Jie Mi

Capital institute of Pediatrics, Peping, Beijing, China

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Publications (111)337.3 Total impact

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    ABSTRACT: There are few studies investigating the long-term association between childhood blood pressure (BP) and adult cardiovascular remodeling. We seek to examine the effect of elevated childhood BP on cardiovascular remodeling in early or middle adulthood. We used the "Beijing BP Cohort Study", where 1259 subjects aged 6-18years old were followed over 24years from childhood (1987) to early or middle adulthood (2011). Anthropometric measures and BP were obtained at baseline and follow-up examinations. Carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT), and left ventricular mass index (LVMI) were measured to assess cardiovascular remodeling in early or middle adulthood. Multiple logistic regression models were used to assess the odds ratio (OR) and 95% confidence interval (CI) for cardiovascular remodeling. 82 out of 384 children with elevated BP (21.4%) had adult hypertension. Compared to those with normal BP, children with elevated BP were at 2.1 times (95% CI: 1.4-3.1) likely to develop hypertension in early or middle adulthood. Compared to those with normal BP, children with elevated BP were at higher OR of developing high cfPWV (OR=1.8, 95% CI=1.3-2.4), high cIMT (1.4, 1.0-1.9), or high LVMI (1.4, 1.0-1.9) in early or middle adulthood. The ORs for remodeling (for any measures) were 1.4 (0.9-2.0) in early adulthood for children age 6-11years, and 1.6 (1.1-2.4) in middle adulthood for those aged 12-18years. Children with elevated BP from 6years old have accelerated remodeling on both cardiac and arterial system in early or middle adulthood. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
    International Journal of Cardiology 11/2014; 177(3):836-839. · 6.18 Impact Factor
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    ABSTRACT: To examine the impact of single nucleotide polymorphisms in obesity-related genes on risk of obesity and metabolic disorder in childhood. A total of 3 503 Chinese children aged 6 to 18 years participated in the study, including 1 229 obese, 655 overweight and 1 619 normal weight children (diagnosed by the Chinese age- and sex- specific BMI cutoffs). Body size parameters were assessed and venipuncture blood samples were collected after a 12-hour overnight fast. Plasma glucose, insulin and serum lipid profiles were measured.Genomic DNA was isolated from peripheral blood white cells using the salt fractionation method. A total of 11 single nucleotide polymorphisms were genotyped by TaqMan allelic discrimination assays with the GeneAmp 7900 sequence detection system (Applied Biosystems, Foster City, CA, USA) (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, FAIM2 rs7138803, BDNF rs6265, NPC1 rs1805081, PCSK1 rs6235, KCTD15 rs29941, BAT2 rs2844479, SEC16B rs10913469 and SH2B1 rs4788102). Multiple factor analysis was performed to estimate the association between the variant and obesity-related traits. The false discovery rate (FDR) approach was used to correct for multiple comparisons. After sex, age and pubertal stage adjustment and correction for multiple testing, the rs9939609-A, rs17782313-C, rs10938397-G, and rs7138803-A alleles were associated with higher BMI (β = 0.352-0.747), fat mass percentage(β = 0.568-1.113), waist circumference (β = 0.885-1.649) and waist-to-height ratio(β = 0.005-0.010) (all P values < 0.01) in Chinese children. The rs6265-G allele increased BMI(β = 0.251, P = 0.020). The rs9939609-A, rs17782313-C, and rs10938397-G and rs6265-G alleles were also associated with risk of obesity (OR = 1.386, 95%CI:1.171-1.642; OR = 1.367, 95%CI:1.196-1.563; OR = 1.242, 95%CI:1.102-1.400; OR = 1.156, 95%CI:1.031-1.296).Rs7138803 was associated with risk of obesity only in boys (OR = 1.234, 95%CI:1.043-1.460). GNPDA2 rs10938397-G allele was associated with risk of insulin resistance(OR = 1.205, 95%CI:1.069-1.359), but there was no significance after adjusting for BMI. The association of FTO rs9939609-A, MC4R rs17782313-C, GNPDA2 rs10938397-G, and FAIM2 rs7138803-A with higher BMI, fat mass percentage, waist circumference, and waist-to height ratio and risk of obesity, and BDNF rs6265-G allele may increase BMI and obesity risk in Chinese children. GNPDA2 rs10938397-G may increase the risk of childhood insulin resistance depending on BMI.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 09/2014; 48(9):776-83.
