Xiaoya Hu

Yangzhou University, Wu-hsien, Jiangsu Sheng, China

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Publications (122)386.32 Total impact

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    ABSTRACT: A novel magnetic metal organic frameworks adsorbent modified with mercapto groups was synthesized and developed for extraction and spectrophotometric determination of trace lead. The adsorbent was characterized by Fourier transforms infrared spectrometer, X-ray diffraction, scanning electron microscopy and vibrating sample magnetometry. The results indicated the adsorbents exhibited high adsorption capacities for lead due to the chelation mechanism between metal cations and mercapto groups. Meanwhile, the lead sorption onto the adsorbents could be easily separated from aqueous solution using a magnetic separation method. Under the optimal conditions, a linear calibration curve in the range from 1 to 20μgL(-1) was achieved with an enrichment factor of 100. The limits of detection and quantitation for lead were found to be 0.29 and 0.97μgL(-1), respectively. The developed method was successfully applied to the determination of trace amounts of lead in food samples and certified reference material with satisfactory results. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Food Chemistry 08/2015; 181. DOI:10.1016/j.foodchem.2015.02.080 · 3.26 Impact Factor
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    ABSTRACT: In this paper, a label-free electrochemical impedance immunosensor for the detection of carbofuran was prepared by immobilizing l-cysteine on a gold electrode. The carbofuran antibodies were immobilized on the electrode by the using glutaraldehyde as a cross linker. The stepwise assembly of the electrode surface was confirmed by atomic force microscope (AFM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under the optimized conditions, a linear relationship between the resistance change and the logarithm value of carbofuran concentration was obtained in the carbofuran concentration range of 1.0 × 10−1 – 1.0 × 103 ng/mL, with a detection limit of 1.0 × 10−1 ng/mL. The immunosensor performed good reproducibility and stability. Additionally, the proposed method can be applied for monitoring carbofuran residual in agricultural and environmental samples.
    Food Control 07/2015; 53. DOI:10.1016/j.foodcont.2015.01.009 · 2.82 Impact Factor
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    ABSTRACT: Carbon functionalized metal organic frameworks (C/Al-MIL-53-(OH)2) were successfully prepared for the first time by a solvothermal technique and characterized by Fourier transform infrared spectroscopy, X-ray diffraction spectrometry, and scanning electron microscopy. This composite was coated with a Nafion film so as to form a Nafion/C/Al-MIL-53-(OH)2 modified glassy carbon electrode. The modified electrode was then used as a novel electrocatalyst for dopamine (DA) oxidation in phosphate buffer solution. Due to the synergistic effects of the different materials, including the high conductivity of carbon, the large surface area of Al-MIL-53-(OH)2, and the film-forming ability of a cation-exchange polymer, the modified electrode exhibited a remarkable enhancement effect on voltammetric response of DA. Under the optimal conditions, the response peak currents had a linear relationship with the DA concentration in the range from 3.0 × 10−8 to 1.0 × 10−5 mol L−1. The limits of detection and quantitation for DA were found to be 0.8 × 10−8 mol L−1 and 2.6 × 10−8 mol L−1, respectively. The analytical utilities of the proposed biosensor were achieved by analyzing the content of DA in biological fluids.
