Kyeong Min Kim

Korea Institute of Radiological & Medical Sciences, Sŏul, Seoul, South Korea

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Publications (86)181.68 Total impact

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    ABSTRACT: Cadmium zinc telluride (CZT)-based small-animal single-photon emission computed tomography (SPECT) has desirable characteristics such as superior energy resolution, but data acquisition for SPECT imaging has been widely performed with a conventional energy window. The aim of this study was to determine the optimal energy window settings for technetium-99 m (99mTc) and thallium-201 (201Tl), the most commonly used isotopes in SPECT imaging, using CZT-based small-animal SPECT for quantitative accuracy.
    Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment 05/2015; 782. DOI:10.1016/j.nima.2015.02.018 · 1.32 Impact Factor
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    ABSTRACT: The purpose of this research is to evaluate the prospects for the use of 4-(trans-18F-fluoranylmethyl)-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexane-1-carboxamide (18F-Mefway) in comparison to 18F-trans-4-fluoro-N-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide (18F-FCWAY) for the quantification of 5-HT1A receptors in human subjects. Five healthy male controls were included for two positron emission tomography (PET) studies: 18F-FCWAY PET after the pretreatment with 500 mg of disulfiram and two months later, 18F-Mefway PET without disulfiram. Regional time-activity curves (TACs) were extracted from nine cortical and subcortical regions in dynamic PET images. Using cerebellar cortex without vermis as reference tissue, in vivo kinetics for both radioligands were compared based on the distribution volume ratio (DVR) calculated by non-invasive Logan graphical analysis and area under the curve ratio of the TACs (AUC ratio). Although the pattern of regional uptakes in the 18F-Mefway PET was similar to that of the 18F-FCWAY PET (highest in the hippocampus and lowest in the cerebellar cortex), the amount of regional uptake in 18F-Mefway PET was almost half of that in 18F-FCWAY PET. The skull uptake in 18F-Mefway PET was only 25% of that in 18F-FCWAY PET with disulfiram pretreatment. The regional DVR values and AUC ratio values for 18F-Mefway were 17-40% lower than those of 18F-FCWAY. In contrast to a small overestimation of DVR values by AUC ratio values (< 10%) in 18F-FCWAY PET, the overestimation bias of AUC ratio values was much higher (up to 21%) in 18F-Mefway PET. As 18F-Mefway showed lower DVR values and greater overestimation bias of AUC ratio values, 18F-Mefway may appear less favorable than 18F-FCWAY. However, in contrast to 18F-FCWAY, the resistance to in vivo defluorination of 18F-Mefway obviates the need for the use of a defluorination inhibitor. Thus, 18F-Mefway may be a good candidate PET radioligand for 5-HT1A receptor imaging in human.
    PLoS ONE 04/2015; 10(4):e0121342. DOI:10.1371/journal.pone.0121342 · 3.53 Impact Factor
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    Journal of Instrumentation 01/2015; 10:P01004. DOI:10.1088/1748-0221/10/01/P01004 · 1.53 Impact Factor
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    ABSTRACT: Gastrin‑releasing peptide receptor (GRPR) is overexpressed by a variety of human tumors and in particular, identified to be upregulated in prostate cancers. The current study aimed to develop clinically translatable BBN analogue‑based radioligands for positron emission tomography (PET) of GRPR‑positive tumors. We developed radiolabeled BBN analogues and modified radiolabeled galacto‑BBN analogues and then investigated their tumor‑targeting efficacy in vivo. The chelator 1,4,7‑triazacyclononane, 1‑glutaric acid‑4,7 acetic acid (NODAGA) was used to radiolabel the peptides with 64Cu. The peptides were evaluated by measuring cell‑based receptor‑binding affinities. Biodistribution experiments and small animal imaging using PET were performed in nude mice bearing subcutaneous PC3 human prostate cancer xenografts. The conjugates were radiolabeled with yields >99%. The stability assay showed that [64Cu]NODAGA‑BBN and [64Cu]NODAGA‑galacto‑BBN remained stable in both human and mouse serum for 1 h at 37˚C. PET images of PC3 tumor‑bearing nude mice were acquired at 1, 3, 24, 48 and 72 h after injection. [64Cu]NODAGA‑galacto‑BBN showed retention in tumors for 72 h, low liver uptake, and rapid renal clearance. PET imaging results were also confirmed by biodistrubution 1 and 3 h after injection. [64Cu]NODAGA‑BBN and [64Cu]NODAGA‑galacto‑BBN are promising new PET probes for GRPR‑positive prostate cancer.
