Barbara Terelak-Borys

Publications of Barbara Terelak-Borys

• Comparative study of the retinal nerve fibre layer thickness performed with optical coherence tomography and GDx scanning laser polarimetry in patients with primary open-angle glaucoma.

  Authors: Jaromir T Wasyluk, Irmina Jankowska-Lech, Barbara Terelak-Borys, Iwona Grabska-Liberek

  Medical science monitor : international medical journal of experimental and clinical research. 02/2012; 18(3):CR195-9.

  We compared the parameters of retinal nerve fibre layer in patients with advanced glaucoma with the use of different OCT (Optical Coherence Tomograph) devices in relation to analogical measurementsWe compared the parameters of retinal nerve fibre layer in patients with advanced glaucoma with the use of different OCT (Optical Coherence Tomograph) devices in relation to analogical measurements performed with GDx VCC (Nerve Fiber Analyzer with Variable Corneal Compensation) scanning laser polarimetry. Study subjects had advanced primary open-angle glaucoma, previously treated conservatively, diagnosed and confirmed by additional examinations (visual field, ophthalmoscopy of optic nerve, gonioscopy), A total of 10 patients were enrolled (9 women and 1 man), aged 18-70 years of age. Nineteen eyes with advanced glaucomatous neuropathy were examined. 1) Performing a threshold perimetry Octopus, G2 strategy and ophthalmoscopy of optic nerve to confirm the presence of advanced primary open-angle glaucoma; 2) performing a GDx VCC scanning laser polarimetry of retinal nerve fibre layer; 3) measuring the retinal nerve fibre layer thickness with 3 different optical coherence tomographs. The parameters of the retinal nerve fibre layer thickness are highly correlated between the GDx and OCT Stratus and 3D OCT-1000 devices in mean retinal nerve fibre layer thickness, retinal nerve fibre layer thickness in the upper sector, and correlation of NFI (GDx) with mean retinal nerve fibre layer thickness in OCT examinations. Absolute values of the retinal nerve fibre layer thickness (measured in µm) differ significantly between GDx and all OCT devices. ConCLUSIONS: Examination with OCT devices is a sensitive diagnostic method of glaucoma, with good correlation with the results of GDx scanning laser polarimetry of the patients.

• [Complications of intravitreal injections--own experience].

  Authors: Agnieszka Jamrozy-Witkowska, Katarzyna Kowalska, Irmina Jankowska-Lech, Barbara Terelak-Borys, Agnieszka Nowosielska, Iwona Grabska-Liberek

  Klinika oczna. 01/2011; 113(4-6):127-31.

  PURPOSE: Authors present complications associated with intravitreal injection perfomed in Ophthalmic Clinic CMKP MATERIAL AND METHODS: retrospective study, between January 2006 and July 2009 wePURPOSE: Authors present complications associated with intravitreal injection perfomed in Ophthalmic Clinic CMKP MATERIAL AND METHODS: retrospective study, between January 2006 and July 2009 we performed intravitreal injections with triamcinolone acetonide (Kenalog, 4 mg), ranibizumab (Lucentis, 0.5 mg), bevacizumab (Avastin, 1.25 mg) and pegaptanib (Macugen, 0.3 mg). We treated eyes with age-related macular degeneration, diabetic macular edema, after retinal venous occlusion, with uveitis, Irvine-Gass syndrome, idiopathic juxtafoveolar teleangiectasia and central serous retinopathy. RESULTS: 943 eyes received intravitreal injections. The most common ocular complication was subconjunctival hemorrhage which was seen in 36% cases. Temporary elevated intraocular pressure above 21 mmHg was noticed in 18 eyes (5%) after anti-VEGF agents injections and in 30 eyes (23.4%) after Kenalog injection. Anterior uveitis developed in sixteen cases (1.7%) from the Avastin (5 eyes) and Lucentis (3 eyes) group. Anterior-posterior inflammation occurred in 8 eyes (0.8%), including four eyes (0.4%) with sterile endophthalmitis (3 following bevacizumab and 1 following ranibizumab injection), one eye (0.1%) with pseudoendophthalmitis (after triamcinolone). There were three cases of suspected endophthalmitis (2 following bevacizumab and 1 following triamcinolone injection). The infectious endophthalmitis after triamcinolone injection was culture-proven and revealed Staphylococcus epidermidis. Cataract formation or progression was noted in 34 eyes totally. In Kenalog group progression of cataract was seen in 23.4% of eyes (30 cases) during 2-years of follow-up and in anti-VEGF agents group--in two cases (0.6%) and 2 cases of iatrogenic cataract. Three diabetic patients suffered systemic adverse events: one patient developed renal insufficiency, one patient developed cerebrovascular accidents and one suffered a myocardial infarction resulting in death. Conclusions: Intravitreal injections are associated with a low incidence of serious adverse events. The most common ocular complication was subconjunctival hemorrhage. There was one case of serious complication--the culture-proven infectious endophthalmitis after Kenalog injection. Cataract formation and increase of intraocular pressure were more often observed following intravitreal triamcinolone injection.

