I Pommepuy

Publications (6)15.75 Total impact

• Article: [Calciphylaxis treated by cinacalcet: a medical alternative to parathyroidectomy].

  S Prey, A Sparsa, H Durox, V Allot, I Pommepuy, A Salem, C Roux, F Labrousse, J-M Bonnetblanc
  [show abstract] [hide abstract]
  ABSTRACT: Calciphylaxis is a rare necrotizing calcifying arteriolopathy, with a poor prognosis, for which there is currently no effective treatment. One of the major challenges of the therapy is normalizing the calcium-phosphate balance. Therefore, cinacalcet, which inhibit the production of parathormone by negative feedback, was considered a treatment option to control the evolution of calciphylaxis in a dialysed patient suffering from cholangiocarcinoma.
  La Revue de Médecine Interne 07/2008; 30(2):186-9. · 0.61 Impact Factor
• Article: Platelet-activating factor and human meningiomas.

  Y Denizot, R De Armas, F Caire, I Pommepuy, V Truffinet, F Labrousse
  [show abstract] [hide abstract]
  ABSTRACT: Meningiomas are common primary intracranial tumours. Platelet-activating factor (PAF) is an inflammatory and angiogenic lipid mediator involved in several types of cancer. The presence of PAF receptor (PAF-R) transcripts, the levels of PAF, the phospholipase A2 activity (PLA2, the enzymatic activity implicated in PAF formation) and the PAF acetylhydrolase activity (AHA, the PAF degrading enzyme) were investigated in 49 human meningiomas. PAF-R transcripts, PAF, PLA2 and AHA were detected in meningiomas. However, their levels did not correlate with biological parameters such as the tumour grade, the presence of associated oedema, necrosis, mitotic index as well as intensity of the neovascularization and chronic inflammatory response. In conclusion, PAF is present in meningiomas where it might act on tumour growth by altering the local angiogenic and/or cytokine networks as previously suggested for human breast and colorectal cancer.
  Neuropathology and Applied Neurobiology 01/2007; 32(6):674-8. · 3.80 Impact Factor
• Article: A report of a desmoplastic ganglioglioma in a 12-year-old girl with review of the literature.

  I Pommepuy, M Delage-Corre, J J Moreau, F Labrousse
  [show abstract] [hide abstract]
  ABSTRACT: Desmoplastic infantile ganglioglioma is a supratentorial tumor that typically occurs in infants below the age of 24 months. Rare tumors with the same radiological and histological characteristics have been described in older subjects. We report a case of desmoplastic ganglioglioma in a 12-year-old girl with a 13 years follow-up. The patient presented with an inaugural generalized seizure. CT scan demonstrated a large superficial parieto-occipital mass, attached to the dura with solid and cystic components. Surgical resection was macroscopically complete. No adjuvant treatment was given. Thirteen years after surgery, the patient is symptom free. Histological examination revealed a pleomorphic tumor involving the meningeal space and the cortex. Meningeal portion was made of neoplastic astrocytes enmeshed in a dense network of connective tissue. The cortical component showed abnormal neurons, tumoral astrocytes and small foci of poorly differentiated cells with rare mitoses. Our observation and the seven others found in the literature indicate that desmoplastic gangliogliomas can occur in children and even in young adults. Despite some worrisome radiological and histological features, these tumors should not be misdiagnosed as malignant glioma. Like infantile cases, non-infantile desmoplastic gangliogliomas seem to have a favorable prognosis without additional therapy, if a total surgical resection can be performed.
  Journal of Neuro-Oncology 03/2006; 76(3):271-5. · 3.21 Impact Factor
• Source

  Available from: PubMed Central

  Article: Detection of human cytomegalovirus genome and gene products in central nervous system tumours.

  J Sabatier, E Uro-Coste, I Pommepuy, F Labrousse, S Allart, M Trémoulet, M B Delisle, P Brousset
  [show abstract] [hide abstract]
  ABSTRACT: Human cytomegalovirus (HCMV) genome and related proteins have been reported in a great proportion of malignant gliomas. However, these results are unexpected since HCMV is not known as an oncogenic virus. By immunohistochemistry (with an anti-IE1 monoclonal antibody) and in situ hybridisation (with biotinylated DNA probes) on tissue microarrays and frozen sections, we investigated a French series of central nervous system (CNS) tumours, including 97 glioblastomas. In 10 cases of glioblastoma, rare astrocyte-like cells, admixed with tumour cells, stained positively for HCMV and in one case a doubtful staining of rare cells was noticed. This may indicate a reactivation of the virus under local immunosuppression but none of the cases of CNS tumours (n=132) contained HCMV genomes and/or proteins in a significant proportion of tumour cells. Our results strongly suggest that HCMV is unlikely to be implicated in the development of human malignant gliomas, at least in French cases.
  British Journal of Cancer 03/2005; 92(4):747-50. · 5.04 Impact Factor
• Article: Ulcerative terminal ileitis after BCG therapy for bladder carcinoma.

  D Satgé, I Pommepuy, T Hassan, J Goburdhun, J-F Flejou
  [show abstract] [hide abstract]
  ABSTRACT: We evaluated the aetiology of ulcerative ileitis in a 77-year-old patient receiving BCG therapy for recurring bladder carcinoma. Histological examination, laboratory data and the clinical history allowed us to exclude a classical cause such as Crohn's disease, tuberculosis or ischaemia. The important locoregional reaction suggests a BCG ileitis of the terminal ileum. Intestinal BCG ileitis has been exceptionally described after BCG vaccination. Our observation of ulcerative ileitis indicates that a digestive tract location is possible as a reaction to BCG therapy.
  Histopathology 10/2002; 41(3):266-8. · 3.08 Impact Factor
• Article: Bronchiolitis obliterans organizing pneumonia in a patient with rheumatoid arthritis.

  I Pommepuy, M Farny, T Billey, P Olivier, S Lassoued
  [show abstract] [hide abstract]
  ABSTRACT: A 75-year old man with rheumatoid arthritis developed bronchiolitis obliterans organizing pneumonia (BOOP), which responded to treatment with prednisolone (1 mg/kg/d) and cyclophosphamide (100 mg/d).
  Revue du rhumatisme (English ed.) 01/1998; 65(1):65-7.