Publications (13)24.86 Total impact
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Article: Relationship of Intraocular Pressure and Frequency of Spontaneous Retinal Venous Pulsation in Primary Open-Angle Glaucoma.
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ABSTRACT: PURPOSE: To investigate the relationship of intraocular pressure (IOP) and the frequency of spontaneous venous pulsation (SVP) in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional study. PARTICIPANTS: A total of 229 eyes of 229 patients with POAG and 205 eyes of 205 glaucoma suspects as a control. METHODS: The SVP was assessed using a confocal scanning laser ophthalmoscope (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany) movie tool. Patients with POAG were divided into 3 groups on the basis of the frequency distribution of untreated IOP: lower tertile (IOP ≤15 mmHg; group A), middle tertile (IOP >15 and ≤21 mmHg; group B), and upper tertile (IOP >21 mmHg; group C). The frequency of SVP was compared between the glaucoma suspects and patients with POAG and among the 3 groups of POAG. Logistic regression analysis was performed to determine the factors associated with the frequency of SVP. MAIN OUTCOME MEASURES: Frequency of SVP in patients with POAG and glaucoma suspects. RESULTS: Spontaneous venous pulsation was more frequently found in glaucoma suspects than in patients with POAG (86.3% vs. 53.3%, P<0.0001). Within the POAG group, the frequency of SVP was significantly lower in group A (40.2%) than in group B (57.3%, P = 0.03) and group C (63.9%, P = 0.003). There was no significant difference between groups B and C (P = 0.42). In addition to IOP (P = 0.007), visual field mean deviation (MD) and refractive error were associated with the frequency of SVP (P<0.0001 and P = 0.011, respectively). When analyzed within the same stage of disease, SVP was less frequently found in group A than in group C in early (P = 0.011) and advanced (P = 0.044) glaucoma and marginally less frequently found in moderate glaucoma (P = 0.080). CONCLUSIONS: Spontaneous venous pulsation was less common in patients with POAG than in glaucoma suspects. Among the patients with POAG, SVP was less common in patients with low IOP at all stages of disease. These results are consistent with vascular factors having a more significant role in patients with POAG with low IOP than in patients with POAG with higher IOP. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.Ophthalmology 09/2012; · 5.45 Impact Factor -
Article: Detection of localized retinal nerve fiber layer defects with posterior pole asymmetry analysis of spectral domain optical coherence tomography.
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ABSTRACT: To investigate the diagnostic ability of posterior pole asymmetry analysis (PPAA) with spectral domain optical coherence tomography (SD-OCT) for detecting localized retinal nerve fiber layer defects (RNFLD). Eighty-four open-angle glaucoma subjects (84 eyes) with localized, wedge-shape RNFLDs by red-free RNFL photography and 122 eyes of healthy subjects were enrolled. The subjects were examined by SD-OCT to obtain circumpapillary RNFL (cpRNFL) thickness as well as PPAA. The PPAA provides a corresponding cell to cell comparison between hemispheres within the central 20° and presents the difference using gray scale. Area under the receiver operating characteristic curve (AUROC) was calculated. The sensitivity and specificity of PPAA to detect glaucoma with the localized defects were also examined using various criteria; two consecutive black cells (criterion A), three consecutive black cells (criterion B), and four consecutive black cells (criterion C). An AUROC of PPAA based on the number of black cells was 0.958 ± 0.013. The sensitivity and specificity of PPAA were 95.2% and 81.1% for criterion A, 83.3% and 92.6% for criterion B, and 69.0% and 98.4% for criterion C, respectively. The sensitivity and specificity of the cpRNFL thickness were 85.7% and 95.1%, respectively. SD-OCT PPAA detects localized RNFLDs with high sensitivity and specificity, which are comparable to the cpRNFL thickness profile of OCT. These findings suggest that the PPAA can be complementary to other tests for diagnosing glaucoma in patients with localized RNFLDs.Investigative ophthalmology & visual science 05/2012; 53(8):4347-53. · 3.43 Impact Factor -
Article: Antituberculosis medication as a possible epigenetic factor of Leber's hereditary optic neuropathy.
