Takao Enomoto

Publications (17)24.16 Total impact

• Source

  Available from: brainlife.org

  Article: Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma - three case reports - .

  Noriaki Sakamoto, Eiichi Ishikawa, Tetsuya Yamamoto, Kaishi Satomi, Kei Nakai, Masayuki Sato, Takao Enomoto, Yukio Morishita, Shingo Takano, Tadao Ohno, Koji Tsuboi, Akira Matsumura
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  ABSTRACT: Temozolomide (TMZ), an alkylating agent widely used for patients with glioblastoma multiforme (GBM), has the potential to enhance the acquired immune response to GBM. Here, we describe 3 cases of GBM patients treated with autologous formalin-fixed tumor vaccine (AFTV) combined with TMZ. All cases demonstrated pathological changes associated with the therapy. After a 4-week break from the standard initial treatments, 1 patient with primary GBM and 2 patients with secondary GBM received adjuvant TMZ for 5 days combined with AFTV injection and were subsequently treated with multiple cycles of adjuvant TMZ for 5 days every 28 days (AFTV/TMZ therapy). Adverse effects related to AFTV plus TMZ were very minor in all patients. Magnetic resonance imaging revealed partial response in 2 patients. CD3(+)CD8(+) lymphocytes were frequently detected in surgical specimens and MIB-1 labeling index in 2 cases decreased after AFTV/TMZ therapy. AFTV/TMZ therapy is suitable for larger scale clinical trials.
  Neurologia medico-chirurgica 01/2011; 51(4):319-25. · 0.61 Impact Factor
• Source

  Available from: tsukuba.ac.jp

  Article: Percutaneous transesophageal gastrotubing: alternative tube nutrition for a patient with a ventriculoperitoneal shunt.

  Tetsuya Yamamoto, Takao Enomoto, Akira Matsumura
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  ABSTRACT: We report a patient who underwent percutaneous transesophageal gastrotubing (PTEG), that is, nonsurgical esophagostomy under ultrasonographic control, as an alternative to percutaneous endoscopic gastrostomy (PEG). The PTEG was placed for shunt protection from inadvertent infection in a 29-year-old male patient in whom a ventriculoperitoneal (VP) shunt had previously been inserted. During the 3-year follow-up period, no complications associated with PTEG were experienced. Percutaneous transesophageal gastrotubing is a good alternative to PEG in a patient with a VP shunt. Further investigation concerning the risk of infection related to PTEG and PEG in VP shunt patients is needed.
  Surgical Neurology 08/2008; 72(3):278-9; discussion 280. · 1.67 Impact Factor
• Article: Clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients.

  Eiichi Ishikawa, Koji Tsuboi, Tetsuya Yamamoto, Ai Muroi, Shingo Takano, Takao Enomoto, Akira Matsumura, Tadao Ohno
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  ABSTRACT: A pilot study was performed to investigate the safety and feasibility of autologous formalin-fixed tumor vaccines (AFTV) and the clinical responses to these vaccines by glioblastoma multiforme (GBM) patients. Twelve primary GBM patients were recruited. Eight had recurrent disease while four had been treated for primary disease but retained a visible tumor mass. AFTV were prepared from formalin-fixed and/or paraffin-embedded tumor tissue obtained upon surgery and premixed with original adjuvant materials. The patients were given three five-site intradermal inoculations at weekly intervals. A delayed-type hypersensitivity test was performed before and after each vaccination. In addition, the tumor tissues were subjected to immunohistochemical analysis to determine whether MIB-1, p53, and major histocompatibility complex (MHC) class-I complex expression could predict the response to the treatment. The treatment was well tolerated, with only local erythema, induration, and low-grade fever being reported. Of the 12 patients, one showed a complete response, one showed a partial response, two showed minor responses, one had stable disease, and seven exhibited progressive disease. The median survival period was 10.7 months from the initiation of the AFTV treatment but three of the five responders survived for 20 months or more after AFTV inoculation. Low p53 and high MHC class-I expression by the tumor may help predict the efficacy of this therapy. Thus, the AFTV is safe and feasible, and could significantly improve the outcome of GBM. Further clinical investigations to confirm this are highly desirable.
  Cancer Science 09/2007; 98(8):1226-33. · 3.33 Impact Factor
• Article: Endoscopic observation of pathophysiology of ventricular diverticulum.