• [Evaluation of retinal thickness in macular region in diabetic patients with RTA analyzer]

  Authors: Barbara Polaczek-Krupa, Iwona Grabska-Liberek, Barbara Terelak-Borys

  Klinika oczna. 02/2009; 111(4-6):119-21.

  PURPOSE: Aim of the study is an evaluation of the anatomic state of retina in the macular region in diabetic patients with various stages of retinopathy by using RTA analyzer, and an assessment ofPURPOSE: Aim of the study is an evaluation of the anatomic state of retina in the macular region in diabetic patients with various stages of retinopathy by using RTA analyzer, and an assessment of applicability of this method in early diagnosis of diabetic macular edema. MATERIAL AND METHODS: Forty diabetic patients (68 eyes) underwent full ophthalmologic examination and also retinal thickness analysis with RTA analyzer. In particular, foveal average thickness FAV and posterior pole average thickness PPAV were determined. The data were statistically evaluated. RESULTS: Both FAV and PPAV are strongly correlated with the eyeground state and increased with increasing the severity of retinopathy and macular edema. The patients with minimal and mild nonproliferative retinopathy without any visible macular edema showed an increased retinal thickness when compared both with diabetic patients without any retinopathy and with control patients. The thickness was however lower than that in patients with diabetic macular edema. CONCLUSIONS: The eyes with minimal and mild nonproliferative diabetic retinopathy without any visible macular edema should be examined by some independent methods, like RTA. The method can be recommended for screening the macular edema in diabetic patients.

• [Application of retinal nerves fiber layer examination--GDx in patients with multiple sclerosis]

  Authors: Irmina Jankowska-Lech, Barbara Terelak-Borys, Iwona Grabska-Liberek, Jaromir Wasyluk, Witold Palasik

  Klinika oczna. 02/2008; 110(1-3):28-30.

  PURPOSE: The purpose of our study is to evaluate retinal fiber layer thickness with scanning polarymetry laser (GDx), in patients suffering from SM with or without optic nerve symptoms. MultiplePURPOSE: The purpose of our study is to evaluate retinal fiber layer thickness with scanning polarymetry laser (GDx), in patients suffering from SM with or without optic nerve symptoms. Multiple sclerosis proceeds to neurodegenerative changes and commonly appears with retrobulbar optic nerve damage. Examination of retinal nerves fiber layer examination with scanning laser polarymetry (GDx) enables to perform quantitative evaluation of retinal nerves fiber layer thickness within the area around the optic nerve disc. It finds application in diagnosis and monitoring of glaucoma, however its usefulness as a tool evaluating optic nerve in multiple sclerosis, has not been proved yet. MATERIALS AND METHODS: Subjects diagnosed with multiple sclerosis (SM) were divided into 2 groups. First group was comprised of subjects, who suffered from at least one episode of retrobulbar neuritis, in at least one eye. Second group was made up of 8 subjects with no history of retrobulbar neuritis. Retinal nerves fiber layer thickness was measured with scanning polarymetry laser (GDx). RESULTS: Symptoms of retinal nerves fiber layer damage, were discovered with GDx significantly more common in first group (70% vs 18.75% accordingly). CONCLUSIONS: Moreover, we stated that evaluation with scanning polarymetry laser might be precious method in discovering retinal nerves fiber layer damage in the course of multiple sclerosis. Presence of defects in retinal nerves fiber layer in patients suffering from multiple sclerosis with no history of retrobulbar neuritis may suggest subclinical damage of optic nerve.

• [Glaucoma neuropathy and neuropathy in multiple sclerosis--common elements of pathogenesis?]

  Authors: Irmina Jankowska-Lech, Barbara Terelak-Borys, Iwona Grabska-Liberek, Witold Palasik

  Klinika oczna. 02/2007; 109(7-9):317-20.

