Elif Ozer

Ankara Numune Training and Research Hospital, Engüri, Ankara, Turkey

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Publications (18)29.43 Total impact

  • Urology 07/2015; 86(1):206. DOI:10.1016/j.urology.2015.04.025 · 2.13 Impact Factor
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    ABSTRACT: To enhance rat penises experimentally with rectus muscle fascia (RMF) and testicular tunica vaginalis grafts (TVG). Twelve Wistar albino rats were distributed into two equal Groups, A and B. There were six rats in each group. RMF and TVG were used to enhance rat penises in Groups A and B, respectively. Circumferences of the penises were measured preoperatively and at three different times after the operation. Two, two and eight rats were killed 10 days, 1 month and 2 months after the operation, respectively, for histopathological examinations. When we compared the measurements of preoperative and immediately postoperative circumferences, the mean increase was 23.4 ± 2.9 % in Group A and 19.9 ± 1.7 % in Group B. According to paired t test, the difference was significant (p < 0001), but the comparison between preoperative and postoperative first-month measurements was not found to be significant (p > 0.05). Histological examinations revealed an intensive inflammatory process at 10 days after the operation. Grafts were found to be totally absorbed in the first- and second-month examinations. In our study, implanted TVG and RMF could not survive because of insufficient vascularization and failure to maintain satisfactory surgical success. More studies are needed to increase the effectiveness of surgical techniques.
    International Urology and Nephrology 04/2015; 47(6). DOI:10.1007/s11255-015-0961-9 · 1.29 Impact Factor
  • European Urology Supplements 11/2014; 13(7):e1416-e1416a. DOI:10.1016/S1569-9056(14)61617-1 · 3.37 Impact Factor
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    ABSTRACT: Ischemia reperfusion injury can cause testicular damage and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We aimed to investigate prevention of both ipsilateral and contralateral testicular damage with two different phosphodiesterase inhibitors after testicular detorsion in rats. Twenty eight adult male rats were randomly divided into four groups as follows: group 1, sham operated, (n=7); group 2, testicular torsion and detorsion (T/D) (n=7); group 3, T/D and sildenafil administered before detorsion (T/D+S) (n=7); group 4, T/D and udenafil administered before detorsion (T/D+U) (n=7). The tissue levels of malondialdehyde (MDA), total sulfhydryl (T-SH) and nitrite were evaluated. Also histopathological changes of the groups were examined. As compared to group 1, significant increased tissue levels of MDA (p=0.001), significant decreased levels of T-SH (p=0,038) insignificant increased levels of nitrite were found in group 2. In contrast, as compared to group 2, levels of MDA decreased significantly and T-SH levels increased significantly in group 3 and 4. The decrease in nitrite levels were insignificant in the last two groups. Histopathologically in group 2 rats increased hemorrhage, congestion and edema were found. Testicular injury score was lower in sildenafil and udenafil treated rats. In T/D group grades II, III and IV injury was detected while most of the specimens in the treated groups showed grade II injury. This study indicates that, intraperitoneal administration of both sildenafil and udenafil efficiently supress radical production while they decrease the histologic changes after testicular ischemia reperfusion injury.
    The Journal of urology 04/2014; 192(4). DOI:10.1016/j.juro.2014.04.011 · 3.75 Impact Factor
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    ABSTRACT: Although renal cystic formations are seen frequently and arise with diverse symptoms, epidermal cyst is a very unusual cause of renal masses. A50-year-old woman was admitted to our clinic because of lumbar pain, hematuria and dysuria that lasted for 2 months. An atrophic and dysfunctional right kidney was identified. Transperitoneal laparoscopic simple nephrectomy was performed. Microscopic examination revealed typical findings of epidermoid cyst. According to the literature, intrarenal epidermal cysts are usually treated by nephrectomy because they cannot be differentiated from renal masses. To the best of our knowledge, this case report of an epidermoid cyst located in the renal parenchyma of a female patient is the first in the English-language literature.
    The Kaohsiung journal of medical sciences 10/2010; 26(10):555-7. DOI:10.1016/S1607-551X(10)70085-1 · 0.81 Impact Factor
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    ABSTRACT: A 45-year-old woman with metastatic renal cell carcinoma to the nasal septum was presented in this study. Metastatic neoplasms of the paranasal region are so rare that they have been usually reported as case reports. Although there are reported cases of renal cell carcinoma to the paranasal sinuses, this case was unique in that it is an isolated metastasis to the nasal septum. The clinical presentation, radiologic and pathologic investigations, and the treatment of patient with surgery and chemotherapy with sunitinib malate (Sutent) were discussed.