    04/2015; DOI:10.1039/C4TB01869A
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    ABSTRACT: In this work, we reported an efficient platinum nanoparticles functionalized nitrogen doped graphene (PtNPs@NG) nanocomposite for devising novel electrochemical glucose biosensor for the first time. The fabricated PtNPs@NG and biosensor were characterized using transmission electron microscopy, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, static water contact angle, UV-vis spectroscopy, electrochemical impedance spectra and cyclic voltammetry, respectively. PtNPs@NG showed large surface area and excellent biocompatibility, and enhanced the direct electron transfer between enzyme molecules and electrode surface. The glucose oxidase (GOx) immobilized on PtNPs@NG nanocomposite retained its bioactivity, and exhibited a surface controlled, quasi-reversible and fast electron transfer process. The constructed glucose biosensor showed wide linear range from 0.005 to 1.1mM with high sensitivity of 20.31mAM(-1)cm(-2). The detection limit was calculated to be 0.002mM at signal-to-noise of 3, which showed 20-fold decrease in comparison with single NG-based electrochemical biosensor for glucose. The proposed glucose biosensor also demonstrated excellent selectivity, good reproducibility, acceptable stability, and could be successfully applied in the detection of glucose in serum samples at the applied potential of -0.33V. This research provided a promising biosensing platform for the development of excellent electrochemical biosensors. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 02/2015; 871. DOI:10.1016/j.aca.2015.02.029 · 4.52 Impact Factor
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    ABSTRACT: Bovine interferon gamma (BoIFN-γ) released by T cells plays very important roles in early diagnosis of Mycobacterium tuberculosis (MTB) infections and control of bovine tuberculosis. In this work, a label-free electrochemical impedance immunosensor is for the first time developed for highly sensitive determination of BoIFN-γ. Cylinder-shaped TiO2 nanorods are synthesized by a facile hydrothermal method, and show high surface area and good hydrophicility. The immunosensor is fabricated by the immobilization of BoIFN-γ monoclonal antibody on the TiO2 nanorods modified glassy carbon electrode. The prepared TiO2 and immunosensor are characterized using transmission electron microscopy, scanning electron microscopy, X-ray diffraction, contact angle measurement, cyclic voltammetry, and electrochemical impedance spectra. The BoIFN-γ concentration is measured through the relative increase of impedance values in corresponding specific binding of BoIFN-γ antigen and BoIFN-γ antibody. The relative increased impedance values are proportional to the logarithmic value of BoIFN-γ concentrations in a wide range of 0.0001 to 0.1 ng/mL with a low detection limit of 0.1 pg/mL. The developed BoIFN-γ immunosensor shows a 249-fold decrease in detection limit in comparison with current enzyme-linked immunosorbent assay. This study provides a new, simple, and highly sensitive approach for very potential application in early diagnosis of MTB infections and control of bovine tuberculosis.
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    ABSTRACT: We have developed an impedimetric immunosensor for the determination of bovine interleukin-4, a cytokine involved in the immune response to certain parasites and the development of some bovine diseases. Monoclonal antibody against bovine interleukin-4 was immobilized on a glassy carbon electrode modified with reduced graphene oxide and chitosan. Transmission electron microscopy, static contact angle measurement, and electrochemical impedimetry are used to characterize the immunosensor. The nanocomposite possesses a high surface area that is well suited for the immobilization of antibody. The relative increase in impedance on exposure of the sensor to solutions containing bovine interleukin-4 is linearly proportional to its logarithmic concentration in the 0.1 to 50 ng mL−1 and the detection limit is 80 pg mL−1. The immunosensor is selective, well reproducible, and acceptably stable. It presents a useful tool for further studies on the role of this cytokine in the immunology and pathogenesis of bovine diseases. Graphical Abstract An electrochemical impedance immunosensor is for the first time developed for label-free detection of bovine interleukin-4 (bov-IL-4) by immobilizing bov-IL-4 monoclonal antibody at reduced graphene oxide (rGO)/chitosan nanocomposite modified electrode.
    Microchimica Acta 01/2015; 182(1-2). DOI:10.1007/s00604-014-1331-5 · 3.72 Impact Factor
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    ABSTRACT: An enzymatic procedure based on a catalase biosensor for the detection of forchlorfenuron (CPPU) has been reported in this work. Catalase was immobilized on boron nitride (BN) sheets dispersed in chitosan by adsorption. The immobilized catalase exhibited direct electron transfer character and excellent electrocatalytic activity towards H2O2 reduction. After introducing CPPU into the H2O2 containing phosphate buffer solution, the catalase-catalyzed H2O2 reduction current decreased. By measuring the current decrease, CPPU can be determined in the range of 0.5–10.0 µM with the detection limit of 0.07 μM. The non-competitive inhibition behavior of CPPU towards catalase was verified by the Lineweaver–Burk plots. Long stability character has been ascribed to this biosensor. Possible use of this biosensor in flow systems is illustrated. The proposed biosensor has been successfully applied to CPPU determination in fruits samples with satisfactory results.
