Publications (21)27.23 Total impact
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Article: [Limonoids from fruits of Melia toosendan].
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ABSTRACT: To study the chemical constituents of the fruits of Melia toosendan, three limonoids were isolated and purified by repeated silica gel column chromatography and preparative HPLC from the EtOAc extract of M. toosendan. Their structures were determined by their physico-chemical properties and spectroscopic data (1D-NMR, 2D-NMR) as: 24, 25, 26, 27-tetranorapotirucalla-(apoeupha)-1alpha-tigloyloxy-3alpha, 7alpha-dihydroxyl-12alpha-acetoxyl-14, 20, 22-trien-21, 23-epoxy-6, 28-epoxy (1), nimbolinin B (2), and trichilinin D (3), separately. Compound 1 is a new compound, and compound 2 is obtained from this plant for the first time.Yao xue xue bao = Acta pharmaceutica Sinica 04/2010; 45(4):475-8. -
Article: Protolimonoids from Melia toosendan.
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ABSTRACT: Toosendanone A (1), a new euphane (tirucallane)-type triterpene bearing a five-membered ring in the side chain and the first cyclopentanyl protolimonoid, was isolated from the bark of Melia toosendan, along with two new tirucallanes, toosendanic acids A (2) and B (3). The structure and absolute configuration of compound 1 was elucidated by spectroscopic data interpretation and X-ray diffraction analysis. Compounds 1-3 were evaluated for cytotoxicity against a small panel of cancer cell lines.Journal of Natural Products 05/2009; 72(5):917-20. · 3.13 Impact Factor -
Article: [Studies on bioactive constituents of whole herbs of Vernonia cinerea].
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ABSTRACT: To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model. The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods. Four compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated. Compounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 09/2008; 33(16):1986-8. -
Article: [Structure modification on sesquiterpene lactones from Elephantopus scaber].
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ABSTRACT: In order to look for lower toxic and strongly active compounds, the structure of sesquiterpene lactones from Elephantopus scaber was modified. Deoxyelephantopin and scabertopin were isolated from the whole plant of Elephantopus scaber and hydrogenated and epoxidated. Five sesquiterpenoide derivatives were prepared and their structures were identified by IR, NMR and MS spectra analysis. Four sesquiterpenoides are new compounds. Part of the compounds show definite antitumor activity.Yao xue xue bao = Acta pharmaceutica Sinica 12/2007; 42(11):1159-61. -
Article: Minor limonoids from Melia toosendan and their antibacterial activity.
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ABSTRACT: In this study five new limonoids, toosendone [24,25,26,27-tetra-nor-6alpha-acetoxy-21,22-epoxy-7alpha-tigloyl-1alpha,3alpha,28-trihydroxyapotirucalla-(apoeupha)-14,20,22-trien-12-one, 1] and 12-ethoxynimbolinins A-D (2-5), together with five known limonoids, 1-acetyltrichilinin (6), 1-cinnamoyltrichilinin (7), trichilinin B (8), 1,7-di-O-acetyl-14,15-deoxyhavanensin (9) and 12-O-methylnimbolinin B (10),were isolated from the fruits of Melia toosendan. Their structures and relative configurations were established based on spectroscopic analysis. Compound 4 exhibited significant antibacterial activity against the oral pathogen, Porphyromonas gingivalis ATCC 33 277, with an MIC value of 15.6 microg/mL. Compounds 7 and 8 were also active against P. gingivalis ATCC 33 277, with MIC values of 31.3 and 31.5 microg/mL respectively.Planta Medica 11/2007; 73(12):1298-303. · 2.15 Impact Factor -
Article: Antibacterial diterpenoids from Sagittaria pygmaea.
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ABSTRACT: There were five new diterpenoids, 18-beta-D-3',4'-diacetoxyxylopyranosyl-ent-kaur-16-ene (1), 18-beta-L-3',5'-diacetoxyarabinofuranosyl-ent-kaur-16-ene (2), 18-beta-D-3',6'-diacetoxyglucopyranosyl-ent-kaur-16-ene (3), ent-isopimar-8(14),15-dien-19-oic acid (4), and 5alpha-hydroxy-ent-rosa-15-en-18-oic acid (5), isolated from the whole herb of Sagittaria pygmaea. Their structures and relative configurations were established based on spectroscopic studies, chemical methods, and X-ray crystallographic analysis. Compound 2 exhibited significant antibacterial activity against the oral pathogens, Streptococcus mutans ATCC 25 175 and Actinomyces viscosus ATCC 27 044, with MIC values against both pathogens of 15.6 microg/mL. Compound 3 was active against only A. viscosus ATCC 27 044 with an MIC value of 62.5 microg/mL. Compounds 4 and 5 were active against S. mutans ATCC 25 175 and A. viscosus ATCC 27 044, with MIC values against both pathogens of 125.0 microg/mL.Planta Medica 02/2007; 73(1):84-90. · 2.15 Impact Factor -
Article: ent-rosane and labdane diterpenoids from Sagittaria sagittifolia and their antibacterial activity against three oral pathogens.
