Ethem Beskonakli

Publications (11)17.35 Total impact

• Article: The History Of Neurosurgery In Anatolia And Turkey The Turkish Neurosurgical Society.

  Ihsan Solaroglu, Feridun Acar, Murad Bavbek, Ethem Beskonakli, Ugur Ture
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  ABSTRACT: Although the history of neurosurgery in Anatolia goes back to 10 thousand years ago, modern surgery started in 1890 in Turkey. Neurosurgery in Turkey started in the first half of the 20th century. However, the earlier application of neurosurgical techniques was started in the late 19th century by general surgeons. Most of these applications included procedures for cranio-cerebral traumas and infections.
  World Neurosurgery 11/2012; · 0.68 Impact Factor
• Article: Tenosynovial giant cell tumor in the cervico-thoracic junction.

  Ozerk Okutan, Ihsan Sola Roglu, Ozlem Ozen, Baris Saygili, Ethem Beskonakli
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  ABSTRACT: Tenosynovial giant cell tumor (TGT) rarely arises from the posterior coloumn of the cervical spine. Most lesions of TGT involve the tendon sheath and joint lining of the small joints of the fingers and hands, and consecutively the knee, ankles and feet, and hips. Rate of extra-articular presentation is about 5-15% in all cases. In this report, a case with paraparesis caused by TGT in the cervico-thoracic junction is presented. The clinical manifestations, diagnosis, and treatment of this unusual condition are discussed. In the treatment of TGT of the vertebral column, the main aim should be total surgical excision of the tumor.
  Turkish neurosurgery 01/2012; 22(6):769-71. · 0.62 Impact Factor
• Source

  Available from: ku.edu.tr

  Article: The ATA and its surgical importance: a newly described ligament lying between the dural sac and the ligamentum flavum at the L5 level.

  Ihsan Solaroglu, Ozerk Okutan, Ethem Beskonakli
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  ABSTRACT: The anatomy of a new ligament in the human spine the ATA is described. To describe a new ligament; the ATA, which lies between the dural sac and the ligamentum flavum at the L5 level and to discuss it's surgical importance. Postoperative cerebrospinal fluid (CSF) leakage translates into longer hospital stays with significant implications for the patient, the health care system, and society as a whole. To avoid injury to the dural sac during lumbar surgery, it is crucial to know the surgical anatomy and its variations. The length and the number of ATAs were examined in 14 consecutive patients, which underwent an L5 laminoflavectomy in our department. The ATA and its anatomic landmarks are described here for the first time in the literature. We named this ligament the ATA; reminding us to pay attention to the Terminal Attachment. The presence of the ATA is demonstrated in 10 patients (71%). There was a double ATA in four patients (40%). The mean length of the ATA was 7.7 ± 1.8 mm. The ATA originates from the dorsal surface of the dura mater at the level of the superior border of the superior facet of the S1 vertebra and projects toward the ligamentum flavum. Histologic examination of the ATA revealed fibrous connective tissue. In this preliminary study, we have described a new ligament, the ATA, between the dural sac and the ligamentum flavum at the L5 level. The ATA is an important structure that creates a potential risk for inadvertent dural lacerations during flavectomy. Dissecting the ATA before the flavectomy may be an important step in reducing postoperative cerebrospinal fluid leaks, which may result in significant benefits for patients and health care organizations.
  Spine 01/2011; 36(16):1268-72. · 2.08 Impact Factor
• Article: Electrophysiological and clinical assessment of response to surgery in carpal tunnel.

  Nebi Yilmaz, Gokhan Akdemir, Ali Riza Gezici, Mehmet Basmaci, Mehmet Fikret Ergungor, Yusuf Asalanturk, Ethem Beskonakli, Davut Ucar
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  ABSTRACT: The objective of this study was to assess the clinical and electrophysiological changes before and after surgery in 44 patients who underwent surgical intervention due to the diagnosis of carpal tunnel syndrome (CTS). Patients who were diagnosed with a slight, moderate, and severe idiopathic CTS were assessed clinically and by electrophysiological tests before (mean 2-4 weeks) and after surgery (at sixth month). Improvement in clinical parameters was achieved more significantly than electrophysiological recovery.
  The International journal of neuroscience 04/2010; 120(4):261-4. · 0.86 Impact Factor
• Source

  Available from: Julian Cahill

  Article: Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation.