    The Journal of craniofacial surgery 07/2009; 20(4):1204-6. DOI:10.1097/SCS.0b013e3181acdd2e · 0.68 Impact Factor
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    ABSTRACT: We investigated the effect of Glubran(R)2 cyanoacrylic glue on rat cavernous tissue after forming penile fractures experimentally as well as the histopathological effect. We also investigated its clinical use. Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in 32 Wistar Albino rats. The rats were randomly assigned to 4 main groups of 8 each. In the control group the incision was not repaired and it was left to secondary healing. In the glue group cyanoacrylic glue was only applied to the incision region. In the primary repair group the incision was primarily repaired and in the final group cyanoacrylic glue was applied to the incision region following primary repair. Three weeks later penectomy materials were examined histopathologically. When the control group was compared with the other groups, the differences in cavernous tissue healing with fibrosis and hyperemia-bleeding were statistically significant (p = 0.043 and 0.003, respectively). In the glue group fibrosis was observed in 2 rats. This group was the best according to cavernous healing. Although there was no significant difference between the control group and the other groups according to inflammation (p = 0.057), the glue group was better than the primary repair group (p = 0.026). No significant inflammation or hyperemia-bleeding was observed in the glue group. When the experimental groups were evaluated for histopathological parameters, it was observed that the best results were obtained in the glue group. Cyanoacrylic glue can be used in cavernous surgery due to its hemostatic, adhesive and anti-inflammatory properties.
    The Journal of urology 09/2008; 180(2):749-52. DOI:10.1016/j.juro.2008.03.181 · 3.75 Impact Factor
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    ABSTRACT: To assess ocular surface changes in patients with chronic renal failure (CRF), to compare the results with the duration of illness. Impression cytology from 48 patients with CRF on regular hemodialysis and 16 age- and sex-matched control subjects were studied. Specimens were taken from the temporal bulbar conjunctiva using cellulose acetate filter paper. Among the patients with CRF who were ill for 0-10 years, 25 patients (78.1%) disclosed grade 0-1, and 7 patients (21.9%) disclosed grade 2-3 cytologic changes, whereas in those with the duration of CRF > 10 years, 9 patients (56.2%) had grade 0-1 and 7 patients (43.8%) had grade 2-3 changes. Specimens from the control group revealed 93.8% grade 0-1 and 6.2% grade 2-3 changes (p < 0.05). The ocular surfaces of patients with CRF differ significantly from those of normal individuals, and the severity of conjunctival changes is related to the duration of CRF.
    Acta cytologica 05/2008; 52(3):309-12. DOI:10.1159/000325512 · 1.56 Impact Factor
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    ABSTRACT: A 53-year-old woman was admitted to the hospital one year after the onset of her complaints. She suffered from epiphora and swelling in the lacrimal sac region. Biopsy revealed islets of classical basal cell carcinoma with peripheral formation of palisades within a hyperemic stroma. During surgery, the lacrimal drainage system and neighboring bony structures were completely excised. No local recurrences were detected on orbital tomography performed 6 and 15 months postoperatively. As far as the authors know, this is the first case of basal cell carcinoma in the lacrimal sac reported in the literature.
    Orbit 01/2008; 26(4):303-7. DOI:10.1080/01676830600987441
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    ABSTRACT: BACKGROUND: Myoepithelial cells are widely present in the breast, and their hyperplasia may result in a spectrum of disease ranging from myoepitheliosis to myoepithelial carcinoma. CASE REPORT: A 46-year-old woman presented with a palpable mass in her right breast. Mammography and ultrasonography showed a lesion in the upper quadrant of the right breast with spiculated borders and shape. Excisional biopsy showed adenomyoepithelial adenosis. CONCLUSIONS: Although considered benign, adenomyoepithelial lesions tend to recur due to inadequate excision. Therefore, possibility of recurrence and even metastasis should be considered during follow-up of patients with a diagnosis of adenomyoepithelial lesions.