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ABSTRACT: Seven new ent-rosane diterpenoids, sagittines A-G (1-7), together with one new labdane diterpene, 13-epi-manoyl oxide-19-O-alpha-l-2',5'-diacetoxyarabinofuranoside (8), were isolated from the whole plant of Sagittaria sagittifolia. The structures and relative configurations of 1-8 were characterized using spectroscopic means, chemical methods, and X-ray crystallography. Compounds 1-4 exhibited antibacterial activity against the oral pathogens Streptococcus mutans ATCC 25175 and Actinomyces naeslundiis ATCC 12104, with MIC values between 62.5 and 125 microg/mL. Compound 5 was active against only A. naeslundiis ATCC 12104, with an MIC value of 62.5 microg/mL.Journal of Natural Products 03/2006; 69(2):255-60. · 3.13 Impact Factor -
Article: Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata.
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ABSTRACT: Three new diterpenoids, yuexiandajisu D (1), E (2) and F were isolated from the roots of Euphorbia ebracteolata, along with eight known diterpenoids, jolkinolide B (4), jolkinolide A, ent-11alpha-hydroxyabieta-8(14),13(15)-dien-16,12alpha-olide (6), ent-(13S)-hydroxyatis-16-ene-3,14-dione, ent-3beta,(13S)-dihydroxyatis-16-en-14-one, ent-3-oxokaurane-16alpha,17-diol, ent-16alpha,17-dihydroxyatisan-3-one and ent-atisane-3beta,16alpha,17-triol. The structures of all compounds were deduced using spectroscopic methods and confirmed for 1 and 2 by single-crystal X-ray diffraction. A biogenetic pathway for the formation of 1 and 2 is proposed briefly. Cytotoxic activities were evaluated against ANA-1, B 16 and Jurkat tumor cells. Jolkinolide B (4) displayed modest activity on ANA-1, B 16 and Jurkat tumor cells with IC50 values 4.46 x 10(-2), 4.48 x 10(-2), 6.47 x 10(-2) microM, and ent-11alpha-hydroxyabieta-8(14),13(15)-dien-16,12alpha-olide (6) showed significant activity against ANA-1 and Jurkat cells with IC50 values 7.12 x 10(-3) and 1.79 x 10(-2) microM. Compound 1 was found to be slightly active against ANA-1 cells with an IC50 value 2.88 x 10(-1)microM. Structure-activity relationships of isolated compounds are also discussed.Planta Medica 05/2005; 71(4):349-54. · 2.15 Impact Factor -
Article: Two compounds from Peucedanum dissolutum.
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ABSTRACT: A new compound, 3'(R)-O-beta-D-glucopyranosyl-3',4'-dihydroxanthyletin (1), and a known compound, prim-O-glucosylcimifugin (2), were isolated from the roots of Peucedanum dissolutum. The structure of 1 was elucidated by spectral evidence and chemical reaction. The NMR signals of carbons and protons of 2 were assigned for the first time by analysis of (1)H-(1)H COSY, HMQC and HMBC spectra.Journal of Asian Natural Products Research 01/2005; 6(4):301-5. · 0.94 Impact Factor -
Article: Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay.
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ABSTRACT: Three new macrocyclic diterpenes, kansuinins F (1), G (2), and H (3), together with four known jatrophane diterpenes, kansuinins D (4), E (5), and A (6) and 3beta,5alpha,7beta,15beta-tetraacetoxy-9alpha-nicotinoyloxyjatropha-6(17)-11E-dien-14-one, were isolated from the roots of Euphorbia kansui. Compounds 1 and 2 were assigned as 6(17)-en-11,12-epoxy-14-one-type jatrophane diterpenes, and compound 3 as a 6(17)-en-11,14-epoxy-12-one jatrophane diterpene. The structures of compounds 1-3 and the relative configurations of compounds 4 and 5 were determined by spectral data analysis. Kansuinin E (5) exhibited a specific survival effect on fibroblasts that expressed TrkA, a high-affinity receptor for nerve growth factor.Journal of Natural Products 10/2004; 67(9):1548-51. · 3.13 Impact Factor -
Article: [A new alkaloid from Opuntia vulgaris].