  Ihsan Solaroglu, Julian Cahill, Tamiji Tsubokawa, Ethem Beskonakli, John H Zhang
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  ABSTRACT: The molecular mechanisms of the anti-apoptotic and anti-inflammatory properties of granulocyte-colony stimulating factor (G-CSF) following focal cerebral ischemia in rats were examined in this study. Sprague-Dawley rats were randomly divided into three groups: sham, middle cerebral artery occlusion (MCAO) non-treatment and MCAO with G-CSF treatment. Focal ischemia was induced with the suture occlusion method for 90 minutes, and treatment was given at the onset of reperfusion. All animals were killed 24 hours after reperfusion. Assessment included neurological scores, infarction volumes, histology, immunofluorescent staining and Western blotting. G-CSF significantly reduced the infarct volume and ameliorated the early neurological outcome scores. Western blot analysis showed that G-CSF treatment significantly elevated the cIAP2 levels and decreased the activation of caspase 3 in the ischemic cortex compared with the non-treated rats. Immunofluorescent works also showed that G-CSF treatment inhibited both neuronal and glial tumor necrosis factor alpha and interleukin 1beta expressions. The neuronal anti-apoptotic action of G-CSF may be mediated in part by the anti-apoptotic protein cIAP2. G-CSF also exerts anti-inflammatory actions after focal cerebral ischemia by preventing both neuronal and glial pro-inflammatory cytokine expressions.
  Neurological Research 04/2009; 31(2):167-72. · 1.52 Impact Factor
• Article: Primary intracranial low-grade fibromyxoid sarcoma (Evans tumor).

  Kagan Tun, Ozlem Ozen, Erkan Kaptanoglu, Oktay Gurcan, Ethem Beskonakli, Bulent Celasun
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  ABSTRACT: Low-grade fibromyxoid sarcoma was first described in 1987 as a rare soft tissue neoplasm characterized by a bland and deceptively benign histological appearance but with aggressive behavior. A 20-year-old male patient presented with a recent history of headache and seizure. A right frontal mass was detected on MRI and he was operated upon to remove the intracranial mass. Histological examination revealed mildly atypical fibroblastic cells embedded within a myxoid matrix. Nuclear atypia and pleomorphism were minimal, and necrosis was not present. The lesion was diagnosed as a low-grade fibromyxoid sarcoma. Although primary intracranial low-grade fibromyxoid sarcoma has characteristic histological features, clinical and radiological correlation is necessary to make the correct diagnosis.
  Journal of Clinical Neuroscience 10/2008; 15(11):1298-301. · 1.25 Impact Factor
• Article: Dermoid tumour of the lateral wall of the cavernous sinus.

  Kagan Tun, Ramazan C Celikmez, Ozerk Okutan, Oktay Gurcan, Ethem Beskonakli
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  ABSTRACT: Congenital intracranial dermoid tumors are very rare. Supratentorial dermoid cysts have been more frequently reported over the past decade and they are known to have a predilection for the cavernous sinus. Dermoid tumors originating from the cavernous sinus are usually interdural and thus, presentation with ophthalmoplegia is uncommon. They are congenital benign tumors and are believed to originate from ectopic inclusion of epithelial cells during closure of the neural tube during embryonic development. The location of these dermoid lesions in the cavernous sinus and the complexity of the operative procedure for these lesions have been noted by several authors. In this report, we describe the case of a dermoid cyst that was embedded in the lateral wall of the cavernous sinus and review the literature relating to related cavernous dermoid lesions.
  Journal of Clinical Neuroscience 08/2008; 15(7):820-3. · 1.25 Impact Factor
• Article: Intracranial sewing needle.

  Kagan Tun, Erkan Kaptanoglu, O Faruk Turkoglu, R Cengiz Celikmez, Ethem Beskonakli
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  ABSTRACT: A 45-year-old patient was found to have an intracranial sewing needle, located in the left frontal lobe. The needle was detected incidentally after minor head trauma. The clinical and radiological findings suggested that it might have entered the brain through the anterior fontanelle.
  Journal of Clinical Neuroscience 11/2006; 13(8):855-6. · 1.25 Impact Factor
• Article: Late angiographic and clinical follow-up results of 100 consecutive aneurysms treated with Onyx reconstruction: largest single-center experience.