  The optic neuropathy in multiple sclerosis and glaucoma neuropathy are very common ophthalmological diseases. Multiple sclerosis /MS/ is the chronic inflammatory central nervous systemThe optic neuropathy in multiple sclerosis and glaucoma neuropathy are very common ophthalmological diseases. Multiple sclerosis /MS/ is the chronic inflammatory central nervous system demyelinisation disease with an autoimmunological ethiology. The last investigation of multiple sclerosis indicate the molecular and cellular autoimmunisation aspects. Te role of vasoactive factors is underlines in its pathogenesis which also suggests the common elements of glaucoma and MS pathogenesis. The over expressed vasoconstrictive mechanisms in both diseases can conduct to optic nerve injury. The aim of this study is evaluation of the optic disc morphological changes in sclerosis multiplex patients /MS/ with or without neuritis optica in anamnesis in glaucoma "remodeling" aspects. MATERIAL AND METHODS: We present two patients with coexsist sclerosis multiplex and glaucoma neuropathy, which underwent retrobulbar neuritis. CONCLUSION: Coexistance of glaucoma neuropathy and multiple sclerosis neuropathy may indicate common elements of glaucoma and SM pathogenesis. The authors recommend precise morphological optic disc evaluation in multiple sclerosis patients because glaucoma neuropathy may appear.

• [Neuro-hormonal regulation of aqueous humor dynamics as the basis of glaucoma pharmacotherapy. Part I. Aqueous humor secretion]

  Authors: Barbara Terelak-Borys, Iwona Liberek

  Klinika oczna. 02/2007; 109(1-3):60-3.

  The aim of this article is to present current opinion on aqueous humor dynamics regulation and antiglaucoma drugs mechanisms of action. Glaucoma pharmacotherapy is based mainly on neuro-hormonalThe aim of this article is to present current opinion on aqueous humor dynamics regulation and antiglaucoma drugs mechanisms of action. Glaucoma pharmacotherapy is based mainly on neuro-hormonal processes controlling aqueous humor dynamics. Systemic hormones as well as local hormones and autonomic nervous system mediators are involved in the processes of aqueous humor formation and drainage. Antiglaucoma medications act mainly through activation or inhibition of these systems' receptors, helping to decrease aqueous humor production or improve aqueous humor outflow. In this article (part 1) we describe three groups of antiglaucoma medications (beta-antagonists, adrenergic agonists, carbonic anhydrase inhibitors), inhibiting the aqueous humor production and mechanisms of their hypotensive effect in the eye.

• [Neuro-hormonal regulation of aqueous humor dynamics as the basis of glaucoma pharmacotherapy. Part II - Aqueous humor outflow]

  Authors: Barbara Terelak-Borys, Iwona Liberek

  Klinika oczna. 02/2007; 109(1-3):64-7.

  The aim of this article is to present current opinion on aqueous humor dynamics regulation and antiglaucoma drugs mechanisms of action. Pharmacotherapy of glaucoma is based mainly on neuro-hormonalThe aim of this article is to present current opinion on aqueous humor dynamics regulation and antiglaucoma drugs mechanisms of action. Pharmacotherapy of glaucoma is based mainly on neuro-hormonal processes controlling aqueous humor dynamics. Systemic hormones as well as local hormones and autonomic nervous system mediators are involved in the processes of aqueous humor formation and drainage. Antiglaucoma medications act mainly through activation or inhibition of these systems' receptors, helping to decrease aqueous humor production or improve aqueous humor outflow. In this article (part 2) we describe two groups of antiglaucoma medications (parasympathicomimetics, prostaglandin analogues), inhibiting the aquoeus humor outflow and mechanisms of their hypotensive effect in the eye.

• [Are endothelin-1 and neuropeptide Y involved in the pathogenesis of glaucoma?]

  Authors: Barbara Terelak-Borys

  Klinika oczna. 02/2005; 107(4-6):306-11.

  Vasospasm in the vessels, supporting the optic disc, is nowadays considered one of the possible etiological factors leading to development of glaucomatous neuropathy. This article describesVasospasm in the vessels, supporting the optic disc, is nowadays considered one of the possible etiological factors leading to development of glaucomatous neuropathy. This article describes physiological regulatory mechanisms of blood circulation in these vessels, including influence of autonomic nervous system and blood flow autoregulation; it also explains why vasospasm may disturb autoregulation. Special attention is paid to the role of vascular endothelial mediators, which are responsible for autoregulation. Observations indicating that vasospasm may be a risk factor of glaucomatous damage are also presented. The article describes data concerning vasospastic effects of two mediators: endothelin-1 (ET-1), released by vascular endothelium, and neuropeptide Y (NPY), a sympathetic nervous system neurotransmitter, on the vessels supporting the optic disc and their possible role in producing blood flow disturbances in these vessels. Investigation results indicating that endothelial dysfunction, connected with increased ET-1 plasma levels and sympathetic nervous system disorders, may be involved in the pathogenesis of normal-tension glaucoma, are presented.