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ABSTRACT: To study the chemical constituents of the stems of Opuntia vulgaris Mill(Cactaceae). The compounds of Opuntia vulgaris were isolated by chromatography of Amberlite Dowex 50 and silica gel, and identified by means of UV, IR, MS, 1D and 2D NMR. Three compounds were isolated and identified as: opuntin B(I), 4-hydroxyproline(II) and tyrosine(III). Compound I is a new alkaloid.Yao xue xue bao = Acta pharmaceutica Sinica 10/2003; 38(9):677-9. -
Article: [Semi-synthesis of derivatives with C-3' and C-4' trans-configuration from (+)-praeruptorin A].
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ABSTRACT: In order to compare the calcium antagonist activity between the derivatives of (+)-praeruptorin A with C-3' and C-4' cis-configuration and trans-configuration, and to look for new active compounds, some derivatives with C-3', C-4' trans-configuration of (+)-praeruptorin A were semi-synthsized. (+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum. Basic hydrolysis of (+)-praeruptorin A was carried out. From the alkaline hydrolysis product (2), eight new products (5-12) with C-3', C-4' trans-configuration were semi-synthsized whose C-3' was linked to angeloyloxy and C-4' was linked to various acyloxy, using respective acids as acylating agents, DCC as a dehydrant, DMAP as catalyst. From the alkaline hydrolysis product (4), five new products (13-17) with C-3', C-4' trans-configuration were obtained whose C-3', C-4' is linked to various same acyloxys, using respective acids as acylating agents, DCC as dehydrant, DMAP as catalyst. Also from the alkaline hydrolysis product (4), using respective acyl chlorides as acylating agents, anhydrous dichloromethane containing minor pyridine as a solvent, the improved Schotten-Baumann reactions were carried out, two new products (18, 20) with C-3', C-4' trans-configuration were obtained whose only C-3' linked to acyloxy and two other new products (19, 21) with C-3', C-4' trans-configuration were obtained whose C-3' and C-4' linked two acyloxys. The structures of all the products were elucidated by spectral analyses including IR, 1HNMR and EIMS. The calcium antagonist activity of all of the products were tested by inhibition of the systole of rat artery ring. Seventeen compounds with C-3', C-4' trans-configuration were semi-synthesized from (+)-praeruptorin A for the first time and their calcium antagonist activity were evaluated. All of the derivatives were new compounds. Bioactivity assay indicated that some new compounds with C-3', C-4' trans-configuration showed obvious calcium antagonist activity, but they are not as strong as (+)-praeruptorin A. The activity of some products was shown to be similar to that of the derivatives with C-3', C-4' cis-configuration for the first time.Yao xue xue bao = Acta pharmaceutica Sinica 06/2003; 38(5):358-63. -
Article: [Studies on the constituents from the herb of Vernonia patula].
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ABSTRACT: To isolate and elucidate the chemical constituents of the whole plant of Vernonia patula, and to provide samples for biological activity screening. The chromatography on silica gel was used and the structures were determined by IR, NMR and MS spectra analysis and physicochemical property comparion. Four triterpenoids were isolated and identified as bauerenyl acetate(I), friedelin(II), epifriedelanol(III), 20(30)-taraxastene-3 beta, 21 alpha-diol(IV). Compounds I and IV were isolated from genus Vernonia for the first time and compounds II and III were isolated from the whole plant of V. patula for the first time. The four compounds show no inhibitory effect on the growing of PC-12 cells.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 04/2003; 28(3):235-7. -
Article: Two new triterpenoid saponiins from Adina pilulifera.
