Suzuko Moritani

National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan

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Publications (96)213.61 Total impact

  • Pathology International 06/2015; DOI:10.1111/pin.12321 · 1.69 Impact Factor
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    ABSTRACT: Granular cell tumors are uncommon, usually benign tumors of Schwann cell origin. The malignant variant is extremely rare, representing <2% of all granular cell tumors. Therefore, standard systemic chemotherapy for this disease does not exist. The present study reports the case of a 40-year-old female with a malignant granular cell tumor that originally arose in the right orbit and subsequently relapsed. The patient was started on pazopanib monotherapy following treatment with two investigational drugs, a smoothened inhibitor and then a phosphatidylinositol 3-kinase inhibitor, as part of a clinical trial. Although additional radiotherapy for local control was necessary, the lung metastases remained stable during the pazopanib monotherapy, which lasted for 7 months, following which a clinically stable disease state was determined. This case suggests that pazopanib can be a treatment option for the stabilization of disease progression in metastatic malignant granular cell tumor.
    Oncology letters 05/2015; 10(2). DOI:10.3892/ol.2015.3263 · 1.55 Impact Factor
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    ABSTRACT: Breast cancer is occasionally complicated by sclerosing adenosis (SA). Although both lesions usually originate in the terminal duct lobular unit, their pathogenetic relationship has not yet been elucidated. The present study analyzed 63 breast cancer patients with SA (involving a total of 75 breasts) to clarify if coexisting SA increased the frequency of multicentric breast cancer or not. Using the topographical classification proposed in our previous study, breast cancers with SA were classified into the following three types: type A (n = 22), cancer area was completely surrounded by the SA; type B (n = 26), cancer area partially overlapped the SA; and type C (n = 27), cancer area was located separate from the SA. Breast cancers with SA had a significant (P < 0.001) increase in frequency of harboring bilateral and multicentric cancers [17 of 63 (27 %) and 15 of 63 (24 %), respectively] when compared to breast cancer patients without SA, regardless of topographical type. Breast cancers with SA were less invasive (P < 0.001), of lower histological grade (P = 0.034), and had similar frequency of estrogen receptor-positive (P = 0.21) and HER2-positive (P = 0.74) tumors. In conclusion, contralateral and ipsilateral multicentric breast cancers occurred at a higher frequency in those with SA. Our data suggest that SA is, in addition to lobular neoplasia, a predictor of multicentric breast cancers.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 04/2015; 467(1). DOI:10.1007/s00428-015-1769-9 · 2.65 Impact Factor
  • Toshinobu Kubota · Suzuko Moritani · Masashi Sakuma
    Jama Ophthalmology 02/2015; 133(2):e143272. DOI:10.1001/jamaophthalmol.2014.3272 · 3.32 Impact Factor
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    ABSTRACT: Background: During bronchoscopy, small biopsy forceps are increasingly used for the diagnosis of peripheral pulmonary lesions. However, it is unclear whether the formalin-fixed paraffin-embedded specimens sampled with the small biopsy forceps are suitable for the determination of genotypes which become indispensable for the management decision regarding patients with non-small cell lung cancer. Objectives: The aim of this study was to evaluate the feasibility and accuracy of molecular testing in the specimens obtained with 1.5-mm small biopsy forceps. Methods: We examined specimens in 91 patients, who were enrolled in our previous 3 studies on the usefulness of thin bronchoscopes and given a diagnosis of non-small cell lung cancer by bronchoscopy with the 1.5-mm biopsy forceps, and then underwent surgical resection. An experienced pathologist examined paraffin-embedded specimens obtained by bronchoscopic biopsy or surgical resection in a blind fashion on epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements and KRAS mutations. Results: Twenty-five (27%), 2 (2%) and 5 (5%) patients had an EGFR mutation, ALK rearrangement and KRAS mutation, respectively, based on the results in surgical specimens. EGFR, ALK and KRAS testing with bronchoscopic specimens was feasible in 82 (90%), 86 (95%) and 83 (91%) patients, respectively. If molecular testing was feasible, the accuracy of EGFR, ALK and KRAS testing with bronchoscopic specimens for the results with surgical specimens was 98, 100 and 98%, respectively. Conclusion: The results of molecular testing in the formalin-fixed paraffin-embedded specimens obtained with the small forceps, in which the genotype could be evaluated, correlated well with those in surgically resected specimens. © 2015 S. Karger AG, Basel.
