Dan-Yi Li

Shenyang Pharmaceutical University, Feng-t’ien, Liaoning, China

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Publications (13)10.22 Total impact

  • Dan-Yi Li · Jin-Xia Wei · Hui-Ming Hua · Zhan-Lin Li
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    ABSTRACT: A new 1-aryl-isochroman, trolliusol A (1), was isolated from the flowers of Trollius chinensis, along with seven known phenolic compounds in an antimicrobial activity-directed phytochemical investigation. The structures of these compounds were elucidated by spectroscopic methods, and their inhibitory activities against one fungus and four bacterial strains were measured.
    Journal of Asian Natural Products Research 07/2014; 16(10):1-6. DOI:10.1080/10286020.2014.927868 · 0.91 Impact Factor
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    ABSTRACT: The marine-derived fungus Ascotricha sp. ZJ-M-5, which can produce cyclonerodiol analogues, a 3,4-seco lanostane triterpenoid, and diketopiperazines in an eutrophic medium, was subjected to a one strain-many compounds (OSMAC) analysis. It was found to produce three new caryophyllene derivatives (1-3) and the known 1,3,6-trihydroxy-8-methylxanthone (4) in an oligotrophic medium, Czapek Dox broth with or without Mg(2+). (+)-6-O-Demethylpestalotiopsin A (1) and (+)-6-O-demethylpestalotiopsin C (2), which have a five-membered hemiacetal structural moiety, showed growth inhibitory effects against HL-60 and K562 leukemia cell lines with the lowest GI50 value of 6.9 ± 0.4 μM. It can be concluded that modification of the culture media is still effective in the discovery of novel bioactive fungal secondary metabolites.
    Journal of Natural Products 05/2014; 77(6). DOI:10.1021/np500110z · 3.80 Impact Factor
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    ABSTRACT: Two new anthraquinones, emodin-3-O-sulphate (1) and citreorosein-3-O-sulphate (2), as well as five known anthraquinones, were isolated from a marine-derived fungus Penicillium oxalicum. The structures of these compounds were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS).
    Natural product research 11/2013; 28(5). DOI:10.1080/14786419.2013.856906 · 0.92 Impact Factor
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    ABSTRACT: Three new diterpenoids, liquidambolide A (1) and liquiditerpenoic acids A (2) and B (3), together with 10 known diterpenes were isolated from the resin of Liquidambar formosana Hance, whose structures were elucidated by detailed analysis on the NMR and HR-ESI-MS spectra.
    Natural product research 08/2013; 28(1). DOI:10.1080/14786419.2013.825915 · 0.92 Impact Factor
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    ABSTRACT: To study the secondary metabolites of a marine-derived fungus Ascotricha sp. ZJ-M-5, several chromatographic methods including macroporous resin, silica gel, ODS and Sephadex LH-20 were used to isolate the compounds, and their structures were elucidated on the basis of physicochemical properties and spectroscopic methods. Ten compounds were obtained and identified as ascotrichic acid B (1), (3R)-6-hydroxymellein (2), beta-carboline (3), (22E, 24R)-ergosta-7, 22-diene-3beta, 5alpha, 6beta-triol (4), (22E, 24R)-ergosta-7, 22-diene-3beta, 5alpha, 6beta, 9alpha-tetraol (5), cyclo (Leu-Pro) (6), cyclo (Ile-Leu) (7), cyclo (Pro-Val) (8), cyclo (Pro-Gly) (9), and cyclo (Hpro-Ala) (10). Among them, compound 1 is a new 3, 4-seco-lanostane triterpenoid which has been isolated from the filamentous fungi for the first time, and compounds 2-10 are firstly isolated from Ascotricha genus.
    Yao xue xue bao = Acta pharmaceutica Sinica 04/2013; 48(1):89-93.
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    ABSTRACT: A new sesquiterpene, ascotrichic acid (1), was isolated from a marine-derived fungus Ascotricha sp., together with the other two known analogues, cyclonerodiol (2) and 10(Z)-cyclonerotriol (3). Its structure was established by spectroscopic methods (1D and 2D NMR, HR-ESI-MS).
    Natural product research 07/2012; 27(9). DOI:10.1080/14786419.2012.711327 · 0.92 Impact Factor
