J Nijssen

Publications of J Nijssen

• A-specific autoantigenic ovarian glycolipids inducing production of 'natural' anti-A antibody.

  Authors: P Arend, J Nijssen

  Nature. 10/1977; 269(5625):255-7.

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• Age-dependent appearance of A-specific ovarian glycolipids and syngeneic "natural" anti-A hemolysin in mice.

  Authors: P Arend, J Nijssen

  Zeitschrift für Immunitätsforschung. Immunobiology. 05/1977; 153(1):74-84.

  C57BL/10 inbred mice produce a "natural" antibody which in the presence of complement selectively lyses human blood group A erythrocytes, and the sera of females display significantly higher levelsC57BL/10 inbred mice produce a "natural" antibody which in the presence of complement selectively lyses human blood group A erythrocytes, and the sera of females display significantly higher levels than the sera of males. This pronounced anti-A hemolysin production in females follows the appearance of specific endogenous A-determinants which are associated with water-soluble ovarian glycolipids specifically blocking the syngeneic anti-A hemolysin activity. Moreover, this hemolysin activity develops poorly in mice ovariectomized at the age of 20 days. The coincidental production of (auto)antigenic structures in morphologically and functionally normal ovarian tissue and of antibodies against them is thought to be tolerated through the modulation of a thymusdirected control mechanism.

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• Significance of specific ovarian receptors for syngeneic naturally-occurring haemagglutinating anti-A antibodies.

  Authors: P Arend, J Nijssen

  Journal of immunogenetics. 01/1977; 3(6):373-82.

  Haemagglutinins which specifically combine with membrane determinants of human blood group A erythrocytes and which are distinguishable from any other haemagglutinin specificities display marked sexHaemagglutinins which specifically combine with membrane determinants of human blood group A erythrocytes and which are distinguishable from any other haemagglutinin specificities display marked sex dependency in C57BL/10 mice. All the sera of 80-day-old C57BL/10 females exert moderate to strong anti-A haemagglutinin activities which could be detected only in approximately half of the sera of the males of the same age. Investigations of the murine tissues revealed that the production of anti-A haemagglutinins in females is reflected by simultaneous synthesis of strong endogenous receptors detected in the ovaries and associated with water-soluble glycolipid fractions. The receptor activity was demonstrated by means of haemagglutination inhibition in comparison with appropriate controls and glycolipid preparations from seventeen other different male and female tissues, and the inhibitory effects exerted by the ovarian glycolipids were statistically significant on the basis of multiple comparisons at the 1% level in each possible pair of effects.

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