    Breast Care 01/2008; 3(6):427-430. DOI:10.1159/000170277 · 0.91 Impact Factor
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    ABSTRACT: To evaluate preoperative and postoperative conjunctival surface changes in multinodular goiter (MNG) patients and to compare their results with healthy control subjects. Twenty MNG patients who had undergone near total thyroidectomy were evaluated pre- and postoperatively at the end of the 3rd month and the 1st year by performing tear function tests and conjunctival impression cytologic analysis. These results were compared with the results of 15 healthy volunteers. When preoperative and postoperative tear function parameters were compared, the mean Schirmer test value and BUT value were decreased, the mean Rose Bengal staining score was increased during the postoperative period. These differences were statistically significant at the end of the 1st year (p < 0.001). The average goblet cell density of the MNG patients decreased significantly during the postoperative period when compared with the preoperative values (p < 0.001). All these findings of the MNG cases were significantly different from the results of the control group both before and after the operation. Tear function tests and the impression cytology findings of the MNG cases were statistically different from the results of the control group during the pre- and postoperative period. We recommend postoperative follow-up of these patients for ocular surface changes.
    Ophthalmologica 02/2007; 221(4):264-8. DOI:10.1159/000101929 · 1.87 Impact Factor
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    ABSTRACT: Evaluate the rabbit augmented bladder with Pelvicol. Twenty New Zealand rabbits were divided into 4 groups. Bladder augmentation was performed using a 10 x 10 mm sized porcine acellular collagen matrix. The material was placed on the dome of the bladder wall as a patch with 5-0 polyglycolic sutures. The bladder was resected on the 7th, 14th day, 30th and 90th days, and processed for histological analysis. No stone formation was found in the first, second and fourth weeks. In the first week, there was inflammatory appearance and roughness in the reconstructed area when compared to other sites on the bladder wall. The material could not be seen in some bladders because of acute inflammatory reaction. The normal bladder epithelium was found on the part of the bladder wall that follows the surface of the eroded material. In the second week, edema was observed through the bladder wall. Perivesical fat tissue increased and it was not easy to distinguish it from the surrounding area. In the fourth week, the bladder wall was thickened and there was a sensation of hardness present. The inner and outer surface of the material was darker than in the other bladders. In the third month, there was no inflammatory reaction; however, there was micro calcification and irregular detrusor regeneration. Pelvicol cannot be suitable material for bladder augmentation because of the resultant micro calcification, thickening of the bladder wall and irregular development of detrusor regeneration.
    International braz j urol 01/2006; 32(1):88-92; discussion 92-3. DOI:10.1590/S1677-55382006000100015 · 0.96 Impact Factor
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    ABSTRACT: Acrochordons are flesh-coloured pedunculated lesions which occur in areas of skin folds. Although they are common in other sites of the body, we report the first case of huge penile acrochordon in the literature. Clinical, pathological and surgical findings of this lesion were presented and discussed.
    International Urology and Nephrology 02/2004; 36(4):563-5. DOI:10.1007/s11255-004-0852-y · 1.29 Impact Factor
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    ABSTRACT: In this article, a 6-month-old infant with cystic dysplasia of the testis (CDT) is presented. Although different genitourinary abnormalities associated with CDT have been reported, this is the first case of the association of CDT with penoscrotal hypospadias, unilateral undescended testicle, bilateral scrotal hernia, small and hypocompliant bladder and urethral obstruction. Orchiectomy was carried out for the treatment of this rare cause of testicular cystic mass.
    Scandinavian Journal of Urology and Nephrology 05/2001; 35(2):153-5. · 1.06 Impact Factor
  • MO Tan · C Uygur · E Ozer · D Erol
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    ABSTRACT: A 9-year-old boy presented with left, intermittent testicular pain that was present for 3 days. On physical examination, left testis was grossly enlarged and firm but mildly tender. Serum alpha-fetoprotein and beta-human chorionic gonadotropin levels were within normal range. Color doppler ultrasonography which was performed to rule out testicular torsion revealed an intratesticular mass located at the upper pole of left testis and left radical orchiectomy was performed. The histopathological diagnosis was Sertoli cell tumor.
