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ABSTRACT: The incidence of Burkitt lymphoma (BL) during pregnancy is rare. We report a case of nasal BL with symptoms mimicking chronic rhinosinusitis and extensive unilateral polyposis in a pregnant woman. Functional endoscopic sinus surgery was performed. Histopathologic examination suggested a BL, and chemotherapy was initiated. She was not given radiotherapy. She has kept free of disease for 9 months since the completion of treatment. When a physician is confronted with unusual localization among the polypoid tissue described here, a complete differential diagnosis must be done.
The Journal of craniofacial surgery 08/2009; 20(4):1059-60. · 0.81 Impact Factor
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ABSTRACT: Snoring is a common complaint, especially among the elderly individuals. In the treatment of snoring, many options, surgical or nonsurgical, are available. In this randomized study, we used a modified technique including some components of radiofrequency-assisted uvulopalatoplasty (RAUP) and Uvulopalatopharyngoplasty UPPP (modified-RAUP, MRAUP) and RAUP in a control group. A total of 60 patients (58 male and 2 female), 30 in each group (MRAUP and RAUP groups), with an average age of 38 +/- 9 years were included in the study. In the MRAUP group, in addition to the modified surgery, preoperative steroid injection was used as a preemptive analgesic and pre-incisional steroid injection and closure of the edges of the incision were performed to achieve better relief of pain. Snoring score, pain at rest and during swallowing, analgesic consumption and speech score were evaluated using standard 10 cm visual analog scales (VAS). Operation time and other complications were recorded. The patients in the MRAUP group had better pain scores, both at rest and during swallowing, and less analgesic consumption. Although operation time was longer in the MRAUP group compared to that of the RAUP group, snoring score, evaluated from day 1 to the 6th month after operation, was significantly better in the MRAUP group. Postoperative speech scores at each visit were similar in both groups. In the MRAUP group, 87% of the patients (26 patients) had a final VAS for snoring below 3, while in the RAUP group 63% of the patients (19 patients) were below 3 on the scale (P < 0.05). Thus, MRAUP seems to be a promising technique for surgery as a treatment for snoring.
Archives of Oto-Rhino-Laryngology 03/2009; 266(11):1807-14. · 1.29 Impact Factor
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ABSTRACT: Silicosis due to denim (or jean) sandblasters is newly described cause of silicosis. In such cases lungs are severely affected due to heavy exposure to silica without serious protection. We aimed to investigate whether silica had an effect on the upper airways and eyes.
The study included the patients recently diagnosed with silicosis. For comparisons, a control group was constituted. Firstly, a questionnaire was performed to obtain demographic and exposure characteristics of the cases. Later, routine nasal examination by endoscope and routine eye examination by slit-lamp microscope were performed to investigate presence of rhinitis and/or adenoid vegetation and eye findings associated with dust exposure, respectively, in both patient and control groups. Punch biopsies of the adenoid tissue were obtained using an endoscopic telescope with the patient under local anesthesia and sent for histopathologic examination. In addition, nasal pH and mucociliary clearance were investigated. Both pH and saccharin nasal transport time (SNTT) measurements were performed by two physicians, who reached a final consensus.
The study group consisted of 83 male silicotics with an average age of 23 +/- 6 years, and the control group consisted of 84 age and gender matched healthy individuals. Their mean exposure time was 40 +/- 26 months. On routine nasal examination, silicotics had higher rates of rhinitis (28.9% versus 16.7%) mostly ipsilaterally (p = 0.01), adenoid vegetation (32.5% versus 13.3%/, p < 0.05), conjunctival hyperaemia (70% versus 45%, p < 0.001), pingueculae (68% versus 23%, p < 0.01), papillar formation (40% versus 28%), and higher nasal pH values (7.9 +/- 0.7 versus 6.9 +/- 0.6, p < 0.001), higher SNTT values (19.9 +/- 2.9 versus 10.9 +/- 1.9, p < 0.001) compared with the controls.
The results of our study suggest that upper airways and eyes are considerably affected in the patients with silicosis. Thus, appropriate protection is required to prevent the development of such problems in denim sandblasters.
Rhinology 12/2008; 46(4):328-33. · 1.32 Impact Factor
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ABSTRACT: Postoperative vomiting (POV) is a common complication after tonsillectomy. Dexamethasone is known to decrease postsurgical vomiting. In this study, we compared the effects of dexamethasone alone to dexamethasone plus propofol on postoperative vomiting in children undergoing tonsillectomy.
In a randomized double-blinded study, we evaluated 80 healthy children, aged 4-12 years, who underwent tonsillectomy with or without adenoidectomy. After anesthesia was induced by inhalation of sevoflurane, 0.15 mg x kg(-1) dexamethasone and 2 microg x kg(-1) fentanyl was administered i.v. to all patients. The patients in the dexamethasone plus propofol group received 1 mg x kg(-1) propofol before intubation and continuously after intubation at a rate of 20 microg x kg(-1) x min(-1) until the surgery was completed. Data for postoperative vomiting were grouped into the following time periods: 0-4 and 4-24 h. Data were analyzed using a Student's t-test and chi-squared analysis.
