I Jelencsik

Országos Idegsebészeti Tudományos Intézet, Budapeŝto, Budapest, Hungary

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Publications (12)32.38 Total impact

  • J Afra, C Ertsey, G Bozsik, I Jelencsik
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    ABSTRACT: Central serotonergic neurotransmission was assessed using intensity dependence of cortical auditory evoked potentials (IDAP) in cluster headache (CH) patients during both the active and interictal period. In 15 episodic CH patients and 13 controls previously described methods were used and amplitude-stimulus intensity function (ASF) slopes were computed. In the cluster group mean ASF slope was significantly steeper than in the control group both during the active period (1.53+/-0.90 vs. 0.77+/-0.85, P=0031) and interictally (1.85+/-1.20 vs. 0.77+/-0.85, P=0012). In the cluster group IDAPs of active and interictal period did not differ significantly (P=0378). Duration of the disease or the present bout, distance from the last attack did not correlate with ASF slopes. In conclusion, our results are compatible with decreased level of serotonergic neurotransmission in raphe-cortical pathways. Diminished serotonergic activity in raphe-hypothalamic serotonergic pathways might be hypothesized influencing the activity of hypothalamic neurons and thus play a role in the genesis of cluster headache.
    Cephalalgia 02/2005; 25(1):36-40. · 3.49 Impact Factor
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    ABSTRACT: Health-related quality of life was studied in 35 episodic cluster headache (CH) patients during and after the cluster period, using a generic (SF-36) and a headache-specific (MSQ2.1) instrument. The results were compared with those of age- and sex-matched migraineurs (n = 53) and healthy persons (n = 62). During the cluster period patients had lower scores than controls in all SF-36 and MSQ2.1 domains. The difference was significant for most SF-36 and all MSQ2.1 domains. Although CH patients had lower scores than migraineurs on most scales, the difference was significant only on SF-36 scores measuring bodily pain and social functioning. There was a good correlation between the two instruments. After the termination of the cluster period the quality of life of patients was similar to that of headache-free controls. Generic and headache-specific QoL are severely impaired in CH and this impairment is at least as severe as in migraine.
    Cephalalgia 04/2004; 24(3):188-96. · 3.49 Impact Factor
  • Edina Vitaszil, Ilona Jelencsik, Imre Szirmai
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    ABSTRACT: The clinical diagnosis of inherited spinocerebellar ataxias is difficult, because phenotypes frequently overlap. The authors attempt to review the different inherited ataxia syndromes, discussing the most frequent one, Friedreich-ataxia in detail. The case of a patient with Friedreich-ataxia is presented, where the genetically supported diagnosis has been made more than ten years following the onset of the symptoms, after several hospitalizations and misdiagnosis. The correct diagnosis can be established based on the Geoffroy-Harding criteria and gene mutation analysis.
    Ideggyógyászati szemle 12/2002; 55(11-12):382-93. · 0.35 Impact Factor
  • S Ilniczky, I Jelencsik, J Kenéz, I Szirmai
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    ABSTRACT: Vitamin B12 deficiency causes haematological and neurological diseases. Subacute combined degeneration (SCD) of the spinal cord is characterized by degeneration of the posterior and lateral columns. We report two cases of SCD induced by nitrous oxide (N2O) anaesthesia. In both cases magnetic resonance imaging (MRI) of the spinal cord showed symmetric, reversible changes in the posterior columns, correlating well with patients' symptoms.
    European Journal of Neurology 02/2002; 9(1):101-4. · 4.16 Impact Factor
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    ABSTRACT: Three members of a family with inherited prion disease are reported. One additional family member had a progressive neurological disease without details. Two developed symptoms of ataxia, dementia, myoclonus, rigidity, and hemiparesis, and one had a different phenotype with the combination of lower motor neuron deficit, parkinsonism, intellectual decline, and ataxia. In this last patient cell loss of the anterior horn motor neurons and chronic neurogenic muscle atrophy was evident. Immunostaining for the prion protein disclosed unicentric and multicentric plaques, and coarse and fine granular positivity. Genetic analysis of the prion protein gene of the propositus showed a 117 codon alanine to valine mutation and homozygous 129 valine/valine genotype.
    Journal of Neurology Neurosurgery & Psychiatry 07/2001; 70(6):802-5. · 4.92 Impact Factor
  • C Ertsey, I Jelencsik
    Cephalalgia 07/2000; 20(5):518-20. · 3.49 Impact Factor
  • European Journal of Neurology 12/1999; 6(6):725-6. · 4.16 Impact Factor
  • T G Nagy, I Jelencsik, I Szirmai
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    ABSTRACT: We report a 69-year-old male patient whose motor aphasia started at the age of 61. The language disability remained isolated and progressed over a period of eight years without any additional cognitive deficits. Computed tomography (CT) and magnetic resonance imaging (MRI) showed moderate cortical atrophy with frontal dominance. Single photon emission tomography (SPECT) showed hypoperfusion in the frontotemporoparietal region, positron emission tomography (PET) demonstrated a global cortical reduction of glucose utilization with a lesser decrement in the occipital lobes. The clinical symptoms and the neuropsychological findings fit the diagnosis of primary progressive aphasia.
    European Journal of Neurology 08/1999; 6(4):515-9. · 4.16 Impact Factor
  • I Jelencsik
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    ABSTRACT: The majority of headache complaints are caused by primary headaches (migraine, tension headache, cluster headache and rare headache types). The diagnosis of headache syndromes is based on the anamnesis, therefore it is only made possible by a thorough knowledge of the clinical symptoms. Although the exclusion of any intracranial pathology is a diagnostic criterion, performing a neuroimaging examination is only necessitated by an atypical clinical picture which rarely occurs. A common characteristic of this headache group is that the etiology and pathomechanism are still not clear, nevertheless we have a plenty of therapeutical possibilities which can improve the patients' quality of life. Beside the pharmacotherapy one must stress the long-term follow-up of the patients.
    Orvosi Hetilap 08/1998; 139(29):1723-8.
  • Gy. Bozsik, I. Jelencsik, Cs. Ertsey, J. Áfra
    Journal of The Neurological Sciences - J NEUROL SCI. 01/1997; 150.
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    ABSTRACT: After a 4-month history of intermittent headache an intrasellar benign teratoma was found and totally removed in a 19-year-old male patient who became symptom-free. Three years later a third ventricle germinoma developed which was also totally removed, followed by local radiotherapy. Eight months later a spinal tumour evolved, chemotherapy and radiotherapy resulted in full recovery. Eighteen months later a frontal meningeal tumour appeared and was treated by chemotherapy. Three months later—with chemotherapy—tumorous meningitis developed and the patient died 5 years after the first operation. The results of tumour-markers monitoring, histology, electronmicroscopy and immunohistochemistry referred to a germinoma with multiple metastases and meningeal seeding after total removal of an intrasellar mature teratoma.
    European Journal of Neurology 01/1996; 3(1). · 4.16 Impact Factor
  • T. G. Nagy, I. Jelencsik, I. Szirmai
    Neurobiology of Aging - NEUROBIOL AGING. 01/1996; 17(4).