Jihua Li

Sichuan University, Hua-yang, Sichuan, China

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Publications (38)79.15 Total impact

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    ABSTRACT: Protrusion of the zygoma is commonly considered undesirable and unattractive among East-Asians, and many try to achieve a harmonious oval midface by having various cosmetic operations. However, effective contouring for a severe protruding zygoma has rarely been reported .The objectives of this study therefore were to investigate the feasibility and effectiveness of a horizontal V-shaped ostectomy for correction of protrusion of the zygoma and zygomatic arch, and to discuss its indications. From January 2008 to December 2011 we treated 27 patients by contouring of the zygoma with a horizontal V-shaped ostectomy through intraoral and preauricular incisions. The effectiveness was then evaluated with cephalometric radiographs, 3-dimensional computed tomography, and standard facial photographs taken before and after operation. The postoperative appearance of all 27 patients showed that the protrusion had been effectively reduced with no serious complications, and the facial contour had improved. The final aesthetic outcomes were satisfactory for both surgeons and patients. The horizontal V-shaped osteotomy is a good technique for the reduction of protrusion of the zygoma and zygomatic arch, and it has the advantages of more convenient multishifting, better results, and fewer complications. It also ensures the integrity of the structure of the malar complex.
    British Journal of Oral and Maxillofacial Surgery 05/2014; · 2.72 Impact Factor
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    ABSTRACT: Purpose: The objective of this study was to investigate cancellous bone response to strontium-doped hydroxyapatite (SrHA) in ovariectomized (OVX) rats. Methods: Hydroxyapatite (HA) and 10%SrHA (HA with 10 mol% calcium substituted by strontium) implants were prepared and characterized by scanning electronic microscopy (SEM), energy dispersive microanalysis (EDX) and X-ray diffraction (XRD). Twelve weeks after bilateral ovariectomy, 20 rats randomly received HA or 10%SrHA implants in the right distal femur, with 10 animals in each group. Eight weeks after implantation, specimens were harvested and analyzed by micro-computed tomography (micro-CT) and histology.ResultsCompared with HA, 10%SrHA raised the percentage bone volume by 42.6%, bone-to-implant contact by 47.1%, mean trabecular number by 27.3%, mean trabecular thickness by 31.5% and mean connectivity density by 37.4%, while it decreased mean trabecular separation by 20.1% in micro-CT evaluation. 10%SrHA also increased the bone area density by 47.6% in histological analysis. Conclusions: With the HA implants as controls, the 10%SrHA implants were shown to increase bone density and bone-to-implant contact, and improve trabecular architecture in the vicinity of implant surfaces.
    Journal of applied biomaterials & functional materials. 04/2014;
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    ABSTRACT: Purpose: This study compared the effect of magnesium-incorporated hydroxyapatite (MgHA) coating with that of HA coating on implant fixation in ovariectomized (OVX) rats. Materials and Methods: Coatings of HA and MgHA (10 mol% Ca²⁺ replaced by Mg²⁺) were prepared on the surface of titanium substrates using the sol-gel dip-coating method, and powders of HA and MgHA were produced by the same method. The two kinds of materials were then characterized by scanning electron microscopy and x-ray diffraction. Twelve weeks after bilateral ovariectomy, 18 OVX rats received implants in the distal femora; half of the implants were HA-coated and the other half were MgHA-coated. After 12 weeks of healing, rats were selected randomly for histomorphometry, microcomputed tomography evaluation, and biomechanical testing. Results: Surface characterization analysis demonstrated that the addition of Mg did not dramatically change the surface topography or apatite patterns of the coating. Histomorphometry revealed higher bone-to-implant contact and bone area ratio for MgHA-coated implants than for HA-coated implants. Microcomputed tomographic evaluation revealed improved trabecular parameters and increased osseointegration for MgHA-coated implants. Biomechanical testing revealed that the MgHA coating increased the maximum push-out force and interfacial shear strength compared to the HA coating. Conclusion: Mg incorporated into an HA coating on titanium implants could improve the biologic fixation of implants in osteoporotic bone.