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    ABSTRACT: Previous studies showed that prevalence of abdominal obesity among US children and adolescents increased significantly between 1988-1994 and 2003-2004. However, little is known about recent time trends in abdominal obesity since 2003-2004.This study was to provide recent updated national estimates of childhood abdominal obesity and examine the trends in childhood abdominal obesity from 2003 to 2012.METHODS: Data were from the National Health and Nutrition Examination Survey (NHANES) conducted during 5 time periods (2003-2004, 2005-2006, 2007-2008, 2009-2010, and 2011-2012). A total of 16 601 US children and adolescents aged 2 to 18 years were included. Abdominal obesity is defined as a waist circumference (WC) ≥ gender- and age-specific 90th percentile based on data from NHANES III (1988-1994) and a waist-to-height (WHtR) ≥0.5, respectively.RESULTS: In 2011-2012, 17.95% of children and adolescents aged 2 to 18 years were abdominally obese defined by WC, and 32.93% of those aged 6 to 18 years were abdominally obese defined by WHtR. Mean WC and WHtR and prevalence of abdominal obesity kept stable between 2003-2004 and 2011-2012, independently of gender, age, and race/ethnicity. However, there was a significant decrease in abdominal obesity among children aged 2 to 5 years.CONCLUSIONS: The prevalence of abdominal obesity leveled off among US children and adolescents from 2003-2004 to 2011-2012.
    Pediatrics. 07/2014;
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    ABSTRACT: To explore the relationship between high-sensitivity C-reactive protein (hsCRP) and obesity/metabolic syndrome (MetS) related factors in children.
    06/2014; 35(6):621-625.
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    ABSTRACT: The associations between common variants in the fat mass- and obesity-associated (FTO) gene and obesity-related traits may be age-dependent and may differ by sex. The present study aimed to assess the association of FTO rs9939609 with body mass index (BMI) and the risk of obesity from childhood to adolescence, and to determine the age at which the association becomes evident. Totally 757 obese and 2,746 non-obese Chinese children aged 6-18 years were genotyped for FTO rs9939609. Of these, a young sub-cohort (n = 777) aged 6-11 years was reexamined 6 years later. Obesity was defined using the sex- and age-specific BMI cut-offs recommended by the International Obesity Task Force. The associations of FTO rs9939609 with BMI and obesity did not appear until children reached 12-14 years. The variant was associated with an increased BMI in boys (β = 1.50, P = 0.004) and girls (β = 0.97, P = 0.018), respectively. Thereafter, the magnitude of association increased in girls at ages 15-18 years (β = 2.02, P<0.001), but not boys (β = 0.10, P>0.05). Age was found to interact with the variant on BMI (P<0.001) and obesity (P = 0.042) only in girls. In the sub-cohort, the associations of FTO rs9939609 with BMI (β = 1.07, P = 0.008) and obesity (OR = 2.09, 95% CI: 1.12, 3.91) were only observed 6 years later (ages 12-18 years) in girls, even after adjusting for baseline BMI. The association between FTO rs9939609 and obesity-related traits may change from childhood to adolescence in Chinese individuals, and the association may start as early as age 12 years, especially in girls.
    PLoS ONE 05/2014; 9(5):e97545. · 3.53 Impact Factor
  • Jie Mi
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 05/2014; 48(5):337-9.
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    ABSTRACT: To study the dietary habits of school-age children in urban and rural districts and their association with blood pressure levels in Beijing, China.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 05/2014; 48(5):340-4.
  • International journal of cardiology 04/2014; · 6.18 Impact Factor
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    Jie Mi, Fangchao Liu
    The Lancet 04/2014; 383(9927):1463-4. · 39.21 Impact Factor
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    International journal of cardiology 04/2014; · 6.18 Impact Factor
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    ABSTRACT: To understand the current status of physical activity among urban school-aged children and its association with obesity.
