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ABSTRACT: Recent evidence suggests that there are age-related neurocognitive implications for fragile X premutation carriers, including deficits in executive function, and that such deficits are more common in male than female premutation carriers. The purpose of the current study is to examine one aspect of executive function, language dysfluencies, in a group of 193 women with the premutation, and to contrast them with a comparison group (mothers of children with autism spectrum disorders). Our results demonstrate a linguistic profile in the female premutation carriers characterized by dysfluencies associated with deficits in organization and planning, with a clear impact of age. The comparison group, matched on both age and education level, did not demonstrate the age effect. Our results suggest dysfluencies could be an early indicator of cognitive aging in some female premutation carriers, and could be used to target early intervention.
Brain and Cognition 03/2013; 82(1):84-89. · 3.17 Impact Factor
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ABSTRACT: a b s t r a c t Recent evidence suggests that there are age-related neurocognitive implications for fragile X premutation carriers, including deficits in executive function, and that such deficits are more common in male than female premutation carriers. The purpose of the current study is to examine one aspect of executive func-tion, language dysfluencies, in a group of 193 women with the premutation, and to contrast them with a comparison group (mothers of children with autism spectrum disorders). Our results demonstrate a lin-guistic profile in the female premutation carriers characterized by dysfluencies associated with deficits in organization and planning, with a clear impact of age. The comparison group, matched on both age and education level, did not demonstrate the age effect. Our results suggest dysfluencies could be an early indicator of cognitive aging in some female premutation carriers, and could be used to target early intervention.
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ABSTRACT: We examine how the family environment is associated with aspects of the Fragile X syndrome phenotype during childhood, adolescence, and adulthood. Mothers of children (n = 48), adolescents (n = 85), and adults (n = 34) with Fragile X syndrome participated in a multisite study. For children and adults with Fragile X syndrome, the presence of warmth and positivity and the absence of criticism were associated with fewer behavior problems. Although a higher level of criticism was significantly associated with greater behavior problems, there were only trend-level associations between levels of warmth and positivity and behavior problems during the adolescent years. The provision of family psychoeducation programs, which can reduce parental criticism, would likely benefit both the individual with Fragile X syndrome and the family.
American Journal on Intellectual and Developmental Disabilities 07/2012; 117(4):331-46. · 2.08 Impact Factor
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ABSTRACT: The primary goal of this study was to calculate the prevalence of the premutation of the FMR1 gene and of the "gray zone" using a population-based sample of older adults in Wisconsin (n = 6,747 samples screened). Compared with past research, prevalence was relatively high (1 in 151 females and 1 in 468 males for the premutation and 1 in 35 females and 1 in 42 males for the gray zone as defined by 45-54 CGG repeats). A secondary study goal was to describe characteristics of individuals found to have the premutation (n = 30, 7 males and 23 females). We found that premutation carriers had a significantly higher rate of divorce than controls, as well as higher rates of symptoms that might be indicative of fragile X-associated tremor ataxia syndrome (FXTAS; numbness, dizziness/faintness) and fragile X primary ovarian insufficiency (FXPOI; age at last menstrual period). Although not statistically significant, premutation carriers were twice as likely to have a child with disability.
American Journal of Medical Genetics Part B Neuropsychiatric Genetics 05/2012; 159B(5):589-97. · 3.70 Impact Factor
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ABSTRACT: Using population data, this study included parents of individuals with intellectual and developmental disabilities (n = 220) and parents of individuals without disabilities (n = 1,042). Parents of individuals with intellectual and developmental disabilities were further divided into those who co-resided with their adult child and those whose adult child lived elsewhere, and the 3 groups were compared regarding parental patterns of attainment, social participation, psychological functioning, and health in midlife and early old age. In midlife, parents of individuals with intellectual and developmental disabilities were similar in general to comparison parents. However, by early old age, these parents had poorer health and mental health. Co-residence between the adult with intellectual and developmental disabilities and the parent was prevalent during midlife (51.4%) and in the early years of old age (38.6%), and there were different patterns of parental outcomes, depending on the residential status of the adult with intellectual and developmental disabilities.
American Journal on Intellectual and Developmental Disabilities 11/2011; 116(6):479-99. · 2.08 Impact Factor
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ABSTRACT: We compared the occurrence and timing of divorce in 391 parents of children with an autism spectrum disorder (ASD) and a matched representative sample of parents of children without disabilities using a survival analysis. Parents of children with an ASD had a higher rate of divorce than the comparison group (23.5% vs. 13.8%). The rate of divorce remained high throughout the son's or daughter's childhood, adolescence, and early adulthood for parents of children with an ASD, whereas it decreased following the son's or daughter's childhood (after about age 8 years) in the comparison group. Younger maternal age when the child with ASD was born and having the child born later in the birth order were positively predictive of divorce for parents of children with an ASD. Findings have implications for interventions focused on ameliorating ongoing and long-term marital strains for parents of children with an ASD.
Journal of Family Psychology 08/2010; 24(4):449-57. · 1.66 Impact Factor
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ABSTRACT: Using daily diary methods, mothers of adolescents and adults with ASD (n = 86) were contrasted with a nationally representative comparison group of mothers of similarly-aged unaffected children (n = 171) with respect to the diurnal rhythm of cortisol. Mothers of adolescents and adults with ASD were found to have significantly lower levels of cortisol throughout the day. Within the ASD sample, the son or daughter's history of behavior problems interacted with daily behavior problems to predict the morning rise of the mother's cortisol. A history of elevated behavior problems moderated the effect of behavior problems the day before on maternal cortisol level. Implications for interventions for both the mother and the individual with ASD are suggested.