  Satoru Osuka, Shingo Takano, Takao Enomoto, Eiichi Ishikawa, Koji Tsuboi, Akira Matsumura
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  ABSTRACT: BACKGROUND: Although there have been reports dealing with ventricular diverticulum (VD) analyzed by cisternography and computed tomography (CT), those focusing on magnetic resonance imaging (MRI) or neuroendoscopic findings are rare. CASE REPORT: We present a case of noncommunicating hydrocephalus caused by aqueductal stenosis with cystic lesion located in supracerebellar region. Third ventriculostomy was performed on this case. The conventional CT and MRI were compatible with usual VD, but neuroendoscopic examination suggested otherwise. The endoscopic view inside of the cystic lesion demonstrated passing veins and no membrane. We diagnosed this cystic lesion as a unique subtype of advanced VD mimicking spontaneous ventriculostomy. Endoscopic observation of the cyst was very useful for accurate diagnosis and safe treatment.
  Child s Nervous System 09/2007; 23(8):897-900. · 1.54 Impact Factor
• Article: Reversible holocord edema associated with intramedullary spinal abscess secondary to an infected dermoid cyst.

  Takao Tsurubuchi, Akira Matsumura, Kei Nakai, Keishi Fujita, Takao Enomoto, Nobuaki Iwasaki, Tadao Nose
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  ABSTRACT: We report a case of a holocord high-intensity lesion extending from L1 up to the medulla oblongata on T2-weighted spinal magnetic resonance imaging (MRI) associated with an intramedullary spinal abscess secondary to an infected dermoid cyst. The intraoperative findings revealed that the high-intensity lesion on the T2-weighted image was edematous tissue. The MRI change in the spinal cord gradually improved in response to the use of postoperative antibiotics. The change was considered to represent reversible inflammatory changes, as there was no neurological deficit found at the cervical level and it resolved after surgery and medical treatment. The pathomechanism is discussed herein.
  Pediatric Neurosurgery 01/2003; 37(6):282-6. · 0.70 Impact Factor
• Article: Semitransparent meningocele at the occipital region.

  Ai Muroi, Takao Enomoto, Eiichi Ishikawa, Kiyoyuki Yanaka, Tadao Nose
  Journal of Pediatrics 09/2002; 141(2):294. · 4.11 Impact Factor
• Article: Myelopathy caused by tics in an adolescent, associated with T2 signal intensity changes of the spinal cord.

  Ai Muroi, Akira Matsumura, Hiroyuki Asakawa, Takao Enomoto, Nobuaki Iwasaki, Tadao Nose
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  ABSTRACT: A 15-year-old boy who had suffered motor tics since age 9 developed progressive cervical myelopathy involving both his hands and his lower extremities. T2-weighted MRI revealed mild canal stenosis and increased signal intensity in the cervical spinal cord beginning at the C-4 level and continuing upward to the medulla oblongata. After C-3 to C-7 laminoplasty, the patient's clinical symptoms improved. It is possible that movement disorders such as tics may contribute to the development of cervical myelopathy owing to the effects of involuntary movements on the neck. Such an intensity change on a T2-weighted image has never been reported in an adolescent tic disorder. Despite such changes, surgical treatment may bring about clinical improvement.
  Child s Nervous System 05/2002; 18(3-4):191-4. · 1.54 Impact Factor
• Article: Moyamoya disease associated with hemophilia A. Case report.

