T A Korol'kova

Russian Academy of Medical Sciences, Moskva, Moscow, Russia

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Publications (61)7.98 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The characteristics of the temporospatial organization of cerebral cortical potentials at different levels of genetically determined emotionality were analyzed by constructing topograms of instantaneous EEG levels in the inbred rat strains MR and MNRA. Two parameters were calculated for each topogram: the total level and the similarity coefficient. Power spectra were calculated for the values and these were found to change in an oscillatory manner. Interstrain differences were found in the correlated changes in total levels and similarity coefficients, in the durations of changes in the total level, which were more marked than those of similarity coefficients, and the nature of interhemisphere asymmetry. In MR rats, the power spectra of both measures showed significant peaks with modes at 2.0, 6.5, and 9.0 Hz. In MNRA rats, peaks in the spectra of these measures both coincided (2.0 Hz) and differed (7.0 Hz in the spectrum of the total level and 3.0, 4.5, and 6.0 Hz in the spectrum of the similarity coefficient). These data suggest different types of functioning of the reticulothalamocortical and hippocampocortical systems in rats of these strains.
    Neuroscience and Behavioral Physiology 08/2006; 36(6):663-70.
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    ABSTRACT: The features of the EEG spatial organization in two rat strains, i.e., with expressed emotional reactions (Maudsley reactive, MR) and less reactive (Maudsley nonreactive, MNR) were compared in two stress situations: during exposure to the action of pain (P) (i.p. injection of 0.9% NaCl solution) and during 24-hour water deprivation (D). Multichannel EEG recording (24 derivations) and their multiparametric estimation (840 signs) made it possible to differentiate characteristic features of the EEG spatial organization in rats with initially increased emotional reactions and passive behavioral strategy during exposure to stress. In both stress-inducing conditions, an increase in crosscorrelation and coherence between cortical potentials in parallel with rise of the spectral power in the range of high-frequency theta and its drop in the range of EEG high-frequency band was observed in the MR rats. The MNR rats showed the opposite changes. Different reactivity of the ratio between the coherence and spectral power of potentials was observed in two strains of rats. This index characterizes the level of the information-energy component of the spatial organization of cortical potentials. It is suggested that different character of the EEG changes reflects the features of interhemispheric relations, information-energy processes, and cortical regulation of autonomic processes in the system of adaptive stress reactions at different levels of emotionality and behavioral strategy.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/2001; 51(5):617-25. · 0.25 Impact Factor
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    ABSTRACT: Effect of the anxiolytic drugs afobazole, diazepam, and chlordiazepoxide on the cortical biopotential coherency was studied in MR and MNRA rats with increased and decreased level of emotionality, respectively. Afobazole increased a difference in the biopotential coherency between rats of the two lines in the range of EEG theta, alpha, and beta rhythms. In the subrange of dominating theta activity (6.00-7.25 Hz), this effect took place at the expense of reduced coherency in MNRA rats in the absence of changes in the MR line. Afobazole decreased the biopotential coherency in the alpha activity band (7.5-8.25 Hz) in the rats of both lines. This is indicative of the presence of a CNS-stimulating component in the pharmacological activity spectrum of afobazole. The expediency of using afobazole in patients with different levels of anxiety is discussed.
    Eksperimental'naia i klinicheskaia farmakologiia 01/2001; 64(4):3-6.
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    ABSTRACT: The influence of scopolamine (1 mg/kg, i.p.) on the spatial organization of the neocortical electrical activity was studied in rats. A decrease in the spectral power and coherence of brain potentials in the range of the dominant theta-rhythm peak (6.00-7.25 Hz) and their increase in the adjacent low-frequency band were observed. Both indices were decreased in the wide beta band (19.00-30.00 Hz). The described changes took place over the whole areas of the right hemisphere and parieto-temporal region of the left hemisphere. The obtained results are discussed with respect to the role of the cholinergic brain system in the higher nervous activity.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/2001; 49(6):1052-6. · 0.25 Impact Factor
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    ABSTRACT: Effect of the new antimigraine drug tropoxin on the EEG profile was studied in MR and MNRA rats with genetically determined high and low levels of emotionality, respectively. In MR rats, tropoxin decreased the number of the bioelectric activity parameters changed by the stressor action (0.9% NaCl, i.p.). The drug reduced the spectral power in the EEG delta band, and increased that in the theta, beta-1, and beta-2 bands. This was evidence of the central stimulating action and the possible enhancement of the exploratory activity. In MNRA rats no changes in bioelectric activity were observed in the low-frequency delta and theta bands, while the spectral power in the beta-1, and beta-2 bands showed a decrease. It was concluded that a neural component is present in the mechanism of the tropoxin action, which may play an important part in the therapeutic effect of the new drug.
    Eksperimental'naia i klinicheskaia farmakologiia 01/2001; 64(5):3-6.
  • Neuroscience and Behavioral Physiology 01/2001; 31(1).
