-
International Journal of Radiation OncologyBiologyPhysics 11/1996; 36(3):758. · 4.11 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Fifty-four patients with musculo-aponeurotic fibromatosis treated with surgery, surgery and planned post-operative radiotherapy, or radiotherapy alone between 1936 and 1982 have been retrospectively reviewed. Twenty-seven patients had a previous excision before definitive treatment. All patients in whom surgery was known to be incomplete and who had no further treatment relapsed. Nine patients had a complete surgical excision alone and 1 relapsed. Twenty-nine patients were treated with surgery and post-operative radiotherapy and 7 relapsed. Relapse was associated with small field size, orthovoltage irradiation, and doses less than 50 Gy. Radiotherapy was effective in preventing relapse in 6 of 8 cases incompletely excised and in all of these cases the total dose was more than 50 Gy. In 13 assessable patients with clinically evident disease, 14 fields were treated with radiotherapy. Complete response was achieved in 9 fields (although one subsequently relapsed and 2 had a marginal relapse), partial response in 4, and disease stasis in one. Complete resolution took up to 21 months and total doses ranged from 35.2 Gy to 64 Gy. Radiotherapy is indicated in cases of incomplete excision and inoperable disease. Doses should be radical and fields should be sufficiently generous to encompass the anatomical limits of the infiltrated tissues.
International Journal of Radiation OncologyBiologyPhysics 11/1988; 15(4):851-7. · 4.11 Impact Factor
-
Indian Journal of Cancer 10/1986; 23(3):141-5.
-
[show abstract]
[hide abstract]
ABSTRACT: Seventeen patients with metastatic disease from malignant melanoma received treatment with injections of Human lymphoblastoid interferon. Fifteen of these had the drug by intramuscular injections. One started treatment by the intramuscular route but later proceeded with slow intravenous infusions. The remaining patient had interferon injected into the tumor only. With one exception, all patients had been pretreated with other methods for advanced regional or blood-borne metastases. A partial response (UICC criteria) lasting six months was seen in one patient who was treated with intramuscular injections for intransit cutaneous metastases in one leg. Human lymphoblastoid interferon appears to have minimal activity relating only to skin metastases in advanced and previously treated malignant melanoma. This activity is not superior to existing treatments.
Cancer 02/1983; 51(2):273-6. · 4.77 Impact Factor
-
Cancer Treatment Reviews 10/1980; 7 Suppl 1:87-90. · 6.05 Impact Factor
-
European Journal of Cancer (1965) 10/1979; 15(9):1175-7.
-
[show abstract]
[hide abstract]
ABSTRACT: Eight patients with 12 chondrosarcomas were treated with radiation and razoxane (ICRF 159). Two tumors in 1 patient progressed unequivocally, 3 tumors in 3 patients showed no change, and 7 tumors in 5 patients had complete or partial (more than 50%) regressions. At least 2 complete regressions have responded for more than 2 1/2 years at the present time.
Cancer 10/1979; 44(3):891-5. · 4.77 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: The antitumour effect of vindesine (desacetyl vinvlastine amide sulfate) in disseminated malignant melanoma has been investigated in our oncology service in a phase-II study. Of 25 patients exposed to the drug, 23 were evaluable, and seven of these (30%) were considered objective responders. The observed response of malignant effusions is of particular interest. Side effects related to vindesine are similar to those of the other vinca alkaloids, although alopecia may be more pronounced with the doses used in this study.
Cancer Chemotherapy and Pharmacology 02/1979; 2(4):257-60. · 2.83 Impact Factor
-
The Lancet 09/1978; 2(8084):324-5. · 38.28 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Comparison of the recurrence rates of soft tissue sarcomas treated by radiotherapy (14 patients) or radiotherapy and synchronous administration of razoxane (19 patients) has shown a statistically significant benefit for those patients treated by the combination. No increase in tissue reactions or adverse side-effects (apart from a readily reversible leukopenia) was observed. The implication is that razoxane acts as a well tolerated adjuvant for radiotherapy.
Cancer 02/1978; 41(1):100-7. · 4.77 Impact Factor
-
British medical journal 07/1977; 1(6074):1447-8.
-
British medical journal 06/1977; 1(6071):1259.
-
[show abstract]
[hide abstract]
ABSTRACT: Fifty-six patients with disseminated malignant melanoma were randomly allocated to two treatment groups. The first group C received combination chemotherapy consisting of DTIC and ICRF 159. The second group (C+I) received the same chemotherapy but were also immunized with 2 X 10(7) irradiated allogeneic melanoma cells mixed with 50 mug of percutaneous BCG. The survival rates in both treatment groups C and (C+I) were not significantly different, and only minor enhancement of the chemotherapy was found in the (C+I) group. A similar pattern of tissue response was observed in both groups: lymph node, skin and, to some extent liver metastases, respond better than other sites.
British Journal of Cancer 09/1976; 34(2):174-9. · 5.04 Impact Factor
-
Clinical oncology 10/1975; 1(3):235-8. · 2.85 Impact Factor
-
Cancer 11/1974; 34(4):1040-5. · 4.77 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Two hundred and fifty cases of histologically proven Hodgkin's disease have been reviewed. These cases were classified according to the Rye Conference histological classification (Lukes et al., 1966a) and according to the Cross classification (Cross, 1969). Overall, both classifications were reasonably effective in predicting prognosis but that of Cross with its seven sub-groups proved more difficult to use than the simpler Rye classification. In all cases the follow-up period exceeded 5 years. A study was made of the influence of clinical symptoms on survival with particular reference to night sweats, fever, pruritus, anorexia, lassitude, weight loss, haematological abnormalities and splenic enlargement. The presence of these abnormalities adversely affected prognosis. The spread of the disease from one group of nodes to the next was also documented. Considering all cases the 5-year survival was 54%. The 5-year survivals according to histological type were: lymphocytic predominance 69%, nodular sclerosis 57%, mixed cellularity 41%, lymphocytic depletion 40%. The 10-year survival was 23% which, when corrected by the actuarial method (Berkson and Gage, 1950), rose to 36%. The importance of symptomatology as well as histological grading in the prognosis of Hodgkin's disease is confirmed.
British Journal of Cancer 02/1973; 27(1):80-91. · 5.04 Impact Factor
-
Geriatrics 12/1971; 26(11):122 passim. · 1.35 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Seventy-five cases of malignant solid tumours treated by a quadruple chemotherapy regime are described. These tumours originated in the breast, head and neck, bronchus, genital tract, cutaneous melanoma, soft tissue and gastro-intestinal tract. All 14 patients with breast carcinoma underwent remission and in 6 this was complete. Significant remissions were seen in gastro-intestinal and head and neck malignancies, and also in the soft tissue group. A short response was noted in 6 of 14 cases of bronchial carcinoma. Malignant melanoma, testicular, ovarian and cervical carcinomata failed to respond.In all, 40 of 75 patients underwent objective remission.
British Journal of Cancer 10/1971; 25(3):462-78. · 5.04 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Sixty cases of liposarcoma are presented. The pathological appearances, clinical features and methods of treatment are described. The overall 5-year survival was 64%.
British Journal of Cancer 01/1971; 24(4):696-704. · 5.04 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Of 19 patients with proved metastases from malignant melanoma treated by inoculations of smallpox vaccine, intradermal deposits disappeared completely in six out of ten cases. Five of these remained well 2 to 22 months after initial treatment. The response was limited strictly to the site of inoculation. The mechanism of action of vaccinia virus in malignant melanoma is not clear.
British medical journal 06/1970; 2(5708):512-5.
