Fumio Yamasaki

Social Insurance Chukyo Hospital, Nagoya, Aichi, Japan

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Publications (33)64.79 Total impact

  • 01/2015; 30(2):436-440. DOI:10.5180/jsgoe.30.436
  • 01/2014; 53(1):13-18. DOI:10.5795/jjscc.53.13
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    ABSTRACT: Primary Sjögren syndrome is an immune-mediated exocrinopathy characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands. Various systemic extraglandular disorders are associated with primary Sjögren syndrome, and the thorax is commonly affected. The pulmonary manifestations of primary Sjögren syndrome may be categorized as airway abnormalities, interstitial pneumonias, and lymphoproliferative disorders; in each category, bronchiectasis or centrilobular nodules, nonspecific interstitial pneumonia, and lymphoid interstitial pneumonia are common. These manifestations do not usually occur in isolation; they are concomitantly seen with other types of lesions. Mucosa-associated lymphoid tissue (MALT) lymphoma and amyloidosis are key components of lymphoproliferative disorders, and MALT lymphoma should always be considered because its morphologic characteristics are similar to those of benign lymphoproliferative disorders. Amyloidosis is rare but important because it carries a risk for underlying MALT lymphoma or plasmacytoma, and it may lead to hemoptysis during biopsy. In addition, thin-walled air cysts are characteristic of primary Sjögren syndrome, irrespective of the main pulmonary manifestations. Lymphadenopathy and multilocular thymic cysts may be seen in the mediastinum. During the follow-up period, there is a risk for acute exacerbation of interstitial pneumonia and development of malignant lymphoma. Often, primary Sjögren syndrome is subclinical, but there are various underlying risks. Thus, imaging findings are important. In addition to the various types of interstitial pneumonia and airway abnormalities, air cysts and mediastinal manifestations may help diagnose primary Sjögren syndrome. © RSNA, 2013.
    Radiographics 11/2013; 33(7):1933-49. DOI:10.1148/rg.337125107 · 2.73 Impact Factor
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    ABSTRACT: Phosphaturic mesenchymal tumors of the mixed connective tissue type (PMT-MCTs) are rare neoplasms, most of which are benign and cause tumor-induced osteomalacia because of overproduction of a phosphaturic hormone, fibroblast growth factor 23 (FGF23). This entity may have been unrecognized or misdiagnosed as other mesenchymal tumors, such as giant cell tumor, hemangiopericytoma, and osteosarcoma. Ten percent of these tumors, without phosphaturia, were diagnosed only by their histologic features. We report here the first case of malignant PMT-MCT, nonphosphaturic variant, resulting in fatal multiple lung metastases. Chondromyxoid matrix with "grungy" calcification, multinucleated giant cell proliferation, and expression of FGF23 mRNA (reverse transcription-polymerase chain reaction) and fibroblast growth factor 23 protein (immunohistochemistry) were seen in the primary and recurrent tumors of the right foot. The lung metastases showed flocculent calcification and FGF23 protein expression as well as giant cell proliferation. This unique case highlights the need for careful histologic assessment of PMT-MCTs, especially the nonphosphaturic variant, and the need for recognition of its rare malignant behavior.
    Human pathology 08/2013; 44(11). DOI:10.1016/j.humpath.2013.04.027 · 2.81 Impact Factor
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    ABSTRACT: Primary malignant cardiac tumors occur extremely rarely. Among these, leiomyosarcomas are exceptionally rare. We described a case of left atrial leiomyosarcoma in which surgical intervention was followed by adjuvant radiation therapy. A 74-year-old male was admitted for dyspnea. Chest X-ray showed severe pulmonary congestion. Echocardiography revealed large tumor in the left atrium. Emergency operation was performed. The tumor invaded the left atrial wall and the mitral valve, and the lesion was resected as extensively as possible. Postoperative pathologic examination confirmed leiomyosarcoma. He underwent adjuvant radiotherapy postoperatively. However, early local recurrence was recognized. He died due to sudden circulatory collapse in 8th postoperative month. As cardiac leiomyosarcomas have extremely poor prognosis, complete resection and effective postoperative adjuvant therapy are necessary.
    Kyobu geka. The Japanese journal of thoracic surgery 11/2012; 65(12):1057-61.
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  • 06/2012; 21(3).