    Respiration 02/2015; 89(3). DOI:10.1159/000369860 · 2.59 Impact Factor
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    ABSTRACT: To determine which immunohistochemical markers are useful for the identification of neoplastic myoepithelial cells in adenomyoepithelioma of the breast, the expression of seven myoepithelial markers (α-smooth muscle actin (α-SMA), calponin, p63, CD10, cytokeratin 5/6, cytokeratin 14, and S-100) was examined in 19 lesions from 16 patients. The lesion consisted of seven spindle and 12 clear cell lesions. For normal myoepithelial cells, α-SMA, calponin, and p63 were significantly more sensitive than cytokeratin 5/6, cytokeratin 14, and S-100. There was no significant difference in the expression of α-SMA, calponin, p63, and CD10 in neoplastic myoepithelial cells of adenomyoepithelioma regardless of spindle or clear cell types. In spindle cell lesions, high-molecular weight cytokeratins (HMWCK; cytokeratin 5/6 and cytokeratin 14) tended to show higher staining scores and S-100 showed lower staining scores than other markers. In clear cell lesions, HMWCK showed significantly lower staining scores than the other five markers. There was no significant difference in staining scores among the other five markers. HMWCK showed a unique paradoxical staining pattern in clear cell lesions, with diffusely positive inner epithelial cells and completely negative outer myoepithelial cells. Although the sensitivity of HMWCK in clear cell lesions is low, with this unique paradoxical staining pattern and relatively high sensitivity in spindle cell lesions, HMWCK could be useful in diagnosing adenomyoepithelioma. In choosing immunohistochemical markers, any of the seven markers are useful, but combining HMWCK and any one of α-SMA, calponin, and p63 would be a good panel for the diagnosis of adenomyoepithelioma.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 12/2014; 466(2). DOI:10.1007/s00428-014-1687-2 · 2.65 Impact Factor
  • Naoto Kuroda · Suzuko Moritani · Shu Ichihara
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    ABSTRACT: We report the first case of combined hepatoid and serous adenocarcinoma arising in the uterine corpus here. The patient is a 63-year-old Japanese woman. She presented with vaginal abnormal bleeding and subsequent imaging analysis disclosed a mass in the uterine corpus. This article is protected by copyright. All rights reserved.
    Histopathology 11/2014; 67(1). DOI:10.1111/his.12614 · 3.45 Impact Factor
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    ABSTRACT: The apocrine type of encapsulated papillary carcinoma (ECP-A), of the breast is a rare neoplasm and there are only eight cases reported to date. Herein, we report the ninth case. A 68-year-old Japanese woman presented with a left breast mass. The cytoplasm of the tumour cells showed positive immunostaining for GCDFP-15. Myoepithelial cells were absent within the papillary structures and at the periphery of the lesion. The clinical course of the patient was uneventful 11 months after surgery. We postulate that EPC-A belongs to the molecular apocrine type of breast carcinoma.
    The Malaysian journal of pathology 08/2014; 36(2):139-143.
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    ABSTRACT: ABSTRACT Immunological status of patients with EBV-positive diffuse large B-cell lymphoma (EBV(+)DLBCL) without obvious immunodeficiency has not been elucidated. A multi-center prospective study was conducted to assess pretreatment T-cell responses to EBV, EBV-DNA load, and anti-EBV antibody in these patients. The proliferative and interferon (IFN)-γ-producing capacity of T-cells in response to autologous B-lymphoblastoid cell lines was determined using CFSE-based assay. Frequencies of EBV-specific CD4+ T-cells in EBV(+)DLBCL patients (n=13) were significantly higher than in healthy controls (HCs) (n=16) after both ex vivo and in vitro stimulation. Frequencies of EBV-specific CD8(+) T-cells in EBV(+)DLBCL patients tended to be higher than HCs after in vitro stimulation. EBV(+)DLBCL patients also showed increased IgG responses to lytic EBV-encoded antigens. Pretreatment plasma EBV-DNA level was significantly higher in EBV(+)DLBCL patients than EBV(-)DLBCL patients or HCs. In conclusion, EBV-specific T-cells showed increased reactivity, accompanied by higher levels of plasma virus DNA in patients with EBV(+)DLBCL.
