G Brandenberger

CHRU de Strasbourg, Strasburg, Alsace, France

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Publications (145)467.23 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Endothelin-1 (ET-1) is overexpressed in pulmonary arteries of pulmonary hypertension (PH) patients and contributes to the sustained vasoconstriction, remodeling process, and thrombosis of vessels that underlie development and progression of this disease. Increased circulating ET-1 correlates with markers of PH severity, and ET-1 is regarded as a potential diagnostic and prognostic biomarker in PH. Because the within-individual variability measured in PH patients and in healthy subjects contributes to determine the biomarker predictive value and must be taken into account to establish cutoff values, we determined the short-term variability of circulating ET-1 in controls and in PH patients.
    Translational Research 04/2008; 151(3):119-21. · 3.49 Impact Factor
  • Anne Charloux, Gabrielle Brandenberger, François Piquard, Bernard Geny
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    ABSTRACT: Atrial and brain natriuretic peptides (ANP and BNP) are cardiac hormones connecting heart and kidney and playing a key role in hydromineral and hemodynamic homeostasis. In contrast with the renin-angiotensin-aldosterone system, circulating ANP and BNP are not temporally related with rapid eye movement (REM)-nonREM sleep cycles, autonomic activity, or blood pressure. Cardiac natriuretic peptides are secreted in a pulsatile manner, with short periods of 20-48min, in normal as well as in pathological conditions. The frequency of pulses seems to be unchanged with aging, whereas the absolute amplitude of the oscillations seems to increase, most likely as a result of an increase in the plasma hormone levels observed in elderly. Enhanced cardiac secretion and decreased degradation partly explain the higher ANP and BNP concentrations observed in elderly. Despite higher levels, the natriuretic system seems to loose efficiency at the renal site in elderly. This more probably relies on reduced target organ responsivity and not on deeply altered hormone secretion. Here we review the impact of aging on the renal effects of the natriuretic peptides, and point out the lack of knowledge on the precise interactions between the ultradian rhythms of the systems involved in salt and water balance in elderly. Additional studies focusing on potential age-induced alterations of the intracellular signaling pathway are now needed.
    Ageing research reviews 03/2008; 7(3):151-63. · 5.62 Impact Factor
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    ABSTRACT: We examined the mechanisms of renal resistance to atrial and brain natriuretic peptides (ANP and BNP) in pulmonary hypertension (PH). Compared to eight controls, nine PH patients showed a reduced ability to excrete an acute sodium load despite increased circulating ANP, BNP and cyclic guanosine monophosphate (cGMP), their second messenger. Patients' reduced urinary cGMP/BNP and natriuresis/urinary cGMP ratios demonstrated impaired generation of and reduced renal response to cGMP, respectively. Therefore, PH patients hyporesponsiveness to cardiac natriuretic peptides is likely located both upstream and downstream cGMP generation. Natriuretic peptide signalling pathway disruptions might be accessible to therapy.
    Peptides 12/2006; 27(11):2993-9. · 2.52 Impact Factor
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    ABSTRACT: In middle-aged persons, moderate physical activity energy expenditure (PAEE) has been shown to be associated with increased vagal-related heart rate variability (HRV) indexes and better health status. The purpose of this study was to determine whether a very high PAEE has greater effect on vagal-related HRV indexes and self-estimates of well-being in middle-aged subjects having distinct long-term physical activity profiles. Forty-four subjects were divided into three groups on the basis of the sport score of the Modified Baecke Questionnaire for Older Adults: sedentary (SED, n = 15), moderately-trained (MT, n = 16), and highly-trained subjects (HT, n = 13). PAEE was estimated by triaxial accelerometry during one week. Time and frequency domain HRV indexes were determined during quiet periods in the morning on 5-min R-R interval segments under controlled breathing. Quality of life was evaluated using the SF-36 health survey questionnaire. PAEE was significantly different for each group (374.5 +/- 13.8, 616.8 +/- 22.4, and 1086.6 +/- 43.2 kcal . day (-1) for SED, MT, and HT, respectively, p < 0.001). MT presented significantly higher vagal-related HRV indexes than SED and HT (p < 0.05). None of the HRV indexes was significantly greater in HT than in SED. MT and HT had similar health status scores, which were significantly higher than for SED. These results indicate that in middle-aged subjects, habitual moderate PAEE is associated with greater vagal tone and self-estimates of well-being compared to low PAEE. In contrast, very high PAEE is associated with similar vagal-related indexes as low PAEE, despite better overall health status.