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    ABSTRACT: Purpose To compare the cerebral uptake and binding potential of [(18) F]FCWAY and [(18) F]Mefway in the rodent to assess their potential for imaging serotonin 1A (5-HT1A ) receptors. Materials and methods In vitro liver microsomal studies were performed to evaluate the degree of defluorination. Dynamic positron emission tomography (PET) studies were then conducted for 2 h with or without an anti-defluorination agent. The regions of interest were the hippocampus and frontal cortex (5-HT1A target regions) and the cerebellum (5-HT1A non-target region). The in vivo kinetics of the radioligands were compared based on the brain uptake values and target-to-non-target ratio. We also performed a comparison of binding potential (BPND ) as a steady-state binding parameter. Finally, binding affinities to 5-HT1A receptors were assessed in Chinese hamster ovary cells (CHO-K1) cells expressing human recombinant 5-HT1A receptors. Results The radiochemical yield of [(18) F]Mefway was slightly higher than that of [(18) F]FCWAY (19% vs. 15%). With regard to metabolic stability against defluorination, both compounds exhibited similar stability in rat liver microsomes, but [(18) F]Mefway displayed higher stability in the human microsome (defluorination ratio at 30 min: 32 vs. 29 in rat liver microsomes, 31 vs. 64 in human liver microsomes for [(18) F]Mefway and [(18) F]FCWAY, respectively). There were no significant differences in brain uptake, the target-to-non-target ratios, and the BPND (at hippocampus, peak brain uptakes: 6.9 vs. 8.5, target-to-non-target ratios: 6.9 vs. 8.5, BPND : 5.2 vs. 6.2 for [(18) F]Mefway and [(18) F]FCWAY). The binding affinity of [(18) F]Mefway was considerably higher than that of [(18) F]FCWAY (IC50 : 1.5 nM vs. 2.2 nM). Conclusion [(18) F]Mefway exhibits favorable characteristics compared to [(18) F]FCWAY in rodents, and may be a promising radioligand for use in human subjects. Synapse, 2014. © 2014 Wiley Periodicals, Inc.
    Synapse 12/2014; 68(12). DOI:10.1002/syn.21771 · 2.43 Impact Factor
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    ABSTRACT: Two new MRI contrast agents, Gd-DOTA-c(RGD-ACP-K) (1) and Gd-DOTA-c(RGD-ACH-K) (2), which were designed by incorporating aminocyclopentane (ACP)- or aminocyclohexane (ACH)-carboxylic acid into Gd-DOTA (gadolinium-tetraazacyclo dodecanetetraacetic acid) and cyclic RGDK peptides, were synthesized and evaluated for tumor-targeting ability in vitro and in vivo. Binding affinity studies showed that both 1 and 2 exhibited higher affinity for integrin receptors than cyclic RGDyK peptides, which were used as a reference. These complexes showed high relaxivity and good stability in human serum and have the potential to improve target-specific signal enhancement in vivo MR images.