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ABSTRACT: To investigate if antituberculosis medication including ethambutol could be a possible epigenetic factor in visual loss in Leber's hereditary optic neuropathy (LHON). The authors reviewed the medical records of 46 patients registered at Bundang Seoul National University Hospital from 2002 to 2006, who developed the typical clinical neuro-ophthalmologic features of LHON and possessed a mtDNA mutation at nucleotide 11778, 14484, 3460 or 4171. Three of the 46 patients developed visual loss while taking antituberculosis medication. These three patients had the mtDNA 11778 mutation with a mean age of 32.7 years at the onset of visual loss, whereas the mean age of other 43 patients was 21.2 years. One of these three patients was female. Antituberculosis medication may be an epigenetic factor of LHON in patients with a primary LHON mutation. This risk should be recognized by physicians and LHON carriers.Clinical and Experimental Ophthalmology 05/2010; 38(4):363-6. · 1.98 Impact Factor -
Article: Effects of white-to-white diameter and anterior chamber depth on implantable collamer lens vault and visual outcome.
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ABSTRACT: To investigate the effects of anterior chamber depth (ACD) and white-to-white (WTW) diameter on vault in eyes with implantable collamer lenses (ICL V4, STAAR Surgical AG) and to evaluate the effect of vault on visual outcomes and other biometric changes. Twenty-eight eyes of 16 patients who underwent ICL implantation were retrospectively reviewed. Patients were divided into two groups (A1, A2) according to preoperative ACD (> or = 3.3 mm and < 3.3 mm, respectively), two groups (B1, B2) based on WTW diameter (> or = 11.55 mm and < 11.55 mm, respectively), and two groups (C1, C2) according to the difference of ICL diameter and sulcus length (> or = 0.25 mm and < 0.25 mm, respectively). Vault, endothelial cell density, and visual performance were compared between each set of groups. Correlations of vault with WTW diameter, ACD, and diametric difference of the ICL from the sulcus were analyzed. The high ACD and WTW groups showed significantly higher vaults (0.59 +/- 0.32 mm and 0.57 +/- 0.36 mm, respectively) than the low ACD and WTW groups (0.26 +/- 0.17 mm and 0.25 +/- 0.14 mm, respectively; P = .01 and .01), whereas the differences of diameter between the sulcus and ICL were not related to significant vault differences. The WTW diameter wascorrelated more closely to the vault than the ACD or sulcus diameter (r = 0.70, P < .001), whereas the vault difference did not affect visual quality or endothelial cell density. A high WTW diameter or ACD is likely to render a high vault, regardless of any difference in the ICL and sulcus diameters.Journal of refractive surgery (Thorofare, N.J.: 1995) 09/2009; 25(8):730-8. · 2.54 Impact Factor -
Article: Assessment of functional vision score and vision-specific quality of life in individuals with retinitis pigmentosa.
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ABSTRACT: To determine the relationship between the American Medical Association's (AMA) functional vision score (FVS) and vision-specific quality of life in retinitis pigmentosa (RP) patients using the National Eye Institute's Visual Functioning Questionnaire (NEI-VFQ 25). One hundred eight patients with RP participated in the study. We measured best-corrected visual acuity, conducted Goldmann perimetry, and collected the self-reported NEI-VFQ 25. The FVS was calculated using the functional field score (FFS) and the functional acuity score (FAS). The correlations of the VFQ composite scores to the FVS, FFS, and FAS were determined using correlation and regression analyses. FVS was highly correlated to the BCVA (r=0.69, p<0.001), the FFS (r=0.86, p<0.001) and the FAS (r=0.73, p<0.001). Significant correlations of the VFQ composite score to the BCVA (r=0.60, p<0.001), FFS (r=0.44, p<0.001), FAS (r=0.60, p<0.001), FVS (r=0.58, p<0.001) were also found. However, the correlation strengths of BCVA, FVS, FAS, and FFS to NEI-FVQ were not different. In RP patients, the vision-specific quality of life was correlated with the AMA guidelines' FVS, FFS, and FAS. Their correlation degrees to NEI-FVQ were not different. This result suggests that vision-specific quality of life can be explained by both visual acuity and visual field in RP patients.Korean Journal of Ophthalmology 09/2009; 23(3):164-8. -
Article: A case of Vogt-Koyanagi-Harada disease in a patient with Graves disease.