    International Journal of Sports Medicine 09/2006; 27(9):697-701. · 2.27 Impact Factor
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    Bernard Geny, Anne Charloux, Gabrielle Brandenberger, Francois Piquard
    The Journal of thoracic and cardiovascular surgery 07/2006; 131(6):1417-8. · 3.41 Impact Factor
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    ABSTRACT: A pulsatile secretory pattern is assumed to improve hormonal efficiency. We examined the short-term time courses of circulating atrial (ANP) and brain natriuretic peptides (BNP) in patients with pulmonary hypertension (PH) and reduced renal efficiency of ANP-BNP, reflected by low natriuresis/ANP or BNP ratios. Compared to controls, we observed a persistence of ANP and BNP pulsatility in PH patients with a similar periodicity of 20min. Pulse amplitude increased proportionally to the rise in mean plasma level observed in patients (around 27%). In PH patients, the decrease in ANP-BNP renal efficiency is not attributable to a loss of the rhythmic pulsatility of these hormones.
    Peptides 05/2006; 27(4):864-70. · 2.52 Impact Factor
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    ABSTRACT: Renal transplantation is an excellent therapeutic alternative for end-stage renal diseases. Nevertheless, the cardiac function is often impaired in renal-transplant patients (RTR) and importantly determines their prognosis. Adrenomedullin (ADM), a peptide involved in cardiovascular homeostasis, is believed to protect both cardiac and renal functions - by increasing local blood flows, attenuating the progression of vascular damage and remodelling and by reducing glomerular injury - and might be involved in renal-transplantation physiopathology. This work was performed to investigate whether an increase in circulating ADM might be related to RTR cardiac function. Twenty-nine subjects, 19 RTR and 10 healthy subjects, participated in the study. After 15 min rest in supine position, heart rate and systemic blood pressure were measured together with cyclosporine through levels, creatinine and ADM. Systolic and diastolic cardiac functions were assessed, using Doppler echocardiography. Subjects were similar concerning age, weight, heart rate and blood pressure. Creatinine and ADM (53.8 +/- 6.9 vs. 27.2 +/- 4.1 pmol/L, p = 0.02) were significantly increased in RTR (73 +/- 10 months after transplantation). Cardiac systolic function was normal, but a reduced mitral E:A ratio was observed in RTR (0.90 +/- 0.06 vs. 1.38 +/- 0.10, p < 0.001), reflecting their impaired left ventricular relaxation. Such a ratio was negatively correlated with ADM (r = -0.55, p = 0.002). RTR present with an increased ADM is likely related to cardiac diastolic dysfunction. In view of its protective effect on the cardiovascular system, these data support further studies to better define the role and the therapeutic potential of ADM after renal transplantation.
    Clinical Transplantation 01/2006; 20(3):330-5. · 1.63 Impact Factor
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    Gabrielle Brandenberger, Jean Ehrhart, Martin Buchheit
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    ABSTRACT: It is generally thought that the electroencephalogram of sleep stage 2 is not uniform, depending on whether sleep stage 2 evolves toward slow-wave sleep (SWS) or toward rapid eye movement (REM) sleep. We provide here further evidence of the duality of sleep stage 2 on the basis of its autonomic and hormonal background. Fourteen healthy men (aged 21-29 years) underwent 1 experimental night. Sleep and cardiac recordings were taken from 11:00 PM to 7:00 AM. Blood was sampled continuously over 10-minute periods. Autonomic activity, as inferred from heart rate variability analysis and hormone profiles, were examined with regard to the normalized hypnograms. We found a dual activity of the autonomic nervous system during sleep stage 2, with a progressive decrease in heart rate variability sympathetic indexes during the transition toward SWS contrasting with high and rather stable levels during sleep stage 2 that evolve toward REM sleep. Also, different profiles were observed in 2 major hormone systems, the activating adrenocorticotropic system and the renin-angiotensin system. Cortisol, in its active period of circadian secretion, was stable during sleep stage 2 preceding SWS and increased significantly when sleep stage 2 preceded REM sleep. For plasma renin activity, sleep stage 2 played a transitional role, initiating increasing levels that peaked during SWS and decreasing levels that reached a nadir during REM sleep. These results indicate an autonomic and hormonal duality of sleep stage 2 that is characterized by a "quiet" period preparing SWS and an "active" period preceding REM sleep. These differences may confer a fundamental role on this sleep stage in ultradian sleep regulation.