    04/2014; 35(4):376-80.
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    ABSTRACT: To analyze the trends on the prevalence rates of obesity and cardiometabolic among children and adolescents in Beijing, during 2004-2013.
    04/2014; 35(4):370-5.
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    ABSTRACT: Information tracking changes of birthweight is scarce in China. To examine trends of low birthweight (birthweight <2500 g) and macrosomia (birthweight >=4000 g) and potential risk factors in Beijing, hospital records from two major obstetrics and gynecology hospitals in urban districts in Beijing were analyzed. Hospital records from 1996 to 2010 were retrieved. Information of prenatal examination and birth outcomes was entered into a structured database. Live births were used for trend analysis. Information of live births in 2010 was used to identify potential risk factors. A total of 63 661 live births were delivered during 1996-2010 in the study hospitals. The average birthweight increased from 3271 g in 1996 to 3 359 g in 2000 and slightly declined to 3 331 in 2010. The percentage of low birthweight fluctuated around 4.0%. No significant increase or decrease was observed. Preterm birth was the main cause of low birthweight, accounting for more than 73% of low birthweight. The average percentage of macrosomia was 7.6%. The percentages of macrosomia increased from 6.6% in 1996 to 9.5% in 2000 and declined to 7.0% in 2010. Excessive gestational weight gain and gestational diabetes were significantly associated with macrosomia. Continuously monitoring abnormal birthweight is needed and intervention should focus on appropriate gestational weight gain and reduction of preterm birth and gestational diabetes.
    BMC Pregnancy and Childbirth 03/2014; 14(1):105. · 2.15 Impact Factor
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    ABSTRACT: A great number of body mass index (BMI)/obesity-related loci have been identified by recent genome-wide association studies. The objective of the study is to investigate the associations of 11 obesity-related loci with insulin resistance (IR) in a Chinese children population. Participants included 3,468 Chinese children, aged 6-18 years. The 75 percentile (equal to 2.93) of homeostasis model assessment of IR (HOMA-IR) index was considered as the cut-off of IR. A total of 868 IR cases and 2,600 control children were identified. In age- and sex-adjusted model, only two SNPs in/near GNPDA2 and KCTD15 genes were significantly associated with risk of IR [GNPDA2 rs10938397: allelic odds ratio (OR) = 1.19, 95 % confidence interval (CI) 1.06-1.34, P = 0.003; KCTD15 rs29941: allelic OR = 1.15, 95 % CI = 1.01-1.31, P = 0.034]; genetic risk score was also significantly associated risk of IR (OR = 1.08, 95 % 1.04-1.12, P = 1.18 × 10(-4)). After additional adjustment for BMI, none remained significant. The associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR remained statistically significant after correction for multiple testing. The present study demonstrated that the associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR were statistically significant, which were dependent on BMI.
    Endocrine 03/2014; · 3.53 Impact Factor
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    ABSTRACT: To describe the trend of multiple pregnancies and to compare the results with single pregnancy in Beijing from 1996 to 2010. Prevalence rates of pregnancy complications were compared between multiple and single pregnancies. In 1996, 1997, 1998, 1999, 2000, 2005, 2010, live births in two hospitals in Beijing were included to describe the trend of multiple and single pregnancy. Case-retrospective analyses were used. Information was collected, including maternal age, fetus number, delivery mode, with/without pregnancy induced diseases as hypertension, diabetes or anemia, gender of the baby, birth-weight and gestation etc. Linear regression analyses were applied to assess the trend of birth-weight and the rates of prevalence. 63 661 babies and 62 895 puerperal were involved in this study. From 1996 to 2010, prevalence of multiple pregnancies increased by 0.02%, prevalence of cesarean delivery among multiple pregnancy women increased by 2.25% and the proportion of women older than 30 years increased by 3.52% and 2.89% among multiple or single pregnancy women, annually. However, the birth-weight did not show obvious change in both multiple and single birth babies. No obvious change was observed in the prevalence of low birth weight. Prevalence rates of premature birth increased by 1.62% and 0.16% among multiple and single pregnancy women, annually. From 1996 to 2010, the mean values of birth-weight among single birth babies were larger than 3 250 grams and under 2 500 gram among multiple birth babies. Rates of prevalence on pregnancy induced hypertension and anemia were higher in multiple pregnancy women than in single pregnancy women. Differences of rates on prevalence rates of pregnancy diabetes between multiple and single pregnancy women were not statistically significant. Prevalence of multiple pregnancies increased from 1995 to 2010 in Beijing. Mothers of multiples were more likely to get pregnancy complication than the single pregnancy women.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 03/2014; 35(3):276-9.