    Biosensors & Bioelectronics 01/2015; 63:294–300. DOI:10.1016/j.bios.2014.07.055 · 6.45 Impact Factor
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    ABSTRACT: Metal-organic frameworks composite materials have received tremendous attention because of their versatile structures and tunable porosity for various applications. Herein, amino-functionalized metal-organic frameworks (NH2-Cu3(BTC)2; BTC=benzene-1,3,5-tricarboxylate) was prepared and used as a novel electrode modifier for the determination of trace levels of lead. NH2-Cu3(BTC)2 shows quite a good capability for the efficient adsorption of lead from aqueous solutions. The parameters affecting the electrochemical process, such as electrolyte solution pH, the amount of NH2-Cu3(BTC)2 suspension, accumulation potential and accumulation time, were investigated in detail. Under the optimal conditions, the electrochemical sensor exhibited a linear response to the concentration of lead in the range of 1.0×10(-8)-5.0×10(-7)molL(-1) (R(2)=0.9951) with a detection limit of 5.0×10(-9)molL(-1). The relative standard deviation of 11 successive scans was 3.10% for 1.0×10(-8)molL(-1) lead. The method was validated with certified reference material (stream sediment and milk powder) and the analytical results coincided well with the certified values. Furthermore, the method was successfully applied to the determination of target analytes in tap and lake water samples and good recoveries were obtained from different spiked values.
    Talanta 11/2014; 129:100–105. DOI:10.1016/j.talanta.2014.05.014 · 3.51 Impact Factor
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    ABSTRACT: In this work, a novel chemically modified electrode is constructed based on metal-organic frameworks and β-cyclodextrin (Cu3(BTC)2/β-CD, BTC = benzene-1,3,5-tricarboxylate) composite material. The electrode was used for simultaneous determination of guanine and adenine in a sequential injection lab-on-valve format and exhibited sensitive responses to guanine and adenine oxidation due to the π-π stacking interaction of Cu3(BTC)2 and the inclusion behavior of β-CD. The analytical performance was assessed with respect to the supporting electrolyte and its pH, accumulation time and accumulation potential, and the fluid flow rates. Under optimal conditions, linear calibration ranges for both guanine and adenine were from 1.0 × 10(-7) to 1.0 × 10(-5) mol L(-1), and detection limits (S/N = 3) were found to be 5.2 × 10(-8) and 2.8 × 10(-8) mol L(-1), respectively. The proposed sensor showed advantages of high sensitivity, simple sample preparation protocol, enhanced throughput and good reproducibility. Finally, the practical application of the proposed sensor has been performed for the determination of guanine and adenine in real samples with satisfactory results.
    The Analyst 10/2014; 139(23). DOI:10.1039/c4an00901k · 3.91 Impact Factor
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    ABSTRACT: NH2-MIL-125(Ti), as a highly porous titanium-based MOF, has been firstly reported to show an efficient photooxidation activity toward Mn2+ in pH 8.5 NH3-NH4Cl (0.04 M) buffer under visible light. Mn2+ was detected quantitatively by cathodic stripping voltammetric method based on the oxidized manganese product. The stripping peak currents on NH2-MIL-1 25(Ti)/CPE was linearly proportional to the concentration of Mn2+ in the range from 1.0 x 10(-8) to 1.0 x 10(-5) M with the detection limit of 4.0 10-9 M. This method has been successfully applied for the detection of Mn2+ in tea samples, and the results were in close agreements with those obtained by atomic absorption spectroscopic method.
    Sensors and Actuators B Chemical 10/2014; 201:274–280. DOI:10.1016/j.snb.2014.05.017 · 3.84 Impact Factor
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    ABSTRACT: Nonelectroactive acetochlor can be indirectly determined through the photocatalytical degradation of acetochlor. A derivative visible light photoelectrochemical sensor for indirect detection of the herbicide acetochlor using TiO2-poly(3-hexylthiophene)-ionic liquid nanocomposite is constructed. Poly(3-hexylthiophene) (P3HT) was synthesized via chemical oxidative polymerization with anhydrous FeCl3 as oxidant, 3-hexylthiophene as monomer, chloroform as solvent, and the functional TiO2 nanoparticles were facilely prepared by blending TiO2 nanoparticles and P3HT at room temperature ionic liquid, 1-Butyl-3-methylimidazolium hexafluorophosphate solution. Operational parameters, including the photolysis time, ratios of TiO2 to P3HT, bias voltage and pH of buffer solution have been optimized. Under optimal conditions, the proposed photoelectrochemical method could detect acetochlor ranging from 0.5 to 20μmolL(-1) with a detection limit of 0.2nmolL(-1) at a signal-to-noise ratio of 3. The assay results of acetochlor in water samples with the proposed method were in acceptable agreement with those of the gas chromatograph-mass spectrometer (GC-MS) method. The promising sensor opens a new opportunity for fast, portable, and sensitive analysis of acetochlor in environmental samples.