    Sleep 01/2006; 28(12):1535-40. · 5.10 Impact Factor
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    ABSTRACT: In the middle-aged, it has been shown that moderate physical activity is associated with increased global HR variability (HRV) and vagal-related HRV indexes. However, the relative effect of quantity and intensity of physical activity on HRV is still unknown. The purpose of this study was to compare HRV indexes in three groups of subjects presenting different long-term physical activity profiles: sedentary subjects (SED) with low-energy expenditure (PAEE) and two groups of subjects with equivalent moderate PAEE, but differing in terms of intensity of physical activity (active (ACT) and sportive (SP) individuals). Forty-three middle-aged subjects (61.2 +/- 4.3 yr) were divided into the three groups on the basis of a physical activity questionnaire (Modified Baecke Questionnaire for Older Adults). Physical activity was evaluated by accelerometry for 1 wk. Time and frequency domain HRV indexes were determined during quiet periods in the morning on 5-min stationary R-R interval segments under controlled breathing. Quality of life was evaluated using the SF-36 Health Survey Questionnaire. SP spent more time in moderate to very high activities than ACT (2.1 +/- 0.1 vs 0.6 +/- 0.1 h.wk(-1); P < 0.05) and less time in very light to light activities (62.8 +/- 2.0 vs 73.7 +/- 1.7 h.wk(-1); P < 0.05). SP presented higher vagal-related HRV indexes than SED (P < 0.05), whereas increases in ACT were less marked. ACT and SP had similar health status scores, which were higher than for SED (P < 0.05). In older adults with different lifestyles, habitual moderate PAEE is associated with better self-estimated overall health status and higher vagal-related HRV indexes compared with subjects with low PAEE, especially when moderate- to very high-intensity physical activities are undertaken.
    Medicine &amp Science in Sports &amp Exercise 10/2005; 37(9):1530-4. · 4.48 Impact Factor
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    ABSTRACT: Heart rate variability (HRV) analysis holds increasing interest but electrocardiographic (ECG) recordings are strongly disturbed by body movements, changes in environment and respiration. Here we give arguments for the use of slow wave sleep (SWS) as an appropriate recording condition. Sixteen healthy subjects aged 21-31 years (10 males, 6 females) underwent polygraphic sleep, ECG, and respiratory recordings during one experimental night. HRV was analyzed in 5-min SWS segments and compared to data collected during quiet wake in the morning with controlled breathing, using for each individual the same respiratory frequency as that recorded during SWS. SWS has two major advantages. First, it is a quiet sleep period, free of any external confounding events and is characterized by fewer body movements or arousals that cause abrupt heart rate (HR) increases which disrupt the ECG signal. Second, SWS avoids the deleterious effect of controlled breathing on HRV. Respiratory cycles were spontaneously more regular during SWS than during generally used wake (Standard deviation (SD) of the respiratory cycles was 0.27+/-0.02 s during SWS vs 0.42+/-0.07 s during wake under controlled breathing; p<0.01). Compared to quiet wake, the SD of normal R-R intervals reflecting global variability was significantly lower during SWS (54.3+/-4.7 vs 78.8+/-6.1 ms; p<0.001) and the normalized high frequency power was increased (0.57+/-0.04 vs 0.51+/-0.03; p<0.05), suggesting a higher parasympathetic control of the heart. Thus, SWS offers a "self-controlled" and undisturbed moment of observation for assessing time and frequency domain HRV indexes. Its relevance as an optimal ECG recording condition has to be confirmed in various experimental conditions.