  Masahide Matsuda, Takao Enomoto, Kiyoyuki Yanaka, Tadao Nose
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  ABSTRACT: A 10-year-old boy who had been diagnosed as having hemophilia A presented with episodes of transient ischemic attack. Cerebral angiography showed occlusions of the bilateral anterior cerebral arteries and the right middle cerebral artery with the development of an abnormal vascular network. The patient was diagnosed as having moyamoya disease associated with hemophilia A and subsequently underwent multiple burr hole surgery for revascularization under sufficient factor VIII supplementation. He remained asymptomatic after surgery, and follow-up cerebral angiography 5 months after the operation demonstrated significant neovascularization through the burr holes. Multiple burr hole surgery is proposed as a method of choice for the treatment of moyamoya disease associated with a bleeding tendency.
  Pediatric Neurosurgery 04/2002; 36(3):157-60. · 0.70 Impact Factor
• Article: Crouzon disease associated with sinus pericranii: a report on identical twin sisters

  Susumu Yasuda, Takao Enomoto, Yuzou Yamada, Tadao Nose, Nobuaki Iwasaki
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  ABSTRACT: Crouzon disease is a form of craniosynostosis with the autosomal dominant mode of inheritance. Among the anomalies associated with craniosynostosis, aberrant dural sinus is well known. We report on identical twin sisters with Crouzon disease and sinus pericranii who were successfully treated surgically. In one of the sisters hydrocephalus was present, which eventually needed a shunt operation. The association of these anomalies is discussed.
  Child s Nervous System 03/1993; 9(2):119-122. · 1.54 Impact Factor
• Article: Reversible porencephaly

  Koichi Sugimoto, Takao Enomoto, Tadao Nose
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  ABSTRACT: The cases of four infants (five lesions) are reported, where porencephalic cysts, located along the ventricular catheter after shunt malfunction and ommaya reservoir insertion, disappeared after ventriculoperitoneal (VP) shunt revision and combined cyst peritoneal (CP) shunt, or after VP shunt alone. This pathological state is thought to be a rare postoperative complication. Its pathogenesis and therapy are discussed. Shunt malfunction or Ommaya reservoir insertion may result in a hypertensive hydrocephalic state. Cerebrospinal fluid (CSF) flows out through a catheter penetrating the site of the ventricular wall and expands in the surrounding white matter to form a porencephalic cavity. Once this porencephalic state occurs, it will not disappear spontaneously because the CSF flows in one direction. As treatment for closed porencephaly, CP shunt following a VP shunt revision was markedly effective; for communicating porencephaly, a VP shunt revision alone was effective.
  Child s Nervous System 10/1991; 7(7):394-398. · 1.54 Impact Factor
• Article: Postinflammatory arachnoid cyst of the quadrigeminal cistern

  Kiyoyuki Yanaka, Takao Enomoto, Tadao Nose, Yutaka Maki
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  ABSTRACT: Arachnoid cysts of the quadrigeminal cistern are rare. Patients with this lesion are usually normal at birth, and signs of increased intracranial pressure (IICP) develop at about 4 to 12 months of age. However, there has been no report about this mechanism. A case of arachnoid cyst of the quadrigeminal cistern is presented. In this case, the process of the cyst growth was observed during the course of follow-up for shunted hydrocephalus. Symptoms coincided with the growth of the cyst. Therefore, the development of the clinical symptoms was thought to be due to IICP caused by cyst expansion. Our case was complicated by inflammation, something that may offer a key to solving the mechanism of cyst fluid accumulation and the relationship between symptoms and development of the cyst.
  Child s Nervous System 09/1988; 4(5):302-305. · 1.54 Impact Factor
• Article: Moyamoya disease

  Yutaka Maki, Takao Enomoto
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  ABSTRACT: The authors reviewed the Japanese literature on moyamoya disease. In the article we discuss the history of such investigations in Japan, the signs and symptoms, the diagnosis (especially concerning diagnostic criteria and magnetic resonance imaging), the pathology in relation to its etiology, and the current methods of treatment. On the whole, the main aim of the paper was to introduce our concept of moyamoya disease that is now current in Japan.
  Child s Nervous System 07/1988; 4(4):204-212. · 1.54 Impact Factor
• Article: A case of porencephaly associated with aneurysm