    The International journal of oral & maxillofacial implants 01/2014; 29(1):196-202. · 1.91 Impact Factor
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    ABSTRACT: Purpose Osteochondroma is a benign tumor that is rare in the craniofacial region. When it occurs, the condyle and the coronoid process are the most commonly affected sites. The secondary progressive malocclusion and facial asymmetry are common physical signs in most cases. The traditional surgical treatment for osteochondroma of the mandibular condyle has been condylectomy with or without reconstruction of the condyle. We opine that more attention should be paid in restoring the joint function, improving facial appearances and correcting malocclusion, as well as re-establishing harmony among them. Patients and Methods From Jan. 2000 to Mar. 2013, 27 patients (17 female and 10 male) who were diagnosed with osteochondroma of unilateral mandibular condyle underwent condylectomy and condylar reconstruction by use of pedicled posterior mandibular border obtained by ramus osteotomy. The secondary dentofacial deformities were simultaneously corrected by use of orthognathic and facial contouring procedures, followed by orthodontic treatment when necessary. Occlusion and temporomandibular joint pain and function including maximal mouth opening and maximum protrusion were recorded preoperatively and postoperatively. Results :The patients were followed-up for an average of 13 months (range 24–48 months). The outcomes and the feedback information of patients showed apparent improved joint function with no cases of recurrence of osteochondroma. The secondary dentofacial deformities were corrected significantly. Satisfactory occlusion was achieved with orthognathic and orthodontic treatment. Conclusion Our data suggest that condylectomy and condylar reconstruction; simultaneous correction of the secondary dentofacial deformities by use of orthognathic procedures might be a better approach to manage osteochondroma accompanied by dentofacial deformities. In addition to facial contouring procedures, orthodontic treatment should be considered for better improvement in facial esthetics and occlusion.
    Journal of Oral and Maxillofacial Surgery. 01/2014;
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    ABSTRACT: From an East Asian traditional esthetic viewpoint, a soft facial appearance seems to be more attractive. A prominent mandibular angle, a high zygomatic bone, and an inharmonious chin strongly lessen the attributes of femininity. Attention should be paid to the zygomatic projection and square mandible from the frontal view and the gonial angle and mental region configuration from the lateral view to obtain a slender oval face (melon seed face). From January 2005 through December 2010, 47 patients underwent a combination of 4 operative techniques to reshape a square face: L-shaped osteotomy, V-line osteotomy, mandibular outer cortex splitting ostectomy, and sliding genioplasty. Outcomes in and feedback information from patients showed that these methods made the square face look more harmonious, with significant improvement of the middle and lower facial contours. Asians with a square face have different combinations of facial features; thus, surgeries should be customized and designed comprehensively to achieve optimal results.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 07/2013; · 1.58 Impact Factor
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    ABSTRACT: Surgical correction of craniosynostosis in children is associated with substantial intraoperative bleeding. Intraoperatively administered tranexamic acid (TXA) can lessen blood loss during orthopedic and cardiovascular surgery, but its efficacy in craniosynostosis surgery is uncertain. Therefore, a meta-analysis performed with published comparative studies was to determine whether TXA could reduce packed red blood cells (or erythrocytes) (PRBCs) transfused and blood loss during pediatric craniosynostosis surgery. Two PubMed and EMBASE electronic databases were searched until June 2012. Eligible studies were restricted in comparative controlled trials. Four studies in 3 articles with 138 patients were included. The results showed that intraoperative administration of TXA can significantly reduce transfusion of PRBCs (weighed mean difference [WMD] = -10.81, 95% confidence interval [CI] = -16.84 to -4.78, P < 0.00001). In the level of blood loss, the meta-analysis on 4 studies showed that the difference was statistically significant (WMD = -20.53, 95% CI = -32.26 to -8.80, P = 0.0006) between the TXA groups and the control groups. However, the subgroup analysis on randomized controlled trials showed that TXA did not significantly reduce blood loss during surgery compared with the placebo group (WMD = -30.79, 95% CIs = -71.72 to 10.14, P = 0.14). Tranexamic acid can significantly reduce the transfusion of PRBCs in children undergoing craniosynostosis surgery. However, there is a controversy on the efficacy of TXA in reducing blood loss. Therefore, new randomized controlled trials to assess the effects of TXA in children with craniosynostosis surgery should be conducted.
