Alper Alkan

Erciyes Üniversitesi, Kayseri, Kayseri, Turkey

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Publications (57)61.1 Total impact

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    ABSTRACT: The central giant cell granuloma (CGCG) is benign, nonodontogenic, and intraosseous lesion of the jaw. Aggressive subtypes of CGCG have a tendency to recur after excision and require wide resection that leads to major defects in the jaw. In this case report a patient who had severe mandibular bony deficiency as a result of excision of aggressive CGCG, orthodontic, and prosthetic treatment was described. The defect was reconstructed with iliac bone graft. Four years later vertical distraction osteogenesis was performed on the grafted mandible in order to obtain a satisfactory bony height of mandibular ridge. After healing period three endosseous dental implants were placed to grafted region. Because of pubertal growth stage, a hybrid removable denture was constructed. The construction of a hybrid removable denture markedly improved the patient's speech, mastication, and appearance. After pubertal growth stage, a fixed partial denture construction was planned and future parts of treatment procedures were described to the patient. Distraction osteogenesis and endosseous dental implants can be a good alternative method for the unsatisfactory reconstructions of mandibular deficiencies.
    Nigerian journal of clinical practice 07/2014; 17(4):528-33. · 0.26 Impact Factor
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    ABSTRACT: Cholesterol granuloma (CG) is a foreign body reaction to the deposition and inadequate drainage of cholesterol crystals that are frequently found in association with chronic middle ear diseases but an uncommon entity in maxillary sinuses. The clinical symptoms are non-specific and depend on the localization and extent in each individual case. Bone erosion may be seen in cholesterol granuloma showing expansive growth. The differential diagnosis of CG includes cysts, mucocoeles and neoplasms. Radiological and histopathological findings are essential for diagnosis of CG. In this report it is aimed to introduce two new CG cases with its clinical, histopathological and radiological findings
    Journal of the Pakistan Medical Association 01/2014; 64(1):86-8. · 0.41 Impact Factor
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    ABSTRACT: The purpose of the present study was to explore the potential use of platelet-rich-plasma (PRP) in the treatment of temporomandibular joint osteoarthritis (TMJ-OA). Surgical defects were created bilaterally on the condylar fibrocartilage, hyaline cartilage, and bone to induce an osteoarthritic TMJ in rabbits. PRP was applied to the right joints of the rabbits (PRP group), and the left joints received physiologic saline (control group). After 4 weeks, the rabbits were sacrificed for histologic and scanning electron microscopy (SEM) examinations. The data were analyzed statistically. The new bone regeneration was significantly greater in the PRP group (P < .011). Although the regeneration of the fibrocartilage and hyaline cartilage was greater in the PRP group, no statistically significant difference was found between the 2 groups. SEM showed better ultrastructural architecture of the collagen fibrils in the PRP group. PRP might enhance the regeneration of bone in TMJ-OA.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 11/2013; · 1.58 Impact Factor
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    ABSTRACT: During implantology procedures, one of the most serious complications is damage of the inferior alveolar nerve (IAN). The mandibular incisive nerve is described as a terminal branch of the IAN and provides innervation to the lower anterior teeth and canines. The incisive nerve and canal are located in the interforaminal area. Although numerous studies report IAN damage during implant placement, few reports in the literature describes sensory disturbances, such as neuropathic pain, related to mandibular incisive nerve damage.The purpose of this retrospective clinical study was to evaluate the risk of neuropathic pain caused by implant placement in the interforaminal region of the mandible.Panaromic radiographs of patients who were treated with dental implants in the Department of Maxillofacial Surgery, Faculty of Dentistry at Erciyes University, between 2007 and 2012, were examined. Fifty-five patients with suspected relationship between mandibular incisive canal and dental implant were included into this study. Computed tomography scans were obtained from 10 patients who have postoperative neuropathic pain. Relationship between dental implant and mandibular incisive nerve was evaluated using a three-dimensional software program. Mandibular incisive nerve perforation by at least 1 implant was observed in all 10 patients. Descriptive analyses were also provided.Neuropathic pain may occur after implant placement in the interforaminal region due to the perforation of the incisive canal and nerve. According to the results of this retrospective study, the incisive canal and nerve perforation should be considered as a complication of implant surgery in the mandibular anterior area.