    Leukemia and Lymphoma 06/2014; 56(4):1-24. DOI:10.3109/10428194.2014.938326 · 2.89 Impact Factor
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    ABSTRACT: Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder characterized by clinical features of skin lesions, pulmonary lesions and renal tumor. The gene responsible for this syndrome is located on chromosome 17p11.2 and designated as FLCN. In this article, we review renal tumors associated with BHDS with a focus on clinical and pathobiological aspects. Renal tumors often occur multifocally or bilaterally in the imaging analyses or gross examination. Histological examination of renal tumors includes a variety of subtypes such as hybrid oncocytic tumor, chromophobe renal cell carcinoma (RCC), oncocytoma, clear cell RCC and papillary RCC. The histologic discordance in multiple tumors seems to be characteristic of this syndrome. Oncocytosis is observed histologically in about half of the cases. Several investigations have elucidated that folliculin may be involved in the mammalian target of rapamycin (mTOR) pathway recently. Renal tumors composed of clear cells may behave in an aggressive fashion. However, renal tumors including hybrid oncocytic tumor, chromophobe RCC and oncocytoma behave mostly in an indolent fashion.
    Polish journal of pathology: official journal of the Polish Society of Pathologists 06/2014; 65(2):93-99. DOI:10.5114/pjp.2014.43958 · 1.13 Impact Factor
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    ABSTRACT: In this paper, we searched for the common histologic features characteristic of renal tumors in patients with Birt-Hogg-Dubé syndrome (BHDS). We selected six patients with histologically confirmed renal tumor in BHDS. Germline FLCN gene mutation has been identified in five patients. Multifocality and bilaterality of the renal tumors were pathologically or radiologically confirmed in five and two cases, respectively. Histological subtypes of the dominant tumor included three previously described hybrid oncocytic tumors, one composite chromophobe /papillary/clear cell RCC and one unclassified RCC resembling hybrid chromophobe/clear cell RCC. In one case, chromophobe RCC and clear cell RCC were separately observed. Small papillary lesions located in the peripheral area of the tumor, which we designated as intratumoral peripheral small papillary tuft (ITPSPT), were identified in all patients. In conclusion, multifocality/bilaterality of renal tumors, discordance of histologic subtypes and the presence of ITPSPT may be important clues to identify BHDS -associated renal tumors.
    Annals of diagnostic pathology 06/2014; 18(3). DOI:10.1016/j.anndiagpath.2014.03.002 · 1.12 Impact Factor
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    ABSTRACT: The introduction of combined antiretroviral therapy (ART) has reduced the mortality of patients with human immunodeficiency virus-1 infection worldwide. However, malignant lymphoma is a severe and frequent complication seen in patients with acquired immunodeficiency syndrome (AIDS). The diagnostic criteria for some categories of AIDS-related lymphoma were revised in the World Health Organization International Classification of Lymphoma, fourth edition. The purpose of this study was to assess the clinicopathological characteristics of Japanese patients with AIDS-related lymphoma according to the revised classification. In this retrospective study, 207 AIDS-related lymphoma cases diagnosed between 1987 and 2012 in Japan were subjected to histological subtyping and clinicopathological analyses. Diffuse large B-cell lymphoma (DLBCL) was the predominant histological subtype throughout the study period (n = 104, 50%). Among the DLBCL cases, 24% were of the germinal center (GC) type and 76% were of the non-GC type. Non-GC-type cases showed a significantly lower 1-year survival rate (43%) than the GC-type cases (82%). Cases of Burkitt lymphoma (n = 57, 28%), plasmablastic lymphoma (n = 16, 8%), primary effusion lymphoma (n = 9, 4%), Hodgkin lymphoma (n = 8, 4%), and large B-cell lymphoma arising in Kaposi sarcoma-associated herpesvirus-associated multicentric Castleman disease (n = 2, 1%) were also observed. Hodgkin lymphoma was more common in patients receiving ART (11.1%) than in ART-naïve patients (1.4%). Statistical analyses identified CD10 negativity, BCL-6 negativity, Epstein-Barr virus positivity, and Kaposi sarcoma-associated herpesvirus positivity as risk factors for poor prognosis. This information will help in the early diagnosis of lymphoma in patients with AIDS.
    Cancer Medicine 02/2014; 3(1). DOI:10.1002/cam4.178 · 2.50 Impact Factor
  • Toshinobu Kubota · Suzuko Moritani · Shu Ichihara · Hiroko Terasaki
    Journal of clinical pathology 11/2013; 67(1). DOI:10.1136/jclinpath-2013-201929 · 2.92 Impact Factor
  • Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 06/2013; DOI:10.1007/s00428-013-1431-3 · 2.65 Impact Factor
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    ABSTRACT: To clarify the diagnostic clues of ductal carcinomas in situ (DCIS) associated with papilloma and optimal clinical management of papilloma diagnosed on core needle biopsy (CNB). A total of 50 surgically resected cases were examined histopathologically and topographically. Thirty-nine cases (78%) spread in segmental fashion. Papilloma and DCIS were intermingled closely in 44 cases (88%), occupying the same areas in varying proportions from DCIS-predominant to papilloma-predominant. The two components occupied discrete areas and collided focally in six cases (12%). Most were non-high-grade. Cribriform and solid architectures with fibrovascular stroma were frequent. The cribriform pattern was unique, consisting of fused tubules separated by fibrovascular stroma. Intraductal myoepithelial cells were present to varying degrees in 40 cases (80%). In 38 cases (76%), points were identified where papilloma and DCIS coexisted or collided within a single lumen (CC point). Forty-eight cases (96%) had either intraductal myoepithelial cells or CC points, implying that DCIS and papilloma existed in the same duct system. Radiology showed segmental abnormalities in 83% of the available cases. Intraductal myoepithelial cells do not always guarantee benignity. Surgical resection is recommended for papilloma in CNB when radiology shows segmental abnormalities.