    Autonomic Neuroscience 09/2005; 121(1-2):81-6. · 1.85 Impact Factor
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    Chantal Simon, Laurence Weibel, Gabrielle Brandenberger
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    ABSTRACT: The development of nocturnal socio-professional activities has followed the expansion of artificial lighting, a characteristic of the modern world. Currently, a fifth of the active population work in shifted schedules or during night. The psychological, relational and social repercussions of this shift are obvious and well demonstrated. These situations are also associated with various health problems : sleep and vigilance disturbances, digestive disorders, metabolic abnormalities and cardiovascular morbidity. From 20% to 50% of the night-workers cease their night occupation invoking health problems. If the origin of these abnormalities is not univocal, different data indicate that shift-work led to a desynchronization of the circadian rhythms, source of hormonal and metabolic disturbances that may partly explain the clinical disorders. All occurs as if the circadian system of these subjects was in a phase of compromise between the requirements of their night activity and the maintenance, at least during the weekend, of a social and family diurnal activity. The debt of sleep frequently observed in these subjects may also play a role, which underlines the interactions between sleep and nutrition.
    Cahiers de Nutrition et de Diététique 01/2005; 40(3):154-160.
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    M Buchheit, C Simon, F Piquard, J Ehrhart, G Brandenberger
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    ABSTRACT: There is little doubt that moderate training improves cardiac vagal activity and thus has a cardioprotective effect against lethal arrhythmias. Our purpose was to learn whether a higher training load would further increase this beneficial effect. Cardiac autonomic control was inferred from heart rate variability (HRV) and analyzed in three groups of young subjects (24.5 +/- 3.0 yr) with different training states in a period free of stressful stimuli or overload. HRV was analyzed in 5-min segments during slow-wave sleep (SWS, a parasympathetic state that offers high electrocardiographic stationarity) and compared with data collected during quiet waking periods in the morning. Sleep parameters, fatigue, and stress levels checked by questionnaire were identical for all three groups with no signs of overtraining in the highly trained (HT) participants. During SWS, a significant (P <0.05) increase in absolute and normalized vagal-related HRV indexes was observed in moderately trained (MT) individuals compared with sedentary (Sed) subjects; this increase did not persist in HT athletes. During waking periods, most of the absolute HRV indexes indistinctly increased in MT individuals compared with controls (P < 0.05) but did not increase in HT athletes. Normalized spectral HRV indexes did not change significantly among the three groups. Heart rate was similar for MT and Sed subjects but was significantly (P <0.05) lower in HT athletes under both recording conditions. These results indicate that SWS discriminates the state of sympathovagal balance better than waking periods. A moderate training load is sufficient to increase vagal-related HRV indexes. However, in HT individuals, despite lower heart rate, vagal-related HRV indexes return to Sed values even in the absence of competition, fatigue, or overload.
    AJP Heart and Circulatory Physiology 12/2004; 287(6):H2813-8. · 4.01 Impact Factor
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    Gabrielle Brandenberger, Laurence Weibel
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    ABSTRACT: The 24-h rhythm of growth hormone (GH) is thought to be controlled primarily by sleep processes with a weak circadian component. This concept has been recently questioned in sleep-deprived persons. To test the notion of a high sleep-dependency of GH release, we established simultaneous 24-h rhythms of GH and melatonin, a circadian marker, in night workers who form a model for challenging sleep and circadian processes. Ten day-active subjects and 11 night workers were studied during their usual sleep-wake schedule, with sleep from 23:00 to 07:00 hours and 07:00 to 15:00 hours, respectively. Experiments were conducted in sleep rooms under continuous nutrition, bed rest, and dim light. Melatonin and GH were measured every 10 min over 24 h. In day-active subjects, melatonin and GH showed the well-known 24-h profiles, with a major sleep-related GH pulse accounting for 52.8 +/- 3.5% of the 24-h GH production and the onset of the melatonin surge occurring at 21:53 hours +/- 18 min. In night workers, melatonin showed variable circadian adaptation, with the onset of secretion varying between 21:45 and 05:05 hours. The sleep-related GH pulse was lowered, but the reduction was compensated for by the emergence of large individual pulses occurring unpredictably during waking periods, so that the total amount of GH secreted during the 24 h was constant. One cannot predict the degree of GH adaptation from the highly variable melatonin shift. These results argue against the concept that sleep processes exert a predominant influence on GH release whatever the conditions. When sleep and circadian processes are misaligned, the blunting of the sleep-related GH pulse is counteracted, as in sleep-deprived persons, by a compensatory mechanism promoting GH pulses during wakefulness.