    Biochemical and Biophysical Research Communications 11/2014; 455(3-4). DOI:10.1016/j.bbrc.2014.10.155 · 2.28 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate whether the development of hepatocellular carcinoma (HCC) in murine models resembles tumor progression in humans, using non‑invasive molecular imaging methods. Murine HCC models were generated by treating mice with diethylnitrosamine (DEN) or by the transgenic expression of hepatitis B virus X (HBx) protein (HBx-Tg model). Tumor development was detected using 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The histopathological changes and expression of glucose transporter 1 (Glut1) and hexokinase 2 (HK2) were evaluated using hematoxylin and eosin and immunohistochemical staining, respectively. Tumor lesions as small as 1 mm in diameter were detected by MRI. Tumor development was monitored using 18F-FDG PET/CT at 6.5‑10 months after DEN treatment or 11‑20 months after birth of the HBx-Tg model mice. A correlation study between the 18F-FDG uptake levels and expression levels of HK2 and Glut1 in developed HCC showed a high 18F-FDG uptake in poorly differentiated HCCs that expressed high levels of HK2, in contrast to that in well-differentiated tumors. The progression of primary HCCs resembling human HCC in murine models was detected and monitored by 18F-FDG PET/CT. The correlation between tumor size and SUVmax was verified in the two HCC models. To the best of our knowledge, this is the first study to demonstrate that in vivo 18F-FDG uptake varies in HCCs according to differentiation grade in a preclinical study.
    Oncology Reports 10/2014; 33(1). DOI:10.3892/or.2014.3575 · 2.19 Impact Factor
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    ABSTRACT: Two new bicyclic arginine-glycine-aspartic acid (RGD) peptides, c(RGD-ACP-K) (1a) and c(RGD-ACH-K) (1b), incorporating the aminocyclopentane (ACP) and aminocyclohexane (ACH) carboxylic acids, respectively, were synthesized by grafting the aminocycloalkane carboxylic acids onto the tetra-peptide RGDK sequence. These peptides and their conjugates with DO3A (1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid) (2a-b) exhibit high affinity toward U87MG glioblastoma cells. Their affinity is greater than that exhibited by c(RGDyK). Labeling these conjugates with radiometal (64)Cu resulted in high radiochemical yields (>97%) of the corresponding complexes, abbreviated as c(RGD-ACP-K)-DOTA-(64)Cu (3a) and c(RGD-ACH-K)-DOTA-(64)Cu (3b). Both 3a and 3b are stable for 24 h in human and mouse serums and show high tumor uptake, as observed by positron emission tomography (PET). Blocking experiments with 3a and 3b by preinjection of c(RGDyK) confirmed their target specificity and demonstrated their promise as PET radiotracers for imaging ανβ3-positive tumors.
    ACS Medicinal Chemistry Letters 09/2014; 5(9):979-82. DOI:10.1021/ml500135t · 3.07 Impact Factor
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    ABSTRACT: Although statistical parametric mapping (SPM) analysis is widely used in neuroimaging studies, to our best knowledge, there was no application to myocardial PET data analysis. In this study, we developed the voxel based statistical analysis method for myocardial PET which provides statistical comparison results between groups in image space. PET Emission data of normal and myocardial infarction rats were acquired For the SPM analysis, a rat heart template was created. In addition, individual PET data was spatially normalized and smoothed. Two sample t-tests were performed to identify the myocardial infarct region. This developed SPM method was compared with conventional ROI methods.
    Journal of Instrumentation 09/2014; 9(09):P09005. DOI:10.1088/1748-0221/9/09/P09005 · 1.53 Impact Factor
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    ABSTRACT: The aim of this study was to investigate the potential of FDG PET/CT and MRI in predicting disease-free survival (DFS) after neoadjuvant chemotherapy (NAC) and surgery in patients with advanced breast cancer.
