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ABSTRACT: To our knowledge, the occlusion of arteries and platelet hyperaggregation have not been reported in patients with malignant mesothelioma. However, venous thromboembolism, especially in the pulmonary vasculature in association with thrombocytosis and hyperfibrinogenemia, are commonly noticed in this disorder. Furthermore, we detected enhanced platelet aggregation in a case of malignant peritoneal mesothelioma with internal carotid artery occlusion in whom there were postsplenectomy thrombocytosis and hyperfibrinogenemia. The possible mechanisms of ICA occlusion in this patient, including the role of MPM and postsplenectomy state, thrombocytosis, platelet functional changes, and other factors were investigated and discussed.
The American Journal of the Medical Sciences 05/2000; 319(4):265-7. · 1.39 Impact Factor
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The American Journal of Gastroenterology 04/2000; 95(3):846-8. · 7.28 Impact Factor
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Journal of Clinical Gastroenterology 11/1998; 27(3):275-6. · 3.16 Impact Factor
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Transplantation Proceedings 06/1998; 30(3):754-5. · 1.00 Impact Factor
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Nephrology Dialysis Transplantation 01/1998; 12(12):2807. · 3.40 Impact Factor
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Annals of Pharmacotherapy 01/1998; 31(12):1548-9. · 2.13 Impact Factor
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Endoscopy 01/1998; 30(1):S3-4. · 5.21 Impact Factor
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ABSTRACT: Fibronectin concentrations both in plasma and pleural effusion were prospectively determined in 60 patients with exudative pleural effusions. Fibronectin concentrations in plasma and pleural fluid in 12 patients with infectious and exudative pleural effusions (mean +/- SD) were 240 +/- 103 and 212 +/- 115 micrograms.mL-1, in 17 patients with primary or metastatic lung carcinoma 242 +/- 104 and 210 +/- 82 micrograms.mL-1, in 13 patients with pleural tuberculosis 246 +/- 77 and 231 +/- 133 micrograms.mL-1, and in 18 patients with confirmed malignant pleural mesothelioma 261 +/- 119 and 276 +/- 188 micrograms.mL-1. There were no significant differences either in the plasma or serum concentrations of fibronectin between groups (p > 0.05). Although pleural fluid fibronectin content appeared to have high specificity (85%), it was found to be an inefficient biological marker for differentiating nonmalignant from malignant pleural effusions due to its low sensitivity (6%).
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 08/1997; 52(4):335-8.
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Endoscopy 02/1997; 29(1):55. · 5.21 Impact Factor
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Acta Haematologica 02/1995; 93(1):54-5. · 1.35 Impact Factor
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ABSTRACT: We investigated plasma and gastric mucosal selenium levels in patients with Helicobacter pylori (HP)-associated histopathologic findings in their gastric antral mucosa.
Before and after a successful HP eradication therapy, we quantitated the plasma and antral selenium levels in patients with HP-associated chronic antral gastritis using atomic absorption flame emission spectrometry. The same measurements were done in patients with dyspeptic complaints who had normal antral histology and negative urease test.
Thirty-four patients were studied, of whom 24 had HP-associated chronic antral gastritis confirmed by histology and positive urease test; the control group included 10 healthy patients. There was no difference between the groups with regard to age, gender, and number of smokers. All patients with HP infection were diagnosed with diffuse antral gastritis. Histopathology showed that 11 (49%) had some degree of atrophy. Of the 11 patients, 7 were classified as having chronic atrophic gastritis (CAG) without intestinal metaplasia (IM), 4 had IM, and none had dysplasia. The plasma concentrations of selenium were found to be very similar in controls and HP-infected subjects (68.0 +/- 25.97 microg/L and 71 +/- 32.9 microg/L, respectively; p > 0.05). The antral biopsy samples of the patients with HP-associated gastritis contained significantly higher levels of tissue selenium than the controls (20.17 +/- 19.74 microg/g and 2.83 +/- 1.42 microg/g, respectively; p < 0.05). Also, it was shown that antral tissue selenium levels decrease after successful HP eradication therapy (20.17 +/- 19.4 microg/g and 7.4 +/- 4.56 microg/g, respectively; t < 0.05). The patients with HP gastritis were assigned to mild, moderate, and severe gastritis groups, according to the histopathologic degree of inflammation present. The antral gastric selenium levels were significantly higher in patients with moderate and severe HP gastritis (21.13 +/- 22.5 microg/g and 22.81 +/- 17.35 microg/g, respectively) than in patients with mild gastric inflammation (9.53 +/- 10.3 microg/g; p < 0.05). The selenium concentrations in the biopsies of patients with CAG were significantly lower than in those with HP gastritis who did not have CAG (9.45 +/- 6.44 microg/g vs. 19.13 +/- 22.48 microg/g, respectively; p < 0.05).
Selenium accumulates in gastric tissue when it is needed, as is the case in HP-related antral inflammation. This reactive increase in gastric mucosal selenium seems to disappear in the presence of precancerous gastric lesions in the setting of HP-associated gastritis.
Journal of Clinical Gastroenterology 32(5):405-8. · 3.16 Impact Factor