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    ABSTRACT: Effect of the central M-cholinolytic scopolamine on spatial organization of the rat brain electrical activity was studied under conditions of high and low emotional-stress responses. The EEG changes were estimated by 840 parameters. A possibility of the EEG discrimination by means of interstrain differences in responses to scopolamine, was shown. A more obvious decrease in spectral power and potentials coherence was revealed in Maudsley Reactive rats (MR) as compared with the Maudsley Nonreactive rats (MNRA), in parieto-temporal and occipital areas of the right hemisphere, and the reverse interrelationship occurred in the anterior parts of the right and posterior parts of the left hemisphere. These findings suggest some specifics in the spatial distribution of the maximum scopolamine action foci depending on the initial emotional level. Changes occurring under the scopolamine effect in different EEG frequency bands are different in the MR and the MNRA rats. The findings are discussed in respect to the EEG indices of anxiolytic component of cholinergic regulation of the brain activity.
    Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 06/2000; 86(5):588-97.
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    ABSTRACT: In order to study the possibility of EEG discrimination of genetically determined emotionality (increased propensity to emotional and stress reactions and anxiety) brain electrical activity was recorded in rats of two strains: Maudsley Reactive and Maudsley Nonreactive (24 derivations from the convexital skull surface were used). The program package "Synchro-EEG" was used for EEG processing. It was demonstrated that the two rat strains were significantly different in 120 EEG parameters of 840 ones analyzed. On the basis of 37 parameters, each rat was correctly recognized as belonging to the respective group with the error of 4.89%. The analysis of the detected signs allowed their classification to be performed in accordance with the peculiarities of the emotional and cognitive processes and the level of nonspecific activation. Specific forms of interaction between these components in the system of emotional reactions were revealed.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/2000; 50(3):447-56. · 0.25 Impact Factor
  • Doklady Biological Sciences 01/2000; 372:251-4.
  • Biulleten' eksperimental'noĭ biologii i meditsiny 12/1999; 128(11):500-3.
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    ABSTRACT: The effect of 2-[2-(morpholin)ethylthio]-5-ethoxybenzimidazole (CM-346) on the EEG of MR and MNRA rats was compared with that of diazepam. Both CM-346 and diazepam reversed stress-induced changes in bioelectrical activity after intraperitoneal injection of 0.9% NaCl. In MR and MNRA rats both drugs decreased the EEG spectral power in the high-frequency θ-band (7.5–8.2 Hz). In MR rats, CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. The data suggest that CM-346 exerts antistressor and anxiolytic effects in animals with passive reactions to emotional stress.
    Bulletin of Experimental Biology and Medicine 10/1999; 128(5):1090-1093. · 0.34 Impact Factor
  • N E Sviderskaya, T A Korol'kova
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    ABSTRACT: Theoretical questions of the spatial organization of electrical activity in the brain are discussed in terms of a multilevel realization of the synergetic principle for formation of functional systems underlying behavior and mental function. The role of the spatial-temporal superimposition of coherent structures of biopotentials in generating fields of increased activity in the cerebral cortex is discussed, these being responsible for integrative and associative functions. A hypothesis is proposed regarding the relationship between the energy and information factors of coherent structures as one of the important characteristics describing the efficiency of energy-informational processes. Emphasis is placed on the need for considering not only linear, but also nonlinear associations of biopotentials in considerations of the form and functional sense of their spatial organization.
    Neuroscience and Behavioral Physiology 01/1998; 28(6):620-35.
  • N E Sviderskaia, O I Gorbatov, T A Korol'kova
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    ABSTRACT: Spatial organization of human EEG was studied by means of topographic mapping methods with the multiparametric data estimations in the state altered by ketamine in terms of the concept of coherent structures of brain electrical activity. Two main features of the altered state of consciousness were reflected in the opposite shifts: an increase in the spatial synchronization in the left hemisphere (especially, in the posterior area) and its decrease in the left frontal and right temporal one. The obtained data are discussed from the viewpoint of dissociative effects of ketamine at the neurochemical and neurophysiological levels.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1998; 48(2):195-205. · 0.25 Impact Factor
  • N E Sviderskaia, T A Korol'kova
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    ABSTRACT: The influence of cognitive styles (analytic versus synthetic style, rigid versus flexible cognitive control, impulsivity versus reflexivity, field-dependence versus independence) on the information brain processes was estimated by means of analysis of spatial organization of cortical electrical activity (48 derivations) in 40 right-handed subjects (aged from 18 to 40) during their realization of verbal and non-verbal tasks using successive and simultaneous processing modes. Modulation of the "cognitive axis" (activity of the left anterior and right posterior cortical areas) was revealed connected with the factor of task subjective difficulty, especially in case of simultaneous processing mode. The combination of the synthetic cognitive style and flexibility of the cognitive control may be thought of as being the most favourable for the activation of the "cognitive axis" and utilization of the left- and right-hemispheric information processing, especially in non-standard situations.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1996; 46(4):689-98. · 0.25 Impact Factor
  • N E Sviderskaia, V R Agaronov, T A Korol'kova
