Sheng-Hsiang Lin

Fu Jen Catholic University, T’ai-pei, Taipei, Taiwan

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Publications (47)107.68 Total impact

  • Chien-Ming Chao · Chih-Cheng Lai · Shih-Horng Huang · Sheng-Hsiang Lin
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    ABSTRACT: Background: The aim of this study was to compare skin and soft tissue infections (SSTIs) caused by Vibrio and Aeromonas spp. Methods: Patients whose cultures yielded Vibrio or Aeromonas spp. from July 2004 to June 2010 were retrieved from the computerized database of the bacteriology laboratory at a hospital in southern Taiwan. The medical records were reviewed for all patients fulfilling the criteria of monomicrobial Vibrio or Aeromonas spp. SSTIs and the clinical characteristics were analyzed. Results: During the study period, there were 28 patients with Vibrio spp. and 26 patients with Aeromonas spp., respectively. Vibrio vulnificus (n=25) and A. hydrophila (n=14) were the most common spp. There were no significant differences in age, gender, underlying diseases between patients with Vibrio and Aeromonas SSTIs. In comparison to Aeromonas SSTIs, more patients with Vibrio SSTIs were complicated with acute respiratory failure (39.3% vs. 3.8%, p=0.002) and required intensive care unit admission (50.0% vs. 7.7%, p<0.001). Furthermore, patients with Aeromonas SSTIs had a higher likelihood of discharge alone within 30 days than Vibrio SSTIs (p=0.049). The difference in in-hospital mortality among the two groups was not statistically significant (p=0.11). Conclusion: Both Aeromonas and Vibrio spp. cause SSTIs in southern Taiwan and the pathogenicity of Vibrio spp. might be higher than Aeromonas spp.
    Surgical Infections 08/2014; 15(5). DOI:10.1089/sur.2013.065 · 1.45 Impact Factor
  • Sheng-Hsiang Lin · Yu-Shu Liao · Shih-Horng Huang · Wan-Hsiu Liao
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    ABSTRACT: Background: The association between betel quid (BQ) chewing and oral cancer is well established. However, evidence regarding the relationship between BQ chewing and cardiovascular disease (CVD) is still insufficient. Methods: This cross-sectional study included 2002 men and 1175 women aged 50 and older in a city-level health examination survey of an agricultural and fishing population in 2013. In addition to anthropometric parameters, CVD risks were estimated using high-sensitivity C-reactive protein (hs-CRP), brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index. Age, gender, smoking and alcohol drinking status were all incorporated into the multivariate logistic regression model to delineate the effect of BQ chewing on CVD risks. Results: Two hundred forty-one (12%) males and eight (0.7%) females were ever chewers. BQ chewing was an independent risk factor for general obesity (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.07-1.91, p=0.017), central obesity (OR 2.27, 95% CI 1.53-3.37, p<0.001) and an elevated hs-CRP level (OR 1.38, 95% CI 1.03-1.85, p=0.029). Subjects who chewed more frequently had a higher systolic blood pressure (p=0.025) and baPWV (p=0.006). The waist circumference (p=0.015) and waist-to-height ratio (p=0.022) were greater in current chewers than in former chewers. Conclusion: These findings suggest that BQ chewing is associated with obesity and a higher CVD risk as estimated by hs-CRP. Furthermore, potential beneficial effects of BQ chewing cessation on central obesity were also found.
    Drug and Alcohol Dependence 06/2014; 141. DOI:10.1016/j.drugalcdep.2014.05.020 · 3.42 Impact Factor
  • Wan-Hsiu Liao · Chih-Cheng Lai · Shih-Horng Huang · Sheng-Hsiang Lin
    Surgical Infections 05/2014; 15(4). DOI:10.1089/sur.2013.183 · 1.45 Impact Factor
  • Sheng-Hsiang Lin · Chih-Cheng Lai · Shih-Horng Huang
    Surgical Infections 05/2014; 15(3). DOI:10.1089/sur.2013.105 · 1.45 Impact Factor