    The Journal of craniofacial surgery 07/2013; 24(4):e405-e408. · 0.81 Impact Factor
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    ABSTRACT: Oral infections have been implicated in adverse pregnancy outcomes such as pre-eclampsia, premature delivery and growth retardation. A 28-year-old and 9 months pregnant otherwise healthy woman with a complaint of facial swelling and dental pain was referred to the Department of Oral and Maxillofacial Surgery. Oral examination revealed perimandibular and masticator space infection related to the left mandibular third molar tooth. Eight hours after surgical intervention, fetal distress developed. The patient was immediately taken into surgery and a male baby delivered by Caesarean section. The baby was then admitted to the intensive care unit. On the twelfth day of his admission, the baby was discharged in good health. Severe maxillofacial infection in pregnancy is a medically complicated situation which should be treated by an oral and maxillofacial surgeon in consultation with an obstetric and gynaecology service.
    Australian Dental Journal 03/2013; 58(1):117-9. · 1.37 Impact Factor
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    ABSTRACT: The widespread use of endosseous osseointegrated implants to replace missing natural teeth increases the chances of implant complications and failures, despite the high initial success rate reported in the literature. Implant and healing cap fracture are possible rare complications that can cause significant problems for both clinicians and patients. This article reports on 2 unique cases of implant and healing cap fracture, their possible causes, and how the cases were managed.
    General dentistry 01/2013; 61(1):52-5.
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    ABSTRACT: OBJECTIVES: Profuse hemorrhage and airway obstruction may occur during or after the implant surgery in the interforaminal region. The prevention from this complication requires identifying the location of the mandibular lingual vascular canals (MLVCs). The purpose of this study was to evaluate the anatomical variations of MLVCs and to determine the safety margins for implant placement in interforaminal region. MATERIALS AND METHODS: Computer tomography (CT) images of 200 consecutive patients were reexamined retrospectively by a radiologist and a maxillofacial surgeon to evaluate the presence of the MLVCs entering the mandible. The diameter and the number of the canals, the distance between the entrance of the canal and mandibular midline, and the height of the entrances of the canals from the inferior mandibular margin were measured. RESULTS: Two hundred and thirty-six median lingual canals (MLCs) and 159 lateral lingual canals (LLCs) were found in 200 patients. Significant differences were found between the number of lingual canals in the midline and canine regions (P < 0.001). CONCLUSION: There is a potential risk of complications due to the injuries of the vessels entering the lingual cortical bone through a number of bone canals during implant placement in the interforaminal region.
    Clinical Oral Implants Research 11/2012; · 3.43 Impact Factor
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    ABSTRACT: OBJECTIVE: The aim of this study was to evaluate and compare dental and skeletal changes in surgically assisted rapid palatal expansion (SARPE) patients with (+PP) and without (-PP) pterygomaxillary disjunction. STUDY DESIGN: The study casts of 18 maxillary constriction patients indicated for SARPE formed the sample of this retrospective review. The sample was divided into 2 groups. Twenty linear and 2 angular measurements were performed on the study models. RESULTS: All transversal measurements increased after expansion in both the +PP and -PP groups. The -PP group showed greater expansion at the midpalatal and gingival levels, while the +PP group exhibited a greater increase of 0.78 mm at the apical base level and 11.25° less tipping in the molar teeth. A greater expansion of nearly 0.7 mm was measured in the premolar region of the +PP group. CONCLUSIONS: Both SARPE techniques resulted in significant maxillary expansion.
    Oral surgery, oral medicine, oral pathology and oral radiology. 08/2012;
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    ABSTRACT: Abstract Pyogenic granuloma (PG) is a benign hyperplasia of the oral soft tissues. It usually occurs as a response to chronic trauma, local irritants, and in female patients due to the changes in hormone levels; its occurrence due to dental implant is uncommon.Clinically PG presents as a painless, smooth or lobulated shape and it is classed as a hemorrhagic lesion because of its vascular structure. Colors can range vary from pink to dark red. In addition it bleeds very quickly when touched.The best of our knowledge and from a survey of the literature this is the 3rd case in the literature. Our aim is to explain the possible causes of PG and the treatment of such a lesion.