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    ABSTRACT: The polymorphism of reaction to emotionally significant stimuli is discussed in the context of pathological incentive. Using the "Synchro-EEG" technique 41 patients and 11 healthy volunteers were examined. Analysis of the spatial organization of cortical electrical activity revealed three types of reactions in patients. Intergroup differences were reflected in generalized and local cortical processes (mainly, in the frontal regions of the left and temporo-parieto-occipital regions of the right hemispheres). They were probably related to the sign of emotions, behavioural and autonomic nervous tension and the attitude to the object of motivation ("approach-withdrawal"). This suggestion was substantiated by the finding that the aversive therapy can change the pattern of cortical processes. Intergroup differences were revealed not only in the reactive (to emotionally significant stimulus) but also in the background electrical activity. The groups were different in the dominance of different narrow-frequency processes in one group as compared to the other. These findings suggest determination of emotional reactions by the initial functional state of patients.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1996; 46(6):999-1007. · 0.25 Impact Factor
  • N E Sviderskaia, T A Korol'kova
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    ABSTRACT: The influence of the formal-dynamic characteristics on the activity of the two brain operation systems, the left-hemispheric one (successive analysis) and the right-hemispheric one (simultaneous analysis) was studied in 20 right-handed subjects using the technique of topographic mapping of cortical electrical processes. The psychological testing was performed according to Strelyau while the temperament was tested by Eysenck. A set of variables was determined which positively affect both brain operation systems as well as each of them separately. We believe that the interindividual variability of the brain information processing is a result of its modulation by different psychological characteristic blocks.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1996; 46(5):849-58. · 0.25 Impact Factor
  • N E Sviderskaya, T A Korol'kova
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    ABSTRACT: The within-pair similarity of the topographical maps of the spatial synchronization of the cerebral cortical potentials was studied in 11 pairs of monozygotic twins and 20 genetically unrelated subjects in the resting state and during four types of intellectual activity. It was demonstrated that the degree of similarity of the topographical maps is higher in the resting state in the monozygotic twins than in the genetically unrelated subjects. No frequency band of the EEG which exerts a special influence on the formation of the high degree of similarity of the spatial synchronization of the potentials was found. The maximal similarity in the topographical maps of the monozygotic twins is observed in the anterior regions of the left hemisphere and in the temporoparietal regions of the right. Differences between groups are recorded in both regions; however they are especially distinct in the right hemisphere. The data obtained make it possible to draw an inference regarding the influence of a genetic factor not only on individual components of the EEG (which had been previously demonstrated by a number of authors), but also on the systemic organization of the cortical processes. The right-hemispheric activity apparently relates to the most controllable genetic processes. The results of the analysis of the similarity of topographical maps during various types of activity confirm this: the coefficient of similarity reaches the level of significance in the majority of pairs of monozygotic twins only in a "right-hemispheric" test (simultaneous analysis of nonverbal material).
    Neuroscience and Behavioral Physiology 01/1995; 25(5):370-7.
  • N E Sviderskaia, T A Korol'kova
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    ABSTRACT: Within-pair similarity of topographic maps of the cortical electrical activity was studied in 11 monozygotic pairs of twins (MZ) and 20 genetically unrelated persons (UP) during rest and solving four mental tasks. During rest similarity of topographic maps higher in MZ in comparison with UP. We showed that no specific frequency band influenced formation of high similarity between MZ maps. The maximal similarity between MZ maps was seen in the anterior zones of the left hemisphere and in parieto-temporal areas of the right hemisphere. Differences between MZ and UP maps were revealed both in the anterior areas of the left hemisphere and parieto-temporal areas of the right hemisphere, but they were most pronounced in the right hemisphere. The data obtained lead to the conclusion that genetic factor influences not only the separate EEG components, but the system organization of the cortical processes. This was confirmed by the results of topographic similarity analysis carried out for various tasks, i.e. similarity coefficients attained the level of significance only for the right-hemispheric tasks (simultaneous analysis of non-verbal material).
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1994; 44(4-5):640-9. · 0.25 Impact Factor
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    ABSTRACT: Analysis of constraints, which are imposed on correctness of conclusions drawn from the studies of the spectrum-correlation model of cortex electrical activity, and necessity of enlarging interaction forms which have to be studied, brought to development a new index for estimating spatial order of cortex electrical processes. This index and the technique were called "multiple entropy" (ME). The algorithm of calculating ME and its properties are discussed. The results of studying spatial structure of cortex electrical processes by estimating their spatial synchronization and ME were compared. It was shown that these approaches complemented each other. Using both these techniques in combination gives more complete picture of integration of cortex processes.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/1994; 44(6):925-31. · 0.25 Impact Factor
  • Neuroscience and Behavioral Physiology 01/1993; 23(1):101-6.

Publication Stats

74 Citations
7.98 Total Impact Points

Institutions

  • 2001
    • Russian Academy of Medical Sciences
      • Institute of Pharmacology
      Moskva, Moscow, Russia
  • 1983–1998
    • Russian Academy of Sciences
      • Institute of Higher Nervous Activity and Neurophysiology
      Moscow, Moscow, Russia