  • Chih-Cheng Lai · Wan-Hsiu Liao · Shih-Horng Huang · Sheng-Hsiang Lin
    Internal Medicine 03/2014; 53(5):517. DOI:10.2169/internalmedicine.53.1604 · 0.90 Impact Factor
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    ABSTRACT: It is essential to investigate the serotype distribution of pneumococcal diseases in each region and its associated clinical features. This study investigated the annual incidence of invasive pneumococcal disease (IPD) and the distribution of serotypes of isolates causing IPD at a medical center in northern Taiwan during the period 2000 to 2012. Serotypes of all available Streptococcus pneumoniae isolates causing IPD were determined using the latex agglutination test. During the study period, the annual incidence (per 10,000 admissions) of IPD decreased significantly from 9.8 in 2000 to 2.1 in 2012 (P < 0.001). The annual incidence of all-cause bacteremia, primary pneumococcal bacteremia, bacteremic pneumonia, peritonitis, and meningitis also decreased significantly during the study period (P < 0.05). In contrast to the decrease in annual incidence of pneumococcal serotypes 14, 23F and 6B, the incidence and the proportion of serotype 19A significantly increased with time (P < 0.001). The coverage rate of 7-valent protein conjugated vaccine (PCV-7) and PCV-10 decreased significantly; however, the coverage rate of PCV-13 and pneumococcal polysaccharide vaccine (PPV-23) remained stable over time. Serotype 14 and 19A isolates were commonly isolated from blood and pleural effusion, respectively. Serotypes 14 and 23F were the two most common serotypes found in adult patients, and serotypes 14 and 19A were the two most common serotypes isolated from children. Although the incidence of IPD has decreased, serotype 19A is an emerging problem in Taiwan. The distribution of serotypes of pneumococci varied with clinical symptoms and age. As the changing distribution of pneumococcal serotype with time, the coverage rate of pneumococcal vaccines would be different.
    BMC Infectious Diseases 02/2014; 14(1):76. DOI:10.1186/1471-2334-14-76 · 2.61 Impact Factor
  • Sheng-Hsiang Lin · Shih-Horng Huang · Wan-Hsiu Liao
    Case Reports 09/2013; 2013(sep29_1). DOI:10.1136/bcr-2013-200658
  • Wan-Hsiu Liao · Chih-Cheng Lai · Shih-Horng Huang · Sheng-Hsiang Lin
    Case Reports 09/2013; 2013. DOI:10.1136/bcr-2013-201004
  • Shih-Horng Huang · Chih-Cheng Lai · Sheng-Hsiang Lin
    Internal Medicine 09/2013; 52(18):2167. DOI:10.2169/internalmedicine.52.0959 · 0.90 Impact Factor
  • Dong-Rong Tsai · Shih-Horng Huang · Sheng-Hsiang Lin
    Case Reports 09/2013; 2013. DOI:10.1136/bcr-2013-200591
  • Wei-Lun Liu · Sheng-Hsiang Lin · Szu-Yi Chiang · Chih-Cheng Lai
    Internal Medicine 09/2013; 52(17):2007-2008. DOI:10.2169/internalmedicine.52.9500 · 0.90 Impact Factor
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    ABSTRACT: To investigate the clinical characteristics of Clostridium difficile infection (CDI) at a medical center in Taiwan. Patients with CDI were identified from medical records at the National Taiwan University Hospital (Taipei, Taiwan). The following information was gathered and analyzed to better understand the clinical manifestations of CDI: age; gender; underlying immunocompromised conditions; laboratory data; in-hospital mortality; and previous use of drugs such as antimicrobial agents, steroids, and antipeptic ulcer agents. During the years 2000-2010, 122 patients were identified as having CDI. This included 92 patients with nontoxigenic CDI (i.e., positive stool culture for C. difficile but negative results for toxins A and B) and 30 patients with toxigenic CDI (i.e., positive stool culture cultures for C. difficile and positive results for toxins A and B). Of the 122 patients, 48 (39%) patients were older than 65 years and most patients acquired the CDI while in the