    Talanta 09/2014; 127:169–174. DOI:10.1016/j.talanta.2014.01.058 · 3.51 Impact Factor
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    ABSTRACT: In this work, a novel streptavidin functionalized graphene oxide/Au nanoparticles (streptavidin/GO/AuNPs) composite is prepared and for the first time used to construct sensitive chemiluminescent immunosensor for the detection of tumor marker. The streptavidin/GO/AuNPs composite and the immunosensor are characterized using scanning electron microscopy, static water contact angle measurement and electrochemical impedance spectroscopy. The biofunctionalized composite has large reactive surface area and excellent biocompatibility, thus the capture antibody can be efficiently immobilized on its surface based on the highly selective recognition of streptavidin to biotinylated antibody. Using α-fetoprotein (AFP) as a model, the proposed chemiluminescent immunosensor shows a wide linear range from 0.001 to 0.1ngmL(-1) with an extremely low detection limit down to 0.61pgmL(-1). The resulting AFP immunosensor shows high detection sensitivity, fast assay speed, acceptable detection and fabrication reproducibility, good specificity and stability. The assay results of serum samples with the proposed method are in an acceptable agreement with the reference values. This work provides a promising biofunctionalized nanostructure for sensitive biosensing applications.
    Analytica Chimica Acta 08/2014; 839:67–73. DOI:10.1016/j.aca.2014.05.033 · 4.52 Impact Factor
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    ABSTRACT: According to previous reports, the concentration of urinary proline (Pro), hydroxyproline (Hyp), and N-ethylglycine (Neg) varies in association with various diseases, especially, Neg as a tumor marker was recently found in association with bone metastasis cancers. We developed a low-cost, highly sensitive precolumn high–performance liquid chromatography (HPLC) method for simultaneous determination of Pro, Hyp, and Neg in urine of patients with cancers, bone metastasis cancers, and bone metastasis cancers that have appeared after radiotherapy and chemotherapy treatment. The analytes in the urine were labeled with 4–methoxybenzenesulfonyl fluoride (MOBS–F) at 40°C. The derivatives were separated on a reversed-phase column by gradient elution and monitored with ultraviolet (UV) detection at 232 nm. The detection limits for Pro, Hyp, and Neg were 6.0 pmol/injection, 4.0 pmol/injection, and 50 pmol/injection (S/N = 3), respectively. To some extent, Neg levels in their urine show there were relevance to their health conditions or therapy progress. We believe that the developed method may be a promising measure for providing a useful reference to diagnose the illness and monitor the results for bone metastasis cancers after radiotherapy and chemotherapy treatment.
    Journal of Liquid Chromatography &amp Related Technologies 07/2014; 37(12). DOI:10.1080/10826076.2013.807468 · 0.64 Impact Factor
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    ABSTRACT: Bovine interferon gamma (BoIFN-γ) released by T cells plays very important roles in early diagnosis of Mycobacterium tuberculosis (MTB) infections and control of bovine tuberculosis. In this work, a label-free electrochemical impedance immunosensor is for the first time developed for highly sensitive determination of BoIFN-γ. Cylinder-shaped TiO2 nanorods are synthesized by a facile hydrothermal method, and show high surface area and good hydrophicility. The immunosensor is fabricated by the immobilization of BoIFN-γ monoclonal antibody on the TiO2 nanorods modified glassy carbon electrode. The prepared TiO2 and immunosensor are characterized using transmission electron microscopy, scanning electron microscopy, X-ray diffraction, contact angle measurement, cyclic voltammetry, and electrochemical impedance spectra. The BoIFN-γ concentration is measured through the relative increase of impedance values in corresponding specific binding of BoIFN-γ antigen and BoIFN-γ antibody. The relative increased impedance values are proportional to the logarithmic value of BoIFN-γ concentrations in a wide range of 0.0001 to 0.1ng/mL with a low detection limit of 0.1pg/mL. The developed BoIFN-γ immunosensor shows a 249-fold decrease in detection limit in comparison with current enzyme-linked immunosorbent assay. This study provides a new, simple, and highly sensitive approach for very potential application in early diagnosis of MTB infections and control of bovine tuberculosis.
