Ali Riza Soylu

Trakya University, Adrianoupolis, Edirne, Turkey

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Publications (28)135.78 Total impact

  • Journal of Crohn s and Colitis 02/2014; 8:S197. DOI:10.1016/S1873-9946(14)60438-4 · 3.56 Impact Factor
  • Journal of Crohn s and Colitis 02/2014; 8:S312-S313. DOI:10.1016/S1873-9946(14)60706-6 · 3.56 Impact Factor
  • Journal of Crohn s and Colitis 02/2013; 7:S96-S97. DOI:10.1016/S1873-9946(13)60240-8 · 3.56 Impact Factor
  • Journal of Crohn s and Colitis 02/2013; 7:S64-S65. DOI:10.1016/S1873-9946(13)60163-4 · 3.56 Impact Factor
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    ABSTRACT: Objective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P < 0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field.
    Gastroenterology Research and Practice 10/2012; 2012:425079. DOI:10.1155/2012/425079 · 1.75 Impact Factor
  • Acta gastro-enterologica Belgica 11/2008; 72(2):277-8. · 0.58 Impact Factor
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    ABSTRACT: The outcome of Helicobacter pylori infection has been related to specific virulence-associated bacterial genotypes. The best known genotypic virulence factors of H. pylori are cytotoxin-associated gene A (cagA) and vacuolating cytotoxin gene A (vacA). The objective of this study was to assess the relationship between H. pylori cagA and vacA status and histopathological findings. Esophagogastrodoedonoscopy was performed in 80 dyspeptic patients. Antrum and corpus biopsies were obtained for isolation of H. pylori and for histopathological assessment. The polymerase chain reaction was used to detect cagA and vacA genes of H. pylori using specific primers. Biopsy samples were stained with hematoxylin and eosin, and histopathological findings were graded using the "updated Sydney system". H. pylori from 57 of the 80 patients was incubated. Of the 57 patients, 44 were cagA positive. In the corpus biopsy specimens there was a significant relationship between the density of H. pylori colonization (P = 0.02) and chronic inflammation (P = 0.02) and cagA-positive genotypes. In the antrum specimens there was a significant relationship between cagA positivity and neutrophil activity (P = 0.003) and glandular atrophy (P = 0.002), but not with H. pylori density, chronic inflammation, and intestinal metaplasia. The odds ratio of cagA-positive vs. cagA-negative strains for the presence of glandular atrophy, irrespective of grading and of gastric localization, was 4.62 (95% CI, 1.18-18.08, P = 0.041). No significant relationships were observed between vacA s1 and s2 genotypes and histopathological parameters. Corpus neutrophil infiltration was found to be more severe in the m1 group than in the m2 group (P = 0.004). Other histopathological features showed no difference between m1 and m2 genotypes. In conclusion H. pylori strains showing cagA positivity are associated with more severe gastritis in some histological features but virulence factors of H. pylori do not appear to determine the overall pattern of gastritis.
    Digestive Diseases and Sciences 06/2008; 54(1):103-10. DOI:10.1007/s10620-008-0316-9 · 2.55 Impact Factor
  • A R Soylu, H Ertan, F Korkusuz
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    ABSTRACT: The purpose of the current study was to compare the repeatability of electromyographic linear envelopes (LE) of archery groups. Surface electromyography (EMG) signals of musculus flexor digitorum superficialis (MFDS) and extensor digitorum (MED) of 23 participants (seven skilled, six beginner archers and ten non-archers) were recorded during archery shooting. Two-second periods (clicker falls at first second) of 12 shots' EMG data were recorded, full-wave rectified and filtered (60 ms moving-average filter) for each participant's drawing arm. Repeatability was investigated by using a statistical criterion, variance ratio (VR). Archers' performances were evaluated in terms of FITA scores. The results showed that FITA scores were significantly correlated to the VRs of MFDS and MED. EMG LEs were more repeatable among archers than non-archers. Therefore, we inferred that VRs of MFDS and MED might be important variables for (a) assessing shooting techniques, (b) evaluation of archers' progress, and (c) selection of talented archers.