    The Journal of craniofacial surgery 01/2013; 24(1):299-303. · 0.81 Impact Factor
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    ABSTRACT: INTRODUCTION: For East Asians, correction of square jaw has become one of the commonly performed procedures in aesthetic surgery. While reviewing unsatisfactory cases of mandibular reduction, the authors discovered that failure was largely due to surgeons generally focussing too much on treatment of the posterior part of the mandible, and ignoring the aesthetic significance of the harmonious and smooth overall curve from the anterior mandible to the inferior margin of the mandible. Thus, our group proposes that a coordinated, balanced and smooth jaw line is considered a key factor in Oriental mandibular contouring. PATIENTS AND METHODS: A total of 128 patients accepted jaw line reshaping by 'V-line' ostectomy, mandibular outer cortex split ostectomy, narrowing and/or sliding genioplasty and porous polyethylene implantation to achieve the desired cosmetic effects. RESULTS: All patients obtained satisfactory cosmetic results, and their square jaw was corrected. After the operation, a natural, harmonised and balanced jaw line was achieved. Lower third of the facial contour was significantly improved. CONCLUSION: Based on different facial features of square jaw deformity, a variety of plastic surgical methods for mandibular contouring were integrated and applied to achieve a balanced and delicate jaw line.
    Journal of Plastic Reconstructive & Aesthetic Surgery 08/2012; · 1.44 Impact Factor
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    ABSTRACT: Orthopedic surgeons and dentists often implant materials to repair bone tissue defects and restore physiological functions of bone organs. The clinical success depends on adequate bone formation in operation sites. However, the real cause of osteogenesis has not yet been fully elucidated. To investigate the bone response to implanted materials, this study examined the bone tissue reaction in rat femoral medullary canal, which received gelatin and collagen as foreign-body materials. A total of 36 six-month-old Sprague-Dawley rats were randomly and meanly divided into three groups. In the gelatin group, the bilateral femora received gelatin material; in the collagen group, they were implanted with type I collagen, and in the control group, the femora suffered from sham operation with no materials inserted. After 2, 4, 8, and 12 weeks, specimens were harvested and subjected to a series of examinations. After 2 weeks of healing, a significant upregulation of both alkaline phosphatase and osteocalcin by both kinds of implanted materials relative to the control (sham implantation group) was seen in gene expression analysis. Strong reactivity of osteoprotegerin and receptor activator of NFκB ligand was detected in the two test groups in immunohistochemistry at 4 weeks of healing. Also, micro-CT revealed an increase in cortical bone thickness in the two test groups as compared to the control group. Densitometry showed increased bone mineral density in the bone receiving materials after 12 weeks, leading to the enhanced maximum load in the test groups. These results indicated that the implanted materials led to an osteogenesis response in rat femoral medullary canal. Thus, we probably should reconsider the potential cascades of tissue reaction when utilizing orthopedic and dental implants and other materials to recover bone related-organ function and repair bone defects.