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    ABSTRACT: We report herein a rare case of typical carcinoid occurring primarily in the epiglottis. The patient was a 70-year-old man. On initial examination, a polypoid lesion with irregular surface near the center right-hand side of the laryngeal surface of the epiglottis was observed, and a biopsy was performed. Pathological examination of the specimen suggested the possibility of adenocarcinoma. Surgical excision was performed by means of laryngomicrosurgery. A Weerda-type laryngoscope was used to open the larynx, supplemented by rigid nasal sinus surgery endoscopes, and the right-hand half of the epiglottis were excised was ensured using a CO(2) laser. Postoperative pathological diagnosis was negative for adenocarcinoma and squamous cell cancer; typical carcinoid was diagnosed according to the World Health Organization criteria. Aspiration occurred postoperatively, swallowing training was therefore provided, and the patient was discharged from hospital 2 months after surgery when he was able to eat normally. As of 4 years after surgery, the patient remains under follow-up observation by means of PET-CT and neck, thoracic, and abdominal CT administered at appropriate intervals, but no findings indicating obvious recurrence or metastasis have been observed, and the patient displays good swallowing function.
    04/2012; 2012:717251. DOI:10.1155/2012/717251
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    ABSTRACT: OBJECTIVE: The objective of this article is to review the clinical, pathologic, and MRI findings of mediastinal neurogenic tumors according to the three tumor origins: the peripheral nerves, sympathetic ganglia, and paraganglia. CONCLUSION: MRI findings reflect pathologic features of mediastinal neurogenic tumors. Integrating consideration of age and clinical findings of the patient, lesion location, and imaging findings is important in the diagnosis of mediastinal neurogenic tumors.
    American Journal of Roentgenology 10/2011; 197(4):W643-52. DOI:10.2214/AJR.10.6119 · 2.74 Impact Factor
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    ABSTRACT: The thyroid is composed of thyroid follicles supported by extracellular matrix, capillary network, and stromal cell types such as fibroblasts. The follicles consist of thyrocytes and C cells. In this microenvironment, thyrocytes are highly integrated in their specific structural and functional polarization, but monolayer and floating cultures cannot allow thyrocytes to organize the follicles with such polarity. In contrast, three-dimensional (3-D) collagen gel culture enables thyrocytes to form 3-D follicles with normal polarity. However, these systems never reconstruct the follicles consisting of both thyrocytes and C cells. Thyroid tissue-organotypic culture retains 3-D follicles with both thyrocytes and C cells. To create more appropriate experimental models, we here characterize four culture systems above and then introduce the models for studying thyroid biology and disorders. Finally, we propose a new approach to the cell type-specific culture systems on the basis of in vivo microenvironments of various cell types.
    07/2011; 2011:275782. DOI:10.5402/2011/275782
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    ABSTRACT: MET, a receptor tyrosine kinase for hepatocyte growth factor, is associated with tumor progression and acquired resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI). Therefore, MET gene alterations could be both prognostic and predictive. Fluorescence in situ hybridization (FISH) is one method for assessing gene alteration, but the frequency of positive cases varies due to a lack of standardized criteria. We evaluated MET gene copy number in lung adenocarcinoma and its association with clinicopathological characteristics. FISH was applied to evaluate high MET gene copy number and true amplification in 138 lung adenocarcinoma patients using two criteria: the Cappuzzo scoring system and PathVysion. MET positive cases according to the Cappuzzo scoring system evidenced both aneuploidy and true amplification, whereas PathVysion revealed only amplification. Proportion of MET FISH positive cases was 15% and 4% determined by the Cappuzzo system and PathVysion, respectively. PathVysion demonstrated higher frequencies of MET FISH positives among men and smokers and evidenced no MET FISH positives in patients with bronchioloalveolar carcinoma. Prognosis was significantly associated with MET FISH positive only as defined by the PathVysion system (gene amplification), not by the Cappuzzo system. However, progression-free survival time of patients with both EGFR mutations and MET FISH positive defined by the Cappuzzo scoring system was significantly shorter than with EGFR mutations alone. These results suggest that MET FISH is a potential prognostic factor and coexistence of MET FISH with EGFR mutations signifies worse prognosis.
    Lung cancer (Amsterdam, Netherlands) 07/2011; 75(1):89-94. DOI:10.1016/j.lungcan.2011.06.004 · 3.74 Impact Factor
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    ABSTRACT: Thecoma of the ovary is a stromal tumor composed of lipid-containing cells with a variable component of fibroblasts. To our knowledge, there have been no reports in the English literature describing detection of intracellular lipid in thecomas by preoperative imaging. We present 2 cases of thecomas of the ovary, in which intratumoral lipid was detected using dual-echo chemical shift magnetic resonance imaging.
