Jilin Tang

Chinese Academy of Sciences, Peping, Beijing, China

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Publications (75)307.47 Total impact

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    ABSTRACT: Epithelial cell adhesion molecule (EpCAM) is a tumor-specific antigen for malignancies of epithelialis lineage. In this study the interaction of DNA-based EpCAM aptamer (SYL3C) and EpCAM was explored with single molecular recognition force spectroscopy (SMFS). The capability of aptamer SYL3C to recognize EpCAM protein and the kinetic parameters were investigated.
    The Analyst 07/2015; DOI:10.1039/C5AN00945F · 3.91 Impact Factor
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    ABSTRACT: We present an aptamer-based microcantilever biosensor for label-free detection of nucleolin. The sensor cantilevers in the microcantilever array were functionalized with nucleolin aptamer (AS1411) while the reference cantilevers were modified by 6-mercapto-1-hexanol (MCH) to eliminate environmental disturbances. The interaction between nucleolin and AS1411 induced surface stress changes, resulting in a differential deflection between sensor and reference cantilevers. The amplitude of differential cantilever deflection had a good linear relationship with the nucleolin concentration ranging from 10 nM to 250 nM with a correlation coefficient of 0.999. The detection limit was about 1.0 nM, at a signal-to-noise ratio of 3. The aptamer-based microcantilever sensor demonstrated good selectivity and was facile, rapid, and reagentless. Our results show the potential for the application of microcantilever biosensor system as a powerful tool to detect tumor markers with high sensitivity and specificity.
    Talanta 06/2015; DOI:10.1016/j.talanta.2015.06.034 · 3.51 Impact Factor
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    ABSTRACT: Designing and developing active, cost-effective and stable electrocatalysts for hydrogen evolution reaction (HER) are still ongoing challenge. Herein, we report the synthesis of binary transition metal phosphides (CoxFe1-xP) nanocubes with different Co and Fe ratio through a phosphidation process by using metal−organic frameworks (MOFs) as templates. MOFs templates contribute well-defined nanocubes architecture features after phosphidation, while suitable phosphidation temperature could construct crystal structure and keep the well-defined structure. The incorporation of binary transition metal results in redistributions of the valence electrons in CoxFe1-xP. The changes imply anionic states of the P and Fe atoms, which act as active sites and thus stronger electron-donating ability. When CoxFe1-xP nanocubes are employed as electrocatalysts, these characteristic features facilitate the performance of HER. Remarkably, Co0.59Fe0.41P nanocubes prepared at 450 oC afford a current density of 10 mA cm-2 at a low overpotential of 72 mV in acidic condition and 92 mV in alkaline condition. Co0.59Fe0.41P nanocubes also exhibit a small Tafel slope of 52 mV decade−1 in acidic condition and 72 mV decade−1 in alkaline condition. Moreover, Co0.59Fe0.41P nanocubes show good stability in both acidic and alkaline conditions. Our method produces the highly active HER catalyst based on binary transition metal MOFs templates, providing a new avenue for designing excellent electrocatalysts.
    Nanoscale 05/2015; DOI:10.1039/C5NR01955A · 6.74 Impact Factor
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    ABSTRACT: Three-dimensional Prussian blue-reduced graphene oxide hydrogel was synthesized with the assistant of sodium dodecyl sulfate (SDS) through a facile hydrothermal method. The hydrogel exhibited strong mechanical properties and was successfully applied as a self-propulsion motor for water treatment. During the self-propulsion degradation process, SDS helped oxygen bubbles quickly exhausting from motor and the oxygen bubbles assisted the rapid diffusion of hydroxyl radicals. In addition, the well-defined structure increased the number of reaction sites and the synergy between reduced graphene oxide and Prussian blue accelerated degradation efficiency. The self-propulsion motor had the average velocity of 0.026±0.013 cm s-1 in 7.5% H2O2 and 0.069±0.032 cm s-1 in 22.5% H2O2. Moreover, the self-propulsion motor keeps high degradation efficiency even after cycling for 9 times. These excellent properties make the motor an ideal candidate for self-propulsion water treatment.