    Journal of Orthopaedic Science 06/2012; 17(5):626-33. · 0.96 Impact Factor
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    ABSTRACT: PURPOSE: Distraction osteogenesis can be used to correct micrognathia after temporomandibular joint (TMJ) ankylosis. However, there is still some controversy over the proper sequencing of management for the ankylosed patients. The objective of the present study was to evaluate a staged treatment of TMJ ankylosis accompanied by micrognathia using arthroplasty, mandibular distraction osteogenesis, and advancement genioplasty. PATIENTS AND METHODS: A total of 12 bilateral TMJ ankylosis patients with micrognathia (aged 17 to 27 years) underwent arthroplasty as the initial surgical procedure, followed by orthodontic treatment and correction of mandibular micrognathia by osteodistraction and advancement genioplasty as the second surgical procedure. The clinical results were evaluated by mouth opening, radiography, medical photography, and respiratory function. RESULTS: The patients were followed up for a minimum of 8 months to a maximum of 36 months. The TMJ ankylosis was released successfully in all the patients, showing an increase in average mouth opening from 3.3 mm preoperatively to 35.8 mm postoperatively. Micrognathia was corrected, and, remarkably, the obstructive sleep apnea and hypopnea syndrome was cured. Satisfactory occlusion was achieved with orthodontic treatment. CONCLUSIONS: Our data suggest that a staged and surgical orthodontic treatment might be a better approach to manage TMJ ankylosis accompanied by mandibular hypoplasia. In addition to mandibular osteodistraction, advancement genioplasty should be considered for better improvement in facial esthetics and respiratory function.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 05/2012; · 1.58 Impact Factor
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    ABSTRACT: Currently, investigating an optimal method to deal with midface hypoplasia has become a significant issue in the field of facial aesthetic surgery. Traditional ways to address this problem primarily include segmental osteotomies and using autogenous bone or cartilage grafts or synthetic implants. For the patients with paranasal hypoplasia but without malocclusion, autogenous bone grafts or implants are recommended. However, some of these patients have a flattened nose and protrusive malar, especially in the Eastern Asian; the nose will seem more flattened after augmentation the paranasal area. Hence, osteotomy is necessary in these patients to bring the flattened nose forward to get a more satisfying contour of the midface. We propose a novel osteotomy through the application of model surgery to solve the problem of midface hypoplasia combined with flattened nose but without malocclusion. When compared with other techniques, this novel method not only allows the augmentation to be performed on a broader scale composed of different segments of the midface skeleton, but also results in a lower surgical risk and maintenance of the stability of occlusion. This novel osteotomy can bring the premaxilla in combination with the nasal bone forward to solve the problem of midface hypoplasia combined with flattened nose in patients with normal occlusion. Through simultaneous augmentation of the different segments of the midface through this novel osteotomy, a more pleasing contour of the midface in all 3 dimensions can be achieved.
    The Journal of craniofacial surgery 05/2012; 23(3):869-71. · 0.81 Impact Factor
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    ABSTRACT: Fracture or defect of the mandible is a serious complication of mandibular angleplasty, and precise reconstruction for such defect is still a huge challenge. This case report provides a new method based on CAD/CAM and rapid prototyped titanium for individual design, fabrication, and implantation of a mandibular ramus and angle. A 25-year-old woman with a square-shaped face, who had undergone mandibular outer cortex split ostectomy (MOCSO) 3 months earlier, was afflicted by a series of symptoms: asymmetric face, collapse of the right face, masticatory problems, deviation during mouth opening, malocclusion, and TMJ clicks. These symptoms were caused by unintentional removal of the fractured ramus during MOCSO. By means of CT scan data, rapid prototyping, reverse engineering, 3D display, and CAD/CAM, the individualized titanium implant was designed and fabricated. The 3D demo system of operative scheme demonstrated the operative procedure, and determined the position of the implant so as to obtain a perfect fit. Postoperatively, the patient regained satisfactory morphologic symmetry, facial appearance, occlusion, and TMJ functions.
    Oral surgery, oral medicine, oral pathology and oral radiology. 03/2012; 113(3):356-61.