    Histopathology 05/2013; 63(3). DOI:10.1111/his.12186 · 3.45 Impact Factor
  • Toshinobu Kubota · Suzuko Moritani · Shu Ichihara
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    ABSTRACT: Background: A primary ductal adenocarcinoma of the lacrimal gland is a rare epithelial malignant tumor, and its clinicopathological and immunohistochemical features have not been well determined. The purpose of this study was to determine the clinicopathological characteristics of lacrimal duct carcinomas and to determine their long-term prognosis. Methods: We performed immunohistochemical studies of biological and proliferative markers of primary ductal adenocarcinomas of the lacrimal gland in five patients, and followed their long term prognosis. We also reviewed nine published cases of primary ductal adenocarcinomas of the lacrimal gland. Results: All specimens were positive for the androgen receptor, and three of five specimens overexpressed the HER-2/neu protein. Nuclear immunostaining for p53 ranged from 10% to 95% and that of Ki-67 from 20% to 70% in the tumor cells. Four of five patients had distant metastases and three patients died from the disease during the 5-year follow-up. Conclusions: Our findings indicate that primary ductal adenocarcinomas of the lacrimal gland express androgen receptors and a wide range of proliferative markers. Their long-term prognosis is poor.
    Albrecht von Graæes Archiv für Ophthalmologie 04/2013; 251(8). DOI:10.1007/s00417-013-2350-3 · 1.91 Impact Factor
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    ABSTRACT: Background Massive lymphadenopathy and direct mediastinal invasion are well-recognized phenomena in patients with small cell lung cancer (SCLC). The aim of this study was to assess the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of SCLC. Methods We retrospectively reviewed the records of 780 patients who underwent EBUS-TBNA at our institution from March 2004 to June 2012. Of these, 101 had a final diagnosis of SCLC. Excluding 3 patients with known SCLC who underwent EBUS-TBNA for staging purposes and including 2 patients who underwent EBUS-TBNA twice for the diagnosis of recurrence after achieving complete response by chemoradiation therapy during the study period, a total of 100 EBUS-TBNA procedures in 98 patients were analyzed. Results Other diagnostic tests prior to the initial EBUS-TBNA had failed to yield a diagnosis in 41 patients. The overall diagnostic yield of EBUS-TBNA for SCLC was 97% (97 of 100). Rapid on-site cytologic evaluation (ROSE) was performed at the operator's discretion in 77 procedures. ROSE did not have any impact on diagnostic yield (99% with ROSE vs. 90% without ROSE, p=0.1), but the use of ROSE was associated with fewer lesions (mean 1.1 with ROSE vs. 1.6 without ROSE, p<0.01) or aspirates (mean 2.3 with ROSE vs. 4.0 without ROSE, p<0.01). Conclusions EBUS-TBNA provided a high diagnostic yield in SCLC with or without ROSE. EBUS-TBNA can be recommended for patients suspected to have SCLC, even if other diagnostic tests have failed.
    Respiratory Investigation 01/2013; 52(3). DOI:10.1016/j.resinv.2013.11.004
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    ABSTRACT: Background: Several studies have reported that specimens from mediastinal lesions located adjacent to the esophagus can be sampled using an ultrasound bronchoscope instead of an ultrasound endoscope. Objectives: The aim of this study was to evaluate the diagnostic utility of transesophageal bronchoscopic ultrasound-guided fine needle aspiration using an ultrasound bronchoscope in patients with stage I/II sarcoidosis. Methods: Thirty-three patients suspected of having stage I/II sarcoidosis were included in this prospective study. Needle aspiration through the esophagus using an ultrasound bronchoscope was performed for hilar and/or mediastinal lymph nodes. The final diagnosis of sarcoidosis was based on clinicoradiological compatibility and pathological findings. Results: A total of 62 lymph nodes with a mean shortest diameter of 13.6 mm were examined. Of the 33 patients enrolled, 29 were given a final diagnosis of sarcoidosis. Four of the residual patients had other diseases (1 lung cancer, 1 tuberculosis, 2 non-specific lymphadenitis). Transesophageal bronchoscopic ultrasound-guided fine needle aspiration showed noncaseating epithelioid cell granulomas in 25 of 29 patients (86%; 95% confidence interval 73-100) with the final diagnosis of sarcoidosis. No complications were observed. Conclusions: Transesophageal bronchoscopic ultrasound-guided fine needle aspiration is feasible, safe and accurate for the diagnosis of stage I/II sarcoidosis.