  Osamu Higuchi, Takao Enomoto, Tadao Nose, Yutaka Maki
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  ABSTRACT: A case of aneurysm of the middle cerebral artery with congenital porencephaly in the same region is reported. The cyst was opened and the aneurysm was wrapped with a muscle strip. The resected specimen of the cyst wall contained a parenchymal layer with hemosiderinladen macrophages. It is speculated that bleeding from the aneurysm during the perinatal period caused the porencephaly.
  Child s Nervous System 12/1986; 3(1):44-46. · 1.54 Impact Factor
• Article: Electroencephalography in minor head injury in children

  Takao Enomoto, Yukio Ono, Tadao Nose, Yutaka Maki, Keiichi Tsukada
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  ABSTRACT: EEG and CT scans of 280 cases of minor head injury in children under 15 years of age were studied. Abnormality on initial EEG was shown in 42.5%. Those who lost consciousness had a higher incidence of abnormality than those who did not, and it was higher between 4 and 13 years of age. The sleep state has much influence on the finding. The patients should be awake or in a light sleep stage. The most frequent abnormality was slow waves, seen predominantly in the occipital regions, and which tended to disappear more easily than the paroxysmal ones. The EEGs became or remained normal in 95%, excluding incompletely followed-up cases. There was no case of post-traumatic epilepsy in our series, but 4 cases of post-traumatic early convulsions, in which the EEGs were variable. CT scan disclosed abnormality in 6%.
  Child s Nervous System 05/1986; 2(2):72-79. · 1.54 Impact Factor
• Article: Computed Tomography in von Recklinghausen’s Disease

  Yutaka Maki, Takao Enomoto, Tadao Nose, Hiroshi Maruyama, Kihei Maekawa
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  ABSTRACT: Though we knew it would be difficult to predict whether a child having von Recklinghausen’s disease would develop a central nervous system lesion in the future, we tried to find a clue to this question in our study, by comparing computed tomography (CT) findings of 18 children with those of 21 adults. 55% of the children and 85% of the adults showed abnormal findings on CT. The most common finding was mild ventricular dilatation without periventricular hypodensity. Some of them showed ventricular stasis without block on radioisotope cisternography.
  Pediatric Neurosurgery 08/1970; 8(6):452-460. · 0.70 Impact Factor
• Article: Multimodality examination for detection of the epileptic foci with special reference to endovascular EEG recording

  Takao Enomoto, Akira Matsumura, Yuji Matsumaru, Kazuyasu Aoki, Tadao Nose
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  ABSTRACT: We started to record cerebral electrical activity from the guide wire introduced into the cerebral vessels during angiography in the patients with epilepsy in 1993, as one of the multimodalities for detecting epileptic foci. It was effective in detecting the epileptogenic activity especially from deep structures of the brain, and on a whole, it was contributory to 87% of all the tracings. However, it was not fruitful in five cases (13%), all of which had a lesion in the convexity. We have experienced complications in two cases, both of which were treated leaving no sequela.
  International Congress Series 1232:655-660.
• Article: Localization of focus in intractable epilepsy with pharmacological (bemegride) SPECT and pharmacological functional MRI

  Akira Matsumura, Takao Enomoto, Takashi Yoshizawa, Izumi Anno, Tomonori Isobe, Ayataka Fujimoto, Shigeru Muraki, Tadao Nose
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  ABSTRACT: The exact localization of the epileptic focus in intractable epileptic patients is essential, when they are candidates for focus resection. There have been various methods to localize epileptic focus such as electroencephalograph (EEG) mapping, magnetoencephalography (MEG), positron emission tomography (PET), single photon emission tomography (SPECT) and, recently, functional magnetic resonance imaging (f-MRI). Here, we report the visualization of the focus in a case of intractable epilepsy using SPECT and f-MRI with bemegride loading and discuss the merit of such methods. They are thought to be useful in demonstrating the epileptic focus in selected cases supplementary to other modalities to prove the epileptic focus.
  International Congress Series.