    European journal of nuclear medicine and molecular imaging 06/2014; 41(10). DOI:10.1007/s00259-014-2797-4 · 5.22 Impact Factor
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    ABSTRACT: The Siemens Biograph TruePoint TrueV (B-TPTV) positron emission tomography (PET) scanner performs 3D PET reconstruction using a system matrix with point spread function (PSF) modeling (called the True X reconstruction). PET resolution was dramatically improved with the True X method. In this study, we assessed the spatial resolution and image quality on a B-TPTV PET scanner. In addition, we assessed the feasibility of animal imaging with a B-TPTV PET and compared it with a microPET R4 scanner. Spatial resolution was measured at center and at 8 cm offset from the center in transverse plane with warm background activity. True X, ordered subset expectation maximization (OSEM) without PSF modeling, and filtered back-projection (FBP) reconstruction methods were used. Percent contrast (% contrast) and percent background variability (% BV) were assessed according to NEMA NU2-2007. The recovery coefficient (RC), non-uniformity, spill-over ratio (SOR), and PET imaging of the Micro Deluxe Phantom were assessed to compare image quality of B-TPTV PET with that of the microPET R4. When True X reconstruction was used, spatial resolution was <3.65 mm with warm background activity. % contrast and % BV with True X reconstruction were higher than those with the OSEM reconstruction algorithm without PSF modeling. In addition, the RC with True X reconstruction was higher than that with the FBP method and the OSEM without PSF modeling method on the microPET R4. The non-uniformity with True X reconstruction was higher than that with FBP and OSEM without PSF modeling on microPET R4. SOR with True X reconstruction was better than that with FBP or OSEM without PSF modeling on the microPET R4. This study assessed the performance of the True X reconstruction. Spatial resolution with True X reconstruction was improved by 45 % and its % contrast was significantly improved compared to those with the conventional OSEM without PSF modeling reconstruction algorithm. The noise level was higher than that with the other reconstruction algorithm. Therefore, True X reconstruction should be used with caution when quantifying PET data.
    Annals of Nuclear Medicine 02/2014; 28(4). DOI:10.1007/s12149-014-0815-z · 1.51 Impact Factor
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    ABSTRACT: Positron emission tomography (PET) is widely used for diagnosis and follow up assessment of radiotherapy. However, thoracic and abdominal PET suffers from false staging and incorrect quantification of the radioactive uptake of lesion(s) due to respiratory motion. Furthermore, respiratory motion-induced mismatch between a computed tomography (CT) attenuation map and PET data often leads to significant artifacts in the reconstructed PET image. To solve these problems, we propose a unified framework for respiratory-matched attenuation correction and motion compensation of respiratory-gated PET. For the attenuation correction, the proposed algorithm manipulates a 4D CT image virtually generated from two low-dose inhale and exhale CT images, rather than a real 4D CT image which significantly increases the radiation burden on a patient. It also utilizes CT-driven motion fields for motion compensation. To realize the proposed algorithm, we propose an improved region-based approach for non-rigid registration between body CT images, and we suggest a selection scheme of 3D CT images that are respiratory-matched to each respiratory-gated sinogram. In this work, the proposed algorithm was evaluated qualitatively and quantitatively by using patient datasets including lung and/or liver lesion(s). Experimental results show that the method can provide much clearer organ boundaries and more accurate lesion information than existing algorithms by utilizing two low-dose CT images.
    Physics in Medicine and Biology 09/2013; 58(20):7355-7374. DOI:10.1088/0031-9155/58/20/7355 · 2.92 Impact Factor
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    ABSTRACT: The purpose of this study is to evaluate the availability of cone-beam computed tomography(CBCT) for gel dosimetry. The absorbed dose was analyzed by using intensity-modulated radiation therapy(IMRT) to irradiate several tumor shapes with a calculated dose and several tumor acquiring images with CBCT in order to verify the possibility of reading a dose on the polymer gel dosimeter by means of the CBCT image. The results were compared with those obtained using magnetic resonance imaging(MRI) and CT. The linear correlation coefficients at doses less than 10 Gy for the polymer gel dosimeter were 0.967, 0.933 and 0.985 for MRI, CT and CBCT, respectively. The dose profile was symmetric on the basis of the vertical axis in a circular shape, and the uniformity was 2.50% for the MRI and 8.73% for both the CT and the CBCT. In addition, the gradient in the MR image of the gel dosimeter irradiated in an H shape was 109.88 while the gradients of the CT and the CBCT were 71.95 and 14.62, respectively. Based on better image quality, the present study showed that CBCT dosimetry for IMRT could be restrictively performed using a normoxic polymethacrylic-acid gel dosimeter.