The percentage of patients exhibiting a complete response (defined as no retching or vomiting for 24 h) increased from 37.5% in the dexamethasone-alone group to 75% in the dexamethasone plus propofol group (P = 0.001). Twenty-two patients (55%) in the dexamethasone-alone and nine patients (22.5%) in the dexamethasone plus propofol groups experienced vomited during 0-4 h (P = 0.003). Eight patients in the dexamethasone-alone group and three patients in the dexamethasone plus propofol group received ondansetron as a rescue antiemetic during the postoperative period.
For children undergoing tonsillectomy, intraoperative subhypnotic propofol infusion combined with dexamethasone treatment provides a better prophylaxis against postoperative vomiting than does dexamethasone alone.
Pediatric Anesthesia 10/2008; 18(9):878-83. · 2.10 Impact Factor
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ABSTRACT: Epithelioid hemangioendothelioma (EH) is a seldom tumor of vascular origin, which occurs at sites such as liver, lung or soft tissues, and has a highly unpredictable malignant potential and clinical course. We submitted a case with epithelioid hemangioendothelioma of submandibular gland. The patient was a 44-year-old woman who presented with left submandibular painly mass. Fine needle aspiration showed a mixed lymphoid population. Contrast enhanced Computerize Tomography (CT) scan revealed that to be a well-circumscribed and including microcalcification in centre 2.5 cm x 2.0 cm mass in diameter without evidence of bony invasion. Submandibular gland was excised. The pathological result was interpretated as epithelioid hemangioendothelioma of the submandibular gland. The patient was seen regularly for recurrence.
Auris Nasus Larynx 04/2008; 35(1):157-9. · 0.76 Impact Factor
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ABSTRACT: In this study we aimed to determine the role of piracetam (PIR) in preventing radiation induced cochlear damage after total-cranium irradiation (radiotherapy; RT). Male albino guinea pigs used in the study were randomly divided into three groups. Group 1 (Control group) (n=11) received neither PIR nor irradiation, but received saline solution intraperitoneally (i.p.) and received sham irradiation. Group 2 (RT group) (n=32) was exposed to total cranium irradiation of 33 Gy in 5 fractions of 6.6 Gy/d for five successive days, with a calculated (alpha/beta=3.5) biological effective dose of fractionated irradiation equal to 60 Gy conventional fractionation, then received saline solution for five successive days i.p. Group 3 (PIR+RT group) (n=33) received total cranium irradiation, plus 350 mg/kg per day PIR for five successive days i.p. After the last dose of RT, the guinea pigs were all sacrificed at the 4th, 24th and 96th hours, respectively. Their cochleas were enucleated for histopathologic examination. It was observed that total cranium irradiation (RT group) promoted degeneration in stria vascularis (SV), spiral ganglion cells (SG), outer hair cells (OHC) and inner hair cell (IHC) of cochleas at these times (p<0.05). While in the PIR+RT group, there was no statistically significant difference on radiation-induced cochlear degeneration in SV and OHC at 4th (p>0.05) and IHC at 4th, 24th hours (p>0.05), there was a significant difference on radiation-induced cochlear degeneration in SV and OHC at 24th and 96th hours (p<0.05), IHC at 96th hour (p<0.05) and SG at 4th, 24th and 96th hours (p<0.05). There was no any cochlear degeneration in the control group. Piracetam might reduce radiation-induced cochlear damage in the guinea pig. These results are pioneer to studies that will be performed with PIR for radiation toxicity protection.
Biological & Pharmaceutical Bulletin 08/2006; 29(7):1460-5. · 1.66 Impact Factor
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ABSTRACT: L-carnitine (LC) protects cells from peroxidative damage. In this study, we tested whether L-carnitine (LC) prevents radiation-induced cochlear damage after total cranial irradiation (radiotherapy; RT). Male albino guinea pigs were randomly distributed in 3 groups. The Control group (n = 11) received neither LC nor irradiation, but saline solution ip and sham irradiation for 5 days. The RT group (n = 32) received saline solution ip as placebo therapy and exposure to total cranial irradiation of 33 Gy in 5 fractions of 6.6 Gy/day on 5 successive days, with a calculated (alpha/beta = 3.5) biological effective dose of fractionated irradiation equal to 60 Gy conventional fractionation. The LC + RT group (n = 36) received total cranial irradiation, plus LC (100 mg/kg/day, ip) for 5 days. The guinea pigs were killed at 4, 24, or 96 hr after the last dose of RT and the cochleas were enucleated for histopathologic examination. There was no cochlear degeneration in the control group. In the RT group, total cranial irradiation caused degeneration in stria vascularis (SV), spiral ganglion (SG), outer hair cells (OHC), and inner hair cells (IHC) of cochleas at 4, 24, and 96 hr. In the LC + RT group, LC administration reduced radiation-induced cochlear degeneration in SV and SG at 4, 24, and 96 hr, and in OHC and IHC at 24 and 96 hr (p <0.05). Thus, this study shows that L-carnitine can ameliorate radiation-induced cochlear damage in guinea pigs.