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    ABSTRACT: Strontium ranelate (SrR) was an effective anti-osteoporotic drug to increase bone formation and decrease bone resorption. However, reports about the effect of SR on osteoblastic and adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) are limited. The purpose of this study is to evaluate whether SrR affects the ability of BMMSCs to differentiate into osteoblasts or adipocytes. Rat BMMSCs were identified by flow cytometry and exposed to SR (0.1 and 1.0mMSr(2+)) under osteogenic or adipogenic medium for 1 and 2weeks. The proliferation and differentiation of BMMSCs were analyzed by MTT, alkaline phosphatase (ALP), Oil red O staining, quantitative real-time RT-PCR and Western blot assays. SrR significantly inhibited the proliferation, increased osteoblastic but decreased adipocytic differentiation of rat BMMSCs dose-dependently. In osteogenic medium, SrR increased the expression of ALP, the mRNA levels of Cbfa1/Runx2, bone sialoprotein, and osteocalcin by RT-PCR, and the protein levels of Cbfa1/Runx2 by Western blot. In adipogenic medium, SrR decreased the mRNA levels of PPARγ2, adipocyte lipid-binding protein 2 (aP2/ALBP), and lipoprotein lipase (LPL) by RT-PCR, and the protein expression of PPARγ in Western blot analysis. These results indicated that the effects of SrR to promote osteoblastic but inhibit adipocytic differentiation of BMMSCs might contribute to its effect on osteoporosis treatment.
    Biochemical and Biophysical Research Communications 02/2012; 418(4):725-30. · 2.28 Impact Factor
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    ABSTRACT: Among the East Asian population, a long or square face produces a characteristic coarse and masculine appearance and is therefore considered undesirable and unattractive. Because of this many Orientals seek to achieve a harmonious contour of their face by undergoing various cosmetic surgical procedures. Mandibular contouring for a long or asymmetrical face with/without square jaw is rarely reported in the literature and the objective of this study was to investigate the effectiveness of total or partial inferior border ostectomy for mandibular contouring and to discuss its indications. From July 2005 to November 2009, 74 patients in this study received mandibular contouring by total or partial inferior border ostectomy procedure to correct a disharmonious facial contour. Postoperatively the appearance of all 74 cases showed that the length of the lower 3rd of the face and the width of the mandible were decreased effectively, and the mandibular contour was improved. The final aesthetic outcomes were satisfactory for both the surgeons and the patients. The results suggest that facial contour could be improved by using total or partial inferior border ostectomy of the mandible thus achieving a harmonious facial outline based on East Asian aesthetics.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 02/2012; · 1.25 Impact Factor
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    ABSTRACT: Treatment of adult patients with temporomandibular joint (TMJ) ankylosis and secondary deformities is a challenging problem. Although various techniques, including arthroplasties, orthognathic surgery, autogenous bone graft, and distraction osteogenesis, have been described for the management of patients with this condition, an appropriate treatment protocol has not been established. The purpose of this report is to describe a 2-stage treatment protocol, comprising TMJ reconstruction as the initial surgery, followed by orthodontic treatment, and correction of secondary deformities as the second surgery, for the management of TMJ ankylosis with secondary deformities in adults. From January 2003 to December 2009, 24 adult patients (30 joints) with TMJ ankylosis and secondary deformities underwent TMJ reconstruction as the initial surgery, followed by orthodontic treatment and correction of secondary deformities as the second surgery. Clinical outcome was assessed based on oral function, radiography, and medical photography. Patients were followed up for a minimum of 12 months to a maximum of 32 months (mean, 18.6 months). No relapse of TMJ ankylosis occurred in any patient during the follow-up period. Oral function and skeletal deformities were significantly improved in all patients. Satisfactory occlusion was achieved with the help of orthodontic treatment. Most of the patients were satisfied with the final outcome. The 2-stage treatment protocol described not only restores oral function but also improves the patient's esthetic appearance. We believe that it is a good approach for management of TMJ ankylosis with secondary deformities in adult patients.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 12/2011; 69(12):e565-72. · 1.58 Impact Factor