    Journal- Korean Physical Society 09/2013; 63(5):1083-1087. DOI:10.3938/jkps.63.1083 · 0.43 Impact Factor
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    ABSTRACT: Positron emission tomography (PET), using 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) as a radioactive tracer, is a useful technique for in vivo brain imaging. However, the anatomical and physiological features of the Harderian gland limit the use of FDG-PET imaging in the mouse brain. In PET studies, this gland shows strong FDG uptake, which in turn results in distorted PET images of the frontal brain region. The purpose of this study was to assess if a simple surgical procedure to remove the Harderian gland could eliminate its influence on FDG uptake, prior to PET imaging of mice brains. Measurement of FDG uptake in unilaterally adenectomized mice showed that the radioactive signal emitted from the intact Harderian gland makes the frontal brain region unclear. Spatial parametric measurement analysis demonstrated that the presence of the Harderian gland could prevent accurate assessment of brain PET imaging. Bilateral Harderian adenectomy efficiently eliminated unwanted radioactive signal spillover into the frontal brain region, beginning at postoperative day 10. Harderian adenectomy did not cause any post operative complications during the experimental period. These findings demonstrate the benefits of performing a Harderian adenectomy prior to PET imaging of mice brains.
    Journal of veterinary science (Suwŏn-si, Korea) 06/2013; 15(1). DOI:10.4142/jvs.2014.15.1.157 · 1.14 Impact Factor
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    ABSTRACT: OBJECTIVE: The aim of this study was to measure the apparent diffusion coefficient (ADC) value at the region with the highest FDG uptake using sequential (18)F-FDG PET and MRI, and to correlate it with the histological grade of invasive ductal carcinoma (IDC) of the breast. METHODS: A retrospective study was conducted on 75 untreated patients with IDC. First, a PET/CT scan and subsequent breast MRI were done and the SUVmax of the each breast tumor was recorded. Then, a PET image and ADC map were co-registered. On the axial slice containing the pixel with SUVmax, we drew multiple circular ROIs within the tumor and measured the mean ADC value of each ROI. The average (ADC-mean) and minimum (ADC-min) of the mean ADC values for all ROIs within the tumor were calculated, respectively. Then, a circular ROI was placed at the corresponding location to the pixel with the highest SUV and the mean ADC value of the ROI was denoted as ADC-PET. We compared the averages of the ADC parameters and assessed the correlations among SUVmax and ADC parameters. ROC curve and logistic regression analyses were performed to assess the utility of ADC and SUVmax for detecting histological grade 3. RESULTS: ADC-min was significantly lower than the ADC-mean or ADC-PET. All of the ADC parameters showed a negative correlation with SUVmax. The area under the ROC curve for identifying histological grade 3 using ADC-PET, ADC-min, ADC-mean and SUVmax was 0.684, 0.660, 0.633 and 0.639, respectively. By multivariate analysis, ADC-PET was a significant, independent predictor of histological grade 3 (p = 0.004). CONCLUSIONS: We estimated the ADC value at the breast tumor region with the highest FDG uptake using sequential (18)F-FDG PET and MRI. This new ADC parameter distinguished high-grade IDC, supporting the feasibility of the combined PET-MRI system in patients with breast cancer.
    Annals of Nuclear Medicine 05/2013; 27(8). DOI:10.1007/s12149-013-0737-1 · 1.51 Impact Factor
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    ABSTRACT: I has a complex decay scheme with high gamma energy and low positron abundance. In this study, comparative performance measurements of I were performed in terms of spatial resolution, sensitivity, and image quality. All measurements were performed using both 2D and 3D PET in both brain mode and whole body mode. The transverse and axial spatial resolutions at 1 cm were 5.56 and 6.07 mm for I, and were 4.58 and 4.77 mm and for F, respectively. Sensitivities were 0.5 kcps/MBq (2D) and 3.4 kcps/MBq (3D) for I, and 1.8 kcps/MBq (2D) and 9.8 kcps/MBq (3D) for F. The %contrast of 3D was higher than that of 2D in I. For I PET imaging, 3D acquisition with brain mode was highest achievable imaging acquisition mode with finer spatial res-olution and higher contrast. This result will be useful for I PET imaging Index Terms—Image quality, reconstruction algorithms, spatial resolution, whole-body PET.