Annals of clinical and laboratory science 01/2006; 36(3):312-8. · 0.96 Impact Factor
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ABSTRACT: Aim. To investigate the protective effect of piracetam in preventing combined cisplatin and gentamicin-induced ototoxicity in a guinea pig model.Methods. Thirty-two male albino adult guinea pigs were used in this study. The animals were separated into three groups: Group I (control group; n = 10) received saline, Group II (CG group; n = 12) received combined cisplatin (3.5 mg/kg = 3.5 ml/kg) and gentamicin (100 mg/kg = 2.5 ml/kg), and Group III (PCG group; n = 10) received piracetam (350 mg/kg = 1.75 ml/kg) plus the combined cisplatin (3.5 mg/kg = 3.5 ml/kg) and gentamicin (100 mg/kg = 2.5 ml/kg) as a single dose/day for 5 consecutive days, intraperitoneally. Auditory brainstem response (ABR), wave absolute latencies (ALs) and interpeak latencies (IPLs) for each ear (n = 64) of all animals (n = 32) were monitored.Results. Significant differences were found between CG and PCG groups in terms of ABR wave II AL (p < 0.01), III AL (p < 0.001), IV AL (p < 0.001), I-III IPL (p < 0.001), III-IV IPL (p < 0.01) and I-IV IPL values (p < 0.001). No significant difference was found in I AL value (p > 0.05).Conclusion. These data show that piracetam has a protective effect against the ototoxicity produced by administration of combined cisplatin and gentamicin.
The Pain Clinic 09/2004; 16(4):427-433.
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ABSTRACT: The aims of this study were: (a) to assess whether the increased oxidative stress in otitis media with effusion (OME) induced in guinea pigs by histamine injection into the middle ear cavity is reflected by lipid peroxidation in erythrocytes, plasma, and middle ear effusion fluid; (b) to survey the alterations of oxidant and antioxidant enzyme activities in experimental OME; and (c) to determine the effects of melatonin and methylprednisolone on this oxidative stress. Malondialdehyde (MDA) level, erythrocyte total (enzymatic plus non-enzymatic) superoxide scavenger activity (TSSA), non-enzymatic superoxide scavenger activity (NSSA), superoxide dismutase (SOD), catalase (CAT), and xanthine oxidase (XO) activities were measured in 4 groups of 7 guinea pigs at 3 hr after injection of 0.1 ml of histamine (or saline) into the middle ear. Group I was the control group, Group II was an experimental group with OME induced by histamine, Group III was a melatonin-pretreated OME group, and Group IV was a methylprednisolone-pretreated OME group. In erythrocyte, plasma, and middle ear effusion samples, MDA levels were significantly increased in guinea pigs with OME (Group II), compared to controls (Group I); erythrocyte TSSA and SOD activities were lower and erythrocyte XO activity was increased in guinea pigs with OME (Group II) compared to controls (Group I). No significant differences were found in erythrocyte NSSA and CAT activities. In Group III, pretreatment of guinea pigs with i.p. melatonin at 1 hr prior to histamine induction of OME decreased the erythrocyte, plasma, and effusion MDA levels, compared to Group II; erythrocyte XO activity was diminished and erythrocyte TSSA, SOD, and CAT activities were increased in Group III compared to Group II. In Group IV, pretreatment of guinea pigs with i.p. methylprednisolone at 1 hr prior to histamine induction of OME decreased the plasma and effusion MDA levels and increased the erythrocyte TSSA and SOD activities, compared to Group II. These results suggest that reactive oxygen species (ROS) play a role in histamine-induced OME. Pretreatment with i.p. melatonin or methylprednisolone both decrease the ROS generated by experimental OME, but melatonin appears to be more effective than methylprednisolone.
Annals of clinical and laboratory science 02/2004; 34(3):341-6. · 0.96 Impact Factor
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ABSTRACT: Nasal polyp (NP) is considered an inflammatory condition in nasal and paranasal sinus cavities and is frequently encountered in otolaryngology clinics. Although the pathophysiology of nasal polyps is poorly understood, it seems likely that the epithelium may play a critical role in the genesis of inflammatory nasal disease. The aim of this study was to investigate the role of free radicals and antioxidant enzymes in NP and compare these findings with concha bullosa (CB). NP and CB were obtained from 27 and 23 patients, respectively. Glutathione peroxidase (GSH-Px), catalase (CAT), xanthine oxidase (XO) total (enzymic plus non-enzymic) superoxide scavenger activity (TSSA), non-enzymic superoxide scavenger activity (NSSA), superoxide dismutase (SOD), and MDA levels in NP and CB were measured. GSH-Px activiy was significantly lower in patients with NP than in the CB group. However, CAT, XO activities and MDA levels were significantly higher in patients with NP than in the CB group, but TSSA, NSSA and SOD activities were unchanged. Increases in the levels of tissue MDA in patients with NP compared to the CB group may indicate the presence of free radical damage in patients with nasal NP.
Cell Biochemistry and Function 24(5):461-5. · 1.77 Impact Factor
