001 may have led to increased awareness and detection of this disease. Because rickettsialpox may be confused with more serious diseases, such as cutaneous anthrax or chickenpox, clinicians should be familiar with its clinical presentation and diagnostic features. Immunohistochemical staining of skin biopsy specimens, particularly from eschars, is a sensitive technique for confirming the clinical diagnosis.
Archives of Dermatology 12/2003; 139(12):1545-52. · 3.89 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Familial leiomyomatosis cutis et uteri may present with numerous cutaneous leiomyomas, or piloleiomyomas, which can be painful. Pharmacologic agents have had limited efficacy in mitigating leiomyoma-associated discomfort. We describe a case of familial piloleiomyomas in which intermittent pain at the site of the lesions was substantially reduced by the administration of oral gabapentin. The unusual unilateral distribution of leiomyomas in this case is discussed.
Journal of the American Academy of Dermatology 03/2002; 46(2 Suppl Case Reports):S27-9. · 3.99 Impact Factor