  H Saruhan Cekirge, Isil Saatci, M Halil Ozturk, Barbaros Cil, Anil Arat, Michel Mawad, Fikret Ergungor, Deniz Belen, Uygur Er, Sami Turk, Murat Bavbek, Zeki Sekerci, Ethem Beskonakli, Osman E Ozcan, Tuncalp Ozgen
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  ABSTRACT: We present the long-term clinical and angiographic follow-up results of 100 consecutive intracranial aneurysms treated with Onyx liquid embolic system (MTI, Irvine, Calif.), either alone or combined with an adjunctive stent, in a single center. A total of 100 aneurysms in 94 patients were treated with endosaccular Onyx packing. Intracranial stenting was used adjunctively in 25 aneurysms including 19 during initial treatment and 6 during retreatment. All aneurysms except two were located in the internal carotid artery. Of the 100 aneurysms, 35 were giant or large/wide-necked, and 65 were small. Follow-up angiography was performed in all 91 surviving patients (96 aneurysms) at 3 and/or 6 months. Follow-up angiography was performed at 1, 2, 3, 4 and 5 years in 90, 41, 26, 6 and 2 patients, respectively. Overall, aneurysm recanalization was observed in 12 of 96 aneurysms with follow-up angiography (12.5%). All 12 were large or giant aneurysms, resulting in a 36% recanalization rate in the large and giant aneurysm group. One aneurysm out of 25 treated with the combination of a stent and Onyx showed recanalization. There was also no recanalization in the follow-up of small internal carotid artery aneurysms treated with balloon assistance only. At final follow-up, procedure- or device-related permanent neurological morbidity was present in eight patients (8.3%). There were two procedure-related and one disease-related (subarachnoid hemorrhage) deaths (mortality 3.2%). Delayed spontaneous asymptomatic occlusion of the parent vessel occurred in two patients, detected on routine follow-up. Onyx provides durable aneurysm occlusion with parent artery reconstruction resulting in perfectly stable 1-year to 5-year follow-up angiography both in small aneurysms treated with balloon assistance only (0% recanalization rate) and large or giant aneurysms treated with stent and Onyx combination (4% recanalization rate). Endosaccular Onyx packing with balloon assistance may not be adequate for stable long-term results in those with a large or giant aneurysm. However, the recanalization rate of 36% in these aneurysms is better than the reported results with other techniques, i.e., coils with or without adjunctive bare stents.
  Neuroradiology 03/2006; 48(2):113-26. · 2.82 Impact Factor
• Article: Protective effect of erythropoietin on type II pneumocyte cells after traumatic brain injury in rats.

  Erkan Yildirim, Kanat Ozisik, Ihsan Solaroglu, Erkan Kaptanoglu, Ethem Beskonakli, Mustafa F Sargon, Kamer Kilinc, Unal Sakinci
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  ABSTRACT: The main objective was to evaluate the protective effect of erythropoietin on lung ultrastructure against damage in rats after traumatic brain injury. We used forty Wistar-Albino female rats weighing 170-200 gr. The rats were allocated into five groups. The first group was the control and the second was the craniotomy without trauma. The third group was the trauma group. The fourth and fifth groups were erythropoietin (1000 IU/kg) and vehicle (0.4 mL/rat) groups, respectively. A weight-drop method was used for achieving head trauma. Samples were obtained from pulmonary lobes 24-hour post injury. Lipid peroxidation levels were determined and electron microscopic scoring model was used to reveal the ultrastructural changes. Ultrastructural evaluation revealed pathologic changes in the trauma group compared with the control group (p < 0.05). Lipid peroxidation levels were found to be higher in the trauma group (p < 0.05). Erythropoietin significantly reduced both the ultrastructural pathologic changes and the lipid peroxidation levels in the treatment group (p < 0.05). Erythropoietin protects the ultrastructure of pneumocyte type II cells against damage after traumatic brain injury.
  The Journal of trauma 06/2005; 58(6):1252-8. · 2.48 Impact Factor
• Source

  Available from: Kanat Ozisik

  Article: Ultrastructural changes in pneumocyte type II cells following traumatic brain injury in rats.

  Erkan Yildirim, Erkan Kaptanoglu, Kanat Ozisik, Ethem Beskonakli, Ozerk Okutan, Mustafa F Sargon, Kamer Kilinc, Unal Sakinci
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  ABSTRACT: We aimed to demonstrate the time-dependent ultrastructural changes in pneumocyte type II cells following brain injury, and to propose an electron microscopic scoring model for the damage. Forty Wistar-Albino female rats weighing 170-200 g were used. The rats were allocated into five groups. The first group was the control and the second was the craniotomy without trauma. The others were trauma groups. Weight-drop method was used for achieving head trauma. Samples were obtained from the right and left pulmonary lobes at 2-, 8-, and 24-h intervals after transcardiac perfusion. An electron microscopic scoring model was used to reveal the changes. There were no ultrastructural pathological findings pointing to lung injury in any rat of the control groups. There was intense intracellular oedema in type II pneumocyte and interstitial oedema in the adjacent tissue in trauma groups. Oedema in mitochondria and dilatation in both smooth endoplasmic reticulum and Golgi apparatus was more evident in the 8- and 24-h trauma groups. The chromatin dispersion was disintegrated in the nucleus in all trauma groups. Scores of all trauma groups were significantly different from the controls (P<0.05). All trauma groups were different from each other at significant levels (P<0.05 for each trauma groups). The data suggested that ultrastructural damage is obvious at 2 h and deteriorates with time. The electron microscopic scoring model worked well in depicting the traumatic changes, which were supported by lipid peroxidation. Further experiments are needed to determine the exact outcome after brain death model.
  European Journal of Cardio-Thoracic Surgery 05/2004; 25(4):523-9. · 2.55 Impact Factor