    Human Movement Science 01/2007; 25(6):767-74. DOI:10.1016/j.humov.2006.05.002 · 2.03 Impact Factor
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    ABSTRACT: Background: Oxidative stress has been associated with tissue injury in alcoholic liver disease. Although this close association is well known, whether prevention of oxidative stress retards tissue injury has not been thoroughly investigated.Objective: The aim of this study was to determine the effects of supplementation with vitamins E and C on antioxidant enzyme status and histologic changes in hepatic tissue in a rat model of alcoholic liver disease.Methods: This 8-week, blinded, controlled study was conducted at the Department of Internal Medicine, Trakya University, Edirne, Turkey. Weanling albino female protein-deficient Wistar rats weighing ∼200 g were randomly assigned to 1 of 6 groups: (1) liquid diet+ethanol+vitamin E 15 mg/kg PO (LDetvitE); (2) liquid diet+ethanol+vitamin C 10 mg/kg PO (LDetvitC); (3) liquid diet+ethanol+vitamin E 15 mg/kg+vitamin C 10 mg/kg PO (LDetvitEC); (4) liquid diet+ethanol (LDet); (5) liquid diet+isocaloric sucrose (LDS); and (6) normal diet (control). The primary end point of the study was to determine whether antioxidant vitamin E/C combination therapy prevents development of hepatic fibrosis (ie, cirrhosis in a period of 1 year). After being euthanized at week 8, the rats were weighed, and their livers and spleens were weighed. Hepatic tissue specimens were histopathologically assessed according to the Brunt system. Hepatic tissue glutathione peroxidase, superoxide dismutase, and catalase activities were determined. Biochemical tissue collagen concentrations were measured to determine the presence of hepatic fibrosis.Results: Seventy-two rats were included in the study (mean [SE] weight, 205 [21] g) (12 rats per group). Initially planned to last 48 weeks, the study was terminated at 8 weeks due to the death of 3 rats in each group (except the LDS group and control group). The relative liver weight was significantly lower in the LDetvitEC group compared with that in the LDet group (mean [SE], 3.7% [0.5%] vs 4.8% [0.9%]; P
    Current Therapeutic Research 03/2006; 67(2):118-137. DOI:10.1016/j.curtheres.2006.04.007 · 0.45 Impact Factor
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    ABSTRACT: Patients with acute leukaemia suffer from various haemorrhages, most frequently due to thrombocytopenia. We could not reach any information regarding the frequency of gastrointestinal bleeding in acute leukaemia and decided to search this complication in patients with acute and chronic leukaemias and myeloproliferative disorders, retrospectively. During a 6-year period, 291 patients with acute leukaemia, 52 patients with chronic leukaemia and 108 patients with myeloproliferative disorders had been followed. Thirty-two cases of overt gastrointestinal haemorrhage episodes (25 upper, 7 lower) were observed during the mentioned period. The frequency of bleeding episodes was 7.1% (32/451) in haematologic malignancies as a whole, 5.8% (17/291) for acute leukaemia, 1.9% (1/52) for chronic leukaemia and 13% (14/108) for myeloproliferative disorders. If the patients with myeloproliferative disorders in blastic phase were analysed separately, the ratio was 30% (6/20). Oesophagogastroduodenoscopy, which could be performed in 8 of 25 upper gastrointestinal haemorrhage episodes, revealed erosive gastritis in five patients and duodenal ulcers in three patients. Neutropenic enterocolitis was the underlying cause in all of the seven patients with lower gastrointestinal haemorhage. Five out of the seven patients had acute leukaemia. In 7 bleeding attacks, out of 32, the ultimate result was death. Generally, the haemorrhage was only a contributing cause of mortality. All of the mortality cases were patients with acute leukaemia. Especially, the patients with myeloproliferative disorders are prone to develop gastrointestinal haemorrhage. The manifestation is generally as upper gastrointestinal bleeding due to gastric erosions and duodenal ulcers. Lower gastrointestinal bleeding is frequently a problem of the patients with acute leukaemia. It is commonly a sign of neutropenic enterocolitis.
    Digestive and Liver Disease 01/2006; 37(12):917-22. DOI:10.1016/j.dld.2005.07.017 · 2.89 Impact Factor
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    H Ertan, A R Soylu, F Korkusuz
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    ABSTRACT: Forearm electromyographic (EMG) data are assumed to be an effective method in estimating performance level in archery. The aim of the current study was to establish archery skill indexes based on EMG data. Elite (n=7, FITA score=1303.4+/-26.2), beginner (n=6, FITA score=1152+/-9.0) and non-archers (n=10, assumed FITA score=250+/-0), were involved in the study. EMG activity of Muscle flexor digitorum superficialis and Muscle extensor digitorum were quantified. Two-second periods--1 s before and 1 s after the fall of the clicker--were used to obtain averaged and rectified EMG data. The averaged and rectified EMG data were filtered by averaging finite impulse response filter with 40 ms time window and then normalized with respect to maximum voluntary contraction. To estimate FITA scores from EMG data, the following skill indexes that based on mean area under some parts of processed EMG waveforms was offered for archery. These were the pre-clicker archery skill index (PreCASI), post-clicker archery skill index (PostCASI), archery skill index (ASI) and post-clicker archery skill index 2 (PostCASI2). The correlations between rank of FITA scores and natural logarithms of archery skill indexes were significant for log(PreCASI): r=-0.66, p<0.0008; for log(PostCASI): r=-0.70, p<0.0003; for log(ASI): r=-0.74, p<0.0001; log(PostCASI2): r=-0.63, p<0.002. It is concluded that EMG skill indexes may be useful for: (a) assessing shooting techniques, (b) evaluation of archers' progress and (c) selection of talented archers.