    IEEE Transactions on Nuclear Science 04/2013; 60(2):797-801. DOI:10.1109/TNS.2013.2240012 · 1.46 Impact Factor
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    ABSTRACT: F-18-FP-CIT PET image was useful for diagnosis of Parkinson's disease (PD). Although spatial normalization step is necessary in SPM analysis, it was difficult to apply the spatial normalization on F-18-FP-CIT PET due to the lack of reference for spatial normalization. Therefore, additional data acquisition such as MRI or FDG PET scans is needed. In this study, we developed the voxel based statistical analysis method for F-18-FP-CIT PET using early phase of F-18-FP-CIT. F-18-FP-CIT PET data was acquired from 7 normal and 1 PD model rat brain. Emission PET data was collected for 1 h at the start of 1 mCi of F-18-FP-CIT. We used the early phase uptake image (from 0 to 1200 s) including perfusion phase as referential information for spatial normalization. Additionally, F-18-FDG PET was acquired as referential data to validate the substitution of F-18-FP-CIT. To validate early phase F-18-FP-CIT PET data for spatial normalization, correlation coefficient between early phase F-18-FP-CIT and F-18-FDG were assessed. Using our proposed method, SPM for F-18-FP-CIT PET was successfully implemented. Early phase F-18-FP-CIT PET corresponding early phase and F-18-FDG PET were highly correlated. When we applied our developed method for the comparison between normal and PD, we can identify the difference of F-18-FP-CIT between the normal and PD in the striatum (P < 0.005, L > 0). The SPM method for F-18-FP-CIT PET data could provide high localization accuracy in PD analysis. This method may be useful for assessment of PD.
    IEEE Transactions on Nuclear Science 04/2013; 60(2):820-823. DOI:10.1109/TNS.2013.2243844 · 1.46 Impact Factor
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    A. Ram Yu, Jin Su Kim, Kyeong Min Kim, Hee Joung Kim
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    ABSTRACT: Ge-68 has conventionally been used for the normalization of F-18 PET. However, because I-124 PET has different characteristics such as a low positron branching ratio (23%), the presence of higher gamma energy (602 keV and 723 keV), and a larger positron range, the use of Ge-68 should be validated for I-124 PET. To the best of our knowledge, there has been no previous report on the effect of normalization between conventional Ge-68 and I-124. In this study, we examined image quality to assess the effect of normalization. For this purpose, we measured the non-uniformities (NUs) and recovery coefficients (RCs) using a NEMA NU4 image quality phantom (NU4 phantom) and compared the values for the conventionally used Ge-68 and I-124. A Siemens Inveon PET scanner was used throughout. Emission data were obtained using the NU4 phantom filled with I-124 solution (3.7 MBq) for 20 min within 250-750 keV. The normalization data were acquired for 40 h using a cylindrical phantom (diameter: 6 cm, length: 13.5 cm) filled with I-124 in a water solution (9.25 MBq). To match the energy window of an emission scan, the energy window setting for the normalization was 250-750 keV. The obtained list mode data were sorted into 3D sinograms. For comparison, normalization data were acquired using a cylindrical Ge-68 normalization phantom (diameter: 6 cm, length: 15 cm). The data with no normalization correction were also acquired. The list mode emission PET data were reconstructed using FBP with a ramp filter and normalization, and attenuation and scatter correction were applied. The image quality of the reconstructed images was assessed in terms of the radial, axial, and volume NUs and RCs as a standard using the NEMA NU4 protocol. There were no significant differences in the NUs and RCs between Ge-68 and I-124. These results indicate that conventional Ge-68 can be used for I-124 PET.