    Urologia Internationalis 02/2000; 65(4):211-3. DOI:10.1159/000064879 · 1.15 Impact Factor
  • M C Uygur · A I Arik · D Erol · E Ozer · H Ustün
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    ABSTRACT: To investigate the applicability of quantitative evaluation of needle biopsy of the testis and any correlation between biopsy score and sperm parameters in infertile or subfertile men with varicocele. A total of 45 infertile men with clinical left varicocele were included in the study. All patients underwent left varicocelectomy and bilateral biopty gun needle biopsy of both testes. Spermiograms were obtained before and three months after the operation. The biopsy specimens were evaluated for Johnsen and Agger score, Leydig cell score, germ cell/Sertoli cell ratio, mean tubular diameter, peritubular fibrosis, and tubular and basement membrane hyalinization. Mean sperm count, motility and normally configured motile sperm counts increased 20%, 25% and 60% by month 3, respectively (P < .05). We did not observe any significant change in normally configured sperm counts. A mean of 14 tubuli per testis were obtained with single-pass needle biopsy. Johnsen and Agger scores, Leydig cell scores, mean tubular diameter and germ cell/Sertoli cell ratios of both testes were comparable. However, there was significantly less peritubular fibrosis, tubular hyalinization and basal membrane hyalinization in the right testis when compared to the varicocele-bearing left testis (P < .05). We found positive correlations between Johnsen and Agger score of varicocele-bearing left testis and preoperative normally configured motile sperm counts (Pearson's r = .34 and P < .05 and Pearson's r = .41 and P < .05, respectively). The Leydig cell score of varicocele-bearing testis correlated inversely with sperm counts (Pearson's r = -0.37, P < .05). These observations may prove of prognostic value in infertile or subfertile men with varicocele.
    The Journal of reproductive medicine 05/1999; 44(5):445-9. · 0.58 Impact Factor
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    ABSTRACT: To evaluate the role of polytetrafluoroethylene (Gore-Tex) as a ureteral substitute in dogs after resection of a 5 to 8-cm-long middle segment. Five mongrel dogs underwent resection of the middle segment of the left ureter and segmental replacement of the resected part with segments of Gore-Tex over a double-J catheter. The double-J stents were removed at 21 days and the dogs were evaluated by excretory urography and abdominal ultrasonography 12 weeks after surgery. They were then killed and the ureters and the kidneys examined both grossly and microscopically. There was radiologic evidence of advanced hydronephrosis on the left side in all 5 dogs. Grossly, the left kidneys showed marked pelvic and proximal ureteral dilatation and atrophy of parenchyma. Severe stricture at the anastomotic sites and marked fibrous tissue around the prostheses were found. No cellular lining was found in the Gore-Tex lumen. There is no potential for ureteral replacement by Gore-Tex tube graft.
    Urology 03/1998; 51(3):400-3. DOI:10.1016/S0090-4295(97)00632-8 · 2.13 Impact Factor
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    ABSTRACT: To evaluate the protective effects of glycosaminoglycan (GAG) administration on shock-wave-induced renal histologic alterations, an experimental study using dermatan sulfate administration (DS) in rabbits was performed. The study included 45 white New Zealand rabbits; 36 were divided into two groups before shock-wave application. Animals in the first group (n = 18) received no specific medication before or after shock-wave treatment; animals in the second group (n = 18) received subcutaneous DS administration for a period of 2 months, beginning 2 weeks before shock-wave application. Following different numbers of shock-wave application (500, 1000, or 1500 shock waves), histopathologic evaluation of treated kidneys was made under light microscopy after 24 hours and 3 months. Nine animals were used for the control group. During 24-hour examination, most of the kidneys in both groups demonstrated varying degrees of histopathologic alterations, depending on the number of shock waves applied. Among the most prominent pathologic features were protein deposition with free erythrocytes in the tubular lumen, glomerular hemorrhage, tubular dilation and degeneration, protein in Bowman's capsule, hyperemia, and mononuclear cell infiltration at the interstitial level. As opposed to the 24-hour evaluation findings, long-term (3-month) follow-up examination revealed histopathologic alterations that decreased but did not totally disappear in animals receiving no DS. Glomerular basement membrane thickening, mononuclear cell infiltration and limited protein deposition in some tubules, together with cortical interstitial fibrosis, were observed to some extent in these animals. On the other hand, no severe histopathologic alteration with normal glomerular basement membrane appearance was noted in animals receiving DS medication. Our results indicated a long-term favorable protective effect of DS administration on morphologic abnormalities in rabbits undergoing shock-wave treatment. Although tubular alterations persisted to some extent, mononuclear cell infiltration has been limited and the natural appearance of the basement membrane has been well preserved in most of the treated animals.
    Urology 02/1997; 49(1):145-50. DOI:10.1016/S0090-4295(96)00446-3 · 2.13 Impact Factor

Publication Stats

103 Citations
29.43 Total Impact Points


  • 2014–2015
    • Ankara Numune Training and Research Hospital
      Engüri, Ankara, Turkey
  • 2008–2010
    • T.C. Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi
      Engüri, Ankara, Turkey