    Journal of Electromyography and Kinesiology 05/2005; 15(2):222-7. DOI:10.1016/j.jelekin.2004.08.004 · 1.73 Impact Factor
  • Journal of Gastroenterology and Hepatology 05/2005; 20(4):657-60. DOI:10.1111/j.1440-1746.2005.03772.x · 3.63 Impact Factor
  • Journal of Hepatology 04/2004; 40:101-101. DOI:10.1016/S0168-8278(04)90331-5 · 10.40 Impact Factor
  • Journal of Clinical Gastroenterology 03/2004; 38(2):134. DOI:10.1097/00004836-200402000-00010 · 3.19 Impact Factor
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    ABSTRACT: This retrospective study evaluated the use of diagnostic and therapeutic ERCP in pre- and postoperative patients with hepatic hydatid disease. For 8 years, ERCP was performed in 39 patients with hepatic echinococcal disease. Indications in the preoperative group of patients (n = 19) included a cholestatic enzyme profile in all cases; jaundice or acute cholangitis also was present in, respectively, 14 and 7 cases. In the postoperative group (n = 20), indications for ERCP included persistent external biliary fistula after surgery in 10 patients, jaundice in 8, acute cholangitis in 7, and right upper quadrant pain in 2 patients. ERCP findings in the preoperative group included cystobiliary fistula (9 patients), external compression of the hepatic biliary system (5), hydatid vesicles and/or membranes within the biliary tract (3), intrahepatic duct stricture (1), and a normal cholangiogram (4). The most common ERCP finding in the postoperative group was external biliary fistula (10 patients); other findings consisted of hydatid cyst material within the bile duct (4), bile duct stenosis (2), cystobiliary fistula and hydatid cyst material in the bile duct (1), cystobiliary fistula (1), hydatid membranes in the gallbladder (1), extrinsic compression to bile ducts (1), and a normal cholangiogram (1). In the preoperative group, endoscopic sphincterotomy was performed in 11 patients, with balloon catheter extraction in 2; complete resolution of findings was achieved in 10 cases. In the postoperative group, sphincterotomy (with balloon or basket extraction as needed) was performed in 19 patients, stents were placed in 2 patients, 1 patient underwent balloon dilatation, and 1 had nasobiliary drainage; there was complete resolution of the findings in 14 of the 20 patients. ERCP and related therapeutic maneuvers are safe and valuable in the pre- and postoperative management of patients with hepatic hydatid disease.
    Gastrointestinal Endoscopy 10/2003; 58(3):384-9. DOI:10.1067/S0016-5107(03)00013-0 · 4.90 Impact Factor
  • The American Journal of Gastroenterology 07/2003; 98(6):1446-8. DOI:10.1111/j.1572-0241.2003.07507.x · 9.21 Impact Factor
  • A Soylu
    The American Journal of Gastroenterology 06/2003; 98(6):1446-1448. DOI:10.1016/S0002-9270(03)00287-9 · 9.21 Impact Factor
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    ABSTRACT: To determine the epidemiological features of ulcerative colitis in the Trakya region of Turkey, southeast Europe, we conducted a descriptive, cross-sectional, hospital-based study. All subjects were followed, and age, sex, place of residence, family history, educational status, tobacco consumption and use of oral contraceptives were recorded. The study included 49 cases of ulcerative colitis. The incidence of the disease was 0.59 per 100,000 in 1998, 0.89 per 100,000 in 1999, 0.89 per 100,000 in 2000 and 0.69 per 100,000 in 2001. The overall prevalence of the disease was 4.9 per 100,000; it was 2.18 per 100,000 in rural areas and 5.87 per 100,000 in urban areas. As in the Mediterranean countries, both the incidence and the prevalence of ulcerative colitis were found to be low. The incidence was significantly higher in urban areas than in rural areas.
    The Journal of international medical research 04/2003; 31(2):141-8. DOI:10.1177/147323000303100211 · 1.10 Impact Factor
  • Journal of Hepatology 04/2003; 38:71-71. DOI:10.1016/S0168-8278(03)80297-0 · 10.40 Impact Factor
  • Journal of Hepatology 04/2002; 36:209-209. DOI:10.1016/S0168-8278(02)80743-7 · 10.40 Impact Factor