    Journal of Sleep Research 10/2004; 13(3):251-5. · 3.04 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the autonomic drive to the heart in cardiac transplant patients (CTP) using heart rate (HR) and HR variability (HRV) analysis during non-rapid eye movement (NREM)-rapid eye movement (REM) sleep cycles, in particular during arousal associated with the emergence from slow wave sleep (SWS). In healthy subjects, this arousal is characterized by a pronounced HR surge, and HRV is lower during SWS than during the subsequent "active" sleep stage 2 and REM sleep. The participants were 24 adults, 14 CTP (men, n = 11; women, n = 3; mean age, 62.2 +/- 2.2 years; time after transplantation, 4-14 years) and 10 control subjects (men, n = 7; women, n = 3; mean age, 61.0 +/- 1.8 years). The subjects underwent polygraphic sleep, cardiac, and respiratory recordings during an experimental night. HR was measured during the arousal. HRV was estimated from the R-R intervals in 5-minute stationary segments preceding and following arousal, ie, during SWS and active sleep stage 2 from the first 2 complete NREM-REM sleep cycles. In controls, HR increased during arousal associated with the emergence from SWS during the 2 sleep cycles (P < .05). Sleep-stage-dependent increases of all HRV indexes were observed in the 2 sleep cycles. Concerning CTP, 5 of them displayed a smaller HR increase at arousal, whereas 9 other patients had no HR variation. This distinction between the 2 groups of CTP was confirmed by HRV analysis. The patients with HR reactivity to arousal presented significant sleep-stage-dependent increases in global HRV and sympathetic HRV indexes, whereas the nonreactive group was characterized by an inability of HRV to change with sleep-stage alternation. Sympathetic HRV indexes were significantly higher in the reactive patients than in nonreactive patients, but high frequency power reflecting parasympathetic activity did not differ. However, the absolute HRV indexes were greatly decreased in both groups of patients compared to controls. HR reactivity during arousal associated with the emergence from SWS, corroborated by HRV surrounding arousal, may suggest a partial improvement of the sympathetic drive to the heart in some CTP, with no indication of increased parasympathetic activity. Other signs of reinnervation have to be identified to validate this hypothesis.
    Sleep 06/2004; 27(4):641-7. · 5.10 Impact Factor
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    ABSTRACT: To characterize plasma endothelin 1 (ET-1) and arterial blood pressure (ABP) time courses during the first complete non-rapid eye movement (NREM)-REM sleep cycle in healthy subjects, together with plasma renin activity (PRA) and plasma atrial natriuretic peptide (ANP). Heart rate (HR), intra-arterial blood pressure and sleep electroencephalographic activity were recorded continuously during the night in eight healthy 20-28-year-old males. Blood was sampled every 10 min during their first complete sleep cycle for simultaneous measurements of plasma ET-1, PRA and ANP. Circulating ET-1 demonstrated significant variations during the sleep cycle (p<0.0001) that paralleled those of ABP (p<0.05) and HR (p<0.005), with a minimum during NREM sleep and a maximum during REM sleep. ET-1 time course opposed that of PRA which increases during NREM sleep and decreases during REM sleep (p<0.0005). Plasma ANP did not demonstrate systematic variation in relation with the sleep cycle. Circulating ET-1, which parallels variations of ABP, may participate in ABP regulation during sleep in healthy subjects, in association with the renin-angiotensin system.