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    ABSTRACT: In East Asian population, a square face is considered unappealing as it imparts a coarse and masculine look. Therefore, Oriental women prefer to have an ovoid and slender facial contour, which is thought to be more feminine and attractive. Nowadays, mandibular contouring surgery has become a commonly performed procedure. Clinical data show that majority of patients who have severe form are characterised by a definite square-shaped face with low gonial angle. A square face is usually visualised in frontal view but the lateral view provides additional information regarding gonial angle, mandibular plane steepness, chin deficiency and more importantly, length of the ramus. These factors are the key points for a precise categorisation, design, selection of surgical methods and choosing the ostectomy line for contouring on a square face with low angle. From 2005 to 2009, 94 women were diagnosed as square face with low angle. Three types of surgical design based on procedures such as mandibular 'V-Line' ostectomy, mandibular outer cortex split ostectomy, sliding genioplasty and inlay bone graft in various combinations were constructed, depending upon the presenting facial features. Precise categorisation, designs and techniques resulted in higher satisfaction as these procedures provided an overall narrowing and harmonising effect on the lower facial contour postoperatively. Patients with square face and low gonial angle come with multitude of features so that design and technique applied should be tailored to each individual to achieve perfection.
    Journal of Plastic Reconstructive & Aesthetic Surgery 09/2011; 65(1):e1-8. · 1.44 Impact Factor
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    ABSTRACT: Nano-hydroxyapatite/polyamide 6 (n-HA/PA6) composite scaffolds were prepared by a combined method of phase separation and particle leaching processing technique. The porous matrices were seeded with allogenic bone marrow-derived stem cells (BMSCs) and implanted in the critical-size calvarial defect (8-mm diameter) in rats. The adhesion, proliferation, and differentiation of BMSCs were demonstrated by (3-{4,5-dimethylthiazol-2yl}-2,5-diphenyl-2H-tetrazoliumbromide) assay, immunohistochemical staining, and scanning electron microscopy in vitro. Cell survival was tracked via fluorescent labeling in vivo. The regeneration process was evaluated by several techniques at 4, 8, and 16 weeks after implantation. According to the results, the porous n-HA/PA6 scaffolds are biocompatible and have no negative effects on the BMSCs in vitro. Nano-hydroxyapatite/polyamide 6 composite combined with BMSCs exhibited good biocompatibility and osteoconductivity and enhanced osteogenesis at the initial stage after implantation. The results demonstrated that porous n-HA/PA6 scaffold is a potential matrix for bone tissue engineering, and using BMSCs as seed cells on porous n-HA/PA6 might be an alternative procedure in repair of large defect due to enhanced osteogenesis and osteointegration.
    The Journal of craniofacial surgery 09/2011; 22(5):1852-8. · 0.81 Impact Factor
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    ABSTRACT: A square face is considered unattractive in Orientals; thus, it has become a frequently encountered reason for patients undergoing face contouring surgery. While reviewing the unsatisfactory cases of mandibular reduction, the authors discovered that some failed cases were related to a square jaw on a short face. The conventional procedures fix only the posterior region of the mandible, resulting in increased prominence of the stunted or square chin and short face. Thus, the authors applied a narrowing and sliding genioplasty procedure combined with a mandibular outer cortex ostectomy technique to reshape a wide, weak chin, and a square jaw on a short lower facial contour into a slender and attractive oval face. From July of 2005 to October of 2009, there were a total of 57 patients in this study who underwent a narrowing and sliding genioplasty combined with a mandibular outer cortex ostectomy procedure to correct a square jaw on a short face. The postoperative appearance of all 57 cases showed that the lower face had narrowed and had become softer, slender, and oval, with a slick mental region. Narrowing and sliding genioplasty combined with a mandibular outer cortex ostectomy procedure could efficiently adjust the shape and position of the chin to obtain a good proportion of the lower face and change a square, short face to a slender, oval one in a single operation in accordance with fashionable aesthetics in Orientals.