    Biosensors & Bioelectronics 07/2014; 63C:190-195. DOI:10.1016/j.bios.2014.07.032 · 6.45 Impact Factor
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    ABSTRACT: We report on the synthesis of Fe3O4-functionalized metal-organic framework (m-MOF) composite from Zn(II) and 2-aminoterephthalic acid by a hydrothermal reaction. The magnetic composite is iso-reticular and was characterized by FTIR, X-ray diffraction, SEM, magnetization, and TGA. The m-MOF was then applied as a sorbent for the solid-phase extraction of trace levels of copper ions with subsequent quantification by electrothermal AAS. The amount of sorbent applied, the pH of the sample solution, extraction time, eluent concentration and volume, and desorption time were optimized. Under the optimum conditions, the enrichment factor is 50, and the sorption capacity of the material is 2.4 mg g−1. The calibration plot is linear over the 0.1 to 10 μg L−1 Cu(II) concentration range, the relative standard deviation is 0.4 % at a level of 0.1 μg L−1 (for n = 10), and the detection limit is as low as 73 ng L−1. We consider this magnetic MOF composite to be a promising and highly efficient material for the preconcentration of metal ions. Figure Magnetic metal-organic frameworks was synthesized and used as a new sorbent for lead adsorption with detection by electrothermal atomic absorption spectrometry.
    Microchimica Acta 07/2014; 181(9-10):949-956. DOI:10.1007/s00604-014-1183-z · 3.72 Impact Factor
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    ABSTRACT: A novel solid-phase extraction sorbent, metal-organic frameworks and graphite oxide hybrid composite, was prepared by a solvothermal technique. The morphology and properties of the resultant material were examined by Fourier transform infrared spectroscopy, X-ray diffraction and field emission scanning electron microscopy. To evaluate the extraction performance of the resultant sorbent, luteolin was chosen as a model analyte. The extraction conditions were optimized. Based on these, a convenient and efficient solid-phase extraction procedure for the determination of luteolin was established and the subsequent quantification step was performed by square wave anodic stripping voltammetry. Under the optimal conditions, the oxidation current increased linearly with increasing the concentration of luteolin in the range of 5.0×10(-9)-5.0×10(-7)molL(-1) with a correlation coefficient of 0.9983 and a detection limit of 7.9×10(-10)molL(-1). The relative standard deviation of seven successive scans was 4.20% for 5.0×10(-8)molL(-1) luteolin. This work not only proposes a useful method for sample pretreatment, but also reveals the great potential of metal-organic frameworks based hybrid materials as an excellent sorbent in solid-phase extraction.
    Talanta 05/2014; 122:91–96. DOI:10.1016/j.talanta.2014.01.049 · 3.51 Impact Factor
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    ABSTRACT: Biomorphic calcium phosphate (CaP) microspheres with hierarchical porous structure were synthesized using natural cole pollen grains as templates and were further employed for the immobilization of horseradish peroxidase (HRP). Scanning electron microscopy and Fourier transform infrared spectroscopy revealed (a) the porous structure of the CaP microspheres, (b) the effective immobilization, and (c) the retention of the conformation of HRP on CaP. The immobilized HRP was placed on a glassy carbon electrode where it underwent a direct, fully reversible, and surface-controlled redox reaction with an electron transfer rate constant of 1.96 s−1. It also exhibits high sensitivity to the reduction of H2O2. The response to H2O2 is linear in the 5.00 nM to 1.27 μM concentration range, and the sensitivity is 30357 μA⋅mM−1⋅cm−2. The detection limit (at an SNR of 3) is as low as 1.30 nM. The apparent Michaelis–Menten constant (K M app ) of the immobilized enzyme is 0.92 μM. This new CaP with hierarchical porous structure therefore represents a material that can significantly promote the direct electron transfer between HRP and an electrode, and is quite attractive with respect to the construction of biosensors. FigureBiomorphic calcium phosphate microspheres with hierarchical porous has been synthesized using natural cole pollen grains as templates and were further employed for the immobilization of horseradish peroxidase to construct biosensors with high sensitivity and selectivity.