    Journal of Oral Implantology 01/2012; · 1.15 Impact Factor
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    ABSTRACT: OBJECTIVES: The objective of this study was to investigate whether a relationship exists between total antioxidant capacity (TAC) and total oxidant status (TOS) of synovial fluids (SFs) of temporomandibular joint (TMJ) pain patients with pain and dysfunction. MATERIALS AND METHODS: Forty-two patients with TMJ pain were included in this study. TAC and TOS values of SFs were measured with a novel colorimetric method. Independent t test and correlations were used to analyze the data. RESULTS: TAC of SFs in patients with TMJ pain and limited mouth opening (LMO; n = 21) were significantly lower (P = 0.03) than patients without LMO (n = 21). TOS of SF was negatively correlated with duration of the disease. There was no correlation between TAC, TOS, and VAS scores of the patients as well as age and maximum mouth opening values. CONCLUSIONS: Antioxidant response to oxidative changes (TAC and TOS) in SF decreased as the stage of dysfunction increased. CLINICAL RELEVANCE: Local administration of antioxidant agents might be considered in management of TMJ pain and dysfunction to prevent possible increased oxidative stress.
    Clinical Oral Investigations 01/2012; · 2.20 Impact Factor
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    ABSTRACT: Langerhans' cell histiocytosis (LCH) is a rare disease where different organs and systems may be affected. Oral involvement generally consists of mucosal ulceration associated with lesions of the underlying bone. Many reports exist about the misdiagnosis of this disease. Various symptoms may lead the clinician to an incorrect diagnosis, especially with multiple organ involvement. Oral manifestations are common, and dentists should be aware of this disease and evaluate intraoral findings accordingly. This study presents an LCH case characterized by oral mucosal ulcerations with no involvement of the underlying bone. A definitive diagnosis was made by open biopsy from the oral mucosa.
    Australian Dental Journal 12/2011; 56(4):433-6. · 1.37 Impact Factor
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    ABSTRACT: We report a case of an accidental injection of benzalkonium chloride (zephiran) instead of a local anesthetic agent during a tooth extraction. The sudden development of chin and neck swelling led to dyspnea and the patient lost consciousness. She was sent to an emergency clinic by her dentist immediately. After medical treatment for 20 days, the necrotic tissue was debrided and a gingival sulcoplasty was performed. Healing was uneventful.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 12/2011; 112(6):e103-5. · 1.50 Impact Factor
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    ABSTRACT: We determined the causes of bone resorption within a distraction gap and determined whether it could be prevented via guided bone regeneration during distraction. Another goal was to determine the effect of periosteum in bone healing in a distraction gap.Twelve sheep mandibles were bilaterally distracted. One side of the 6 sheep mandibles formed the control group; the other side was the study group, from which the periosteum was excised and distraction was performed. In the other 6 sheep, on the study side, guided bone regeneration was applied with distraction; on the other study side, guided bone regeneration was applied, and the periosteum was excised at the distraction. At the end of a 1-week latent period, all subjects were distracted 10 mm (1 mm/d), and we waited 3 months for consolidation. At the end of this period, all animals were killed, and radiologic evaluations of the newly formed bone within the distraction gap were conducted.The surface area of the regenerating bone in the membrane groups was significantly higher than in the groups without a membrane. However, no additional effect of the periosteum on the bone surface area was observed. No significant difference between the groups in densitometric values was observed.Concomitant use of guided bone regeneration with distraction osteogenesis may be the optimal way to generate a flat bone surface within a distraction gap.
    The Journal of craniofacial surgery 09/2011; 22(5):1871-4. · 0.81 Impact Factor