    Nanoscale 05/2015; 7(23). DOI:10.1039/C5NR00759C · 6.74 Impact Factor
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    ABSTRACT: Bacterial spores (endospores), such as those of the pathogens Clostridium difficile and Bacillus anthracis, are uniquely stable cell forms, highly resistant to harsh environmental insults. Bacillus subtilis is the best studied spore-former and we have used it to address the question of how the spore coat is assembled from multiple components to form a robust, protective superstructure. B. subtilis coat proteins (CotY, CotE, CotV and CotW) expressed in E. coli can arrange intracellularly into highly stable macro-structures through processes of self-assembly. Using electron microscopy we demonstrate the capacity of these proteins to generate ordered one dimensional fibres, two dimensional sheets and three dimensional stacks. In one case (CotY), the high degree of order favours strong, co-operative intracellular disulfide cross-linking. Assemblies of this kind could form exquisitely adapted building blocks for higher order assembly across all spore-formers. These physically robust arrayed units could also have novel applications in nano-biotechnology processes. This article is protected by copyright. All rights reserved.
    Molecular Microbiology 04/2015; DOI:10.1111/mmi.13030 · 5.03 Impact Factor
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    ABSTRACT: Developing inexpensive and highly efficient non-precious-metal electrocatalysts has been proposed as a promising alternative to platinum-based catalysts for the hydrogen evolution reaction (HER). Herein, we report novel FeP NPs supported on inexpensive and available candle soot (FeP-CS) derived from Fe3O4-CS hybrid precursors obtained after a phosphidation reaction. As HER electrocatalysts, the FeP-CS hybrids exhibit high electrocatalytic ability for HER with a Tafel slope of 58 mV dec(-1), a low onset overpotential of 38 mV, a large exchange current density of 2.2 × 10(-1) mA cm(-2) and an overpotential of 112 mV to obtain a current of 10 mA cm(-2). The present work shows significant advance in designing and developing non-precious-metal electrocatalysts for hydrogen evolution reaction.
    Nanoscale 02/2015; 7(10). DOI:10.1039/c4nr07436j · 6.74 Impact Factor
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    ABSTRACT: A facile hydrothermal method combined with a post solution reaction is developed to synthesize interconnected three-dimension (3D) hierarchical Co3-xFexO4 ferrite (CF) on nickel foam. By controlling the experimental parameters, the structures of the products are tailored from nanoflowers to microflowers with different sized void interiors. The obtained 3D hierarchical flower-like CF are characterized by field emission scanning electron microscopy, X-ray diffraction, and inductively coupled plasma mass spectrometer analysis. The 3D hierarchical flower-like CF-nickel foam with the rational structural feature could be used as binder and conductive agent-free supercapacitor electrodes directly. Such integrated electrodes exhibit a high specific capacitance and well cycling stability when the charge-discharge current density is high. Remarkably, the 3D hierarchical CF microflowers exhibit specific capacitance values of 768 F g−1 at a constant current density of 6 A g−1. The CF microflowers also show high charge-discharge reversibility with an efficiency of 79.2% after 5000 cycles.
    Electrochimica Acta 11/2014; 152. DOI:10.1016/j.electacta.2014.11.104 · 4.50 Impact Factor
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    ABSTRACT: A synthetic route to FeP-GS hybrid sheets that show good stability and high electrocatalytic activity for hydrogen evolution reaction is reported. The materials are prepared via thermal phosphidation of pre-synthesized Fe3O4-GS hybrid sheets.
    Chemical Communications 08/2014; 50(78). DOI:10.1039/c4cc05285d · 6.72 Impact Factor
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    ABSTRACT: A facile approach was proposed for the synthesis of hierarchical CoxFe3−xO4 nanocubes (CF nanocubes), using Prussian Blue (PB) as precursor. The method consists of the synthesis of hierarchical cobalt–iron Prussian blue analogues (PBAs) through the reaction of PB nanocubes with CoCl2 in a water bath and subsequently calcining the corresponding PBA precursor. The obtained CF nanocubes were characterized using transmission electron microscopy, scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy and N2 adsorption–desorption isotherm measurements. It is found that the hierarchical CF nanocubes have a large specific surface area (108 m2 g−1). Considering the hierarchical structure and the doping of Co in Fe3O4 are beneficial for the catalytic activity of the catalyst, an efficient and simple colorimetric biosensor for H2O2 and glucose was fabricated using CF nanocubes as a peroxidase mimetic. The good catalytic activity and low-cost make the hierarchical CF nanocubes a useful biocatalyst for a wide range of potential applications in medicine and biotechnology.