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ABSTRACT: Two new triterpenoid saponins, 3beta-O-beta-D-xylopyranosyl (1 --> 3)-alpha-L-rhamnopyranosyl-pyrocincholic acid 28-O-beta-D-glucopyranosyl (1 --> 6)-beta-D-glucopyranosyl ester (1), and 3beta-O-beta-D-xylopyranosyl(l --> 3)-alpha-L-rhamnopyranosyl-cincholic acid 28-O-beta-D-glucopyranosyl ester (2) were isolated from the roots of Adina pilulifera, together with 18 known compounds. The structures of 1 and 2 were determined by spectroscopic methods.Journal of Asian Natural Products Research 03/2003; 5(1):11-6. · 0.94 Impact Factor -
Article: New oleanene-type triterpene saponins from Pueraria peduncularis.
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ABSTRACT: Two new oleanane-type triterpene saponins named pedunsaponins B (2) and C (3) were isolated from the roots of Pueraria peduncularis. Their structures were determined to be 3-O-(6-O-methyl)-beta-glucuronopyranosyl-3beta,15alpha-dihydroxyolean-12-en-16-one (2), and 3-O-beta-glucopyranosyl-(1 --> 3)-beta-glucuronopyranosyl-3beta,15alpha-dihydroxyoleana-12-en-16-one (3), on the basis of spectroscopic evidence.Journal of Asian Natural Products Research 12/2002; 4(4):253-7. · 0.94 Impact Factor -
Article: [Studies on structure modification of (+)-praeruptorin A].
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ABSTRACT: In order to look for new active compounds, the structure of (+)-praeruptorin A is modified. (+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out. Eighteen compounds were semi-synthesized from (+)-praeruptorin A. Fourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.Yao xue xue bao = Acta pharmaceutica Sinica 08/2002; 37(7):527-34. -
Article: Cytotoxic diterpenoids from Euphorbia pekinensis.
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ABSTRACT: A new diterpenoid, named euphpekinensin, along with three known diterpenoids, was isolated from the roots of Euphorbia pekinensis for the first time and the structures were elucidated by spectral analysis. The 2D-NMR techniques such as 1H-1H COSY, HMQC, HMBC and NOESY spectra were mainly applied to determine the structure of the new diterpenoid. The four diterpenoids showed cytotoxic activity against human KB cells in vitro.Planta Medica 04/2002; 68(3):249-52. · 2.15 Impact Factor -
Article: A new elemanolide sesquiterpene lactone from Elephantopus scaber.
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ABSTRACT: A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC(50) 8.18-14.08 micromol/l).Journal of Asian Natural Products Research 10(5-6):403-7. · 0.94 Impact Factor -
Article: Melia toosendan regulates PC12 Cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases.
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ABSTRACT: With a history of several thousand years, traditional Chinese medicine has been well documented to be effective in the treatment of various disorders. We have investigated the activities of potential neuroactive compounds in traditional Chinese medicine such as Melia toosendan using an in vitro model system, rat pheochromocytoma PC12 cells. We report here that treatment of PC12 cells with a crude extract of the fruits of M. toosendan reduces cell growth in a dose-dependent manner without detectable cytotoxicity. Upon treatment with M. toosendan, PC12 cells exhibit robust neurite outgrowth, to a greater extent than that observed with nerve growth factor. Results obtained with specific kinase inhibitors and protein kinase A-deficient PC12 cells indicate that the actions of M. toosendan are mediated by the activation of protein kinase A and extracellular signal-regulated kinases.Neurosignals 13(5):248-57. · 2.11 Impact Factor -
Article: Coumarins from Peucedanum praeruptorum
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ABSTRACT: A new angular dihydropyranocoumarin named qianhucoumarin H and four known coumarins, peucedanocoumarin I, 5,8-dimethoxypsoralen, isoscopoletin, umbelliferone along with anchoic acid were isolated from the root of Peucedanum praeruptorum. By spectral analysis and chemical evidence, the structure of qianhucoumarin H was elucidated as 3′(S)-angeloyloxy-4′(R)-isovaleryloxy-3′,4′-dihydroseselin and the absolute configurations were established by chemical correlations with known compounds.Phytochemistry 41(5):1423-1426. · 3.35 Impact Factor
Top co-authors
Top Journals
Institutions
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2010
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shanxi medical university
- School of Pharmaceutical Science
Taiyuan, Shanxi Sheng, China
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2003–2008
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Nanjing Normal University
- School of Life Science
Nanjing, Jiangsu Sheng, China
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2007
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Nanjing Medical University
Nanjing, Jiangsu Sheng, China
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2002–2007
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China Pharmaceutical University
- Department of Natural Medicinal Chemistry
Nanjing, Jiangxi Sheng, China
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