    Microchimica Acta 04/2014; 181(5-6). DOI:10.1007/s00604-013-1134-0 · 3.72 Impact Factor
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    ABSTRACT: We report on label-free immunosensors for the highly sensitive detection of avian influenza virus. The method makes use of the microcantilevers of an atomic force microscope onto which monoclonal antibodies against avian influenza virus were covalently immobilized. The factors influencing the performance of the resulting immunosensors were optimized by measuring the deflections of the cantilever via optical reflection, and this resulted in low detection limits and a wide analytical range. The differential deflection signals revealed specific antigen binding and their intensity is proportional to the logarithm of the concentrations of the virus in solution. Under optimal conditions, the immunosensors exhibit a linear response in the 7.6 ng mL−1 to 76 μg mL−1 concentration range of avian influenza virus, and the detection limit is 1.9 ng mL−1. FigureLabel-free immunosensors based on microcantilevers of an atomic force microscope was fabricated by covalently immobilizing monoclonal antibodies to avian influenza virus onto the microcantilever. The performance and factors influencing the performance of the resulting immunosensors were investigated in detail by measuring the cantilever deflections using the optical reflection technique.
    Microchimica Acta 02/2014; 181(3-4). DOI:10.1007/s00604-013-1129-x · 3.72 Impact Factor
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    ABSTRACT: An electrochemical sensor based on a copolymer poly(4-vinylpyridine)-co-poly(acrylonitrile), P4VP-co-PAN, and Fe2O3 nanoparticle film modified glassy carbon electrode was developed for the determination of glucose. We studied the response of glucose with the proposed electrode, and determined the optimum conditions by changing the potential, pH and P4VP-co-PAN. The current response measurements were performed in PBS (c=0.1M) with a potential of 0.7V. The current response of this glucose sensor showed a linear relationship with the concentration in the range of 2.5μM-0.58mM (r=0.997). The experimental results demonstrate that this method has such merits as simple operation, low cost, high sensitivity, long term stability and good reproducibility, with satisfactory results.
    02/2014; 35:420-5. DOI:10.1016/j.msec.2013.11.030
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    ABSTRACT: A novel glucose electrochemical biosensor was constructed based on the immobilization of glucose oxidase (GOx) in cage-like PbS nanostructure. The fabricated biosensor was characterized by scanning electron microscopy, UV-vis spectroscopy, Fourier transform infrared spectroscopy and cyclic voltammetry, respectively. The direct electrochemistry of GOx at cage-like PbS nanostructure modified glassy carbon electrode was for the first time studied. The cage-like PbS nanostructure has larger surface area and provides a favorable microenvironment for facilitating the direct electron transfer between enzyme and electrode surface. The immobilized enzymes on PbS cage-like nanostructure retains its native structure and bioactivity and shows a surface controlled, reversible two-proton and two-electron transfer reaction with a apparent electron transfer rate constant of 2.85 s(-1). The biosensor shows wide linear range for glucose from 5.0 x 10(-5) M to 1.45 x 10(-3) M with high sensitivity of 11.02 mA M-1 cm(-2). The detection limit was calculated to be 1.0 x 10-5 M at signal-to-noise of 3. Moreover, the proposed glucose biosensor displays excellent selectivity, good reproducibility, and acceptable operational stability and can be successfully applied in the detection of glucose in serum sample. The cage-like PbS nanostructure provides a promising approach for immobilizing proteins and fabricating excellent biosensors.
    Sensors and Actuators B Chemical 01/2014; 190:549-554. DOI:10.1016/j.snb.2013.09.046 · 3.84 Impact Factor