    RSC Advances 08/2014; 4(67). DOI:10.1039/C4RA03859B · 3.84 Impact Factor
  • Baoping Lu, Jilin Tang
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    ABSTRACT: Ultrathin two-dimensional (2D) nanosheets of layered transition-metal chalcogenide are theoretically and technologically intriguing. However, it still remains a great challenge to synthesize ultrathin nanosheets because of the lack of an intrinsic driving force for anisotropic growth of 2D superposed microstructures. Here we demonstrate, for the first time to our knowledge, the in situ synthesis of large-scale ultrathin Sb2S3 nanosheets on graphene sheets (G) by solvothermal method in the water/ethylene glycol mixed solvent. Owing to the synergetic chemical coupling effects between G and Sb2S3, Sb2S3–G hybrid nanosheets exhibit high catalytic performance for degradation of methylene blue in the presence of H2O2. In the meantime, it was found that the resulting Sb2S3–G displays good electrocatalytic activity towards the hydrazine oxidation. This work not only offers a low-cost and high performance alternative technology for synthesizing sheet-like Sb2S3, but also opens the door toward fabrication of varying types of metal sulfide–graphene nanomaterials that will have wide application in the catalysis, environmental, and new energy fields.
    Dalton Transactions 07/2014; 43(37). DOI:10.1039/C4DT01609B · 4.10 Impact Factor
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    ABSTRACT: Binding of antibodies to their cognate antigens is fundamental for adaptive immunity. Molecular engineering of antibodies for therapeutic and diagnostic purposes emerges to be one of the major technologies in combating many human diseases. Despite its importance, a detailed description of the nanomechanical process of antibody-antigen binding and dissociation on the molecular level is lacking. Here we utilize high-speed atomic force microscopy to examine the dynamics of antibody recognition and uncover a principle; antibodies do not remain stationary on surfaces of regularly spaced epitopes; they rather exhibit 'bipedal' stochastic walking. As monovalent Fab fragments do not move, steric strain is identified as the origin of short-lived bivalent binding. Walking antibodies gather in transient clusters that might serve as docking sites for the complement system and/or phagocytes. Our findings could inspire the rational design of antibodies and multivalent receptors to exploit/inhibit steric strain-induced dynamic effects.
    Nature Communications 07/2014; 5:4394. DOI:10.1038/ncomms5394 · 10.74 Impact Factor
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    ABSTRACT: A facile simple hydrothermal method combined with a post-solution reaction is developed to grow interconnected three dimensional (3D) hierarchical Co-Al layered double hydroxides (LDHs) on reduced graphene oxide (rGO). The obtained 3D hierarchical rGO-LDHs are characterized by field emission scanning electron microscopy, X-ray diffraction, and X-ray photo-electron spectroscopy. As LDHs nanosheets directly grow on the surface of rGO via chemical covalent bonding, the rGO could provide facile electron transport paths in the electrode for the fast Faradaic reaction. Moreover, benefiting from the rational 3D hierarchical structural, the rGO-LDHs demonstrate excellent electrochemical properties with a combination of high charge storage capacitance, fast rate capability and stable cycling performance. Remarkably, the 3D hierarchical rGO-LDHs exhibit specific capacitance values of 599Fg(-1) at a constant current density of 4Ag(-1). The rGO-LDHs also show high charge-discharge reversibility with an efficiency of 92.4% after 5000 cycles.