hospital. Active cancer was the most common reason for hospitalization, followed by diabetes mellitus, and end-stage renal disease. More than 90% of the patients had received antibiotics prior to acquiring CDI. The results of fecal leukocyte examinations were positive in 33 (27%) patients. The overall in-hospital mortality rate was 26.2%. There were no significant differences between patients with nontoxigenic CDI and patients with toxigenic CDI. Clostridium difficile infection can develop in healthcare facilities and in community settings, especially in immunocompromised patients.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 08/2013; 47(6). DOI:10.1016/j.jmii.2013.06.007 · 2.35 Impact Factor
  • Sheng-Hsiang Lin · Wan-Hsiu Liao · Shih-Horng Huang
    Case Reports 08/2013; 2013. DOI:10.1136/bcr-2013-200966
  • Chien-Ming Chao · Sheng-Hsiang Lin · Chih-Cheng Lai
    Journal of the American Geriatrics Society 08/2013; 61(8):1432-3. DOI:10.1111/jgs.12375 · 4.57 Impact Factor
  • Chih-Cheng Lai · Shih-Horng Huang · Wan-Hsiu Liao · Sheng-Hsiang Lin
    Postgraduate medical journal 07/2013; 89(1058). DOI:10.1136/postgradmedj-2013-131761 · 1.45 Impact Factor
  • Chih-Cheng Lai · Shih-Horng Huang · Tsu-Tuan Wu · Sheng-Hsiang Lin
    Postgraduate medical journal 05/2013; 89(1053). DOI:10.1136/postgradmedj-2012-131750 · 1.45 Impact Factor
  • Chih-Cheng Lai · Sheng-Hsiang Lin · Wang-Huei Sheng · Po-Ren Hsueh
    International journal of antimicrobial agents 03/2013; 41(6). DOI:10.1016/j.ijantimicag.2013.02.002 · 4.30 Impact Factor
  • The Journal of infection 06/2012; 65(4):372-4. DOI:10.1016/j.jinf.2012.06.011 · 4.44 Impact Factor
  • Source
    Sheng-Hsiang Lin · Yu-Shu Liao
    Canadian Medical Association Journal 03/2012; 184(10):1171. DOI:10.1503/cmaj.111671 · 5.96 Impact Factor
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    ABSTRACT: The aim of this study was to compare the diagnostic performance of 2 interferon-γ release assays, an enzyme-linked immunospot assay (T-SPOT.TB; Oxford Immunotec Ltd., Oxford, UK) and the QuantiFERON-TB Gold in-Tube assay (QFT-GIT; Cellestis Ltd., Carnegie, Australia), in patients with suspected active tuberculosis (TB). From October 2009 to October 2011, a total of 200 patients with suspected TB were enrolled. Clinical and microbiological characteristics of the patients were collected and blood samples were obtained for T-SPOT.TB and QFT-GIT assays. Among the 200 subjects, 98 (49%) had culture-confirmed TB, 18 (9%) had probable TB, and the remaining 84 (42%) subjects did not have TB. The sensitivity, specificity, positive predictive value, and negative predictive value for active TB diagnosis by the T SPOT. TB were 83%, 71%, 81%, and 75%, respectively. For QFT-GIT, the sensitivity, specificity, positive predictive value, and negative predictive value for active TB diagnosis were 66%, 76%, 80%, and 62%, respectively. The QFT-GIT assay resulted in more indeterminate and false-negative results than the T-SPOT.TB assay, especially in immunocompromised patients. In conclusion, T-SPOT.TB had a higher sensitivity and resulted in fewer indeterminate results than the QFT-GIT assay for diagnosing active TB.
    Diagnostic microbiology and infectious disease 08/2011; 71(2):139-43. DOI:10.1016/j.diagmicrobio.2011.05.013 · 2.46 Impact Factor

Publication Stats

127 Citations
107.68 Total Impact Points


  • 2013–2014
    • Fu Jen Catholic University
      T’ai-pei, Taipei, Taiwan
  • 2011–2013
    • New Taipei City Hospital
      T’ai-pei, Taipei, Taiwan
  • 2010–2013
    • Chi-Mei Medical Center
      臺南市, Taiwan, Taiwan
    • Taipei Medical University
      • Department of Internal Medicine
      Taipei, Taipei, Taiwan
    • Far Eastern Memorial Hospital
      • Department of Internal Medicine
      T’ai-pei, Taipei, Taiwan
  • 2007
    • Taipei City Hospital
      T’ai-pei, Taipei, Taiwan