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Ruediger Lessig,
Sascha Willuweit,
Michael Krawczak,
Fang-Chin Wu,
Chang-En Pu,
Wook Kim,
Lotte Henke,
Juergen Henke,
Jasmin Miranda,
Monika Hidding, [......],
António Amorim,
Cintia Alves,
Yiping Hou,
Christine Keyser,
Bertrand Ludes,
Michael Klintschar,
Uta D Immel, Barbara Reichenpfader,
Boriana Zaharova,
Lutz Roewer
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Ruediger Lessig,
Sascha Willuweit,
Michael Krawczak,
Fang-Chin Wu,
Chang-En Pu,
Wook Kim,
Lotte Henke,
Juergen Henke,
Jasmin Miranda,
Monika Hidding, [......],
António Amorim,
Cintia Alves,
Yiping Hou,
Christine Keyser,
Bertrand Ludes,
Michael Klintschar,
Uta D Immel, Barbara Reichenpfader,
Boriana Zaharova,
Lutz Roewer
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ABSTRACT: Catecholamines may contribute to the cause of sudden infant death syndrome (SIDS). TH01, a tetrameric short tandem repeat marker in the tyrosine hydroxylase gene, regulates gene expression and catecholamine production.
We investigated TH01 in 172 German Caucasian SIDS cases and 390 sex- and age-matched control subjects.
The *9.3 alleles were more frequent in patients with SIDS than in control subjects (40.12% vs 31.15%; P = .006). For homozygotes the odds ratio was 1.83 (95% confidence interval: 1.09-3.05), for carriers 1.58 (1.09-2.28). Moreover, *9.3 alleles were significantly more frequent during the winter (47.73% vs 35.38% in the warmer seasons), and the frequency of *9.3 alleles varied significantly with the age at death (weeks 7 to 12: 49.04% vs 29.63% within the first 6 weeks). Other risk factors (sleeping position, gestation, smoking) had no significant impact on the frequency of *9.3.
Our results indicate a relationship between SIDS and TH01 genotype, presumably caused by an impairment of breathing regulation or arousal. We propose that noradrenalinergic neuronal activity contributes to the cause of a major subset of SIDS victims. Moreover, the results further stress that SIDS is a highly heterogenic group.
The Journal of pediatrics 09/2008; 153(2):190-3. · 4.02 Impact Factor
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ABSTRACT: Fungal infestations normally represent additional findings in forensic autopsies, but also may appear as a cause of death. Moreover different kinds of fungi occur during late postmortem decay. In this paper, particular emphasis is put on the context of immunodeficiency and finally, lethal septic states.
Wiener Medizinische Wochenschrift 02/2007; 157(19-20):473-5.
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ABSTRACT: Allele frequencies for the short tandem repeat loci D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, THO1 and FGA were determined in 231 German and 100 Austrian unrelated Caucasoids using the AmpFlSTR SGM plus kit (Applied Biosystems). All loci met Hardy-Weinberg expectations. In 212 meioses per locus, one mutation event for D19S433 was observed.
Forensic Science International 04/2003; 132(1):84-6. · 2.30 Impact Factor
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Ruediger Lessig,
Sascha Willuweit,
Michael Krawczak,
Fang-Chin Wu,
Chang-En Pu,
Wook Kim,
Lotte Henke,
Juergen Henke,
Jasmin Miranda,
Monika Hidding, [......],
António Amorim,
Cintia Alves,
Yiping Hou,
Christine Keyser,
Bertrand Ludes,
Michael Klintschar,
Uta D Immel, Barbara Reichenpfader,
Boriana Zaharova,
Lutz Roewer
[show abstract]
[hide abstract]
ABSTRACT: For several years Y-chromosomal microsatellites (short tandem repeats, STRs) have been well established in forensic practice. In this context, the genetic characteristics of the Y chromosome (i.e. its paternal inheritance and lack of recombination) render STRs particularly powerful. However, genetic differences between male populations appear to be larger for Y-STRs than for autosomal STRs, a fact that is most likely due to the higher sensitivity of Y-chromosomal lineages to genetic drift (Forensic Sci Int 118 (2001) 153). The assessment of probabilities for matches between haplotyped male persons or traces/persons requires the typing of a large number of haplotypes in the appropriate reference populations. The haplotype data of a large number of European as well as South and North American populations have been collected and are continuously published online (Y-STR Haplotype Reference Database--YHRD; http://www.ystr.org). The most recent multicentric effort has led to the establishment of an Asian YHRD (http://www.ystr.org/asia) which has been available since January 2002. All databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents.
Legal Medicine 04/2003; 5 Suppl 1:S160-3.
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R Lessig,
Sascha Willuweit,
Michael Krawczak,
Fang-Chin Wu,
Chang-En Pu,
Wook Kim,
Lotte Henke,
Jürgen Henke,
Jasmin Miranda,
Monika Hidding, [......],
Antonio Amorim,
Cintia Alves,
Yiping Hou,
Christine Keyser,
Bertrand Ludes,
Michael Klintschar,
Uta D. Immel, Barbara Reichenpfader,
Boriana Zaharova,
Lutz Roewer
Legal Medicine, v.5, S160-S163 (2003).