    Journal of computer assisted tomography 03/2010; 34(2):223-5. DOI:10.1097/RCT.0b013e3181c22053 · 1.60 Impact Factor
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    ABSTRACT: The air-liquid interface (ALI) is a common microenvironment of the skin, but it is unknown whether the ALI affects melanoma cell behaviors. Using a collagen gel invasion assay, immunohistochemistry, and Western blots, here we show that melanoma cell proliferation in cultures with an ALI is higher than melanoma cell proliferation in submerged cultures. Bromodeoxyuridine (BrdU) uptake, an indicator of cell proliferation, of melanoma cells at the ALI was about 3 times that of submerged cells, while ALI and submerged melanoma cells had similar levels of single-stranded DNA (a marker of apoptosis). The ALI enhanced the expression of Raf-1, MEK-1 and pERK-1/2 components of the mitogen-activated protein kinase (MAPK) cascade, in cells more than the submerged condition did. The increases in BrdU uptake and pERK-1/2 expression promoted by ALI was abolished by the MEK inhibitor, PD-98059. ALI-treated and submerged melanoma cells did not infiltrate into the collagen gel, and they showed no significant difference in the expression of the invasion- and motility-related molecules, matrix metalloproteinase-1 and -9, laminin 5, and filamin A. Our data indicate that the ALI, a skin microenvironment, accelerates the growth, but not the apoptosis or invasion, of melanoma cells through MAPK activation.
    ACTA HISTOCHEMICA ET CYTOCHEMICA 02/2010; 43(1):1-7. DOI:10.1267/ahc.09036 · 1.22 Impact Factor
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    ABSTRACT: Helicobacter pylori infection is acquired by oral ingestion. H. pylori has been reported to be present in the palatine tonsils. To clarify the route and mode of infection, the prevalence of tonsillar H. pylori was evaluated, and an attempt was made to culture tonsillar H. pylori. In a prospective study, 55 patients with recurrent pharyngotonsillitis or IgA nephropathy underwent a tonsillectomy. The carbon 13-urea breath test and enzyme-linked immunosorbent assay for the detection of H. pylori IgG antibodies in the serum were performed. Tonsillar H. pylori was cultured under conventional culture conditions for gastric H. pylori with or without the following shock methods; heat shock, hydrogen-peroxide-degrading compounds, or parasitizing amoebae. Immunofluorescence and immunoelectron microscopy using antibodies against H. pylori and cytotoxin-associated antigen A were used to identify tonsillar H. pylori. H. pylori in the coccoid form was present in tonsillar crypts. Of 55 patients, 43 (78.2%) had tonsillar H. pylori, and 15 (27.3%) were infected with gastric H. pylori. All patients with gastric H. pylori also had tonsillar H. pylori (p < 0.01). Cytotoxin-associated antigen A was observed in 38 (88.4%) of 43 tonsillar H. pylori. Tonsillar H. pylori could not be cultured in any culture conditions. All patients with IgA nephropathy had tonsillar H. pylori (p < 0.01). The present research might provide some insight into clarifying the route and mode of H. pylori infection. Our findings may indicate that tonsillar H. pylori is one of the antigens causative of IgAN.
    Journal of Gastroenterology 12/2009; 45(4):406-12. DOI:10.1007/s00535-009-0169-9 · 4.02 Impact Factor
  • Daisuke Mori · Masami Shibaki · Masanori Masuda · Fumio Yamasaki
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    ABSTRACT: Many studies have proven the importance of venous invasion in colorectal cancer with synchronous liver metastasis. The aim was to clarify the relationship between venous invasion and metachronous liver metastasis, which is not fully understood. A histological study of venous invasion in colorectal carcinoma was performed using a total of 156 patients, of whom 52 survived without recurrence for 5 years (Group A); 47 had metachronous liver metastasis (Group B), and 57 had synchronous liver metastasis (Group C). The number and the maximum area of venous invasion were estimated in each case per x 40 field of cancerous lesions, which were divided into intramural and extramural lesions. A high incidence and high average number of foci of venous invasion appeared in Groups B and C. The average maximum areas of extramural venous invasion were much larger in Groups B and C than in Group A. The average number of foci of venous invasion by colorectal cancer with metachronous liver metastasis did not differ significantly from that with synchronous ones. Furthermore, invasion into extramural large veins appeared to be associated with liver metastasis.
    Histopathology 10/2009; 55(6):654-9. DOI:10.1111/j.1365-2559.2009.03428.x · 3.30 Impact Factor
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    ABSTRACT: Adipose tissue consists of mature adipocytes, preadipocytes and mesenchymal stem cells (MSCs), but a culture system for analyzing their cell types within the tissue has not been established. We have recently developed "adipose tissue-organotypic culture system" that maintains unilocular structure, proliferative ability and functions of mature adipocytes for a long term, using three-dimensional collagen gel culture of the tissue fragments. In this system, both preadipocytes and MSCs regenerate actively at the peripheral zone of the fragments. Our method will open up a new way for studying both multiple cell types within adipose tissue and the cell-based mechanisms of obesity and metabolic syndrome. Thus, it seems to be a promising model for investigating adipose tissue biology and regeneration. In this article, we introduce adipose tissue-organotypic culture, and propose two theories regarding the mechanism of tissue regeneration that occurs specifically at peripheral zone of tissue fragments in vitro.