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ABSTRACT: A case of Vogt-Koyanagi-Harada disease (VKH) that developed in a 36-year-old woman with Graves' disease was described. The patient was treated with Lugol's solution and presented with bilateral serous retinal detachment. She had also suffered from methimazole-induced hypersensitivity and steroid-induced myopathy. Fluorescein angiography showed multiple leakage points and a lumbar puncture revealed pleocytosis, which was compatible with VKH. High dose steroid pulse therapy was successful. Altered immune regulation associated with drug-induced hypersensitivity may contribute to the development of VKH in patients with Graves' disease.Korean Journal of Ophthalmology 07/2009; 23(2):112-3. -
Article: A case of carotid aneurysm in familial retinal arterial tortuosity.
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ABSTRACT: A 44-year-old woman who showed recurrent vitreous hemorrhages with vascular tortuosity received CT angiography which revealed an internal carotid artery aneurysm. A case of internal carotid aneurysm was associated with a pattern of retinal arteriolar tortuosity pathognomic for familial retinal arterial tortuosity (fRAT), suggesting possible involvement of the cerebral circulation. We present a case of internal carotid aneurysm associated with a pattern of retinal arteriolar tortuosity pathognomic for fRAT.Korean Journal of Ophthalmology 04/2009; 23(1):57-8. -
Article: Influence of persistent submacular fluid on visual outcome after successful scleral buckle surgery for macula-off retinal detachment.
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ABSTRACT: To determine the influences of the extent and duration of persistent submacular fluid on final visual outcome after successful scleral buckle surgery for acute macula-off rhegmatogenous retinal detachment (RD). Prospective observational case series. Forty-four consecutive patients (44 eyes) who underwent successful scleral buckle surgery for macula-off rhegmatogenous RD were enrolled patients underwent thorough ophthalmologic tests including best-corrected visual acuity (BCVA) assessments and optical coherence tomography (OCT) at one, three, six, nine, and 12 months postoperatively, until at least six months after the disappearance of subretinal fluid (SRF). Patients with persistent submacular fluid one month after surgery were assigned to group A and those without submacular fluid, to group B. In group A, patients whose submacular fluid disappeared before six months were assigned to group A1; the others, to group A2. The natural course of persistent SRF and associations between the extent and duration of SRF and postoperative BCVA were investigated. Twenty-three eyes (52.3%) were in group A and 21 eyes (47.7%) in group B. Twelve eyes (52.2%) were in group A1 and 11 eyes (47.8%) in group A2. SRF disappeared within 12 months after surgery without reoperation in all patients. No significant differences in final visual acuity (VA) were found among groups A, B, A1, and A2. Final VA was not found to be associated with SRF extent or duration. The presence and extent of submacular fluid after successful scleral buckle surgery for acute macula-off rhegmatogenous RD did not influence final VA or anatomic attachment.American Journal of Ophthalmology 06/2008; 145(5):915-22. · 4.22 Impact Factor -
Article: Differences in the histopathology and matrix metalloproteinase expression in Tenon's tissue of primary open-angle glaucoma and primary angle-closure glaucoma.