    Regulatory Peptides 06/2004; 119(1-2):133-8. · 2.06 Impact Factor
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    ABSTRACT: We compare the profiles of heart rate variability (HRV) during sleep stages in 9 healthy controls and one subject with second degree atrioventricular blocks (AVB), investigating the role of sympathovagal balance in such pathology. Sleep and cardiac records were taken for one night in 9 male subjects from 21:00 to 07:00 h and for two nights in a male subject with AVB. Time and frequency domain indexes of HRV were calculated over 5 min-periods. In one subject without any daytime heart disease, 253 and 318 AVB of type 2 (Mobitz 2) were observed during the two experimental nights, predominantly during rapid eye movement (REM) sleep and the surrounding sleep stage 2 in the second half of the night. In the 9 control subjects, absolute HRV indexes and low frequency (LF)/(LF+high frequency, HF) (where LF and HF are low frequency and high frequency power) were low during slow wave sleep, and significantly increased during REM sleep and the preceding sleep stage 2. In the subject with AVB, these HRV indexes were abnormally low during all sleep stages, with a predominant increase in parasympathetic activity as inferred from low LF/(LF+HF). During wake, however, LF/(LF+HF) normally increased, and the tachycardia observed with the arousal that terminates SWS was preserved in the subject with AVB. These results suggest that in the subject with second degree atrioventricular blocks, sleep processes, particularly during REM sleep, create a specific neurological background that prevents an increase in sympathetic tone and triggers cardiac pauses.
    Clinical Neurophysiology 05/2004; 115(4):946-50. · 3.14 Impact Factor
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    ABSTRACT: The purpose of this study was to investigate sympathovagal balance as inferred from heart rate variability (HRV) responses to acute hypoxia at rest and during exercise. HRV was evaluated in 12 healthy subjects during a standardized hypoxic tolerance test which consists of four periods alternating rest and moderate exercise (50 % V.O (2)max) in normoxic and hypoxic conditions. Ventilatory responses were determined and HRV indexes were calculated for the last 5 min of each period. In well-tolerant subjects, hypoxia at rest induced a decrease of root-mean-square of successive normal R-R interval differences (RMSSD) (p < 0.05) and of absolute high frequency (HF) power (p < 0.001). All absolute HRV indexes were strongly reduced during exercise (p < 0.001) with no further changes under the additional stimulus of hypoxia. A significant increase (p < 0.05) in the HF/(LF+HF) ratio (where LF is low frequency power) was found during exercise in hypoxia compared to exercise in normoxia, associated with similar mean changes in ventilation and tidal volume. These results indicate a vagal control withdrawal under hypoxia at rest. During exercise at 50 % V.O (2)max, HRV indexes cannot adequately represent cardiac autonomic adaptation to acute hypoxia, or possibly to other additional stimuli, due to the dominant effect of exercise and the eventual influence of confounding factors.
    International Journal of Sports Medicine 05/2004; 25(4):264-9. · 2.27 Impact Factor
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    ABSTRACT: Heart rate variability (HRV) is a measure of the physiological variation of R-R intervals, reflecting the sympathovagal balance. In both overt and subclinical hyperthyroidism, a relative increase in sympathetic activity has been demonstrated, mainly due to a decrease in vagal activity. The modifications of HRV during orthostatism in normal subjects resemble those seen in hyperthyroidism. We have studied the response of 19 patients with overt hyperthyroidism and 12 with subclinical hyperthyroidism during orthostatism using HRV and compared the results to those of 32 healthy controls. In the three groups, the R-R intervals decreased in the same proportion after orthostatism. The low frequency power (LF)/[LF + high frequency power (HF)] ratio, which reflects the sympathetic tone, also increased in the same proportion in the three groups. However, the mechanisms of the modulation of the sympathovagal balance during orthostatism were different among the three groups. In controls, the relative increase of sympathetic tone after orthostatism was due principally to a decrease in vagal tone (reflected by decreased power in the HF band), while in overt hyperthyroidism, where the power in the HF band was already minimal in the lying position, there was a clear increase in the LF band power during orthostatism. The results were intermediate in the subclinical hyperthyroidism group, reflecting a continuum of effects of the thyroid hormone excess on the autonomic nervous system. Our study shows that despite an apparent normal cardiovascular adaptation to orthostatism in hyperthyroidism, the modulation of the autonomic nervous system is profoundly modified.