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    ABSTRACT: Historical research is limited in changes in pubertal development in Chinese girls. We aimed to identify the timing of pubertal characteristics and the secular trend of menarche age among Beijing girls from the 1980s through the 2000s. Six data sets were analyzed, including the Beijing Child and Adolescent Metabolic Syndrome study in 2004, where 9778 Bejing girls aged 6-18 years were studied. The Fetal Origins of Adult Disease study provided retrospective menarche age from 1940 through 1960. Other four studies were conducted in Beijing to obtain supplementary information to assess secular trend in menarche age. Linear regression method was used to analyze the data. Among Beijing girls in 2004, the median age at menarche was 12.1 years, which was 0.6 years earlier in urban than in rural areas. The median age at Breast Tanner Stage 2 was 9.5±1.2 years, representing 9.4±1.1 years and 9.6±1.2 years for urban and rural girls, respectively. In contrast, the median age at Pubic Hair Tanner Stage 2 was 11.1±1.1 years, representing 10.8±1.1 and 11.4±1.1 years for urban and rural girls, respectively. The menarche age of urban girls decreased by 4.2 months per decade, and that of rural girls by 9.6 months per decade from 1980 to 2004. Urban girls mature earlier than rural girls in Beijing. A secular trend towards earlier menarche was observed between the 1980s and the 2000s.
    World Journal of Pediatrics 02/2014; 10(1):74-9. · 1.08 Impact Factor
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    ABSTRACT: The aim of this paper was to analyze the association between different types of obesity and cardiovascular risk factors (CRFs)in school-aged children. 3508 children aged 6-18 years old including 2 054 non-obese and 1 454 obese children were chosen as the population under study, from Beijing Children and Adolescents Metabolic Syndrome Study. Demographic data was collected through questionnaires while height, weight, waist circumference, and blood pressure were measured through physical check-up. Fasting blood glucose and blood lipids were also tested. Children were divided into four groups:without obesity, with general obesity, with abdominal obesity and with combined obesity. CRFs including dyslipidemia, impaired fasting glucose (IFG), and hypertension were scored. Multiple linear regression and logistic regression analyses were performed to assess the association between different types of obesity and CRFs. From non-obese children, children under general-obesity, abdominal obesity and those with combined types of obesity, there appeared an increasing trend in the levels of blood pressure, blood glucose, and blood lipids, the prevalence dyslipidemia and hypertension (P < 0.001). There were no significant differences in the risks of IFG among four types of obesity. After controlling for age, sex, and puberty stage, when compared with non-obese children, those children with abdominal obesity or combined types of obesity had 1.54 and 2.51 times of risks to only one CRF, while generally obese children had similar risk of dyslipidemia. When compared to the non-obese ones, children with general obesity, abdominal obesity, or combined types of obesity showed 3.32, 2.21 and 7.42 times of risks to ≥2 CRFs and 3.10, 3.67 and 10.75 times of risks to ≥3 CRFs. The cluster of CRFs increased with the levels of obesity (P < 0.001). Levels and cluster of CRFs were increasing along with the levels of obesity in school-aged children in Beijing. Children with combined types of obesity had the highest risk of clustering CRFs, followed by those with abdominal obesity and general obesity.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 01/2014; 35(1):3-8.