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ABSTRACT: To investigate the differences in the histopathology and matrix metalloproteinase (MMP) expression in the Tenon's tissue of primary open-angle glaucoma (POAG) patients, primary angle-closure glaucoma (PACG) patients, and non-glaucomatous patients. POAG and PACG patients, who underwent a trabeculectomy and had no history of ocular disease except glaucoma, were enrolled. The number and instillation period of topical eye drops were reviewed. For the controls, which were patients without glaucoma or a history of ocular surgery, the Tenon's tissue was obtained in the course of retinal detachment surgery. For glaucoma patients, the Tenon's tissue was obtained during the trabeculectomy. H&E and Masson's trichrome staining and immunohistochemistry for MMP-1, MMP-2, and MMP-9 were performed. A total of six eyes of POAG, six eyes of PACG, and four control eyes were evaluated. The duration of topical anti-glaucoma medication and the mean number of anti-glaucoma medications were similar in the POAG and PACG groups. The levels of MMP-1 and 2 were elevated in the POAG and PACG groups compared to the control group (p=0.03, 0.01, respectively). Compared with the control group, the MMP-2 level was higher in the POAG patients (p=0.01), whereas the MMP-1 was higher in the PACG patients (p=0.04). The levels of MMP-9 in the POAG and PACG patients were not significantly different from that of the control patients (p=0.48, 0.26). The levels of MMP-2 were significantly lower in the PACG patients than in the POAG patients (p=0.02). The MMP expression was altered in the Tenon's tissue of glaucoma patients compared to the control group. The levels of MMP-2 were lower in the PACG patients than in the POAG patients. These results suggest that there may be histopathological differences in the Tenon's tissue of POAG and PACG patients.Korean Journal of Ophthalmology 04/2008; 22(1):37-42. -
Article: Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism.
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ABSTRACT: To develop a new foveal hypoplasia grading system using optical coherence tomography (OCT) and to determine the correlations of visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades, respectively, in young albinism patients. Observational case series. Thirteen patients who were clinically diagnosed with oculocutaneous albinism. The authors obtained refraction and correction for participants, who then underwent anterior segment photography and fundus photography. Foveal hypoplasia was evaluated using a fast macular cross-hair scan with StratusOCT (Carl Zeiss Meditec, Dublin, CA). The authors developed a new grading system based on foveal hyporeflectivity, the degree of choroidal transillumination, the presence of the tram-tract sign, and foveal depression as determined from OCT images. Correlations of Snellen visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades were calculated, and areas under receiver operating characteristic curves (AROCs) were measured to evaluate the predictive value of foveal hypoplasia grading using OCT. The AROCs of foveal hypoplasia grading by OCT. Thirteen patients were enrolled. Correlations of visual acuity to the iris transillumination (P<0.001), macular transparency (P = 0.014), and foveal hypoplasia (P = 0.004) grades were significant. The AROC values for foveal hypoplasia measurement by OCT, iris transillumination, and macular transparency measurements were 0.98, 0.91, and 0.87, respectively. The prognostic value of foveal hypoplasia as assessed by OCT in young patients with albinism is superior to grades based on iris transillumination or macular transparency.Ophthalmology 08/2007; 114(8):1547-51. · 5.45 Impact Factor -
Article: Effect of base curve radius of therapeutic lenses on epithelial healing after laser-assisted subepithelial keratectomy.
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ABSTRACT: To determine the effect of the base curve radius (BCR) of therapeutic soft contact lens (T-lens) on epithelial healing after laser-assisted subepithelial keratectomy (LASEK). Ninety-two eyes in 47 patients with myopia were prospectively evaluated after LASEK. All the patients wore T-lenses with the BCR (R1) randomly chosen after LASEK. The T-lenses were removed after complete healing of the epithelial wounds. We calculated an estimated BCR (R2) from postoperative topography using a diopter conversion table. The patients were divided into two groups according to the differences between the BCR (R1) and the estimated BCR (R2). The flat fitting group was R1 > R2 (Group A), and the steep fitting group was R1<R2 (Group B). Patient's age, epithelial healing time, ablation amount, and BCR were compared between these two groups. Group A (R1>R2) had 53 eyes, and Group B (R1<R2) had 39 eyes. Group A showed a shorter epithelial healing time than Group B (5.8+/-1.7 days vs. 6.7+/-2.1 days, p=0.04). The flat fitting group showed a shorter epithelial healing time than the steep fitting group after LASEK.Korean Journal of Ophthalmology 06/2007; 21(2):85-9. -
Article: Comparison of localized retinal nerve fiber layer defects between a low-teen intraocular pressure group and a high-teen intraocular pressure group in normal-tension glaucoma patients.