    Organogenesis 04/2009; 5(2):50-6. DOI:10.4161/org.5.2.8347 · 2.60 Impact Factor
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    ABSTRACT: The authors describe 2 cases in which thymoma spontaneously regressed. The first patient was a 49-year-old woman with myasthenia gravis. A chest radiograph on admission showed an anterior mediastinal mass that spontaneously decreased in size as shown on a radiograph obtained 2 weeks later. Surgical removal of the mass was performed and the histopathologic examination showed a type B2 thymoma with marked coagulation necrosis in the central area. The second patient was a 46-year-old woman who was hospitalized due to chest and back pain. A chest radiograph on admission showed an anterior mediastinal mass and bilateral pleural effusion. The mass decreased in size and the effusion disappeared as shown on a chest radiograph obtained 2 months later. Computed tomography-guided biopsy was performed, and histopathologic examination revealed thymoma with marked necrosis. In both cases, dynamic contrast-enhanced magnetic resonance images showed peripheral ringlike enhancement of the mass. The clinical and radiologic features of spontaneously regressed thymoma may be different from those of common thymoma.
    Journal of thoracic imaging 03/2009; 24(1):62-5. DOI:10.1097/RTI.0b013e31818b6038 · 1.49 Impact Factor
  • The Open Pathology Journal 02/2009; 3(1):4-9. DOI:10.2174/1874375700903010004
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    ABSTRACT: To assess the use of a combination of bipolar sealing and electrosurgical coagulation for pulmonary resection. The procedure was used in both dogs and humans. Initially, lung wedge resections were performed on six healthy, Beagle dogs using a voltage controlled electrosurgical system. The area of lung tissue to be resected was first coagulated to provide a distinct line of seal. The lung was then resected along the peripheral site of the sealing scar. Efficiency of sealing was assessed using a tracheally applied air pressure of 30cmH(2)O. The electro-cauterized tissue was compared histologically to tissue sealed by a standard stapling technique. In the clinical phase, lung resections were performed after cauterization in 17 patients. Bullectomies were performed using video-assisted thoracic surgery in 4 patients, and thoracotomic procedures in 13 (1 bullectomy, 5 wedge resections, and 7 fissure separations). Dogs: Tissue sealing was highly successful, without any air leakage, in all six dogs. Histologically, the clamped lesion showed tissue-fusion probably due to both the compression and thermal effects. The proximal zone adjacent to the clamped lesion revealed both collapsed alveolar spaces and fused alveolar walls. In comparison, the stapled lesions showed no tissue-fusion. Humans: There were no major complications. The median operation time was 189min, and estimated median hemorrhage volume was 67ml. Median chest drainage duration was 3 days (range: 1-7) and no patient suffered from prolonged air leakage (>7 days). Lung parenchymal tissue resection following bipolar sealing and electrosurgical coagulation instead of staples was efficient and simple. Furthermore, the technique reduced the use of staples, reducing the cost of the surgery.
    European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 06/2008; 34(3):505-9. DOI:10.1016/j.ejcts.2008.05.043 · 2.81 Impact Factor
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    ABSTRACT: To investigate the combined effect of the major tea polyphenol, (-)-epigallocatechin gallate (EGCG) and retinoic acid (RA) on cervical adenocarcinoma. Cell growth rate was examined after treatment for 4, 7 and 10 days with 0-100 microM EGCG and/or 1 microM RA in two cervical adenocarcinoma cell lines, HeLa and TMCC-1. The effect of EGCG treatment was examined for the induction of apoptosis by DNA ladder assay and caspase-3-related protease activity in cell lysate. Telomerase activity was detected by stretch PCR telomere extension assay. hTERT expression levels were quantified by a real-time PCR system. Combining EGCG and RA increased the antiproliferative effect in adenocarcinoma cell lines, whereas EGCG or RA treatment alone caused a less sensitive response in these cells. Neither EGCG nor RA treatment alone affected apoptosis and telomerase activity. The combination treatment of EGCG and RA induced apoptosis and inhibited telomerase activity in adenocarcinoma cell lines. These results were consistent with those of an antiproliferative effect of EGCG and/or RA in cervical adenocarcinoma cells. Our data suggest that EGCG and RA combined to prevent the carcinogenesis of cervical adenocarcinoma, induce apoptosis and inhibit telomerase activity. The treatments of combining EGCG and RA may be effective in preventing or treating cervical adenocarcinoma.
    Gynecologic Oncology 03/2008; 108(2):326-31. DOI:10.1016/j.ygyno.2007.10.013 · 3.69 Impact Factor