    Respiration 12/2012; 85(2). DOI:10.1159/000345207 · 2.59 Impact Factor
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    ABSTRACT: PURPOSE: To determine whether serologic factors correlate with early relapse in cases of IgG4-related orbital inflammation, a lymphoproliferative disorder. DESIGN: Retrospective cohort study. METHODS: We examined the orbital images and serum data of 30 patients with (n=24) or without (n=6) corticosteroid treatment before and after corticosteroid treatment and 6 months after discontinuation of corticosteroid treatment. RESULTS: Seven patients (23%) (all with corticosteroid treatment) had elevated serum levels of rheumatoid factor. Of the 24 patients with corticosteroid treatment, 24 (100%) showed regression of the lesion, but 8 of the 24 (33%) showed relapse. The serum IgG4 levels before and after corticosteroid treatment were not significantly different between the relapsed and nonrelapsed groups (P=.5 and P=.2, respectively). However, the incidence of patients who were rheumatoid factor-positive was significantly higher in the relapsed group (P=.02). The 6 patients without corticosteroid treatment showed minor proliferation or regression of the lesion at the 6-month follow-up. CONCLUSIONS: The serum rheumatoid factor level may correlate with proliferative activity in IgG4-related orbital inflammation.
    American Journal of Ophthalmology 10/2012; 155(2). DOI:10.1016/j.ajo.2012.07.024 · 3.87 Impact Factor
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    ABSTRACT: Backgrounds: Nipple discharges from patients with ductal carcinoma in situ (DCIS) can contain high levels (>1,000 ng/ml) of human epidermal growth factor receptor 2 (HER2) protein (Inaji et al. 1993). This leads to a hypothesis that tumor markers are frequently concentrated intraductally in early breast cancers. Methods: To test the hypothesis, HER2-ECD and CA15-3 of the needle washout fluid from 29 benign lesions, 26 DCIS, and 95 invasive carcinomas of the breast were measured. The needle was rinsed out with 2 ml of saline, diluting the biomarkers by 3.5%. The measuring limit for HER2-ECD (0.5 ng/ml) and that for CA 15-3 (4 U/ml) were used as the cutoff values, respectively. Results: The proportion of patients with positive HER2-ECD values was 6.9% in cases of benign lesions, 26.9% in DCIS, and 10.5% in invasive carcinomas. The proportion of patients with positive CA 15-3 values was 6.9% in cases of benign lesions, 42.3% in DCIS, and 10.5% in invasive carcinomas. The proportion of patients with any biomarker elevation was 6.9% in cases of benign lesions, 46.2% in DCIS, and 15.8% in invasive carcinomas. Thus, biomarker elevation was most frequent in DCIS, followed by invasive carcinomas (P<0.01). HER2-ECD values over 6 ng/ml (undiluted value:171.3 ng/ml) or CA 15-3 values over 25 U/ml (undiluted value:1485.7 U/ml) were seen exclusively in DCIS or invasive ductal carcinomas with an extensive intraductal component, supporting the hypothesis. Immunohistochemical studies of cases with elevation of CA15-3 and/or HER2-ECD indicated that intraductal secretions are positive for the markers. Conclusions: Some tumor antigens are concentrated intraductally even if they were not detectable in the serum. Chemiluminescence measurement of these biomarkers could strengthen cytological diagnosis. Furthermore, our approach may be useful to identify a subset of breast cancer patients who are suitable for intraductal molecular targeted therapy.
    24th European Congress of Pathology, Prague, Czech Republic; 09/2012

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815 Citations
213.61 Total Impact Points

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  • 2005–2015
    • National Hospital Organization Nagoya Medical Center
      • Division of Pathology
      Nagoya, Aichi, Japan
  • 2002–2004
    • Shiga University of Medical Science
      • • First Department of Pathology
      • • Department of Pathology
      Ōtu, Shiga Prefecture, Japan