    Journal of Colloid and Interface Science 07/2014; 426:131–136. DOI:10.1016/j.jcis.2014.04.003 · 3.55 Impact Factor
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    ABSTRACT: A reversible detection method for vancomycin was developed utilizing the cantilever array sensor functionalized by a designed peptide consisting of a cysteine (Cys-), a space linker (-Gly-Gly-Gly-Gly-) and a molecular recognition ligand (-l-Lys-d-Ala-d-Ala). It was found that the peptide space linker was necessary and important for the response of the cantilever array sensor. The sensing cantilevers in the array were functionalized with the peptide while the reference cantilevers were modified by 6-mercapto-1-hexanol (MCH) to eliminate the influence of environmental disturbances. The binding between vancomycin and the peptide induced a change of surface stresses in the sensing cantilevers resulting in a differential deflection between the sensing and reference cantilevers. The reciprocal of the differential deflection is linear with the reciprocal of vancomycin concentration within the range of 2μM to 100μM (R=0.993) at a detection limit of 0.2μM (S/N=3). The reversible detection can be realized just by regenerating the sensing cantilevers with running buffer solution. Other antibiotics such as doxycycline, streptomycin, and kanamycin have negligible effect on the response of the sensor. The sensor can also be utilized for reversible detection of vancomycin in serum background, which clearly indicates the potential of the sensor for vancomycin detection in real biological samples.
    Biosensors & Bioelectronics 06/2014; 62C:145-150. DOI:10.1016/j.bios.2014.06.024 · 6.45 Impact Factor
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    ABSTRACT: A facile two-step method was developed for a large-scale growth of hierarchical MnCo2O4.5 nanostructure modified MnOOH nanorods (MC hybrid materials) as an efficient catalyst for water treatment. The synthesis involved a one-step hydrothermal process to prepare MnOOH nanorods and subsequently a simple solution method using hydrothermally synthesized MnOOH nanorods as both the template and Mn source to obtain MnCo2O4.5/MnOOH (MC) hybrid materials. The as-prepared MC hybrid materials with hierarchical structures could provide more active sites for catalytic degradation of methylene blue. These results indicate that the designed MC hybrid materials exhibit a promising capability for the degradation of dyes.
    Catalysis Communications 02/2014; 46:174–178. DOI:10.1016/j.catcom.2013.12.018 · 3.32 Impact Factor
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    ABSTRACT: Human gonadotropin-releasing hormone receptor (GnRH-R; or type I GnRH-R) expressed in tumor cells has gained more and more attention as a distinct target for cancer therapy. Given the diverse clinical utility, improved characterization of the subcellular distribution and organization of GnRH-R is an important step in the development of more effective and possibly new therapeutic strategies. In the present study, the nano-organization of human GnRH-R was analyzed on human bladder cancer cell (T24) by atomic force microscopy (AFM). The recognition images reveal that GnRH-Rs (nano-domains or single GnRH-R) are irregularly distributed on the T24 cell surface with the sizes from ~ 4 to ~ 370 nm. The locations of the GnRH-Rs were identified on the topographical images with nanometer accuracy. The obtained results enrich our understanding of the local distribution of GnRH-Rs on T24 cell membrane and show the ability of biological AFM to obtain more complete and exact information on intact cell surface.
    Analytical Chemistry 01/2014; 86(5). DOI:10.1021/ac403304g · 5.83 Impact Factor
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    ABSTRACT: A label-free detection method of kanamycin using aptamer-based cantilever array sensor was developed. The cantilever array was composed of sensing cantilevers and reference cantilevers. This configuration allowed direct detection of individual cantilever deflections and subsequent determination of differential deflection of sensing/reference cantilever pair. The sensing cantilevers were functionalized with kanamycin aptamer, which was used as receptor molecules while the reference cantilevers were modified with 6-mercapto-1-hexanol (MCH) to eliminate the influence of environmental disturbances. The kanamycin-aptamer interaction induced a change in cantilever surface stress, which caused a differential deflection between the sensing and reference cantilever pair. The surface stress change was linear with kanamycin concentration over the range of 100μM-10mM with a correlation coefficient of 0.995. A detection limit of 50μM was obtained, at a signal-to-noise ratio of 3. The sensor also showed good selectivity against other antibiotics such as neomycin, ribostamycin and chloramphenicol. The facile method for kanamycin detection may have great potential for investigating more other molecules.