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    ABSTRACT: Two new oleanane triterpenoid saponins, xanthohuskisides A (1) and B (2), were isolated from the husks of Xanthoceras sorbifolia. The structures of these two compounds were established as 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranosyl 16-deoxybarringtogenol C (1) and 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl 16-deoxybarringtogenol C (2), respectively, based on the analysis on their spectral data including NMR and HR-ESI-MS. The growth inhibitory activities of compounds 1 and 2 were assayed, and 2 showed moderate activity against U937 cell line with the IG(50) value of 82.85 ± 1.58 µM.
    Natural product research 03/2012; 27(3). DOI:10.1080/14786419.2012.671316 · 0.92 Impact Factor
  • Zhan-Lin Li · Dan Liu · Dan-Yi Li · Hui-Ming Hua
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    ABSTRACT: A novel prenylated xanthone, caloxanthone Q, was isolated from the stems and leaves of Calophyllum inophyllum. The structure elucidation was carried out by detailed spectroscopic analysis.
    Natural product research 05/2011; 25(9):905-8. DOI:10.1080/14786419.2010.513977 · 0.92 Impact Factor
  • ChemInform 12/2009; 40(49). DOI:10.1002/chin.200949196
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    ABSTRACT: To study the xanthones from the leaves of Calophyllum inophyllum Linn., several chromatography methods were employed to isolate the constituents. Investigation on the CHCl3 extract led to the isolation of a new xanthone named inophyxanthone A (1) and four known compounds, which were pancixanthone A (2), gerontoxanthone B (3), jacareubin (4) and pyranojacareubin (5). Among them, compound 2 was obtained from this plant firstly, and compound 3 was obtained for the first time from this genus. The structure of inophyxanthone A (1) was identified as 1, 3, 5-trihydroxy-2-(1, 1-dimethylallyl)xanthone by spectral analysis.
    Yao xue xue bao = Acta pharmaceutica Sinica 03/2009; 44(2):154-7.
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    ABSTRACT: Three new flavone C-glycosides with the substitution of the unusual acyl, 2''-O-veratroylisoswertisin (1), 3''-O-2-methylbutyrylisoswertiajaponin (2), and 3''-O-2-methylbutyrylvitexin (3), together with the known compounds of 2''-O-2-methylbutyrylisoswertisin (4), 3''-O-2-methylbutyrylisoswertisin (5), and trollisin I (6) were isolated from the antibacterial fraction of the aqueous extract of the flowers of Trollius chinensis. The structural elucidations of these compounds were carried out by a detailed analysis of the NMR and MS spectra.
    Journal of Asian natural products research 02/2009; 11(5):426-32. DOI:10.1080/10286020902877747 · 0.91 Impact Factor
  • Zhan-Lin Li · Dan-Yi Li · Xian Li · Ning Li · Da-Li Meng
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    ABSTRACT: To study the chemical constituents from the husk of Xanthoceras sorbifolia Bunge. Repeated column chromatography on silica gel and preparative TLC were used to isolate the compounds whose structures were elucidated based on spectroscopic data (ESIMS, EIMS, 1D and 2D NMR). A new alkaloid was isolated and identified as: 2-methyl-6-(2', 3', 4'-trihydroxybutyl)-pyrazine (I), along with nine known compounds: cleomiscosin D (II), naringenin (III), eriodictyol (IV), kaempferol (V), quercetin (VI), rutin (VII), 5,7-dihydroxychromone (VIII), tyrosol (IX), 1-O-methyl-myo-inositol (X). Compound I is a new alkaloid, compounds II, IV, V, VII - X were isolated from this genus for the first time.
    Yao xue xue bao = Acta pharmaceutica Sinica 01/2007; 41(12):1197-200.
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    ABSTRACT: To establish the RP-HPLC fingerprint analysis for the quality control of Cortex Periplocae. HPLC fingerprint and analysis method of Cortex Periplocae were studied. Kromasil C18 column (250 mm x 4.6 mm, 5 microm) was used, with mixture of acetonitrile and 0.025% phosphate solution as mobile phase in a gradient mode. The flow rate was 1.0 ml/min. The wavelength of measurement was 220 nm. 15 Batches of Cortex Periplocae were determined. The 15 samples were classified as 4 clusters by cluster analysis and the 6 superior in producing area samples were confirmed to establish the mutual model. The samples' quality was assessed by "Similarity Evaluation System for Chromatographic Fingerprint of TCM 2004". The method is simple and reliable. It can be used to evaluate and control the quality of Cortex Periplocae conveniently.
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 08/2006; 29(7):715-7.