    IEEE Transactions on Nuclear Science 04/2013; 60(2):817-819. DOI:10.1109/TNS.2013.2243843 · 1.46 Impact Factor
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    ABSTRACT: Attenuation correction (AC) and scatter correction (SC) are problematic issues for animal positron emission tomography (PET). In this study, the effects of AC and SC were assessed using PET on a phantom and actual rat brain. Transmission (TX) was performed using 57Co for 15 min. After a 15 min TX scan, emission (EM) PET was performed in list mode for 1 h. To assess the effects of AC and SC, the spillover ratio (SOR) was measured using a rat-sized NEMA NU4 image-quality phantom; statistical parametric mapping (SPM) was performed to assess the effects of AC and SC in the rat brain using 18F-FDG (FDG). In addition, the binding potential (BP) was compared for 18F-FP-CIT (FP-CIT) PET. SPM was used to compare PET images to which AC and SC were applied, and BP was used for FP-CIT PET. The SORs of air and water decreased after AC and SC. SPM for FDG PET after AC showed a significant increase in FDG-measured activity in the cerebellum and occipital cortex. After AC/SC, a significant decrease in FDG-measured activity was observed in the frontal and temporal cortices. For FP-CIT PET of the rat brain, the BP decreased by 26% after AC because the FP-CIT uptake increased more in the cerebellum than in the striatum owing to AC. After AC and SC, the mean BP increased by 61%. AC and AC/SC were found to be necessary components of the artifact correction process for both FDG PET and FP-CIT PET of rat brains.
    IEEE Transactions on Nuclear Science 04/2013; 60(2):751-757. DOI:10.1109/TNS.2012.2230338 · 1.46 Impact Factor
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    ABSTRACT: Aims: It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ((131)I-rituximab). Methods: Twenty-four patients were enrolled prospectively and were treated with unlabeled rituximab 70 mg and a therapeutic activity (median 7.3 GBq) of (131)I-rituximab. Contrast-enhanced (18)F-FDG PET/CT scans were performed before and after 1 month of RIT. Tumor sizes and maximum standardized uptake values (SUVmax) of scans were measured. Results: Four of the 24 patients survived. High SUVmax in a pretreatment scan was found to be related to poorer overall survival (OS) and progression-free survival (p = 0.04 and 0.02, respectively). Furthermore, a large tumor size in a pretreatment scan was associated with poorer OS but not with progression-free survival (p < 0.01 and p = 0.07, respectively). By multivariate analyses, a high SUVmax, a large tumor size in a pretreatment scan and diffuse large B-cell lymphoma histology were significantly associated with poorer OS [p = 0.04/hazard ratio (HR) = 3.54, p < 0.01/HR = 5.52, and p = 0.02/HR = 3.38, respectively). Conclusion: SUVmax and tumor size determined by a pretreatment (18)F-FDG PET/CT result as significant predictors of OS in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma treated by RIT.
    Acta Haematologica 03/2013; 130(2):74-82. DOI:10.1159/000346436 · 0.99 Impact Factor

Publication Stats

578 Citations
181.68 Total Impact Points

Institutions

  • 2006–2015
    • Korea Institute of Radiological & Medical Sciences
      Sŏul, Seoul, South Korea
  • 2012
    • Inje University
      • Department of Nano Engineering
      Kŭmhae, South Gyeongsang, South Korea
  • 2011
    • Yonsei University
      • Department of Radiologic Sciences
      Sŏul, Seoul, South Korea
  • 2009
    • National Cancer Center Korea
      Kōyō, Gyeonggi-do, South Korea
  • 2004
    • Keio University
      Edo, Tōkyō, Japan
    • Konkuk University
      Sŏul, Seoul, South Korea
  • 2003
    • National Cerebral and Cardiovascular Center
      • Department of Cardiovascular Medicine
      Ōsaka, Ōsaka, Japan
  • 2002
    • Research Institute for Brain and Blood Vessels-Akita
      Akita, Akita, Japan
    • Kyoto University
      • Department of Systems Science
      Kyoto, Kyoto-fu, Japan
  • 1999
    • Seoul National University Hospital
      • Department of Nuclear Medicine
      Sŏul, Seoul, South Korea
  • 1998
    • Seoul National University
      • Department of Nuclear Medicine
      Seoul, Seoul, South Korea