Journal of Autism and Childhood Schizophrenia 11/2009; 40(4):457-69. · 3.06 Impact Factor
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ABSTRACT: In the present study, 96 co-residing mothers of adolescents and adults with an autism spectrum disorder (ASD) participated in an 8-day diary study and reported on their daily experiences. In comparison with a nationally representative sample of mothers of children without disabilities, mothers of adolescent and adult children with ASD spent significantly more time providing childcare and doing chores, and less time in leisure activities. Fatigue, arguments, avoided arguments, and stressful events were also more common among mothers of individuals with ASD. However, mothers of individuals with ASD reported similar levels of positive interactions and volunteerism as the comparison group. Daily experiences were subsequently related to well-being in both groups. These findings highlight the need for family support services.
Journal of Autism and Childhood Schizophrenia 09/2009; 40(2):167-78. · 3.06 Impact Factor
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ABSTRACT: The primary purpose of this study was to compare the physical and psychological well-being of caregiving fathers of an adult son or daughter with schizophrenia with a comparison group of fathers who do not have children with schizophrenia.
Data for the caregiving fathers (N=95) were drawn from a study of families of adults with schizophrenia; the comparison group of fathers (N=95) was drawn from the Wisconsin Longitudinal Study (WLS). Samples were matched on sociodemographic variables and analyzed with independent-samples t tests.
Fathers of adults with schizophrenia experienced higher levels of depression, poorer perceived health, lower levels of psychological well-being, and less marital satisfaction compared with their age-matched peers in the WLS.
This study found hidden personal costs of caregiving among fathers of adults with schizophrenia; strategies are needed for supporting these fathers.
Psychiatric services (Washington, D.C.) 08/2009; 60(7):982-4. · 2.81 Impact Factor
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ABSTRACT: Medication use was examined in 286 adolescents and adults with ASD over a 4.5 year period. A total of 70% were taking a psychotropic or non-psychotropic medication at the beginning of the study. Both the number of psychotropic and non-psychotropic medications taken, and the proportion of individuals taking these medications, increased significantly over the study period, with 81% taking at least one medication 4.5 years later. Our findings suggested a high likelihood of staying medicated over time. Thus, adolescents and adults with ASD are a highly and increasingly medicated population.
Journal of Autism and Childhood Schizophrenia 06/2009; 39(9):1339-49. · 3.06 Impact Factor
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ABSTRACT: The death of a child is a traumatic event that can have long-term effects on the lives of parents. This study examined bereaved parents of deceased children (infancy to age 34) and comparison parents with similar backgrounds (n = 428 per group) identified in the Wisconsin Longitudinal Study. An average of 18.05 years following the death, when parents were age 53, bereaved parents reported more depressive symptoms, poorer well-being, and more health problems and were more likely to have experienced a depressive episode and marital disruption than were comparison parents. Recovery from grief was associated with having a sense of life purpose and having additional children but was unrelated to the cause of death or the amount of time since the death. The results point to the need for detection and intervention to help those parents who are experiencing lasting grief.
Journal of Family Psychology 05/2008; 22(2):203-11. · 1.66 Impact Factor
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ABSTRACT: The present study examined the impact of autism symptoms and coping strategies on the well-being of mothers of children with autism spectrum disorder (ASD). The sample consisted of 153 mothers of toddlers and 201 mothers of adolescents drawn from two ongoing, longitudinal studies of families of individuals with ASD. For mothers of toddlers, lower levels of emotion-focused coping and higher levels of problem-focused coping were generally associated with better maternal well-being, regardless of the level of child symptomatology. For mothers of adolescents, coping often acted as a buffer when autism symptoms were high. Although there was evidence of maternal distress in both groups, the presence of significant buffering effects reflects adaptation in the face of stress, particularly for mothers of adolescents.
Journal of Autism and Developmental Disorders 11/2007; 38(5):876-89. · 3.34 Impact Factor
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ABSTRACT: Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times parameter constraints, with the homogeneous model being the least constrained, followed by the 2-parameter GRM and 1-parameter GRM. Results show that 4 subscales (Interpersonal Sensitivity, Hostility, Paranoid Ideation, Psychoticism) were consistent with the 1-parameter GRM, and 5 subscales (Somatization, Obsessive-Compulsive, Depression, Anxiety, Phobic Anxiety) were consistent with the 2-parameter GRM. There is evidence that the 9 subscales may be validly used to study change in single constructs over time.
Psychological Assessment 10/2007; 19(3):298-308. · 2.99 Impact Factor
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ABSTRACT: We identified 201 individuals who obtained IQs of 85 or below in high school and participated in the Wisconsin Longitudinal Study (a prospective longitudinal study that followed sample members from age 18 through age 53). Their life course development was contrasted with their siblings who obtained IQs above 100. Life course outcomes were assessed in five domains: Education and Occupational Attainment, Family Formation, Social Participation and Support, Physical Health, and Psychological Well-Being. Compared to their higher IQ sibling, low-IQ individuals completed less schooling, had less prestigious occupations, rated themselves less physically healthy, and reported lower levels of psychological well-being. Differences were not evident, however, in patterns of family formation, social support, job satisfaction, or objective measures of physical health.
American journal of mental retardation: AJMR 12/2005; 110(6):451-68. · 2.51 Impact Factor
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ABSTRACT: This paper examines methodological challenges inherent in conducting research on families of children with autism and in comparing these families with others who are coping with different types of disabilities or who have nondisabled children. Although most comparative research has contrasted families whose child has autism with those whose child has Down syndrome, the range of comparison groups can be expanded to offer additional points of contrast and control. We discuss both matching and statistical control procedures and point to next steps in this line of comparative autism family research.
Journal of Autism and Developmental Disorders 03/2004; 34(1):41-8. · 3.34 Impact Factor
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