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ABSTRACT: To compare the features of localized retinal nerve fiber layer (RNFL) defects between a low-teen intraocular pressure (IOP) group and a high-teen IOP group in normal-tension glaucoma (NTG) patients. Seventy-seven eyes of 77 NTG patients showing localized RNFL defects on RNFL photographs and corresponding visual filed defects at the initial visit to a glaucoma specialist were selected for this study. Patients with range of diurnal IOP within low-teen or high-teen in both eyes were included. All participants completed refraction, diurnal IOP measurement, central corneal thickness (CCT) measurement, stereoscopic disc photography, RNFL photography, and automated perimetry. On RNFL photograph, approximation of the defect to the macula (angle alpha) and width of the defects (angle beta) were measured to represent RNFL defects. The patients were divided into 2 groups according to the level of IOP. A low-teen group had highest IOP of <or=15 mm Hg (group A) and a high-teen group had lowest IOP of >15 mm Hg (group B). Age at diagnosis, percentage of male patients, systemic disease, refraction, CCT, highest IOP, angle alpha, angle beta, and mean deviation and pattern standard deviation of visual field were compared between the 2 groups. Age at diagnosis of NTG, age distribution, percentage of male patients, systemic disease, spherical equivalent of refraction, CCT, mean deviation, and pattern standard deviation were not different between the 2 groups. Highest IOP was 13.8+/-1.2 mm Hg in group A and 19.2+/-1.4 mm Hg in group B (P<0.001). Angle alpha was significantly smaller in group A than in group B (37.0+/-14.0 vs. 56.5+/-21.2 degrees, P<0.001), whereas angle beta was not different between the 2 groups (39.9+/-17.9 vs. 37.5+/-15.9 degrees, P=0.54). There were no significant correlations between spherical equivalent and angle alpha (r=-0.03, P=0.82), between spherical equivalent and angle beta (r=-0.04, P=0.74), and between angle alpha and angle beta (r=-0.21, P=0.07). Localized RNFL defect was closer to the center of the macula in group A than in group B, whereas width of defects was not different between the 2 groups. These findings provide indirect evidence to suggest that more than one pathogenic mechanism may exist in the development of RNFL defects in NTG.Journal of Glaucoma 05/2007; 16(3):293-6. · 1.78 Impact Factor -
Article: Early versus late intravitreal triamcinolone acetonide for macular edema associated with branch retinal vein occlusion.
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ABSTRACT: To compare the effect of early versus late intravitreal injection of triamcinolone in patients with macular edema due to branch retinal vein occlusion (BRVO). Twenty eyes of 20 patients with macular edema from BRVO, including 10 with duration after onset of or <or= 3 months and 10 with duration of 3 months, were treated using a single intravitreal triamcinolone injection (4 mg/0.1 ml). Best-corrected visual acuity and foveal thickness by optical coherence tomography were measured 1, 3, and 6 months post-injection. In patients that received treatment after a disease duration of <or= 3 months, visual acuity and foveal thickness significantly improved from baseline over 6 months of follow-up. However, in those with a duration of >3 months, improvements in visual acuity and foveal thickness, though apparent at 1 month, were not maintained at 3 and 6 months post-triamcinolone. Intravitreal triamcinolone is more effective in patients with BRVO who are treated earlier.Korean Journal of Ophthalmology 03/2007; 21(1):18-20.
Top co-authors
Top Journals
Institutions
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2012
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Seoul National University Bundang Hospital
Seoul, Seoul, South Korea
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2007–2012
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Seoul National University Hospital
Seoul, Seoul, South Korea
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2009
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Seoul National University
- Department of Ophthalmology
Seoul, Seoul, South Korea
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