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    ABSTRACT: Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/obesity. In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (MetS) in a children population from China. A total of 431 children with MetS and 3046 controls were identified based on the modified ATPIII definition. 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265, FAIM2 rs7138803, NPC1 rs1805081, SEC16B rs10913469, SH2B1 rs4788102, PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479) were genotyped by TaqMan 7900. Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR)=1.21, 95% confidence interval (CI)=1.04-1.40, p=0.016; BDNF rs6265: OR=1.19, 95%CI=1.03-1.39, p=0.021; FAIM2 rs7138803: OR=1.20, 95%CI=1.02-1.40, P=0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR=1.09, 95%CI=1.04-1.15, P=5.26×10(-4)). After further adjustment for BMI, none of SNPs were associated with risk of MetS (all P>0.05); the association between GRS and risk of MetS remained nominally (OR=1.02, 95%CI=0.96-1.08, P=0.557). However, after correction for multiple testing, only GRS was statistically associated with risk of MetS in the model without adjustment for BMI. The present study demonstrated that there were nominal associations of GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 with risk of MetS. The SNPs in combination has the significant effect on risk of MetS. These associations above were mediated by adiposity.
    Gene 11/2013; · 2.20 Impact Factor
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    ABSTRACT: The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among Chinese children and adolescents. Moreover, to determine the cut-off values for homeostasis model assessment of insulin resistance (HOMA-IR) at MS risk. 3203 Chinese children aged 6 to 18 years were recruited. Anthropometric and biochemical parameters were measured. Metabolic syndrome (MS) was identified by a modified Adult Treatment Panel III (ATP III) definition. HOMA-IR index was calculated and the normal reference ranges were defined from the healthy participants. Receiver operating characteristic (ROC) analysis was used to find the optimal cutoff of HOMA-IR for diagnosis of MS. With the increase of insulin resistance (quintile of HOMA-IR value), the ORs of suffering MS or its related components were significantly increased. Participants in the highest quintile of HOMA-IR were about 60 times more likely to be classified with metabolic syndrome than those in the lowest quintile group. Similarly, the mean values of insulin and HOMA-IR increased with the number of MS components. The present HOMA-IR cutoff point corresponding to the 95th percentile of our healthy reference children was 3.0 for whole participants, 2.6 for children in prepubertal stage and 3.2 in pubertal period, respectively. The optimal point for diagnosis of MS was 2.3 in total participants, 1.7 in prepubertal children and 2.6 in pubertal adolescents, respectively, by ROC curve, which yielded high sensitivity and moderate specificity for a screening test. According to HOMA-IR > 3.0, the prevalence of insulin resistance in obese or MS children were 44.3% and 61.6% respectively. Our data indicates insulin resistance is common among Chinese obese children and adolescents, and is strongly related to MS risk, therefore requiring consideration early in life. As a reliable measure of insulin resistance and assessment of MS risk, the optimal HOMA-IR cut-off points in this cohort were developed with variation regarding puberty. HOMA-IR may be useful for early evaluating insulin resistance in children and teenagers and could have a long-term benefit of preventive and diagnostic therapeutic intervention.
    Diabetology and Metabolic Syndrome 11/2013; 5(1):71. · 2.50 Impact Factor
  • Bo Xi, Jie Mi
    Biomedical and Environmental Sciences 10/2013; 26(10):787-91. · 1.26 Impact Factor

Publication Stats

741 Citations
337.30 Total Impact Points


  • 2003–2014
    • Capital institute of Pediatrics
      Peping, Beijing, China
  • 2011–2013
    • Shandong University
      • Department of Maternal and Child Health Care
      Jinan, Shandong Sheng, China
  • 2010–2013
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2012
    • Jining Medical University
      Chi-ning-shih, Shandong Sheng, China
  • 2009
    • Shantou University
      Swatow, Guangdong, China
  • 2008
    • Johns Hopkins University
      • Center for Human Nutrition
      Baltimore, MD, United States
    • University of Yaoundé II
      Jaúnde, Centre Region, Cameroon
    • Université du Québec
      Québec, Quebec, Canada
  • 2006–2007
    • Beijing Medical University
      • Department of Pediatrics
      Peping, Beijing, China
    • Peking University
      Peping, Beijing, China