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    ABSTRACT: The maxillary sinus floor elevation procedure has gained popularity with predictable results, and is a safe, acceptable technique for bone augmentation, providing a base for dental implant treatment. Faint radiopaque lesions at the base of the maxillary sinus are frequent diagnoses on radiographs and must be identified during dental implant planning. Pseudocysts classically appear hemispheric, homogeneously opaque, and well delineated in panoramic and periapical radiographs. The great majority of these lesions are asymptomatic and do not require surgical treatment. In this case report, we present 4 patients who had a maxillary sinus floor elevation procedure using either crestal or lateral approaches in the presence of antral pseudocysts. No complications were encountered during follow-up periods in these patients and all implants are functioning successfully.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 08/2011; 112(6):e97-102. · 1.50 Impact Factor
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    ABSTRACT: This study investigated whether shortening of osteotomized jaws is possible. Nine sheep were used (2 as controls and 7 as experimental subjects). Distraction devices that had previously been activated to 10 mm were fixed to the mandibles of all animals bilaterally and used in reverse as a contraction device. Control and experimental animals were sacrificed at 1 month and 3 months. Bone in the area of contraction was evaluated using radiodensitometry and microscopy. The mandibles were shortened an average of 5.5 mm. Exaggerated bone formation was seen around the osteotomized cortical bone. When histologic slices from experimental animals were examined 1 month after the contraction period, fibrous pseudoarthrosis formation was seen centrally, with hyaline cartilage around it, whereas normal bone formation was seen in the outer part. The hyaline cartilage had turned into normal bone 3 months after the end of contraction. It is possible to shorten bones using contraction osteogenesis.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 06/2011; 69(6):e195-200. · 1.58 Impact Factor
  • Osman Etoz, Nilay Er, Alper Alkan
    British Journal of Oral and Maxillofacial Surgery 12/2010; 49(3):e1-2. · 2.72 Impact Factor
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    ABSTRACT: The purpose of this clinical study was to identify a clinical and histopathological relationship between verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma. We evaluated 12 patients who had developed oral verrucous carcinoma in the past 10 years in a follow-up study. In this study, the diagnostic criteria included clinical and histopathological features of the lesions. Each lesion was examined by a single oral pathologist. All the patients were diagnosed with verrucous carcinoma following excisional biopsy. One patient was diagnosed with verrucous hyperplasia and another with verrucous keratosis in their initial histological findings. Mandibular, posterior alveolar crest, and retromolar trigone were the most affected sites (41.6%), followed by the buccal mucosa (16.6%), the palate (16.6%), the floor of the mouth (16.6%), and the lip (8.3%). No patients had evidence of recurrence after treatment. Verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma may not be distinguished clinically or may coexist, resulting in diagnostic difficulties. It should be kept in mind that verrucous hyperplasia may also develop from leukoplakic lesions, and it may transform into verrucous carcinoma or squamous-cell carcinoma, acting as a potential precancerous lesion.
    European journal of dentistry. 04/2010; 4(2):202-7.
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    ABSTRACT: Nasal foreign bodies are a common source of referral to accident and emergency departments, especially in young patients. In adults, intranasal foreign bodies are rare and they result mostly from accidents, trauma, or coexisting mental disorders. Rhinoliths are mineralized, calcareous concretions that form in the nasal cavity by deposition of calcareous salts around an endogenous (e.g., teeth, bone fragments, blood clot, mucus, bacteria, or leukocytes) or exogenous (e.g., fruit seeds, beads, buttons, bits of dirt or pebbles, or remains of a gauze tampon) nucleus. This paper reports two cases of intranasal radiopacity. KeywordsForeign body-Rhinolith-Nasal
    Oral Radiology 01/2010; 26(1):41-45. · 0.17 Impact Factor
  • Erdem Kilic, Kerem Kilic, Alper Alkan
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 10/2009; 67(10):2306-10. · 1.58 Impact Factor
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    Alper Alkan, Osman A Etöz
    British Journal of Oral and Maxillofacial Surgery 08/2009; 48(4):310-1. · 2.72 Impact Factor

Publication Stats

269 Citations
61.10 Total Impact Points

Institutions

  • 2007–2013
    • Erciyes Üniversitesi
      • • Department of Oral and Maxillofacial Surgery
      • • Faculty of Dentistry
      Kayseri, Kayseri, Turkey
  • 2001–2006
    • Ondokuz Mayıs Üniversitesi
      • Department of Oral and Maxillofacial Surgery
      Djanik, Samsun, Turkey
    • Ankara University
      • Department of Oral and Maxillofacial Surgery
      Ankara, Ankara, Turkey
  • 2004
    • T.C. Süleyman Demirel Üniversitesi
      • Department of Oral and Maxillofacial Surgery
      Hamitabat, Isparta, Turkey