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ABSTRACT: Radionuclide left ventricular ejection fraction (LVEF) has been determined in a group of 14 female patients at rest and during graded supine bicycle exercise. One group consisted of 9 patients complaining of chest pain and demonstrating positive exercise electrocardiography (EECG), but with normal contrast angiographic results. The second group of 5 patients had a normal response to EECG and was used as a control group. LVEF increased markedly in both groups during exercise. This study confirms the known fact of high false-positive EECG in female patients and that exercise radionuclide LVEF response can be used as a final screening test for cardiac catheterization in female patients demonstrating positive EECG.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 04/1981; 59(14):482-7. · 2.04 Impact Factor
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ABSTRACT: A non-invasive method for evaluation of regional and global ventricular function by ECG-gated radionuclide blood pool imaging was developed. Cinematic image display is a sensitive method for evaluating wall motion to detect regional ventricular abnormalities and chamber size. A value of r = 0,86 and 0,85 was found for both fixed and variable area radionuclide methods when these ejection fraction values were correlated with cardio-angiographic ejection fraction values in normal subjects and in patients with myocardial infarction. The fixed area method underestimated the ejection fraction in patients with mitra valve stenosis, but this problem can be overcome with the variable area method. The technique developed cannot be used in patients with severe arrhythmias (r = 0,49 and 0,44).
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 08/1979; 56(2):50-3. · 2.04 Impact Factor
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ABSTRACT: A sterile pyrogen-free generator for ultra-short half-life 81mKr has been developed. During initial loading, the binding efficiency of 81Rb is 90--99%. The count rate during perfusion is 3 x 10(5) counts per minute for a 1,9 GBq (50 mCi) 81Rb generator. The generator has been used for routine and special investigations of lung perfusion and ventilation and for myocardial perfusion during catheterization.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 07/1979; 55(23):920-4. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 03/1979; 55(5):166-70. · 2.04 Impact Factor
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ABSTRACT: This article reports on studies of Rh antigens, such as D, Du and d, using uranyl-labelled antibody (ULA) and TcLA (99mTc-pyrophosphate-labelled antibody) methods for the first time for this purpose. TcLA method proved to be simple in labelling and very sensitive (20--100 times more so than the indirect Coombs test) in the detection of Rh antigen-antibody binding. Results of this quantitative study demonstrate convincingly that the d is not an allelic gene of D but rather the weakest of the series D less than Du less than d. Although the evidence from this study demonstrates clearly that differences between D and d are only quantitative, the authors do not think that the Rh nomenclature should be changed but they do think that the present evidence should be used in regard to the understanding of the allelism in the Rh blood group system. The c is an allelic gene of C as the e is an allelic gene of E; specific test sera detecting every one of these antigens exist and the family studies verify these statements. However, the d is not a distinct antigen as c and e are, even if the pattern of inheritance from family studies, using the existent anti-D serum, would suggest the allelism as probability. That is why in the past the anti-Du and anti-d specific test sera never incidentally found or artificially produced.
Journal of Immunological Methods 02/1979; 27(3):273-82. · 2.20 Impact Factor
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ABSTRACT: The value of ferrokinetic studies for determining the prognosis of patients with aplastic anaemia was assessed 17 patients. Plasma 59Fe clearance, red cell 59Fe incorporation (at 10 days), sacral and hepatic 59Fe uptake (at 6,0 h, measured by surface counting), and 59Fe bone marrow scanning were compared with peripheral blood pancytopenia and marrow cellularity on aspiration and biopsy. In this limited study no statistically significant correlation could be found between ferrokinetic determinations and other criteria of bone marrow failure, although there was a tendency for plasma 59Fe clearance and sacral 59Fe uptake to show some correlation with marrow cellularity on biopsy and with degrees of reticulocytopenia, thrombocytopenia and neutropenia. Ferrokinetic measurements did not differentiate between patients with favourable and those with poor prognoses.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 09/1978; 54(6):235-8. · 2.04 Impact Factor
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ABSTRACT: Commerically available collimators are not suitable for the visual demonstration of the kinetics of 59Fe, because of its physical properties. A locally designed collimator, that provides integral visual information of the whole body distribution of erythropoietic marrow, is discussed. Wholebody scans of 4 individuals are also included to demonstrate the capabilities of the collimator.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 02/1977; 51(1):13-8. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 01/1975; 48(59):2464-8. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 01/1975; 48(59):2474-8. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 01/1975; 48(59):2469-74. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 01/1975; 48(59):2482. · 2.04 Impact Factor
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 12/1974; 48(55):2283-8. · 2.04 Impact Factor
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S. Afr. Med. J., v. 48, pp. 2283-2288. 11/1974; 48.
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 01/1974; 47(51):2469-72. · 2.04 Impact Factor
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ABSTRACT: This article reports on studies of Rh antigens, such as D, Du and d, using uranyl-labelled antibody (ULA) and TcLA (99mTc-pyrophosphate-labelled antibody) methods for the first time for this purpose. TcLA method proved to be simple in labelling and very sensitive (20–100 times more so than the indirect Coombs test) in the detection of Rh antigen-antibody binding. Results of this quantitative study demonstrate convincingly that the d is not allelic gene of D but rather the weakest of the series D < Du < d.Although the evidence from this study demonstrates clearly that differences between D and d are only quantitative, the authors do not think that the Rh nomenclature should be changed but they do think that the present evidence should be used in regard to the understanding of the allelism in the Rh blood group system. The c is an allelic gene of C as the e is an allelic gene of E; specific test sera detecting every one of these antigens exist and the family studies verify these statements. However, the d is not a distinct antigen as c and e are, even if the pattern of inheritance from family studies, using the existent anti-D serum, would suggest the allelism as probability. That is why in the past the anti-Du and anti-d specific test sera were never incidentally found or artificially produced.
Journal of Immunological Methods.