    Plastic and reconstructive surgery 05/2011; 127(5):2083-92. · 2.74 Impact Factor
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    ABSTRACT: We describe the use of computer-assisted three-dimensional surgical planning in condylar reconstruction by vertical ramus osteotomy for patients with osteochondroma, and its clinical effects. Seventeen patients with osteochondroma of the mandibular condyle who were seen from March 2005 to March 2009 were divided into 2 groups treated by condylectomy and condylar reconstruction using vertical sliding osteotomy of the mandibular ramus with and without three-dimensional simulation using Surgicase CMF Materialise software. Clinical examination, radiographs, photographs, and details of operation and outcome were used postoperatively to evaluate the clinical effects of the technique. Satisfactory mouth opening was achieved in all cases. Mean (SD) osteotomy and fixation time, duration of intermaxillary fixation, and degree of postoperative numbness of the lower lip were considerably reduced among patients who had three-dimensional simulation. The combined use of computer-assisted three-dimensional surgical planning and simulation with vertical ramus osteotomy to reconstruct the condyle for patients with osteochondroma after excision of the tumour makes the operation more accurate and more convenient, and avoids damage to vital structures.
    British Journal of Oral and Maxillofacial Surgery 04/2011; 49(3):203-8. · 2.72 Impact Factor
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    ABSTRACT: Reconstruction of bone defects by tissue engineered substitutes requires coordinated coupling between osteogenesis and angiogenesis. Basic fibroblast growth factor (bFGF or FGF-2) is a protein which acts actively in osteogenesis and angiogenesis during skeletal healing and development. It is hypothesized that BMSCs transfected with bFGF can directly stimulate regeneration of vascular tissue, and subsequently enhance osseous formation and remodeling after implantation of the tissue engineered bone. This study was designed to examine the impact of bFGF-BMSCs, seeded on nano-hydroxyapatite/polyamide66 (n-HA/PA66) composite scaffold, to enhance angiogenesis and osteogenesis in a calvarial critical-sized defect model in rats. To investigate the vascularization and bone formation of tissue engineered bone, the substrate was removed and processed for immunohistochemical, scanning electron microscopic examinations (SEM), reverse transcriptase-polymerase chain reaction (RT-PCR), dual energy X-ray absorptiometry (DEXA), microvessels counting, and new bone volume assay. The results demonstrate that bFGF mediated ex vivo gene transfer based on BMSCs can accelerate vascularization and bone regeneration on these composite scaffolds. The n-HA/PA66 scaffold combined with the bFGF-BMSCs may mimic the natural process of osteogenesis during repair of defect by tissue engineered bone.
    Journal of Biomedical Materials Research Part A 03/2011; 96(3):543-51. · 2.83 Impact Factor
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    ABSTRACT: The aims of this study were to investigate the impact of dentofacial deformities on quality of life in Chinese patients and to make a comparison between facial deformities that do and do not involve the occlusion. Consecutive patients with dentofacial deformities requiring surgical correction were divided into 2 groups. Group A represented those who had undergone presurgical orthodontic treatment, and group B represented patients with square faces or prominent zygoma. All subjects were assessed by the 36-item Short-Form Health Survey (SF-36) and the 22-item Orthognathic Quality of Life Questionnaire (OQLQ-22) during 2 time periods: preoperatively and 6-8 months postoperatively. The SF-36 revealed that there was significant difference in role physical and bodily pain (P < .05) preoperatively between the 2 groups, whereas postoperatively the difference was not significant. Preoperatively, there was significant difference in oral function and facial esthetics components of OQLQ (P < .001), whereas postoperatively only the oral function domain showed significant difference. Orthognathic surgery had a positive impact on patients' quality of life regardless of the type of deformity. OQLQ showed better discerning ability and was able to point out the subtle differences between the 2 groups.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 03/2011; 112(6):719-25. · 1.50 Impact Factor