    Biosensors & Bioelectronics 01/2014; 56C:112-116. DOI:10.1016/j.bios.2013.12.068 · 6.45 Impact Factor
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    ABSTRACT: A reversible detection method for vancomycin was developed utilizing the cantilever array sensor functionalized by a designed peptide consisting of a cysteine (Cys-), a space linker (-Gly-Gly-Gly-Gly-) and a molecular recognition ligand (-l-Lys-d-Ala-d-Ala). It was found that the peptide space linker was necessary and important for the response of the cantilever array sensor. The sensing cantilevers in the array were functionalized with the peptide while the reference cantilevers were modified by 6-mercapto-1-hexanol (MCH) to eliminate the influence of environmental disturbances. The binding between vancomycin and the peptide induced a change of surface stresses in the sensing cantilevers resulting in a differential deflection between the sensing and reference cantilevers. The reciprocal of the differential deflection is linear with the reciprocal of vancomycin concentration within the range of 2 μM to 100 μM (R=0.993) at a detection limit of 0.2 μM (S/N=3). The reversible detection can be realized just by regenerating the sensing cantilevers with running buffer solution. Other antibiotics such as doxycycline, streptomycin, and kanamycin have negligible effect on the response of the sensor. The sensor can also be utilized for reversible detection of vancomycin in serum background, which clearly indicates the potential of the sensor for vancomycin detection in real biological samples.
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    ABSTRACT: Graphene-based sheets that possess a unique nanostructure and a variety of fascinating properties are appealing as promising nanoscale building blocks of new composites. Herein, we present a general and effective approach for the preparation of metal oxide-graphene (metal oxide-G, metal oxide = Fe3O4, ZnO and Cu2O) by in situ nucleation and growth of metal oxide on the surface of graphene in tetraethylene glycol (TEG) solution. TEG, a nontoxic and environmentally friendly agent, acts as both solvent and reductant. Furthermore, the Fe3O4-G was employed as a two dimensional support for loading noble metal nanoparticles (Au or Pt) to synthesize Au@Fe3O4-G and Pt@Fe3O4-G ternary hybrid materials. The as-obtained Au@Fe3O4-G exhibited excellent catalytic activity in the reduction of 4-nitrophenol by NaBH4, and the Pt@Fe3O4-G showed remarkable electrocatalytic performance for hydrazine oxidation. We believe that the hybrid catalysts fabricated by this simple, efficient method have great potential for applications in other fields, such as electrochemical energy storage, sensors, and so on.
    RSC Advances 01/2014; 4(42):21909. DOI:10.1039/c4ra03184a · 3.84 Impact Factor
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    ABSTRACT: A simple and universal solvothermal method for the synthesis of metal telluride/reduced graphene oxide (MTe/RGO, M = Cd, Co and Ni) by in situ nucleation and growth of MTe nanocrystals on the surface of RGO was reported. The as-synthesized MTe/RGO composites were characterized by transmission electron microscopy, X-ray diffraction, Raman spectroscopy and X-ray photoelectron spectroscopy. The possible formation mechanism of MTe/RGO was also proposed. The obtained CdTe/RGO exhibits higher photocatalytic activity in the degradation of methylene blue compared to pure CdTe. This could be attributed to the efficient charge transport of RGO and hence reduced recombination rate of excited carriers.
    Carbon 11/2013; 63:157-164. DOI:10.1016/j.carbon.2013.06.067 · 6.16 Impact Factor
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    ABSTRACT: A facile process was developed for the synthesis of graphene-supported TiO2 (B) nanosheets (GTBN) composite based on the hydrothermal treatment titanium (III) chloride and graphene oxide in an ethylene glycol. The morphology and microstructure of the composites were examined by X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, and Raman spectroscopy. The obtained GTBN show a high thermal stability and the phase transformation of TiO2 (B) to anatase can be prevented by graphene after pyrolysis of GTBN at 350°C for 2h. Furthermore, GTBN exhibited high rate performance and stability of lithium ion batteries, due to the enhanced conductivity of the electrode and accommodation to volume/strain changes during lithium insertion-extraction.
    Journal of Colloid and Interface Science 08/2013; 409. DOI:10.1016/j.jcis.2013.07.053 · 3.55 Impact Factor

Publication Stats

859 Citations
307.47 Total Impact Points

Institutions

  • 2001–2015
    • Chinese Academy of Sciences
      • • State Key Laboratory of Electroanalytical Chemistry
      • • National Analytical Research Center of Electrochemistry and Spectroscopy
      Peping, Beijing, China
  • 2013
    • Nanchang University
      Nan-ch’ang-shih, Jiangxi Sheng, China
  • 2006–2009
    • Johannes Kepler University Linz
      • Institute of Biophysics
      Linz, Upper Austria, Austria