    Journal of endocrinological investigation 05/2004; 27(4):348-52. · 1.65 Impact Factor
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    ABSTRACT: Aging is associated with decreased heart rate variability (HRV). As aerobic training is known to increase HRV, the purpose of this study was to evaluate the influence of long-term lifestyle on HRV in very old adults with regard to their usual physical activity. Twenty-four older adults (mean 75.7 +/- 0.2 yr) were divided into two groups according to their sport activities assessed by the Modified Baecke Questionnaire for Older Adults. Sedentary subjects (SED) were compared to elderly regularly involved in sport activities (SP). The subjects were supine for 20 min and the last 5 min were used to determine HR and HRV indexes as the standard deviation of normal intervals (SDNN), the root-mean-square differences of successive normal R-R intervals (RMSSD), and the high-frequency (HF) and low-frequency (LF) power. Physical activity was evaluated during 1 wk by triaxial accelerometry and analyzed in terms of intensity and duration. Daily physical activity energy expenditure given by the accelerometer was significantly higher in SP than in SED (P < 0.05). SP spent more time per week in activity of intensity higher than 3 resting metabolic equivalents (METs), but total activity time was significantly higher for SED than for SP (P < 0.05). SP showed significantly (P < 0.05) lower resting heart rate than SED, higher global HRV (SDNN), and higher parasympathetic-related HRV indexes (RMSSD, HF, and HF/(LF+HF)) (P < 0.05). Our results indicate that in very old subjects a long-term sportive lifestyle, which increases total daily energy expenditure and physical activity intensity, is associated with higher global HRV and vagal-related indexes and thus may counteract the age-related decline in cardiac autonomic control better than a sedentary lifestyle.
    Medicine &amp Science in Sports &amp Exercise 04/2004; 36(4):601-5. · 4.48 Impact Factor
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    A Charloux, F Piquard, S Doutreleau, G Brandenberger, B Geny
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    ABSTRACT: The atrial natriuretic peptide (ANP) plays an important role in chronic heart failure (CHF), delaying the progression of the disease. However, despite high ANP levels, natriuresis falls when CHF progresses from a compensated to a decompensated state, suggesting emergence of renal resistance to ANP. Several mechanisms have been proposed to explain renal hyporesponsiveness, including decreased renal ANP availability, down-regulation of natriuretic peptide receptors and altered ANP intracellular transduction signal. It has been demonstrated that the activity of neutral endopeptidase (NEP) is increased in CHF, and that its inhibition enhances renal cGMP production and renal sodium excretion. In vitro as well as in vivo studies have provided strong evidence of an increased degradation of intracellular cGMP by phosphodiesterase in CHF. In experimental models, ANP-dependent natriuresis is improved by phosphodiesterase inhibitors, which may arise as new therapeutic agents in CHF. Sodium-retaining systems likely contribute to renal hyporesponsiveness to ANP through different mechanisms. Among these systems, the renin-angiotensin-aldosterone system has received particular attention, as angiotensin II and ANP have renal actions at the same sites and inhibition of angiotensin-converting enzyme and angiotensin-receptor blockade improve ANP hyporesponsiveness. Less is known about the interactions between the sympathetic nervous system, endothelin or vasopressin and ANP, which may also blunt ANP-induced natriuresis. To summarize, renal hyporesponsiveness to ANP is probably multifactorial. New treatments designed to restore renal ANP efficiency should limit sodium retention in CHF patients and thus delay the progression to overt heart failure.
    European Journal of Clinical Investigation 10/2003; 33(9):769-78. · 3.37 Impact Factor

Publication Stats

2k Citations
467.23 Total Impact Points

Institutions

  • 2004–2008
    • CHRU de Strasbourg
      Strasburg, Alsace, France
  • 1999–2004
    • University of Strasbourg
      • Faculty of Medicine
      Strasbourg, Alsace, France
  • 1990–2002
    • INRS
      Lutetia Parisorum, Île-de-France, France
  • 1989–1997
    • French National Centre for Scientific Research
      Lutetia Parisorum, Île-de-France, France
  • 1992
    • Max Planck Institute of Psychiatry
      München, Bavaria, Germany